UniProtKB - Q6AY87 (THOC6_RAT)
Protein
THO complex subunit 6 homolog
Gene
Thoc6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role in apoptosis negative control involved in brain development (By similarity).By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- central nervous system development Source: UniProtKB
- mRNA export from nucleus Source: RGD
- mRNA processing Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- RNA splicing Source: UniProtKB-KW
- viral mRNA export from host cell nucleus Source: RGD
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Biological process | Apoptosis, mRNA processing, mRNA splicing, mRNA transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-RNO-72187, mRNA 3'-end processing R-RNO-73856, RNA Polymerase II Transcription Termination |
Names & Taxonomyi
Protein namesi | Recommended name: THO complex subunit 6 homologAlternative name(s): WD repeat-containing protein 58 |
Gene namesi | Name:Thoc6 Synonyms:Pdrp, wdr58 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708553, Thoc6 |
Subcellular locationi
Nucleus
- Nucleus By similarity
- Nucleus speckle By similarity
Nucleus
- nuclear chromosome, telomeric region Source: Ensembl
- nuclear speck Source: UniProtKB-SubCell
- nucleus Source: UniProtKB
- THO complex Source: RGD
- THO complex part of transcription export complex Source: RGD
- transcription export complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233160 | 1 – 341 | THO complex subunit 6 homologAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 180 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q6AY87 |
PaxDbi | Q6AY87 |
PRIDEi | Q6AY87 |
PTM databases
iPTMneti | Q6AY87 |
PhosphoSitePlusi | Q6AY87 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000003497, Expressed in thymus and 21 other tissues |
ExpressionAtlasi | Q6AY87, baseline and differential |
Genevisiblei | Q6AY87, RN |
Interactioni
Subunit structurei
Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000004672 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 61 | WD 1Add BLAST | 40 | |
Repeati | 74 – 112 | WD 2Add BLAST | 39 | |
Repeati | 124 – 163 | WD 3Add BLAST | 40 | |
Repeati | 166 – 205 | WD 4Add BLAST | 40 | |
Repeati | 215 – 254 | WD 5Add BLAST | 40 | |
Repeati | 256 – 293 | WD 6Add BLAST | 38 | |
Repeati | 295 – 339 | WD 7Add BLAST | 45 |
Sequence similaritiesi
Belongs to the WD repeat THOC6 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0649, Eukaryota |
GeneTreei | ENSGT00390000015278 |
HOGENOMi | CLU_060667_0_0_1 |
InParanoidi | Q6AY87 |
OMAi | WEVKIPM |
OrthoDBi | 760323at2759 |
PhylomeDBi | Q6AY87 |
TreeFami | TF324760 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR042626, THOC6 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR44411, PTHR44411, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6AY87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHATPLAVP LGQAEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI
60 70 80 90 100
FSLSAALSSE AKEESKKPMV TFHAHDGPVY SMVSTDRHLL SAGDGEVKGW
110 120 130 140 150
LWAEILKKGC KELWRRQPPY RTSLEVPEIN ALLLVPKENS LILAGGDCQL
160 170 180 190 200
HTMDLETGTF TRALRGHTDY IHCLALRERS PEVLSGGEDG AVRLWDLRIA
210 220 230 240 250
KEVQTIEVYK HEECSRPHNG RWIGCLATDS DWMVCGGGPA LTLWHLRSST
260 270 280 290 300
PTTVFPIRAP QKHVTFYQDL ILSAGQGCCV NHWQLSGELK AQVPGSSPGL
310 320 330 340
LSLSLNQQPA APECKVLTAS GNSCRVDVFT NLGYRAFSLS F
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K7G1 | A0A0G2K7G1_RAT | THO complex subunit 6 homolog | Thoc6 | 104 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079149 mRNA Translation: AAH79149.1 |
RefSeqi | NP_077360.2, NM_024384.2 |
Genome annotation databases
Ensembli | ENSRNOT00000004672; ENSRNOP00000004672; ENSRNOG00000003497 |
GeneIDi | 79227 |
KEGGi | rno:79227 |
UCSCi | RGD:708553, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079149 mRNA Translation: AAH79149.1 |
RefSeqi | NP_077360.2, NM_024384.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000004672 |
PTM databases
iPTMneti | Q6AY87 |
PhosphoSitePlusi | Q6AY87 |
Proteomic databases
jPOSTi | Q6AY87 |
PaxDbi | Q6AY87 |
PRIDEi | Q6AY87 |
Genome annotation databases
Ensembli | ENSRNOT00000004672; ENSRNOP00000004672; ENSRNOG00000003497 |
GeneIDi | 79227 |
KEGGi | rno:79227 |
UCSCi | RGD:708553, rat |
Organism-specific databases
CTDi | 79228 |
RGDi | 708553, Thoc6 |
Phylogenomic databases
eggNOGi | KOG0649, Eukaryota |
GeneTreei | ENSGT00390000015278 |
HOGENOMi | CLU_060667_0_0_1 |
InParanoidi | Q6AY87 |
OMAi | WEVKIPM |
OrthoDBi | 760323at2759 |
PhylomeDBi | Q6AY87 |
TreeFami | TF324760 |
Enzyme and pathway databases
Reactomei | R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-RNO-72187, mRNA 3'-end processing R-RNO-73856, RNA Polymerase II Transcription Termination |
Miscellaneous databases
PROi | PR:Q6AY87 |
Gene expression databases
Bgeei | ENSRNOG00000003497, Expressed in thymus and 21 other tissues |
ExpressionAtlasi | Q6AY87, baseline and differential |
Genevisiblei | Q6AY87, RN |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR042626, THOC6 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR44411, PTHR44411, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THOC6_RAT | |
Accessioni | Q6AY87Primary (citable) accession number: Q6AY87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families