UniProtKB - Q6AYD6 (PDLI2_RAT)
Protein
PDZ and LIM domain protein 2
Gene
Pdlim2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).By similarity1 Publication
GO - Molecular functioni
- actin binding Source: GO_Central
- alpha-actinin binding Source: RGD
- filamin binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- muscle alpha-actinin binding Source: RGD
- myosin heavy chain binding Source: RGD
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- heart development Source: GO_Central
- muscle structure development Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: PDZ and LIM domain protein 2 |
Gene namesi | Name:Pdlim2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359203, Pdlim2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Localizes at the cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
Cytoskeleton
- filamentous actin Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- Z disc Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075865 | 1 – 349 | PDZ and LIM domain protein 2Add BLAST | 349 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 127 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 | |
Modified residuei | 134 | PhosphoserineBy similarity | 1 | |
Modified residuei | 137 | PhosphoserineBy similarity | 1 | |
Modified residuei | 138 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 142 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 163 | PhosphoserineBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | PhosphoserineBy similarity | 1 | |
Modified residuei | 205 | PhosphoserineBy similarity | 1 | |
Modified residuei | 209 | PhosphoserineBy similarity | 1 | |
Modified residuei | 210 | PhosphoserineCombined sources | 1 | |
Modified residuei | 263 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6AYD6 |
PRIDEi | Q6AYD6 |
PTM databases
iPTMneti | Q6AYD6 |
PhosphoSitePlusi | Q6AYD6 |
Expressioni
Tissue specificityi
Highly expressed in cornea and lung. Expressed at intermediate level in sclera and combined tissues of the eye irido-corneal angle. Specifically expressed in the corneal epithelial cells but not in other corneal layers.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000008543, Expressed in esophagus and 21 other tissues |
Genevisiblei | Q6AYD6, RN |
Interactioni
Subunit structurei
Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.
1 PublicationGO - Molecular functioni
- actin binding Source: GO_Central
- alpha-actinin binding Source: RGD
- filamin binding Source: RGD
- muscle alpha-actinin binding Source: RGD
- myosin heavy chain binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 253175, 5 interactors |
STRINGi | 10116.ENSRNOP00000011663 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 84 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 281 – 341 | LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST | 61 |
Keywords - Domaini
LIM domainPhylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000160418 |
HOGENOMi | CLU_038114_1_1_1 |
InParanoidi | Q6AYD6 |
OMAi | SKHHTCE |
OrthoDBi | 840552at2759 |
PhylomeDBi | Q6AYD6 |
TreeFami | TF106408 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR031847, DUF4749 IPR001478, PDZ IPR036034, PDZ_sf IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF15936, DUF4749, 1 hit PF00412, LIM, 1 hit PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6AYD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALTVNVVGP APWGFRISGG RDFHTPIIVT KVTERGKAEA ADLRPGDIIV
60 70 80 90 100
AINGESAESM LHAEAQSKIR QSASPLRLQL DRSQTASPGQ INGEGSLDML
110 120 130 140 150
ATRFQGSLRT HHNSQSSQRS ACFSPASLSP RPDSPFSTPP PTSPIALSGE
160 170 180 190 200
NVIGCSFQSL THSPGLAATH HLTYPGQPTS QQAGHSSPSD STVRVLLHSP
210 220 230 240 250
GRPSSPRLSS LDLEEDSEVF KMLQENRQGR AAPRQSSSFR LLQEALEAEE
260 270 280 290 300
RGGTPAFVPS SLSPKASLPT SRALATPPKL HTCEKCSVNI SNQAVRIQEG
310 320 330 340
RYRHPGCYTC ADCGLNLKMR GHFWVGNELY CEKHARQRYS MPGTLSSQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY531526 mRNA Translation: AAS99334.1 BC079091 mRNA Translation: AAH79091.1 |
RefSeqi | NP_001007623.1, NM_001007622.1 XP_006252318.1, XM_006252256.3 XP_006252319.1, XM_006252257.3 XP_006252320.1, XM_006252258.2 XP_006252321.1, XM_006252259.3 XP_008769045.1, XM_008770823.2 |
Genome annotation databases
Ensembli | ENSRNOT00000011663; ENSRNOP00000011663; ENSRNOG00000008543 |
GeneIDi | 290354 |
KEGGi | rno:290354 |
UCSCi | RGD:1359203, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY531526 mRNA Translation: AAS99334.1 BC079091 mRNA Translation: AAH79091.1 |
RefSeqi | NP_001007623.1, NM_001007622.1 XP_006252318.1, XM_006252256.3 XP_006252319.1, XM_006252257.3 XP_006252320.1, XM_006252258.2 XP_006252321.1, XM_006252259.3 XP_008769045.1, XM_008770823.2 |
3D structure databases
SMRi | Q6AYD6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 253175, 5 interactors |
STRINGi | 10116.ENSRNOP00000011663 |
PTM databases
iPTMneti | Q6AYD6 |
PhosphoSitePlusi | Q6AYD6 |
Proteomic databases
PaxDbi | Q6AYD6 |
PRIDEi | Q6AYD6 |
Genome annotation databases
Ensembli | ENSRNOT00000011663; ENSRNOP00000011663; ENSRNOG00000008543 |
GeneIDi | 290354 |
KEGGi | rno:290354 |
UCSCi | RGD:1359203, rat |
Organism-specific databases
CTDi | 64236 |
RGDi | 1359203, Pdlim2 |
Phylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000160418 |
HOGENOMi | CLU_038114_1_1_1 |
InParanoidi | Q6AYD6 |
OMAi | SKHHTCE |
OrthoDBi | 840552at2759 |
PhylomeDBi | Q6AYD6 |
TreeFami | TF106408 |
Miscellaneous databases
PROi | PR:Q6AYD6 |
Gene expression databases
Bgeei | ENSRNOG00000008543, Expressed in esophagus and 21 other tissues |
Genevisiblei | Q6AYD6, RN |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR031847, DUF4749 IPR001478, PDZ IPR036034, PDZ_sf IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF15936, DUF4749, 1 hit PF00412, LIM, 1 hit PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDLI2_RAT | |
Accessioni | Q6AYD6Primary (citable) accession number: Q6AYD6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |