Pdlim2

Functionⁱ

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

alpha-actinin binding
Source: RGD
Inferred from physical interactionⁱ
- 15505042
filamin binding
Source: RGD
Inferred from physical interactionⁱ
- 15505042
metal ion binding Source: UniProtKB-KW
muscle alpha-actinin binding
Source: RGD
Inferred from physical interactionⁱ
- 15505042
myosin heavy chain binding
Source: RGD
Inferred from physical interactionⁱ
- 15505042

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PDZ and LIM domain protein 2
Gene namesⁱ	Name:Pdlim2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 15

Organism-specific databases

Rat genome database More...RGDⁱ	1359203 Pdlim2

RGDⁱ

1359203 Pdlim2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075865	1 – 349	PDZ and LIM domain protein 2Add BLAST		349

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	124	PhosphoserineBy similarity	1
Modified residueⁱ	127	PhosphoserineBy similarity	1
Modified residueⁱ	129	PhosphoserineBy similarity	1
Modified residueⁱ	134	PhosphoserineBy similarity	1
Modified residueⁱ	137	PhosphoserineBy similarity	1
Modified residueⁱ	138	PhosphothreonineBy similarity	1
Modified residueⁱ	142	PhosphothreonineBy similarity	1
Modified residueⁱ	143	PhosphoserineBy similarity	1
Modified residueⁱ	163	PhosphoserineBy similarity	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	204	PhosphoserineBy similarity	1
Modified residueⁱ	205	PhosphoserineBy similarity	1
Modified residueⁱ	209	PhosphoserineBy similarity	1
Modified residueⁱ	210	PhosphoserineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6AYD6
PRIDEⁱ	Q6AYD6

PTM databases

iPTMnetⁱ	Q6AYD6
PhosphoSitePlusⁱ	Q6AYD6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in cornea and lung. Expressed at intermediate level in sclera and combined tissues of the eye irido-corneal angle. Specifically expressed in the corneal epithelial cells but not in other corneal layers.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000008543 Expressed in 9 organ(s), highest expression level in lung
Genevisibleⁱ	Q6AYD6 RN

Interactionⁱ

Subunit structureⁱ

Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.1 Publication

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	253175, 5 interactors
STRINGⁱ	10116.ENSRNOP00000011663

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6AYD6
SMRⁱ	Q6AYD6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 84	PDZPROSITE-ProRule annotationAdd BLAST		84
Domainⁱ	281 – 341	LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST		61

Keywords - Domainⁱ

LIM domain

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00590000082980
HOGENOMⁱ	HOG000290704
HOVERGENⁱ	HBG061371
InParanoidⁱ	Q6AYD6
OMAⁱ	FQSLAHS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A6C
PhylomeDBⁱ	Q6AYD6
TreeFamⁱ	TF106408

Family and domain databases

InterProⁱ	View protein in InterPro IPR031847 DUF4749 IPR001478 PDZ IPR036034 PDZ_sf IPR001781 Znf_LIM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15936 DUF4749, 1 hit PF00412 LIM, 1 hit PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 1 hit PS50023 LIM_DOMAIN_2, 1 hit PS50106 PDZ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6AYD6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALTVNVVGP APWGFRISGG RDFHTPIIVT KVTERGKAEA ADLRPGDIIV 
        60         70         80         90        100
AINGESAESM LHAEAQSKIR QSASPLRLQL DRSQTASPGQ INGEGSLDML 
       110        120        130        140        150
ATRFQGSLRT HHNSQSSQRS ACFSPASLSP RPDSPFSTPP PTSPIALSGE 
       160        170        180        190        200
NVIGCSFQSL THSPGLAATH HLTYPGQPTS QQAGHSSPSD STVRVLLHSP 
       210        220        230        240        250
GRPSSPRLSS LDLEEDSEVF KMLQENRQGR AAPRQSSSFR LLQEALEAEE 
       260        270        280        290        300
RGGTPAFVPS SLSPKASLPT SRALATPPKL HTCEKCSVNI SNQAVRIQEG 
       310        320        330        340 
RYRHPGCYTC ADCGLNLKMR GHFWVGNELY CEKHARQRYS MPGTLSSQA

