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Entry version 136 (16 Oct 2019)
Sequence version 1 (13 Sep 2004)
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Protein

HEAT repeat-containing protein 6

Gene

HEATR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amplification-dependent oncogene.

Miscellaneous

17q23 region is one of the most commonly amplified regions in breast cancer and therefore may harbor genes important for breast cancer development and progression.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 6
Alternative name(s):
Amplified in breast cancer protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEATR6
Synonyms:ABC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24076 HEATR6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6AI08

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63897

Open Targets

More...
OpenTargetsi
ENSG00000068097

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162390774

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q6AI08

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HEATR6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74724525

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371731 – 1181HEAT repeat-containing protein 6Add BLAST1181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei618PhosphothreonineBy similarity1
Modified residuei643PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6AI08

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6AI08

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6AI08

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6AI08

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6AI08

PeptideAtlas

More...
PeptideAtlasi
Q6AI08

PRoteomics IDEntifications database

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PRIDEi
Q6AI08

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66184

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6AI08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6AI08

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6AI08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Amplified in breast cancer cell lines MCF-7 and BT-474.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000068097 Expressed in 206 organ(s), highest expression level in middle temporal gyrus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6AI08 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6AI08 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030789
HPA062157

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121976, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q6AI08, 14 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000184956

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati159 – 198HEAT 1Add BLAST40
Repeati452 – 490HEAT 2Add BLAST39
Repeati515 – 552HEAT 3Add BLAST38
Repeati558 – 595HEAT 4Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi315 – 325Poly-LysAdd BLAST11
Compositional biasi330 – 335Poly-Glu6
Compositional biasi383 – 390Poly-Ser8

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4535 Eukaryota
ENOG410XNWJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016675

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6AI08

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYGCLTG

Database of Orthologous Groups

More...
OrthoDBi
106835at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6AI08

TreeFam database of animal gene trees

More...
TreeFami
TF324244

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR025283 DUF4042

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13251 DUF4042, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q6AI08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVQVVGSW PSVQPREAPR EAIPERGNGF RLLSARLCAL RPDDSSSART
60 70 80 90 100
EIHLLFDQLI SENYSEGSGV APEDVSALLV QACRLVPLNQ NHLVSKVSQL
110 120 130 140 150
IHHLLNRLQV IVDEQHLDFL LAYTISAIHQ CSSWTHREIL QALAALVYCN
160 170 180 190 200
GSKCQKYLPE LLGNTGLLMK LSDLAQSDPE VRRAAVHCMA NLCLSVPGQP
210 220 230 240 250
YLEEPYQNVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK GIQSLLNGGR
260 270 280 290 300
MKLTQTDELG ALLAVLKKFM FHGLPGLNIE MPTVLYPTPL PQYDGRTPIK
310 320 330 340 350
PQQSESSASR PTLNKKKKSK VKPKKIQQGE EEEKESSGEI EAAPVTGTGR
360 370 380 390 400
VNLHEGNTWC PSSLGVQSLP LDGSGAAEKD GVSSSFSSSS WKRVSSSESD
410 420 430 440 450
FSDAEGGMQS KMRSYQAKVR QGALVCFLST IKSIEKKVLY GYWSAFIPDT
460 470 480 490 500
PELGSPQSVS LMTLTLKDPS PKTRACALQV LSAILEGSKQ FLSVAEDTSD
510 520 530 540 550
HRRAFTPFSV MIACSIRELH RCLLLALVAE SSSQTVTQII KCLANLVSNA
560 570 580 590 600
PYDRLKLSLL TKVWNQIKPY IRHKDVNVRV SSLTLLGAIV STHAPLPEVQ
610 620 630 640 650
LLLQQPCSSG LGNSNSATPH LSPPDWWKKA PAGPSLEETS VSSPKGSSEP
660 670 680 690 700
CWLIRLCISI VVLPKEDSCS GSDAGSAAGS TYEPSPMRLE ALQVLTLLAR
710 720 730 740 750
GYFSMTQAYL MELGEVICKC MGEADPSIQL HGAKLLEELG TGLIQQYKPD
760 770 780 790 800
STAAPDQRAP VFLVVMFWTM MLNGPLPRAL QNSEHPTLQA SACDALSSIL
810 820 830 840 850
PEAFSNLPND RQMLCITVLL GLNDSKNRLV KAATSRALGV YVLFPCLRQD
860 870 880 890 900
VIFVADAANA ILMSLEDKSL NVRAKAAWSL GNLTDTLIVN METPDPSFQE
910 920 930 940 950
EFSGLLLLKM LRSAIEASKD KDKVKSNAVR ALGNLLHFLQ PSHIEKPTFA
960 970 980 990 1000
EIIEESIQAL ISTVLTEAAM KVRWNACYAM GNVFKNPALP LGTAPWTSQA
1010 1020 1030 1040 1050
YNALTSVVTS CKNFKVRIRS AAALSVPGKR EQYGSVDQYA RIWNALVTAL
1060 1070 1080 1090 1100
QKSEDTIDFL EFKYCVSLRT QICQALIHLL SLASASDLPC MKETLELSGN
1110 1120 1130 1140 1150
MVQSYILQFL KSGAEGDDTG APHSPQERDQ MVRMALKHMG SIQAPTGDTA
1160 1170 1180
RRAIMGFLEE ILAVCFDSSG SQGALPGLTN Q
Length:1,181
Mass (Da):128,781
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61DA3E2A0CDA0BED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELR8K7ELR8_HUMAN
HEAT repeat-containing protein 6
HEATR6
413Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIX2K7EIX2_HUMAN
HEAT repeat-containing protein 6
HEATR6
1,069Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXZ7A0A087WXZ7_HUMAN
HEAT repeat-containing protein 6
HEATR6
916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK31K7EK31_HUMAN
HEAT repeat-containing protein 6
HEATR6
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKW7K7EKW7_HUMAN
HEAT repeat-containing protein 6
HEATR6
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESP5K7ESP5_HUMAN
HEAT repeat-containing protein 6
HEATR6
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKB1K7EKB1_HUMAN
HEAT repeat-containing protein 6
HEATR6
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELA5K7ELA5_HUMAN
HEAT repeat-containing protein 6
HEATR6
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKF5K7EKF5_HUMAN
HEAT repeat-containing protein 6
HEATR6
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL83912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15229 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15348 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44D → G in CAE45906 (PubMed:17974005).Curated1
Sequence conflicti307S → C in BAB15229 (PubMed:14702039).Curated1
Sequence conflicti336S → F in BAB15229 (PubMed:14702039).Curated1
Sequence conflicti343A → V in BAB15229 (PubMed:14702039).Curated1
Sequence conflicti362 – 363SS → FF in BAB15229 (PubMed:14702039).Curated2
Sequence conflicti383S → Y in BAB15229 (PubMed:14702039).Curated1
Sequence conflicti385S → C in BAB15229 (PubMed:14702039).Curated1
Sequence conflicti474R → C in CAE45895 (PubMed:17974005).Curated1
Sequence conflicti630A → T in BAB15229 (PubMed:14702039).Curated1
Sequence conflicti730L → P in AAL83912 (PubMed:11431322).Curated1
Sequence conflicti753A → T in AAL83912 (PubMed:11431322).Curated1
Sequence conflicti762F → L in AAL83912 (PubMed:11431322).Curated1
Sequence conflicti778R → G in CAE45895 (PubMed:17974005).Curated1
Sequence conflicti992G → R in AAL83912 (PubMed:11431322).Curated1
Sequence conflicti1004L → P in CAE45906 (PubMed:17974005).Curated1
Sequence conflicti1042I → F in AAL83912 (PubMed:11431322).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04367071A → V. Corresponds to variant dbSNP:rs3744376Ensembl.1
Natural variantiVAR_0436711006S → L. Corresponds to variant dbSNP:rs16943991Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK025740 mRNA Translation: BAB15229.1 Different initiation.
AK026070 mRNA Translation: BAB15348.1 Different initiation.
AK127708 mRNA Translation: BAG54555.1
BX640819 mRNA Translation: CAE45895.1
BX640831 mRNA Translation: CAE45906.1
CR627418 mRNA Translation: CAH10506.1
CH471109 Genomic DNA Translation: EAW94369.1
BC119813 mRNA Translation: AAI19814.1
AF349752 mRNA Translation: AAL83912.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11623.1

