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UniProtKB - Q6AI14 (SL9A4_HUMAN)

Entry version 135 (10 Feb 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Sodium/hydrogen exchanger 4

Gene

SLC9A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3- secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).By similarity

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6AI14

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425986, Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.36.1.18, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 4
Alternative name(s):
Na(+)/H(+) exchanger 4
Short name:
NHE-4
Solute carrier family 9 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A4
Synonyms:NHE4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11077, SLC9A4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600531, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6AI14

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000180251.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei14 – 28Name=A/M1Sequence analysisAdd BLAST15
Topological domaini29 – 69CytoplasmicSequence analysisAdd BLAST41
Intramembranei70 – 90Name=B/M2Sequence analysisAdd BLAST21
Topological domaini91 – 94CytoplasmicSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei95 – 115Helical; Name=C/M3Sequence analysisAdd BLAST21
Topological domaini116 – 127ExtracellularSequence analysisAdd BLAST12
Transmembranei128 – 148Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini149 – 154CytoplasmicSequence analysis6
Transmembranei155 – 175Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini176 – 196ExtracellularSequence analysisAdd BLAST21
Transmembranei197 – 217Helical; Name=F/M5ASequence analysisAdd BLAST21
Topological domaini218 – 226CytoplasmicSequence analysis9
Transmembranei227 – 247Helical; Name=G/M5BSequence analysisAdd BLAST21
Topological domaini248 – 270ExtracellularSequence analysisAdd BLAST23
Transmembranei271 – 291Helical; Name=H/M6Sequence analysisAdd BLAST21
Topological domaini292 – 304CytoplasmicSequence analysisAdd BLAST13
Transmembranei305 – 325Helical; Name=I/M7Sequence analysisAdd BLAST21
Topological domaini326 – 356ExtracellularSequence analysisAdd BLAST31
Transmembranei357 – 373Helical; Name=J/M8Sequence analysisAdd BLAST17
Topological domaini374 – 384CytoplasmicSequence analysisAdd BLAST11
Transmembranei385 – 405Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini406 – 420ExtracellularSequence analysisAdd BLAST15
Intramembranei421 – 441Name=LSequence analysisAdd BLAST21
Topological domaini442 – 450ExtracellularSequence analysis9
Transmembranei451 – 471Helical; Name=M/M10Sequence analysisAdd BLAST21
Topological domaini472 – 798CytoplasmicSequence analysisAdd BLAST327

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		389015

Open Targets

More...OpenTargetsi		ENSG00000180251

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35933

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6AI14, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC9A4

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146651 – 798Sodium/hydrogen exchanger 4Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6AI14

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6AI14

PeptideAtlas

More...PeptideAtlasi		Q6AI14

PRoteomics IDEntifications database

More...PRIDEi		Q6AI14

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66186

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6AI14, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6AI14

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6AI14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180251, Expressed in stomach and 55 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000180251, Group enriched (gallbladder, kidney, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHP1 and CHP2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		132934, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295269

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6AI14, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6AI14

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1966, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160774

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005912_4_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6AI14

Identification of Orthologs from Complete Genome Data

More...OMAi		REHHKSH

Database of Orthologous Groups

More...OrthoDBi		316731at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6AI14

TreeFam database of animal gene trees

More...TreeFami		TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR001953, Na/H_exchanger_2
IPR004709, NaH_exchanger
IPR032103, NHE_CaM-bd
IPR036958, NHX4

The PANTHER Classification System

More...PANTHERi		PTHR10110, PTHR10110, 1 hit
PTHR10110:SF103, PTHR10110:SF103, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF16644, NEXCaM_BD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01084, NAHEXCHNGR
PR01086, NAHEXCHNGR2

