UniProtKB - Q6AY86 (VP26A_RAT)
Vacuolar protein sorting-associated protein 26A
Vps26a
Functioni
GO - Biological processi
- intracellular protein transport Source: GO_Central
- retrograde transport, endosome to Golgi Source: UniProtKB
- retrograde transport, endosome to plasma membrane Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-3238698, WNT ligand biogenesis and trafficking |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 26AAlternative name(s): Vesicle protein sorting 26A |
Gene namesi | Name:Vps26a Synonyms:Vps26 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359254, Vps26a |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Peripheral membrane protein By similarity
- Early endosome By similarity
Other locations
- Cytoplasm By similarity
Note: Localizes to tubular profiles adjacent to endosomes. Predominantly found in early not late endosomes.By similarity
Cytosol
- cytosol Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
- endosome Source: UniProtKB
- endosome membrane Source: RGD
- tubular endosome Source: UniProtKB
Lysosome
- lysosome Source: Ensembl
Other locations
- retromer complex Source: ParkinsonsUK-UCL
- retromer, cargo-selective complex Source: RGD
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073009 | 1 – 327 | Vacuolar protein sorting-associated protein 26AAdd BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 315 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q6AY86 |
PaxDbi | Q6AY86 |
PRIDEi | Q6AY86 |
PTM databases
iPTMneti | Q6AY86 |
PhosphoSitePlusi | Q6AY86 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000030683, Expressed in testis and 20 other tissues |
ExpressionAtlasi | Q6AY86, baseline and differential |
Interactioni
Subunit structurei
Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex.
Interacts with VPS29, VPS35, SNX27, SNX1, SNX2, SNX5, SNX6, SNX3, RAB7A, ECPAS, EHD1, WASHC5, SORL1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 263007, 1 interactor |
CORUMi | Q6AY86 |
IntActi | Q6AY86, 3 interactors |
STRINGi | 10116.ENSRNOP00000062170 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3063, Eukaryota |
GeneTreei | ENSGT00950000183064 |
HOGENOMi | CLU_031077_0_0_1 |
InParanoidi | Q6AY86 |
OMAi | KPRTNFH |
OrthoDBi | 987411at2759 |
PhylomeDBi | Q6AY86 |
Family and domain databases
Gene3Di | 2.60.40.640, 2 hits |
InterProi | View protein in InterPro IPR014752, Arrestin_C IPR028934, Vps26-related |
PANTHERi | PTHR12233, PTHR12233, 1 hit |
Pfami | View protein in Pfam PF03643, Vps26, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSFLGGFFGP ICEIDVALSD GETRKMAEMK TEDGKVEKHY LFYDGESVSG
60 70 80 90 100
KVNLAFKQPG KRLEHQGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE
110 120 130 140 150
LTQSRSYDFE FMQVEKPYES YIGANVRLRY FLKVTIVRRL TDLVKEYDLI
160 170 180 190 200
VHQLATYPEV NNSIKMEVGI EDCLHIEFEY NKSKYHLKDV IVGKIYFLLV
210 220 230 240 250
RIKIQHMELQ LIKKEITGIG PSTTTETETI AKYEIMDGAP VKGESIPIRL
260 270 280 290 300
FLAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE
310 320
KLRKQRTNFH QRFESPESQA SAEQPEM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JXT0 | A0A0G2JXT0_RAT | Vacuolar protein sorting-associated... | Vps26a | 299 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079150 mRNA Translation: AAH79150.1 |
RefSeqi | NP_001007741.1, NM_001007740.1 |
Genome annotation databases
Ensembli | ENSRNOT00000067883; ENSRNOP00000062170; ENSRNOG00000030683 |
GeneIDi | 361846 |
KEGGi | rno:361846 |
UCSCi | RGD:1359254, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079150 mRNA Translation: AAH79150.1 |
RefSeqi | NP_001007741.1, NM_001007740.1 |
3D structure databases
SMRi | Q6AY86 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 263007, 1 interactor |
CORUMi | Q6AY86 |
IntActi | Q6AY86, 3 interactors |
STRINGi | 10116.ENSRNOP00000062170 |
PTM databases
iPTMneti | Q6AY86 |
PhosphoSitePlusi | Q6AY86 |
Proteomic databases
jPOSTi | Q6AY86 |
PaxDbi | Q6AY86 |
PRIDEi | Q6AY86 |
Protocols and materials databases
DNASUi | 361846 |
Genome annotation databases
Ensembli | ENSRNOT00000067883; ENSRNOP00000062170; ENSRNOG00000030683 |
GeneIDi | 361846 |
KEGGi | rno:361846 |
UCSCi | RGD:1359254, rat |
Organism-specific databases
CTDi | 9559 |
RGDi | 1359254, Vps26a |
Phylogenomic databases
eggNOGi | KOG3063, Eukaryota |
GeneTreei | ENSGT00950000183064 |
HOGENOMi | CLU_031077_0_0_1 |
InParanoidi | Q6AY86 |
OMAi | KPRTNFH |
OrthoDBi | 987411at2759 |
PhylomeDBi | Q6AY86 |
Enzyme and pathway databases
Reactomei | R-RNO-3238698, WNT ligand biogenesis and trafficking |
Miscellaneous databases
PROi | PR:Q6AY86 |
Gene expression databases
Bgeei | ENSRNOG00000030683, Expressed in testis and 20 other tissues |
ExpressionAtlasi | Q6AY86, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.640, 2 hits |
InterProi | View protein in InterPro IPR014752, Arrestin_C IPR028934, Vps26-related |
PANTHERi | PTHR12233, PTHR12233, 1 hit |
Pfami | View protein in Pfam PF03643, Vps26, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VP26A_RAT | |
Accessioni | Q6AY86Primary (citable) accession number: Q6AY86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families