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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) (DP2472)
  4. Enolase (eno)
  5. Pyruvate kinase (DP3116)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35SubstrateUniRule annotation1
Binding sitei117SubstrateUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Binding sitei201ATPUniRule annotation1
Binding sitei323ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 352ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDPSY177439:G1GHX-98-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:DP0101
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000963391 – 392Phosphoglycerate kinaseAdd BLAST392

Proteomic databases

PRIDEiQ6AS45

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi177439.DP0101

Structurei

3D structure databases

ProteinModelPortaliQ6AS45
SMRiQ6AS45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 21Substrate bindingUniRule annotation3
Regioni58 – 61Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiMFAGAIC
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AS45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLRELELA GKRVLVRVDF NVPMDDKQRI TDDIRIRMVL PTLRYVLEQG
60 70 80 90 100
GRLIICSHMG RPKGKRVEEY SLAPIARHLA GLLGRDVGIA PDCIGAEVEA
110 120 130 140 150
QVAALGVGEV LLLQNLRFYG EETENDAVFA GKLAGLADVY VNDAFAVSHR
160 170 180 190 200
AHASVVGVAE RVAEKCAGFL LQTEIDYFHK SMNDPIRPLV ALVGGAKVSS
210 220 230 240 250
KIGALENMLG KVDKMIIGGA MANTFLMSQG VDVGASKVED DLLVTARNFL
260 270 280 290 300
QAAGERGMKV YLPVDFVVAD RFAADAVHKT VPADSVPEGW MALDVGPASS
310 320 330 340 350
ILFREALQGA GTIVWNGPMG AFEMDAFAGG TMSLCRDVAA SQALSITGGG
360 370 380 390
DSNAAVKKSG EADNISYMST GGGAFLQLME GKTLPGVDAL EA
Length:392
Mass (Da):41,540
Last modified:September 13, 2004 - v1
Checksum:i1AEAE25CCEB4BE88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG34830.1
RefSeqiWP_011187346.1, NC_006138.1

Genome annotation databases

EnsemblBacteriaiCAG34830; CAG34830; DP0101
KEGGidps:DP0101

Similar proteinsi

Entry informationi

Entry nameiPGK_DESPS
AccessioniPrimary (citable) accession number: Q6AS45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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