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Protein

Transmembrane emp24 domain-containing protein 3

Gene

Tmed3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 3
Alternative name(s):
p24 family protein gamma-4
Short name:
p24gamma4
Gene namesi
Name:Tmed3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303327 Tmed3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 184LumenalSequence analysisAdd BLAST154
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 221CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001038631 – 221Transmembrane emp24 domain-containing protein 3Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103Dimethylated arginine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ6AY25
PRIDEiQ6AY25

PTM databases

iPTMnetiQ6AY25
PhosphoSitePlusiQ6AY25

Expressioni

Gene expression databases

BgeeiENSRNOG00000013889
GenevisibleiQ6AY25 RN

Interactioni

Subunit structurei

Monomer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED3; however, there are conflicting reports on the interaction (By similarity). Interacts with GORASP1 and GORASP2.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018603

Structurei

3D structure databases

SMRiQ6AY25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124GOLDPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi208 – 221COPI vesicle coat-bindingSequence analysisAdd BLAST14
Motifi208 – 209COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1693 Eukaryota
ENOG4111JPD LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000160229
HOVERGENiHBG000271
InParanoidiQ6AY25
KOiK20350
OMAiNYDVDCF
OrthoDBiEOG091G0LX8
PhylomeDBiQ6AY25
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEVPRASS FQMLMLLLLL LLLRAERLRG AELTFELPDN AKQCFHEEVE
60 70 80 90 100
QGVKFSLDYQ VITGGHYDVD CYVEDPMGNI IYRETKKQYD SFTYKTEVKG
110 120 130 140 150
VYRFCFSNEF STFSHKTVYF DFQVGDEPPI LPDMGNRVTA LTQMESACVT
160 170 180 190 200
IHEALKTVID SQTHYRLREA QDRARAEDLN SRVSYWSVGE TIALFVVSFS
210 220
QVLLLKSFFT EKRPINRAVH S
Length:221
Mass (Da):25,510
Last modified:September 13, 2004 - v1
Checksum:i739E5B785791C443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079220 mRNA Translation: AAH79220.1
RefSeqiNP_001004249.1, NM_001004249.1
UniGeneiRn.98226

Genome annotation databases

EnsembliENSRNOT00000018603; ENSRNOP00000018603; ENSRNOG00000013889
GeneIDi300888
KEGGirno:300888
UCSCiRGD:1303327 rat

Similar proteinsi

Entry informationi

Entry nameiTMED3_RAT
AccessioniPrimary (citable) accession number: Q6AY25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: September 13, 2004
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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