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Protein

C-X-C motif chemokine 16

Gene

Cxcl16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-380108 Chemokine receptors bind chemokines
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:Cxcl16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1562928 Cxcl16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 198ExtracellularSequence analysisAdd BLAST172
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 247CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000037819327 – 247C-X-C motif chemokine 16Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 65By similarity
Disulfide bondi37 ↔ 79By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AXU5
PRIDEiQ6AXU5

Expressioni

Inductioni

By interleukin-18 and the induction is strongly mediated by an activator protein-1-dependent pathway.1 Publication

Gene expression databases

BgeeiENSRNOG00000026647 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiQ6AXU5 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037160

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8A5 Eukaryota
ENOG4111D6H LUCA
GeneTreeiENSGT00390000002148
HOGENOMiHOG000112116
InParanoidiQ6AXU5
KOiK10035
OMAiVLCKRRR
OrthoDBiEOG091G0P40
PhylomeDBiQ6AXU5
TreeFamiTF337941

Family and domain databases

InterProiView protein in InterPro
IPR026296 CXCL16
PANTHERiPTHR14385 PTHR14385, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGFGPLAL TLFLFFFALL TLPGDGNQGS VAGSCYCDRT IPSGTQIPPA
60 70 80 90 100
TLNHMRKYLK TFHRCQFFIR FQLQSKSVCG GSQDQWVREL VNCFEHKQCG
110 120 130 140 150
IGHGQSFHHQ KHVPQASTRI PEATEGKPPD TSTAVQFQST QQSTFPSGAP
160 170 180 190 200
SLNKELTRHW ETTILPSGYG LEARPVAEAN EKQHKQQKEP GAGAGTQALV
210 220 230 240
PVLSLLAIVF FLVAAMVCVL CNRRVTRQSS SGLQLCYTPV EPRPQGL
Length:247
Mass (Da):27,196
Last modified:September 13, 2004 - v1
Checksum:iEBD43D23E75C7912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ025528 mRNA Translation: AAY42602.1
CH473948 Genomic DNA Translation: EDM05007.1
CH473948 Genomic DNA Translation: EDM05009.1
BC079312 mRNA Translation: AAH79312.1
RefSeqiNP_001017478.1, NM_001017478.1
UniGeneiRn.7070

Genome annotation databases

EnsembliENSRNOT00000032926; ENSRNOP00000037160; ENSRNOG00000026647
GeneIDi497942
KEGGirno:497942
UCSCiRGD:1562928 rat

Similar proteinsi

Entry informationi

Entry nameiCXL16_RAT
AccessioniPrimary (citable) accession number: Q6AXU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 13, 2004
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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