NCBI Reference Sequences

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RefSeqi
NP_071353.4, NM_022070.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000184956; ENSP00000184956; ENSG00000068097

Database of genes from NCBI RefSeq genomes

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GeneIDi
63897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63897

UCSC genome browser

More...
UCSCi
uc002iyk.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025740 mRNA Translation: BAB15229.1 Different initiation.
AK026070 mRNA Translation: BAB15348.1 Different initiation.
AK127708 mRNA Translation: BAG54555.1
BX640819 mRNA Translation: CAE45895.1
BX640831 mRNA Translation: CAE45906.1
CR627418 mRNA Translation: CAH10506.1
CH471109 Genomic DNA Translation: EAW94369.1
BC119813 mRNA Translation: AAI19814.1
AF349752 mRNA Translation: AAL83912.1 Different initiation.
CCDSiCCDS11623.1
RefSeqiNP_071353.4, NM_022070.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121976, 26 interactors
IntActiQ6AI08, 14 interactors
STRINGi9606.ENSP00000184956

PTM databases

iPTMnetiQ6AI08
PhosphoSitePlusiQ6AI08
SwissPalmiQ6AI08

Polymorphism and mutation databases

BioMutaiHEATR6
DMDMi74724525

Proteomic databases

EPDiQ6AI08
jPOSTiQ6AI08
MassIVEiQ6AI08
MaxQBiQ6AI08
PaxDbiQ6AI08
PeptideAtlasiQ6AI08
PRIDEiQ6AI08
ProteomicsDBi66184

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
63897

Genome annotation databases

EnsembliENST00000184956; ENSP00000184956; ENSG00000068097
GeneIDi63897
KEGGihsa:63897
UCSCiuc002iyk.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63897
DisGeNETi63897

GeneCards: human genes, protein and diseases

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GeneCardsi
HEATR6
HGNCiHGNC:24076 HEATR6
HPAiHPA030789
HPA062157
neXtProtiNX_Q6AI08
OpenTargetsiENSG00000068097
PharmGKBiPA162390774

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4535 Eukaryota
ENOG410XNWJ LUCA
GeneTreeiENSGT00390000016675
InParanoidiQ6AI08
OMAiDYGCLTG
OrthoDBi106835at2759
PhylomeDBiQ6AI08
TreeFamiTF324244

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HEATR6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63897
PharosiQ6AI08

Protein Ontology

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PROi
PR:Q6AI08

Gene expression databases

BgeeiENSG00000068097 Expressed in 206 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiQ6AI08 baseline and differential
GenevisibleiQ6AI08 HS

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR025283 DUF4042
PfamiView protein in Pfam
PF13251 DUF4042, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEAT6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AI08
Secondary accession number(s): B3KXP3
, Q6MZX1, Q6MZY2, Q8TDM9, Q9H6B3, Q9H6M7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: October 16, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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