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Entry version 119 (16 Oct 2019)
Sequence version 1 (13 Sep 2004)
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Protein
Submitted name:

LP19005p

Gene

arr

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LP19005pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arrImported
ORF Names:CG5912Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000119 arr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6AWJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000119 Expressed in 34 organ(s), highest expression level in wing disc (Drosophila)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati131 – 181LDL-receptor class BPROSITE-ProRule annotationAdd BLAST51
Repeati182 – 224LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati225 – 270LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati271 – 312LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini360 – 398EGF-likeInterPro annotationAdd BLAST39
Repeati446 – 488LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati489 – 531LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati532 – 576LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati577 – 619LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati620 – 660LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini667 – 704EGF-likeInterPro annotationAdd BLAST38
Repeati753 – 795LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati796 – 838LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati839 – 880LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati881 – 924LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati925 – 965LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini972 – 1011EGF-likeInterPro annotationAdd BLAST40
Repeati1057 – 1097LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati1098 – 1140LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1141 – 1183LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1184 – 1219LDL-receptor class BPROSITE-ProRule annotationAdd BLAST36
Repeati1223 – 1246LDL-receptor class BPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPT4 Eukaryota
ENOG410XSY5 LUCA

Database of Orthologous Groups

More...
OrthoDBi
121310at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000742 EGF-like_dom
IPR000033 LDLR_classB_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00058 Ldl_recept_b, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00135 LY, 20 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51120 LDLRB, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6AWJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALEPYTKSA EIEPQLCQVI DNNEDVTTKA TKCTKSNSGV GWRQMLIGFL
60 70 80 90 100
LICFGISNSW QYKNVHMPSS SSLIASPPAS AFVNTPATLL FTTRHDIQVA
110 120 130 140 150
NITRPTGGPQ IDVIVRDLAE AMAIDFYYAK NLVCWTDSGR EIIECAQTNS
160 170 180 190 200
SALQPLLRAP KQTVISTGLD KPEGLAMDWY TDKIYWTDGE KNRIEVATLD
210 220 230 240 250
GRYQKVLFWT DLDQPRAVAV VPARKLLIWT DWGEYPKIER ASMDGDPLSR
260 270 280 290 300
MTLVKEHVFW PNGLAVDLKN ELIYWTDGKH HFIDVMRLDG SSRRTIVNNL
310 320 330 340 350
KYPFSLTFYD DRLYWTDWQR GSLNALDLQT RELKELIDTP KAPNSVRAWD
360 370 380 390 400
PSLQPYEDNP CAHNNGNCSH LCLLATNSQG FSCACPTGVK LISANTCANG
410 420 430 440 450
SQEMMFIVQR TQISKISLDS PDYTIFPLPL GKVKYAIAID YDPVEEHIYW
460 470 480 490 500
SDVETYTIKR AHADGTGVTD FVTSEVRHPD GLALDWLARN LYWTDTVTDR
510 520 530 540 550
IEVCRLDGTA RKVLIYEHLE EPRAIAVAPS LGWMFWSDWN ERKPKVERAS
560 570 580 590 600
LDGSERVVLV SENLGWPNGI ALDIEAKAIY WCDGKTDKIE VANMDGSGRR
610 620 630 640 650
VVISDNLKHL FGLSILDDYL YWTDWQRRSI DRAHKITGNN RIVVVDQYPD
660 670 680 690 700
LMGLKVTRLR EVRGQNACAV RNGGCSHLCL NRPRDYVCRC AIDYELANDK
710 720 730 740 750
RTCVVPAAFL LFSRQEHIGR ISIEYNEGNH NDERIPFKDV RDAHALDVSV
760 770 780 790 800
AERRIYWTDQ KSKCIFRAFL NGSYVQRIVD SGLIGPDGIA VDWLANNIYW
810 820 830 840 850
SDAEARRIEV ARLDGSSRRV LLWKGVEEPR SLVLEPRRGY MYWTESPTDS
860 870 880 890 900
IRRAAMDGSD LQTIVAGANH AAGLTFDQET RRLYWATQSR PAKIESADWD
910 920 930 940 950
GKKRQILVGS DMDEPYAVSL YQDYVYWSDW NTGDIERVHK TTGQNRSLVH
960 970 980 990 1000
SGMTYITSLL VFNDKRQTGV NPCKVNNGGC SHLCLAQPGR RGMTCACPTH
1010 1020 1030 1040 1050
YQLAKDGVSC IPPRNYIIFS QRNCFGRLLP NTTDCPNIPL PVSGKNIRAV
1060 1070 1080 1090 1100
DYDPITHHIY WIEGRSHSIK RSLANGTKVS LLANSGQPFD LAIDIIGRLL
1110 1120 1130 1140 1150
FWTCSQSNSI NVTSFLGESV GVIDTGDSEK PRNIAVHAMK RLLFWTDVGS
1160 1170 1180 1190 1200
HQAIIRARVD GNERVELAYK LEGVTALALD QQSDMIYYAH GKRIDAIDIN
1210 1220 1230 1240
GKNKKTLVSM HISQVINIAA LGGFVYWLDD KTGVERITVN GERRSA
Length:1,246
Mass (Da):140,678
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF965C3C24D32948B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT015250 mRNA Translation: AAT94479.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT015250 mRNA Translation: AAT94479.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ6AWJ8

Organism-specific databases

FlyBaseiFBgn0000119 arr

Phylogenomic databases

eggNOGiENOG410IPT4 Eukaryota
ENOG410XSY5 LUCA
OrthoDBi121310at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
arr fly

Gene expression databases

BgeeiFBgn0000119 Expressed in 34 organ(s), highest expression level in wing disc (Drosophila)

Family and domain databases

Gene3Di2.120.10.30, 4 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000742 EGF-like_dom
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00058 Ldl_recept_b, 10 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00135 LY, 20 hits
PROSITEiView protein in PROSITE
PS51120 LDLRB, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6AWJ8_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AWJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 16, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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