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Entry version 129 (11 Dec 2019)
Sequence version 2 (18 May 2010)
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Protein

Sodium/hydrogen exchanger 4

Gene

SLC9A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3- secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).By similarity

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425986 Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.18 the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 4
Alternative name(s):
Na(+)/H(+) exchanger 4
Short name:
NHE-4
Solute carrier family 9 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A4
Synonyms:NHE4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180251.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11077 SLC9A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600531 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6AI14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei14 – 28Name=A/M1Sequence analysisAdd BLAST15
Topological domaini29 – 69CytoplasmicSequence analysisAdd BLAST41
Intramembranei70 – 90Name=B/M2Sequence analysisAdd BLAST21
Topological domaini91 – 94CytoplasmicSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei95 – 115Helical; Name=C/M3Sequence analysisAdd BLAST21
Topological domaini116 – 127ExtracellularSequence analysisAdd BLAST12
Transmembranei128 – 148Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini149 – 154CytoplasmicSequence analysis6
Transmembranei155 – 175Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini176 – 196ExtracellularSequence analysisAdd BLAST21
Transmembranei197 – 217Helical; Name=F/M5ASequence analysisAdd BLAST21
Topological domaini218 – 226CytoplasmicSequence analysis9
Transmembranei227 – 247Helical; Name=G/M5BSequence analysisAdd BLAST21
Topological domaini248 – 270ExtracellularSequence analysisAdd BLAST23
Transmembranei271 – 291Helical; Name=H/M6Sequence analysisAdd BLAST21
Topological domaini292 – 304CytoplasmicSequence analysisAdd BLAST13
Transmembranei305 – 325Helical; Name=I/M7Sequence analysisAdd BLAST21
Topological domaini326 – 356ExtracellularSequence analysisAdd BLAST31
Transmembranei357 – 373Helical; Name=J/M8Sequence analysisAdd BLAST17
Topological domaini374 – 384CytoplasmicSequence analysisAdd BLAST11
Transmembranei385 – 405Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini406 – 420ExtracellularSequence analysisAdd BLAST15
Intramembranei421 – 441Name=LSequence analysisAdd BLAST21
Topological domaini442 – 450ExtracellularSequence analysis9
Transmembranei451 – 471Helical; Name=M/M10Sequence analysisAdd BLAST21
Topological domaini472 – 798CytoplasmicSequence analysisAdd BLAST327

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
389015

Open Targets

More...
OpenTargetsi
ENSG00000180251

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35933

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6AI14 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC9A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146651 – 798Sodium/hydrogen exchanger 4Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6AI14

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6AI14

PeptideAtlas

More...
PeptideAtlasi
Q6AI14

PRoteomics IDEntifications database

More...
PRIDEi
Q6AI14

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66186

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6AI14

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6AI14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180251 Expressed in 35 organ(s), highest expression level in fundus of stomach

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHP1 and CHP2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132934, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295269

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6AI14 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6AI14

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966 Eukaryota
COG0025 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160774

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247044

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6AI14

KEGG Orthology (KO)

More...
KOi
K13961

Identification of Orthologs from Complete Genome Data

More...
OMAi
REHHKSH

Database of Orthologous Groups

More...
OrthoDBi
316731at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6AI14

