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Protein

Protein orai-3

Gene

Orai3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

GO - Molecular functioni

  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene namesi
Name:Orai3
Synonyms:Tmem142c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306538 Orai3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343971 – 290Protein orai-3Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AXR8

PTM databases

PhosphoSitePlusiQ6AXR8

Expressioni

Gene expression databases

GenevisibleiQ6AXR8 RN

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025732

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ6AXR8
KOiK16058
OrthoDBiEOG091G0E4P
PhylomeDBiQ6AXR8
TreeFamiTF313576

Family and domain databases

Gene3Di1.20.140.140, 2 hits
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030032 Orai-3
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF6 PTHR31501:SF6, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6AXR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGGEGDTGE QAPLNPEVDS PAGSATYREF VHRGYLDLMG ASQHSLRALS
60 70 80 90 100
WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA
110 120 130 140 150
CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA
160 170 180 190 200
WGFSTALGTF LFLAEVVLVG WVKFVPIGAP MDKPAPVVPM SQVPPVTVSL
210 220 230 240 250
SLASNLTPSS ASVATTQQPP KACPPRQVCG SAHGPGWQAA MASTAIMVPV
260 270 280 290
GLVFMAFALH FYRSLVAHKT DRHKQELEEL SRLQGELQAV
Length:290
Mass (Da):31,311
Last modified:September 13, 2004 - v1
Checksum:i6E7F2E8C113BFBE7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHQ7A0A0H2UHQ7_RAT
Protein orai-3
Orai3
357Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079355 mRNA Translation: AAH79355.1
RefSeqiNP_001014046.1, NM_001014024.1
UniGeneiRn.42186

Genome annotation databases

GeneIDi309000
KEGGirno:309000
UCSCiRGD:1306538 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079355 mRNA Translation: AAH79355.1
RefSeqiNP_001014046.1, NM_001014024.1
UniGeneiRn.42186

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025732

PTM databases

PhosphoSitePlusiQ6AXR8

Proteomic databases

PaxDbiQ6AXR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309000
KEGGirno:309000
UCSCiRGD:1306538 rat

Organism-specific databases

CTDi93129
RGDi1306538 Orai3

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ6AXR8
KOiK16058
OrthoDBiEOG091G0E4P
PhylomeDBiQ6AXR8
TreeFamiTF313576

Miscellaneous databases

PROiPR:Q6AXR8

Gene expression databases

GenevisibleiQ6AXR8 RN

Family and domain databases

Gene3Di1.20.140.140, 2 hits
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030032 Orai-3
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF6 PTHR31501:SF6, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORAI3_RAT
AccessioniPrimary (citable) accession number: Q6AXR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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