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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Nucleophile; for GATase activityUniRule annotation1
Active sitei686For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:DP2915Imported
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)Imported
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi177439.DP2915

Structurei

3D structure databases

ProteinModelPortaliQ6AJ36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 297Glutamine amidotransferase type-2InterPro annotationAdd BLAST224
Domaini367 – 506SISInterPro annotationAdd BLAST140
Domaini540 – 681SISInterPro annotationAdd BLAST142

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AJ36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFPREFLLI VVYLSFLLPQ GHCVKYIWLN FVRGYYFLHK LSKEKTRLQF
60 70 80 90 100
KIHGINIKLS GKNLILPWED VYMCGIVGYC GPKKVVPVIL EGLRRLEYRG
110 120 130 140 150
YDSAGLVYLQ DGKIVKHRAN GKLSCLEDVV GDDLVAPSHL GLGHTRWATH
160 170 180 190 200
GAPTMENAHP HSDCTGELVL VHNGIIENYH SLREELRAKG HVFTSETDTE
210 220 230 240 250
VLAHLIEEYL EQDAHGVDVL VRAIKEALAR VEGSYALGVM WAKAPETLIA
260 270 280 290 300
VRNQSPLVLG IGEEKGMFLA SDTPALLPYT RKVIFLDDME IAVLTADDYQ
310 320 330 340 350
IASLVSGEPV DKEITFIDWS ASMAEKGGYK HFMLKEIFEQ PQAITNTVAG
360 370 380 390 400
RINLESGKAN LPNLGFSDEQ LRDIDRIFLV ACGTSWHAAM VAKYWLEKYA
410 420 430 440 450
KIPVQVDIAS EFRYRHLLID ERVLTICISQ SGETADTLAG IRRAKKMGSK
460 470 480 490 500
ILTICNVVGS TMTREADGVI YTHAGPEIGV ASTKAFTAQL SALLLFTVFL
510 520 530 540 550
GQKRKQLSLE KSLQLGRALV GVATVIEEIL PSLQKKIASL IDDYYDSRDF
560 570 580 590 600
LFIGRGLSFP IALEGALKLK EISYIHAEGY ASGELKHGPI ALIDRDMPIL
610 620 630 640 650
ALVPDDDVYQ KSISNVEEIK ARQGRLILIG SEGDSQLANI SDDVIYLPRV
660 670 680 690
DDDVNPILYT IPAQLLSYEI ATRRGCDVDQ PRNLAKSVTV E
Length:691
Mass (Da):76,807
Last modified:September 13, 2004 - v1
Checksum:i8F486409561825E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG37644.1

Genome annotation databases

EnsemblBacteriaiCAG37644; CAG37644; DP2915
KEGGidps:DP2915

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG37644.1

3D structure databases

ProteinModelPortaliQ6AJ36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177439.DP2915

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG37644; CAG37644; DP2915
KEGGidps:DP2915

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ6AJ36_DESPS
AccessioniPrimary (citable) accession number: Q6AJ36
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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