TreeFam database of animal gene trees

More...
TreeFami
TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10110 PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840 b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6AI14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQMFVTYS PWNCLLLLVA LECSEASSDL NESANSTAQY ASNAWFAAAS
60 70 80 90 100
SEPEEGISVF ELDYDYVQIP YEVTLWILLA SLAKIGFHLY HRLPGLMPES
110 120 130 140 150
CLLILVGALV GGIIFGTDHK SPPVMDSSIY FLYLLPPIVL EGGYFMPTRP
160 170 180 190 200
FFENIGSILW WAVLGALINA LGIGLSLYLI CQVKAFGLGD VNLLQNLLFG
210 220 230 240 250
SLISAVDPVA VLAVFEEARV NEQLYMMIFG EALLNDGITV VLYNMLIAFT
260 270 280 290 300
KMHKFEDIET VDILAGCARF IVVGLGGVLF GIVFGFISAF ITRFTQNISA
310 320 330 340 350
IEPLIVFMFS YLSYLAAETL YLSGILAITA CAVTMKKYVE ENVSQTSYTT
360 370 380 390 400
IKYFMKMLSS VSETLIFIFM GVSTVGKNHE WNWAFICFTL AFCQIWRAIS
410 420 430 440 450
VFALFYISNQ FRTFPFSIKD QCIIFYSGVR GAGSFSLAFL LPLSLFPRKK
460 470 480 490 500
MFVTATLVVI YFTVFIQGIT VGPLVRYLDV KKTNKKESIN EELHIRLMDH
510 520 530 540 550
LKAGIEDVCG HWSHYQVRDK FKKFDHRYLR KILIRKNLPK SSIVSLYKKL
560 570 580 590 600
EMKQAIEMVE TGILSSTAFS IPHQAQRIQG IKRLSPEDVE SIRDILTSNM
610 620 630 640 650
YQVRQRTLSY NKYNLKPQTS EKQAKEILIR RQNTLRESMR KGHSLPWGKP
660 670 680 690 700
AGTKNIRYLS YPYGNPQSAG RDTRAAGFSD DDSSDPGSPS ITFSACSRIG
710 720 730 740 750
SLQKQEAQEI IPMKSLHRGR KAFSFGYQRN TSQEEYLGGV RRVALRPKPL
760 770 780 790
FHAVDEEGES GGESEGKASL VEVRSRWTAD HGHGRDHHRS HSPLLQKK
Length:798
Mass (Da):89,814
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i757DAD603ECFF0D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429V → A in CAH10500 (PubMed:17974005).Curated1
Sequence conflicti784G → S in CAH10500 (PubMed:17974005).Curated1
Sequence conflicti784G → S in CAH10600 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056209116G → S. Corresponds to variant dbSNP:rs17027275Ensembl.1
Natural variantiVAR_056210581I → V. Corresponds to variant dbSNP:rs6742280Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL833048 mRNA Translation: CAH10600.1
CR627411 mRNA Translation: CAH10500.1
AC007278 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33264.1

NCBI Reference Sequences

More...
RefSeqi
NP_001011552.2, NM_001011552.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295269; ENSP00000295269; ENSG00000180251

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389015

UCSC genome browser

More...
UCSCi
uc002tbz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833048 mRNA Translation: CAH10600.1
CR627411 mRNA Translation: CAH10500.1
AC007278 Genomic DNA No translation available.
CCDSiCCDS33264.1
RefSeqiNP_001011552.2, NM_001011552.3

3D structure databases

SMRiQ6AI14
ModBaseiSearch...

Protein-protein interaction databases

BioGridi132934, 2 interactors
STRINGi9606.ENSP00000295269

Protein family/group databases

TCDBi2.A.36.1.18 the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ6AI14
PhosphoSitePlusiQ6AI14

Polymorphism and mutation databases

BioMutaiSLC9A4
DMDMi296452906

Proteomic databases

MassIVEiQ6AI14
PaxDbiQ6AI14
PeptideAtlasiQ6AI14
PRIDEiQ6AI14
ProteomicsDBi66186

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
389015

Genome annotation databases

EnsembliENST00000295269; ENSP00000295269; ENSG00000180251
GeneIDi389015
KEGGihsa:389015
UCSCiuc002tbz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389015
DisGeNETi389015
EuPathDBiHostDB:ENSG00000180251.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC9A4
HGNCiHGNC:11077 SLC9A4
HPAiHPA036096
MIMi600531 gene
neXtProtiNX_Q6AI14
OpenTargetsiENSG00000180251
PharmGKBiPA35933

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00940000160774
HOGENOMiHOG000247044
InParanoidiQ6AI14
KOiK13961
OMAiREHHKSH
OrthoDBi316731at2759
PhylomeDBiQ6AI14
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-HSA-425986 Sodium/Proton exchangers

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389015
PharosiQ6AI14 Tdark

Protein Ontology

More...
PROi
PR:Q6AI14
RNActiQ6AI14 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180251 Expressed in 35 organ(s), highest expression level in fundus of stomach

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AI14
Secondary accession number(s): Q69YK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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