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Entry version 150 (11 Dec 2019)
Sequence version 2 (27 Jun 2006)
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Protein

Zinc finger protein 518A

Gene

ZNF518A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri150 – 172C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 285C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1449 – 1471C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 518A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF518A
Synonyms:KIAA0335, ZNF518
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177853.14

Human Gene Nomenclature Database

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HGNCi
HGNC:29009 ZNF518A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617733 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6AHZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000177853

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410182

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6AHZ1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF518A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
109896331

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408491 – 1483Zinc finger protein 518AAdd BLAST1483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki392Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki425Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki433Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki524Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki596Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei655PhosphoserineCombined sources1
Cross-linki713Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki798Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki889Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki928Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki994Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1015Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1048Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1060Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1083Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6AHZ1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6AHZ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6AHZ1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6AHZ1

PeptideAtlas

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PeptideAtlasi
Q6AHZ1

PRoteomics IDEntifications database

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PRIDEi
Q6AHZ1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66181 [Q6AHZ1-1]
66182 [Q6AHZ1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6AHZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6AHZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177853 Expressed in 215 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6AHZ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6AHZ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029049

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115184, 27 interactors

Protein interaction database and analysis system

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IntActi
Q6AHZ1, 35 interactors

Molecular INTeraction database

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MINTi
Q6AHZ1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000485614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6AHZ1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6AHZ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 172C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 285C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1449 – 1471C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162006

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000155775

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6AHZ1

Identification of Orthologs from Complete Genome Data

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OMAi
MGFKMVD

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6AHZ1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027760 ZNF518A
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR24403:SF81 PTHR24403:SF81, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6AHZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSEQKQLFC DEKQTTLKKD YDVKNEIVDR SAPKPKISGS IHYALKNVKI
60 70 80 90 100
DLPKINIPNE VLLKHEVDKY RKLFQSKQQT ARKSISIKTV SCVEECTLLH
110 120 130 140 150
KSERAEEEGV KMSAKILNFS CLKCRDNTRY SPNDLQKHFQ MWHHGELPSY
160 170 180 190 200
PCEMCNFSAN DFQVFKQHRR THRSTLVKCD ICNNESVYTL LNLTKHFTST
210 220 230 240 250
HCVNGNFQCE KCKFSTQDVG TFVQHIHRHN EIHYKCGKCH HVCFTKGELQ
260 270 280 290 300
KHLHIHSGTF PFTCQYCSYG ATRREHLVRH VITLHKEHLY AKEKLEKDKY
310 320 330 340 350
EKRMAKTSAG LKLILKRYKI GASRKTFWKR KKINSGSDRS IEKNTQVLKK
360 370 380 390 400
MNKTQTKSED QSHVVQEHLS EEKDERLHCE NNDKAPESES EKPTPLSTGQ
410 420 430 440 450
GNRAEEGPNA SSGFMKTAVL GPTLKNVMMK NNKLAVSPNY NATFMGFKMM
460 470 480 490 500
DGKQHIVLKL VPIKQNVCSP GSQSGAAKDG TANLQPQTLD TNGFLTGVTT
510 520 530 540 550
ELNDTVYMKA ATPFSCSSSI LSGKASSEKE MTLISQRNNM LQTMDYEKSV
560 570 580 590 600
SSLSATSELV TASVNLTTKF ETRDNVDFWG NHLTQSHPEV LGTTIKSPDK
610 620 630 640 650
VNCVAKPNAY NSGDMHNYCI NYGNCELPVE SSNQGSLPFH NYSKVNNSNK
660 670 680 690 700
RRRFSGTAVY ENPQRESSSS KTVVQQPISE SFLSLVRQES SKPDSLLASI
710 720 730 740 750
SLLNDKDGTL KAKSEIEEQY VLEKGQNIDG QNLYSNENQN LECATEKSKW
760 770 780 790 800
EDFSNVDSPM MPRITSVFSL QSQQASEFLP PEVNQLLQDV LKIKPDVKQD
810 820 830 840 850
SSNTPNKGLP LHCDQSFQKH EREGKIVESS KDFKVQGIFP VPPGSVGINV
860 870 880 890 900
PTNDLNLKFG KEKQVSSIPQ DVRDSEKMPR ISGFGTLLKT QSDAIITQQL
910 920 930 940 950
VKDKLRATTQ NLGSFYMQSP LLNSEQKKTI IVQTSKGFLI PLNITNKPGL
960 970 980 990 1000
PVIPGNALPL VNSQGIPASL FVNKKPGMVL TLNNGKLEGV SAVKTEGAPA
1010 1020 1030 1040 1050
RGTVTKEPCK TPILKVEPNN NCLTPGLCSS IGSCLSMKSS SENTLPLKGP
1060 1070 1080 1090 1100
YILKPTSSVK AVLIPNMLSE QQSTKLNISD SVKQQNEIFP KPPLYTFLPD
1110 1120 1130 1140 1150
GKQAVFLKCV MPNKTELLKP KLVQNSTYQN IQPKKPEGTP QRILLKIFNP
1160 1170 1180 1190 1200
VLNVTAANNL SVSNSASSLQ KDNVPSNQII GGEQKEPESR DALPFLLDDL
1210 1220 1230 1240 1250
MPANEIVITS TATCPESSEE PICVSDCSES RVLRCKTNCR IERNFNRKKT
1260 1270 1280 1290 1300
SKKIFSKTKT HGSKDSETAF VSRNRNCKRK CRDSYQEPPR RKATLHRKCK
1310 1320 1330 1340 1350
EKAKPEDVRE TFGFSRPRLS KDSIRTLRLF PFSSKQLVKC PRRNQPVVVL
1360 1370 1380 1390 1400
NHPDADAPEV VSVMKTIAKF NGHVLKVSLS KRTINALLKP VCYNPPKTTY
1410 1420 1430 1440 1450
DDFSKRHKTF KPVSSVKERF VLKLTLKKTS KNNYQIVKTT SENILKAKFN
1460 1470 1480
CWFCGRVFDN QDTWAGHGQR HLMEATRDWN MLE
Length:1,483
Mass (Da):166,782
Last modified:June 27, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8202CFBDD12F9CB0
GO
Isoform 2 (identifier: Q6AHZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-530: Missing.

