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UniProtKB - Q6ATV4 (ACA3_ORYSJ)
Protein
Calcium-transporting ATPase 3, plasma membrane-type
Gene
ACA3
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles.
By similarityCatalytic activityi
- EC:7.2.2.10
Activity regulationi
Activated by calmodulin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 461 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 762 | MagnesiumBy similarity | 1 | |
Metal bindingi | 766 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type calcium transporter activity Source: GO_Central
Keywordsi
Molecular function | Calmodulin-binding, Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-transporting ATPase 3, plasma membrane-typeCurated (EC:7.2.2.10)Short name: OsACA31 Publication Alternative name(s): Ca(2+)-ATPase isoform 3Curated |
Gene namesi | Name:ACA31 Publication Ordered Locus Names:Os03g0616400Imported, LOC_Os03g42020Imported ORF Names:OJ1285_H07.3 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 180 | CytoplasmicSequence analysisAdd BLAST | 180 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 268 | CytoplasmicSequence analysisAdd BLAST | 44 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 362 – 382 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 405 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 406 – 426 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 823 – 843 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 844 – 846 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 847 – 867 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 928 – 948 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 949 – 965 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 966 – 986 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 999 – 1019 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1020 – 1033 | CytoplasmicSequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247301 | 1 – 1033 | Calcium-transporting ATPase 3, plasma membrane-typeAdd BLAST | 1033 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6ATV4 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q6ATV4, baseline and differential |
Genevisiblei | Q6ATV4, OS |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 4530.OS03T0616400-01 |
Family & Domainsi
Domaini
The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0204, Eukaryota |
HOGENOMi | CLU_002360_9_2_1 |
InParanoidi | Q6ATV4 |
OMAi | CKRAHRE |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6ATV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSGVNGCCP LRLPAAAAVH GRRIPPLLPP RGAWPGCIAA PALHRKPGRG
60 70 80 90 100
GGGALSSCRR ASHHEKLQVA ALPSKATLEF EHGVSLRSAY IVPEDVQAAG
110 120 130 140 150
FQIDADELAS IVESRDTKKL TVHGQLNGIA DKLGTSLTNG IVTDKDLLNQ
160 170 180 190 200
RQDIYGVNKF AETEIRSFWE FVWEALEDTT LIILSACAIF SLVVGITTEG
210 220 230 240 250
WPQGAHDGVG IVASILLVVS VTGTSNYQQS LQFRDLDKEK RKILVQVTRN
260 270 280 290 300
GLRQRVLIDD LLPGDAVHLA VGDQVPADGL FISGFSVLVD ESSLTGESEP
310 320 330 340 350
VFVNEDNPYL LSGTKVLDGS CKMLVTAVGM RTQWGKLMAV LTDGGDDETP
360 370 380 390 400
LQTRLNGVAN TIGKIGLFFA VLTFIVLSQG IIGQKYLDGL LLSWSGDDVL
410 420 430 440 450
EILDHFAVAV TIVVVAVPEG LPLAVTLSLA FAMKKMMNDK ALVRQLAACE
460 470 480 490 500
TMGSATVICS DKTGTLTTNR MTVVKACICG NTIQVNNPQT PNMSSNFPEV
510 520 530 540 550
AVETLLESIF NNTSGEVVTN QDGKYQILGT PTETALLEFA LLLDGDCKEK
560 570 580 590 600
QLGSKIVKVE PFNSTKKRMS TILELPGGGY RAHCKGASEI VLAACDKFID
610 620 630 640 650
ERGCIVPLDD KTSSKLNDII KAFSSEALRT LCLAYREMEE GFSTQEQIPL
660 670 680 690 700
QGYTCIGIVG IKDPVRPGVR QSVATCRSAG ISVRMITGDN IDTAKAIARE
710 720 730 740 750
CGILTKDGIA IEGAEFREKS AEELHDLIPK MQVLARSSPL DKHTLVKHLR
760 770 780 790 800
TAFNEVVAVT GDGTNDAPAL READIGLAMG IAGTEVAKES ADVVILDDNF
810 820 830 840 850
STIVTVAKWG RSVYVNIQKF VQFQLTVNVV ALLVNFTSAC FTGDAPLTAV
860 870 880 890 900
QLLWVNMIMD TLGALALATE PPNNNLMKKA PVGRKGKFIT NVMWRNIVGQ
910 920 930 940 950
SLYQFAVMWY LQTQGKHLFG LEGYHADIVL NTIIFNTFVF CQVFNEISSR
960 970 980 990 1000
EMEDINVLRG MAGNSIFLGV LTGTIFFQFI LVQFLGDFAN TTPLTQQQWL
1010 1020 1030
ISILFGFLGM PIAAAIKLIA VEPHEKADTR RTP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0P0W110 | A0A0P0W110_ORYSJ | Os03g0616400 protein | Os03g0616400, OSNPB_030616400 | 439 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 750 | R → P in AK065088 (PubMed:12869764).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC135557 Genomic DNA Translation: AAT81659.1 DP000009 Genomic DNA Translation: ABF97637.1 AP008209 Genomic DNA Translation: BAF12575.1 AP014959 Genomic DNA Translation: BAS85276.1 AK065088 mRNA No translation available. |
Genome annotation databases
EnsemblPlantsi | Os03t0616400-01; Os03t0616400-01; Os03g0616400 |
Gramenei | Os03t0616400-01; Os03t0616400-01; Os03g0616400 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC135557 Genomic DNA Translation: AAT81659.1 DP000009 Genomic DNA Translation: ABF97637.1 AP008209 Genomic DNA Translation: BAF12575.1 AP014959 Genomic DNA Translation: BAS85276.1 AK065088 mRNA No translation available. |
3D structure databases
AlphaFoldDBi | Q6ATV4 |
SMRi | Q6ATV4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS03T0616400-01 |
Proteomic databases
PaxDbi | Q6ATV4 |
Genome annotation databases
EnsemblPlantsi | Os03t0616400-01; Os03t0616400-01; Os03g0616400 |
Gramenei | Os03t0616400-01; Os03t0616400-01; Os03g0616400 |
Phylogenomic databases
eggNOGi | KOG0204, Eukaryota |
HOGENOMi | CLU_002360_9_2_1 |
InParanoidi | Q6ATV4 |
OMAi | CKRAHRE |
Gene expression databases
ExpressionAtlasi | Q6ATV4, baseline and differential |
Genevisiblei | Q6ATV4, OS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACA3_ORYSJ | |
Accessioni | Q6ATV4Primary (citable) accession number: Q6ATV4 Secondary accession number(s): A0A0P0W069, Q10GR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | September 13, 2004 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families