Length:349

Mass (Da):37,580

Last modified:September 13, 2004 - v1

Checksum:ⁱ39AE7B31979668D8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY531526 mRNA Translation: AAS99334.1 BC079091 mRNA Translation: AAH79091.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001007623.1, NM_001007622.1 XP_006252318.1, XM_006252256.3 XP_006252319.1, XM_006252257.3 XP_006252320.1, XM_006252258.2 XP_006252321.1, XM_006252259.3 XP_008769045.1, XM_008770823.2
UniGeneⁱ	Rn.105730

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011663; ENSRNOP00000011663; ENSRNOG00000008543
GeneIDⁱ	290354
KEGGⁱ	rno:290354
UCSC genome browser More...UCSCⁱ	RGD:1359203 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6AYD6	PDZ and LIM domain protein 2	)	MOUSE		349	UniRef90_Q6AYD6
UPI0003D0B3C9		RAT		386
UPI000A30ACCE		MUSPA		351
UPI000A31A966		MUSCR		349
PDZ and LIM domain protein 2 (Fragment)		MOUSE		217
+4

Protein	Similar proteins		Species	Score	Length	Source
Q6AYD6	Isoform 3 of PDZ and LIM domain protein 2		HUMAN		366	UniRef50_Q96JY6-3
PDZ and LIM domain protein 2		MACFA		352
PDZ and LIM domain protein 2	)	MOUSE		349
Uncharacterized protein		PONAB		366
Uncharacterized protein		PANPA		366
+109

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY531526 mRNA Translation: AAS99334.1 BC079091 mRNA Translation: AAH79091.1
RefSeqⁱ	NP_001007623.1, NM_001007622.1 XP_006252318.1, XM_006252256.3 XP_006252319.1, XM_006252257.3 XP_006252320.1, XM_006252258.2 XP_006252321.1, XM_006252259.3 XP_008769045.1, XM_008770823.2
UniGeneⁱ	Rn.105730

3D structure databases

ProteinModelPortalⁱ	Q6AYD6
SMRⁱ	Q6AYD6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	253175, 5 interactors
STRINGⁱ	10116.ENSRNOP00000011663

PTM databases

iPTMnetⁱ	Q6AYD6
PhosphoSitePlusⁱ	Q6AYD6

Proteomic databases

PaxDbⁱ	Q6AYD6
PRIDEⁱ	Q6AYD6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011663; ENSRNOP00000011663; ENSRNOG00000008543
GeneIDⁱ	290354
KEGGⁱ	rno:290354
UCSCⁱ	RGD:1359203 rat

Organism-specific databases

CTDⁱ	64236
RGDⁱ	1359203 Pdlim2

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
GeneTreeⁱ	ENSGT00590000082980
HOGENOMⁱ	HOG000290704
HOVERGENⁱ	HBG061371
InParanoidⁱ	Q6AYD6
OMAⁱ	FQSLAHS
OrthoDBⁱ	EOG091G0A6C
PhylomeDBⁱ	Q6AYD6
TreeFamⁱ	TF106408

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6AYD6

PROⁱ

PR:Q6AYD6

Gene expression databases

Bgeeⁱ	ENSRNOG00000008543 Expressed in 9 organ(s), highest expression level in lung
Genevisibleⁱ	Q6AYD6 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR031847 DUF4749 IPR001478 PDZ IPR036034 PDZ_sf IPR001781 Znf_LIM
Pfamⁱ	View protein in Pfam PF15936 DUF4749, 1 hit PF00412 LIM, 1 hit PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 1 hit PS50023 LIM_DOMAIN_2, 1 hit PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDLI2_RAT
Accessionⁱ	Q6AYD6Primary (citable) accession number: Q6AYD6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
	Last sequence update:	September 13, 2004
	Last modified:	September 12, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6AYD6 (PDLI2_RAT)

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PDZ and LIM domain protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