Show »
Length:953
Mass (Da):106,407
Checksum:i20E3A04EA85253B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWK1A0A087WWK1_HUMAN
Zinc finger protein 518A
ZNF518A
338Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30967 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA20793 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231E → G in AAH30967 (PubMed:15489334).Curated1
Sequence conflicti978M → V in CAH10523 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046310946N → H. Corresponds to variant dbSNP:rs3814228Ensembl.1
Natural variantiVAR_0463111328R → Q. Corresponds to variant dbSNP:rs3814226Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0194361 – 530Missing in isoform 2. 1 PublicationAdd BLAST530

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB002333 mRNA Translation: BAA20793.2 Different initiation.
CR627437 mRNA Translation: CAH10523.1
BC030967 mRNA Translation: AAH30967.1 Sequence problems.
BC109045 mRNA Translation: AAI09046.1
BC109046 mRNA Translation: AAI09047.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73170.1 [Q6AHZ1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001265453.1, NM_001278524.1 [Q6AHZ1-1]
NP_001265454.1, NM_001278525.1 [Q6AHZ1-1]
NP_001265455.1, NM_001278526.1 [Q6AHZ1-2]
NP_001317661.1, NM_001330732.1 [Q6AHZ1-1]
NP_001317662.1, NM_001330733.1 [Q6AHZ1-1]
NP_001317663.1, NM_001330734.1 [Q6AHZ1-1]
NP_001317664.1, NM_001330735.1 [Q6AHZ1-1]
NP_001317665.1, NM_001330736.1 [Q6AHZ1-1]
NP_001317666.1, NM_001330737.1 [Q6AHZ1-1]
NP_001317667.1, NM_001330738.1 [Q6AHZ1-1]
NP_055618.2, NM_014803.3 [Q6AHZ1-1]
XP_011538708.1, XM_011540406.2 [Q6AHZ1-1]
XP_011538710.1, XM_011540408.2
XP_011538712.1, XM_011540410.2 [Q6AHZ1-1]
XP_011538714.1, XM_011540412.2 [Q6AHZ1-1]
XP_011538715.1, XM_011540413.2 [Q6AHZ1-1]
XP_011538717.1, XM_011540415.2 [Q6AHZ1-1]
XP_011538720.1, XM_011540418.2 [Q6AHZ1-1]
XP_011538721.1, XM_011540419.2 [Q6AHZ1-1]
XP_011538722.1, XM_011540420.2 [Q6AHZ1-1]
XP_016872475.1, XM_017016986.1 [Q6AHZ1-1]
XP_016872478.1, XM_017016989.1 [Q6AHZ1-1]
XP_016872481.1, XM_017016992.1 [Q6AHZ1-1]
XP_016872483.1, XM_017016994.1 [Q6AHZ1-1]
XP_016872486.1, XM_017016997.1
XP_016872487.1, XM_017016998.1 [Q6AHZ1-1]
XP_016872488.1, XM_017016999.1 [Q6AHZ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000316045; ENSP00000479684; ENSG00000177853 [Q6AHZ1-1]
ENST00000614149; ENSP00000481657; ENSG00000177853 [Q6AHZ1-1]
ENST00000624776; ENSP00000485614; ENSG00000177853 [Q6AHZ1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9849

