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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciDPSY177439:G1GHX-1987-MONOMER
UniPathwayi
UPA00359;UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:DP1936
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002551771 – 386Lipid-A-disaccharide synthaseAdd BLAST386

Interactioni

Protein-protein interaction databases

STRINGi177439.DP1936

Structurei

3D structure databases

ProteinModelPortaliQ6ALW0
SMRiQ6ALW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ALW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKQKRETGS EIMVVTGEAS GDIHGANLVR ALKEKDSSLS FSGMGGPELA
60 70 80 90 100
SLGVEILYDA KKISVVGLVE VFSHLPSIFA AKKILQRRLK NKPPALLIII
110 120 130 140 150
DLPDFNLMLA KKAKALGIPV FYYITPQVWA WRSGRIKTIG ERTDQLGVIL
160 170 180 190 200
PFEEEFFRQR GQAASYVGHP LLDNVSIKLS REEFLTKHRI GPAAKYVGLL
210 220 230 240 250
PGSREKEISA LLPDFLRAAK RLQDECSEKI SFLLPIAATI DREQLLENGL
260 270 280 290 300
AEYQDLLDIH VISEDRYELM ACCDAVVAAS GTVTLELAIL EVPMLVVYRT
310 320 330 340 350
SPISYWVGRK LVKIEFFSLV NLIAGREVVT ELLQDEVTPE RISIEIKELL
360 370 380
YGAKGVAVGK GLREVHGLLG EAGASAKAAD LALSMI
Length:386
Mass (Da):42,466
Last modified:September 13, 2004 - v1
Checksum:i34559C7C93F5DAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG36665.1
RefSeqiWP_011189177.1, NC_006138.1

Genome annotation databases

EnsemblBacteriaiCAG36665; CAG36665; DP1936
KEGGidps:DP1936

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG36665.1
RefSeqiWP_011189177.1, NC_006138.1

3D structure databases

ProteinModelPortaliQ6ALW0
SMRiQ6ALW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177439.DP1936

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG36665; CAG36665; DP1936
KEGGidps:DP1936

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Enzyme and pathway databases

UniPathwayi
UPA00359;UER00481

BioCyciDPSY177439:G1GHX-1987-MONOMER

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPXB_DESPS
AccessioniPrimary (citable) accession number: Q6ALW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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