UniProtKB - Q6AXS3 (DEK_RAT)
Protein
Protein DEK
Gene
Dek
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in chromatin organization.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 340 – 354 | By similarityAdd BLAST | 15 | |
DNA bindingi | 370 – 374 | By similarity | 5 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- histone binding Source: RGD
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- regulation of double-strand break repair Source: RGD
- regulation of double-strand break repair via nonhomologous end joining Source: RGD
Keywordsi
Molecular function | Chromatin regulator, DNA-binding |
Enzyme and pathway databases
Reactomei | R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-8864260, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: Protein DEK |
Gene namesi | Name:Dek |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1303246, Dek |
Subcellular locationi
Nucleus
Note: Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.By similarity
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- contractile fiber Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079860 | 1 – 378 | Protein DEKAdd BLAST | 378 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 16 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 20 | PhosphoserineCombined sources | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 53 | PhosphoserineBy similarity | 1 | |
Modified residuei | 74 | PhosphoserineBy similarity | 1 | |
Modified residuei | 123 | PhosphoserineBy similarity | 1 | |
Modified residuei | 124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 161 | PhosphoserineBy similarity | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 | |
Modified residuei | 206 | PhosphoserineBy similarity | 1 | |
Modified residuei | 212 | PhosphoserineBy similarity | 1 | |
Modified residuei | 229 | PhosphoserineBy similarity | 1 | |
Modified residuei | 232 | PhosphoserineBy similarity | 1 | |
Modified residuei | 233 | PhosphoserineBy similarity | 1 | |
Modified residuei | 234 | PhosphoserineBy similarity | 1 | |
Modified residuei | 245 | PhosphoserineCombined sources | 1 | |
Modified residuei | 246 | PhosphoserineCombined sources | 1 | |
Modified residuei | 253 | PhosphoserineCombined sources | 1 | |
Modified residuei | 282 | ADP-ribosylserineBy similarity | 1 | |
Modified residuei | 290 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 292 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 293 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 299 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 | |
Modified residuei | 306 | PhosphoserineBy similarity | 1 | |
Modified residuei | 309 | PhosphoserineBy similarity | 1 | |
Modified residuei | 310 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA (By similarity).By similarity
Keywords - PTMi
ADP-ribosylation, PhosphoproteinProteomic databases
jPOSTi | Q6AXS3 |
PaxDbi | Q6AXS3 |
PRIDEi | Q6AXS3 |
PTM databases
iPTMneti | Q6AXS3 |
PhosphoSitePlusi | Q6AXS3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000016152, Expressed in thymus and 21 other tissues |
Genevisiblei | Q6AXS3, RN |
Interactioni
Subunit structurei
Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4.
Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2.
Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA (By similarity).
By similarityGO - Molecular functioni
- histone binding Source: RGD
Protein-protein interaction databases
IntActi | Q6AXS3, 5 interactors |
STRINGi | 10116.ENSRNOP00000021751 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 183 | SAPAdd BLAST | 35 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 207 – 223 | Nuclear localization signalSequence analysisAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 51 | Asp/Glu-rich (highly acidic)Add BLAST | 21 | |
Compositional biasi | 230 – 238 | Asp/Glu-rich (acidic) | 9 | |
Compositional biasi | 243 – 256 | Asp/Glu-rich (acidic)Add BLAST | 14 | |
Compositional biasi | 303 – 313 | Asp/Glu-rich (acidic)Add BLAST | 11 |
Phylogenomic databases
eggNOGi | KOG2266, Eukaryota |
GeneTreei | ENSGT00390000017282 |
HOGENOMi | CLU_041060_0_1_1 |
InParanoidi | Q6AXS3 |
OMAi | MHPKSSG |
OrthoDBi | 1505933at2759 |
PhylomeDBi | Q6AXS3 |
TreeFami | TF324696 |
Family and domain databases
InterProi | View protein in InterPro IPR014876, DEK_C IPR003034, SAP_dom |
Pfami | View protein in Pfam PF08766, DEK_C, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6AXS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAAAAPAAE GEDTPTPPAS EKEPEMPGPR EESEEEEEED DDDEDEEEEK
60 70 80 90 100
EKSLIVEGKR EKRKVERLTM QVSSLQREPF TIAQGKGQKL CEIERIHFFL
110 120 130 140 150
SKKKTDELRN LHKLLYNRPG TVSSLKKNVG QFSGFPFEKG STQYKKKEEM
160 170 180 190 200
LKKYRNAMLK SICEVLDLER SGVNSELVKR ILNFLMHPKP SGKPLPKSKK
210 220 230 240 250
SSSKGSKKER NSSGTTRKSK QTKCPEILSD ESSSDEDEKK NKDESSEDEE
260 270 280 290 300
KESEEEQPPK KTSKKEKAKQ KATTKSKKSV KSANVKKADS STTKKNQNSS
310 320 330 340 350
KKESGSEDSS DDEPLIKKLK KPPTDEELKE TVKKLLADAN LEEVTMKQIC
360 370
KEVYENYPAY DLTERKDFIK TTVKELIS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079344 mRNA Translation: AAH79344.1 |
RefSeqi | NP_001004255.1, NM_001004255.1 |
Genome annotation databases
Ensembli | ENSRNOT00000021751; ENSRNOP00000021751; ENSRNOG00000016152 |
GeneIDi | 306817 |
KEGGi | rno:306817 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079344 mRNA Translation: AAH79344.1 |
RefSeqi | NP_001004255.1, NM_001004255.1 |
3D structure databases
BMRBi | Q6AXS3 |
SMRi | Q6AXS3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6AXS3, 5 interactors |
STRINGi | 10116.ENSRNOP00000021751 |
PTM databases
iPTMneti | Q6AXS3 |
PhosphoSitePlusi | Q6AXS3 |
Proteomic databases
jPOSTi | Q6AXS3 |
PaxDbi | Q6AXS3 |
PRIDEi | Q6AXS3 |
Genome annotation databases
Ensembli | ENSRNOT00000021751; ENSRNOP00000021751; ENSRNOG00000016152 |
GeneIDi | 306817 |
KEGGi | rno:306817 |
Organism-specific databases
CTDi | 7913 |
RGDi | 1303246, Dek |
Phylogenomic databases
eggNOGi | KOG2266, Eukaryota |
GeneTreei | ENSGT00390000017282 |
HOGENOMi | CLU_041060_0_1_1 |
InParanoidi | Q6AXS3 |
OMAi | MHPKSSG |
OrthoDBi | 1505933at2759 |
PhylomeDBi | Q6AXS3 |
TreeFami | TF324696 |
Enzyme and pathway databases
Reactomei | R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-8864260, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
Miscellaneous databases
PROi | PR:Q6AXS3 |
Gene expression databases
Bgeei | ENSRNOG00000016152, Expressed in thymus and 21 other tissues |
Genevisiblei | Q6AXS3, RN |
Family and domain databases
InterProi | View protein in InterPro IPR014876, DEK_C IPR003034, SAP_dom |
Pfami | View protein in Pfam PF08766, DEK_C, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DEK_RAT | |
Accessioni | Q6AXS3Primary (citable) accession number: Q6AXS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |