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Protein

Solute carrier family 22 member 13

Gene

Slc22a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name:
ORCTL-3
Gene namesi
Name:Slc22a13
Synonyms:Orctl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143107 Slc22a13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 142ExtracellularSequence analysisAdd BLAST99
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 167CytoplasmicSequence analysis4
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 195ExtracellularSequence analysis7
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 251ExtracellularSequence analysis6
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 332CytoplasmicSequence analysisAdd BLAST60
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354ExtracellularSequence analysis1
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 404CytoplasmicSequence analysisAdd BLAST29
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 427ExtracellularSequence analysis2
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 452CytoplasmicSequence analysis4
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 478ExtracellularSequence analysis5
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 551CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307831 – 551Solute carrier family 22 member 13Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6A4L0
PRIDEiQ6A4L0

PTM databases

iPTMnetiQ6A4L0
PhosphoSitePlusiQ6A4L0

Expressioni

Gene expression databases

BgeeiENSMUSG00000074028 Expressed in 84 organ(s), highest expression level in retina
GenevisibleiQ6A4L0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081855

Structurei

3D structure databases

ProteinModelPortaliQ6A4L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ6A4L0
KOiK08209
OMAiPCLMFRP
OrthoDBiEOG091G05AC
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A4L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQFAQVMAE VGDFGRFQVR LTILMGIPNF LAAFFIFGQV FMVLDEAHHC
60 70 80 90 100
SVSWVKNHTF NLSAAEQLAI SIPNDTAGRP ESCLMFRPPP DSASLEDILS
110 120 130 140 150
HRFNETQACD SGWDYPENRP QSLKKEFDLV CDRKNLKKTS QSVFMAGLLV
160 170 180 190 200
GALVFGPVCD WIGRRPSLLM QVLLSGITSM ATAFVSSFEL YLALRFVLAT
210 220 230 240 250
ANAGFLLSTN VLISEWVGPS WRTQAVVLAQ SNVALGQMVL AGLAYGVRNW
260 270 280 290 300
RLLQITGTAP VLLLFFYFWV LPESPRWLLS QGRTEEAKQL VQKAALVNGR
310 320 330 340 350
PLSPELLNQL VPEKTGPSGN ALDLFRHPHL RKVTLILIAV WFVDSLVYYS
360 370 380 390 400
LSFQVGDFGL DIYVTQLIFG AVEMPGRFLS VLMMEKLGRK WSQLCTLTLA
410 420 430 440 450
GIMYIIIIFI PGDLPTVVTV LAVVGKFASA AAFTISYVYT AELFPTIIRQ
460 470 480 490 500
TGMGLVSIFS RVGGIITPLV MLLEQYHQAI PMVIFGSLPI GAGLLCALLP
510 520 530 540 550
ETRGQTLKDT LQDLEQGLPA GSHKTAPQRQ DMEALGRTSS VRVAVVKSSY

F
Length:551
Mass (Da):60,724
Last modified:July 27, 2011 - v3
Checksum:i2DAAE51ED8352724
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti402I → V in AAQ09528 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77A → T in strain: FVB/N. 1 Publication1
Natural varianti506T → I in strain: FVB/N. 1 Publication1
Natural varianti535L → S in strain: FVB/N. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529220 mRNA Translation: AAQ09528.1
AC055818 Genomic DNA No translation available.
BC021449 mRNA Translation: AAH21449.1
CCDSiCCDS40802.1
RefSeqiNP_598741.2, NM_133980.3
UniGeneiMm.38775

Genome annotation databases

EnsembliENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028
GeneIDi102570
KEGGimmu:102570
UCSCiuc009sal.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529220 mRNA Translation: AAQ09528.1
AC055818 Genomic DNA No translation available.
BC021449 mRNA Translation: AAH21449.1
CCDSiCCDS40802.1
RefSeqiNP_598741.2, NM_133980.3
UniGeneiMm.38775

3D structure databases

ProteinModelPortaliQ6A4L0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081855

PTM databases

iPTMnetiQ6A4L0
PhosphoSitePlusiQ6A4L0

Proteomic databases

PaxDbiQ6A4L0
PRIDEiQ6A4L0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028
GeneIDi102570
KEGGimmu:102570
UCSCiuc009sal.2 mouse

Organism-specific databases

CTDi9390
MGIiMGI:2143107 Slc22a13

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ6A4L0
KOiK08209
OMAiPCLMFRP
OrthoDBiEOG091G05AC
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-MMU-197264 Nicotinamide salvaging

Miscellaneous databases

PROiPR:Q6A4L0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074028 Expressed in 84 organ(s), highest expression level in retina
GenevisibleiQ6A4L0 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22AD_MOUSE
AccessioniPrimary (citable) accession number: Q6A4L0
Secondary accession number(s): E9QP74, Q8VC89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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