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9849

UCSC genome browser

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UCSCi
uc031wpm.2 human [Q6AHZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002333 mRNA Translation: BAA20793.2 Different initiation.
CR627437 mRNA Translation: CAH10523.1
BC030967 mRNA Translation: AAH30967.1 Sequence problems.
BC109045 mRNA Translation: AAI09046.1
BC109046 mRNA Translation: AAI09047.1
CCDSiCCDS73170.1 [Q6AHZ1-1]
RefSeqiNP_001265453.1, NM_001278524.1 [Q6AHZ1-1]
NP_001265454.1, NM_001278525.1 [Q6AHZ1-1]
NP_001265455.1, NM_001278526.1 [Q6AHZ1-2]
NP_001317661.1, NM_001330732.1 [Q6AHZ1-1]
NP_001317662.1, NM_001330733.1 [Q6AHZ1-1]
NP_001317663.1, NM_001330734.1 [Q6AHZ1-1]
NP_001317664.1, NM_001330735.1 [Q6AHZ1-1]
NP_001317665.1, NM_001330736.1 [Q6AHZ1-1]
NP_001317666.1, NM_001330737.1 [Q6AHZ1-1]
NP_001317667.1, NM_001330738.1 [Q6AHZ1-1]
NP_055618.2, NM_014803.3 [Q6AHZ1-1]
XP_011538708.1, XM_011540406.2 [Q6AHZ1-1]
XP_011538710.1, XM_011540408.2
XP_011538712.1, XM_011540410.2 [Q6AHZ1-1]
XP_011538714.1, XM_011540412.2 [Q6AHZ1-1]
XP_011538715.1, XM_011540413.2 [Q6AHZ1-1]
XP_011538717.1, XM_011540415.2 [Q6AHZ1-1]
XP_011538720.1, XM_011540418.2 [Q6AHZ1-1]
XP_011538721.1, XM_011540419.2 [Q6AHZ1-1]
XP_011538722.1, XM_011540420.2 [Q6AHZ1-1]
XP_016872475.1, XM_017016986.1 [Q6AHZ1-1]
XP_016872478.1, XM_017016989.1 [Q6AHZ1-1]
XP_016872481.1, XM_017016992.1 [Q6AHZ1-1]
XP_016872483.1, XM_017016994.1 [Q6AHZ1-1]
XP_016872486.1, XM_017016997.1
XP_016872487.1, XM_017016998.1 [Q6AHZ1-1]
XP_016872488.1, XM_017016999.1 [Q6AHZ1-1]

3D structure databases

SMRiQ6AHZ1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115184, 27 interactors
IntActiQ6AHZ1, 35 interactors
MINTiQ6AHZ1
STRINGi9606.ENSP00000485614

PTM databases

iPTMnetiQ6AHZ1
PhosphoSitePlusiQ6AHZ1

Polymorphism and mutation databases

BioMutaiZNF518A
DMDMi109896331

Proteomic databases

EPDiQ6AHZ1
jPOSTiQ6AHZ1
MassIVEiQ6AHZ1
MaxQBiQ6AHZ1
PeptideAtlasiQ6AHZ1
PRIDEiQ6AHZ1
ProteomicsDBi66181 [Q6AHZ1-1]
66182 [Q6AHZ1-2]

Genome annotation databases

EnsembliENST00000316045; ENSP00000479684; ENSG00000177853 [Q6AHZ1-1]
ENST00000614149; ENSP00000481657; ENSG00000177853 [Q6AHZ1-1]
ENST00000624776; ENSP00000485614; ENSG00000177853 [Q6AHZ1-1]
GeneIDi9849
KEGGihsa:9849
UCSCiuc031wpm.2 human [Q6AHZ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9849
EuPathDBiHostDB:ENSG00000177853.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF518A
HGNCiHGNC:29009 ZNF518A
HPAiHPA029049
MIMi617733 gene
neXtProtiNX_Q6AHZ1
OpenTargetsiENSG00000177853
PharmGKBiPA162410182

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000162006
HOGENOMiHOG000155775
InParanoidiQ6AHZ1
OMAiMGFKMVD
OrthoDBi1318335at2759
PhylomeDBiQ6AHZ1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF518A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9849
PharosiQ6AHZ1 Tbio

Protein Ontology

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PROi
PR:Q6AHZ1
RNActiQ6AHZ1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177853 Expressed in 215 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ6AHZ1 baseline and differential
GenevisibleiQ6AHZ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027760 ZNF518A
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24403:SF81 PTHR24403:SF81, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ518A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AHZ1
Secondary accession number(s): A0PJI5, O15044, Q32MP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: December 11, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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