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6AI14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQMFVTYS PWNCLLLLVA LECSEASSDL NESANSTAQY ASNAWFAAAS 
        60         70         80         90        100
SEPEEGISVF ELDYDYVQIP YEVTLWILLA SLAKIGFHLY HRLPGLMPES 
       110        120        130        140        150
CLLILVGALV GGIIFGTDHK SPPVMDSSIY FLYLLPPIVL EGGYFMPTRP 
       160        170        180        190        200
FFENIGSILW WAVLGALINA LGIGLSLYLI CQVKAFGLGD VNLLQNLLFG 
       210        220        230        240        250
SLISAVDPVA VLAVFEEARV NEQLYMMIFG EALLNDGITV VLYNMLIAFT 
       260        270        280        290        300
KMHKFEDIET VDILAGCARF IVVGLGGVLF GIVFGFISAF ITRFTQNISA 
       310        320        330        340        350
IEPLIVFMFS YLSYLAAETL YLSGILAITA CAVTMKKYVE ENVSQTSYTT 
       360        370        380        390        400
IKYFMKMLSS VSETLIFIFM GVSTVGKNHE WNWAFICFTL AFCQIWRAIS 
       410        420        430        440        450
VFALFYISNQ FRTFPFSIKD QCIIFYSGVR GAGSFSLAFL LPLSLFPRKK 
       460        470        480        490        500
MFVTATLVVI YFTVFIQGIT VGPLVRYLDV KKTNKKESIN EELHIRLMDH 
       510        520        530        540        550
LKAGIEDVCG HWSHYQVRDK FKKFDHRYLR KILIRKNLPK SSIVSLYKKL 
       560        570        580        590        600
EMKQAIEMVE TGILSSTAFS IPHQAQRIQG IKRLSPEDVE SIRDILTSNM 
       610        620        630        640        650
YQVRQRTLSY NKYNLKPQTS EKQAKEILIR RQNTLRESMR KGHSLPWGKP 
       660        670        680        690        700
AGTKNIRYLS YPYGNPQSAG RDTRAAGFSD DDSSDPGSPS ITFSACSRIG 
       710        720        730        740        750
SLQKQEAQEI IPMKSLHRGR KAFSFGYQRN TSQEEYLGGV RRVALRPKPL 
       760        770        780        790 
FHAVDEEGES GGESEGKASL VEVRSRWTAD HGHGRDHHRS HSPLLQKK
Length:798
Mass (Da):89,814
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i757DAD603ECFF0D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429V → A in CAH10500 (PubMed:17974005).Curated1
Sequence conflicti784G → S in CAH10500 (PubMed:17974005).Curated1
Sequence conflicti784G → S in CAH10600 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056209116G → S. Corresponds to variant dbSNP:rs17027275Ensembl.1
Natural variantiVAR_056210581I → V. Corresponds to variant dbSNP:rs6742280Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL833048 mRNA Translation: CAH10600.1
CR627411 mRNA Translation: CAH10500.1
AC007278 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33264.1

NCBI Reference Sequences

More...RefSeqi		NP_001011552.2, NM_001011552.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295269; ENSP00000295269; ENSG00000180251

Database of genes from NCBI RefSeq genomes

More...GeneIDi		389015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:389015

UCSC genome browser

More...UCSCi		uc002tbz.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833048 mRNA Translation: CAH10600.1
CR627411 mRNA Translation: CAH10500.1
AC007278 Genomic DNA No translation available.
CCDSiCCDS33264.1
RefSeqiNP_001011552.2, NM_001011552.3

3D structure databases

SMRiQ6AI14
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132934, 2 interactors
STRINGi9606.ENSP00000295269

Protein family/group databases

TCDBi2.A.36.1.18, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

GlyGeniQ6AI14, 1 site
iPTMnetiQ6AI14
PhosphoSitePlusiQ6AI14

Genetic variation databases

BioMutaiSLC9A4
DMDMi296452906

Proteomic databases

MassIVEiQ6AI14
PaxDbiQ6AI14
PeptideAtlasiQ6AI14
PRIDEiQ6AI14
ProteomicsDBi66186

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49172, 10 antibodies

The DNASU plasmid repository

More...DNASUi		389015

Genome annotation databases

EnsembliENST00000295269; ENSP00000295269; ENSG00000180251
GeneIDi389015
KEGGihsa:389015
UCSCiuc002tbz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		389015
DisGeNETi389015

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC9A4
HGNCiHGNC:11077, SLC9A4
HPAiENSG00000180251, Group enriched (gallbladder, kidney, stomach)
MIMi600531, gene
neXtProtiNX_Q6AI14
OpenTargetsiENSG00000180251
PharmGKBiPA35933
VEuPathDBiHostDB:ENSG00000180251.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1966, Eukaryota
GeneTreeiENSGT00940000160774
HOGENOMiCLU_005912_4_3_1
InParanoidiQ6AI14
OMAiREHHKSH
OrthoDBi316731at2759
PhylomeDBiQ6AI14
TreeFamiTF317212

Enzyme and pathway databases

PathwayCommonsiQ6AI14
ReactomeiR-HSA-425986, Sodium/Proton exchangers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		389015, 4 hits in 865 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		389015
PharosiQ6AI14, Tdark

Protein Ontology

More...PROi		PR:Q6AI14
RNActiQ6AI14, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180251, Expressed in stomach and 55 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR001953, Na/H_exchanger_2
IPR004709, NaH_exchanger
IPR032103, NHE_CaM-bd
IPR036958, NHX4
PANTHERiPTHR10110, PTHR10110, 1 hit
PTHR10110:SF103, PTHR10110:SF103, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF16644, NEXCaM_BD, 1 hit
PRINTSiPR01084, NAHEXCHNGR
PR01086, NAHEXCHNGR2
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AI14
Secondary accession number(s): Q69YK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: February 10, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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