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Entry version 108 (16 Oct 2019)
Sequence version 1 (13 Sep 2004)
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Protein
Submitted name:

HMG box domain-containing 3

Gene

Hmgxb3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi41 – 99HMG boxPROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HMG box domain-containing 3Imported
Submitted name:
Hmgxb3 proteinImported
Submitted name:
RIKEN cDNA A630042L21, isoform CRA_cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hmgxb3Imported
Synonyms:A630042L21RikImported
ORF Names:mCG_130312Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2441817 Hmgxb3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 99HMG boxInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni364 – 390DisorderedSequence analysisAdd BLAST27
Regioni453 – 472DisorderedSequence analysisAdd BLAST20
Regioni658 – 681DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi665 – 681PolarSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF99 Eukaryota
ENOG410XVX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006983

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112914

Database of Orthologous Groups

More...
OrthoDBi
188302at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR039598 HMGXB3
IPR040648 HMGXB3_CxC4

The PANTHER Classification System

More...
PANTHERi
PTHR17609 PTHR17609, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18717 CxC4, 1 hit
PF09011 HMG_box_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6AXF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPYDGAEV TVLMEEIEEA YYTSPGPPKK KKKYKIHGEK AKKPRSAYLL
60 70 80 90 100
YYYDIYLKVQ QELPHLPQSE INKKISESWR LLSVAERSYY LEKAKLEKEG
110 120 130 140 150
LDPNSKLSAL TAVVPDIPGF RKILPRSEYI IIPKSTLQED RSCPQLELCV
160 170 180 190 200
AQNQMSPKGS TLMSNASPDV VASHAGMAEQ CLAVEALAEE VGALPQPGTV
210 220 230 240 250
QEIATSEILS HDMLLEEASL EVGESHQPYQ TSLVIEETLV NGSSDLPTGS
260 270 280 290 300
LAVPHSQVGE SLSVVTVMRD SSESSPSAPA TQFIMLPLPA YSVVENPSSI
310 320 330 340 350
KLTTTYTRRG HGTCTSPGCS FTYVTRHKPP KCPTCGNFLG GKWIPKEKPA
360 370 380 390 400
KVKVELASGV SSKGSVIKRN QQSVTTEQNP SKENASKLTL ENSEAVSQLL
410 420 430 440 450
NVAPPGEGGE DREWEEVIVS DAHVLVKEVP GNRGTAVTKM PVVKSGAQAE
460 470 480 490 500
ISLGTTENDS PGPDILPSAE GTSSSSLLQA HKKSPGVDLF TTGPKAPELK
510 520 530 540 550
GRARGKPSLL AAARPMRAIL PAPTSVGRGS GVGLPRARQA FPLDKTPSVR
560 570 580 590 600
TCGLKPSTLK QLGQPIQQPP STGEVKLSNC ASSRTPQLKI VEVKPDLFPP
610 620 630 640 650
YKYSCTVTLD LGLATSRGRG KCKNPSCSYV YTNRHKPRIC PSCGFNLAKD
660 670 680 690 700
RTEKTPKAIE ASSPHPDVPS TTEALNPTQR EVQRQSTLQL LRKVLQIPEN
710 720 730 740 750
ESELAEVFAL IHELNSSRLI LSNVSEETVT IEQTSWSNYY ESPSTQCLLC
760 770 780 790 800
SSPLFKGGHN SLAGPQECWL LTANRLQVVT AQVKMCLNPH CLALHSFTDI
810 820 830 840 850
YTGLFNVGNK LLVSLDLLFA IRNQIKLGED PRVSVGVVLK SVQEQTEKTL
860 870 880 890 900
TSEELSQLQE LLCNGYWAFE CLTVRDYNDM ICGICGVAPK VEMAQRNEEN
910 920 930 940 950
VLALKSVEFT WPEFLGSSEV NVEDFWTTME TEVIEQVAFP ASIPITKFDA
960 970 980 990 1000
SVIAPFFPPL MRGAVVVNTE KDKTQDMQPV PGNGSALVRL LQEGTCKLEE
1010 1020 1030 1040 1050
LGSYSGEELQ YLLEQCDIPF SPEDSRDQLC FSLLALYESV QNGARARPPP
1060 1070 1080 1090 1100
AHFTGGKIYK VCPHQVVCGS KYLVRGESAR DHVDLLASSR HWPPVYVVDM
1110 1120 1130 1140 1150
ATPVALCADL CYPELTSQMW GKNQGCFSNP TEPVVSVSCP ELLDQHYSVD
1160 1170 1180 1190 1200
VTEAENSVQH PVTKSATRRI VHANTKPDPS DPSAGHRSLS LCPELAPYAS
1210 1220 1230 1240 1250
TTDSKLSSVR QRPIAFDNAT HYYLYNRLMD FLTSREIVNR QIHDIVQSCQ
1260 1270 1280
PGEVVIRDTL YRLGVAQIKT EAQEEGEEEE VASVVE
Length:1,286
Mass (Da):140,730
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2064B330FC7AB79D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9M3G3X9M3_MOUSE
HMG box domain-containing 3
Hmgxb3 A630042L21Rik, mCG_130312
1,254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B973A0A494B973_MOUSE
HMG box domain-containing 3
Hmgxb3
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9M0A0A494B9M0_MOUSE
HMG box domain-containing 3
Hmgxb3
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC124448 Genomic DNA No translation available.
AC148012 Genomic DNA No translation available.
BC079580 mRNA Translation: AAH79580.1
CH466528 Genomic DNA Translation: EDL09782.1

NCBI Reference Sequences

More...
RefSeqi
NP_840061.1, NM_178277.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000235480; ENSMUSP00000158376; ENSMUSG00000024622

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106894

UCSC genome browser

More...
UCSCi
uc008fbr.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124448 Genomic DNA No translation available.
AC148012 Genomic DNA No translation available.
BC079580 mRNA Translation: AAH79580.1
CH466528 Genomic DNA Translation: EDL09782.1
RefSeqiNP_840061.1, NM_178277.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000235480; ENSMUSP00000158376; ENSMUSG00000024622
GeneIDi106894
UCSCiuc008fbr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22993
MGIiMGI:2441817 Hmgxb3

Phylogenomic databases

eggNOGiENOG410IF99 Eukaryota
ENOG410XVX8 LUCA
GeneTreeiENSGT00390000006983
HOGENOMiHOG000112914
OrthoDBi188302at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hmgxb3 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR039598 HMGXB3
IPR040648 HMGXB3_CxC4
PANTHERiPTHR17609 PTHR17609, 1 hit
PfamiView protein in Pfam
PF18717 CxC4, 1 hit
PF09011 HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6AXF8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AXF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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