Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cytoskeletal 40

Gene

KRT40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in late hair differentiation.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei338Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 40
Alternative name(s):
Cytokeratin-40
Short name:
CK-40
Keratin-40
Short name:
K40
Type I hair keratin Ka36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT40
Synonyms:KA36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204889.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26707 KRT40

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616679 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6A162

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147357651

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166218814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148571 – 431Keratin, type I cytoskeletal 40Add BLAST431

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6A162

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6A162

PeptideAtlas

More...
PeptideAtlasi
Q6A162

PRoteomics IDEntifications database

More...
PRIDEi
Q6A162

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66176

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6A162

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6A162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During differentiation of the hair, it is one of the last keratins expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204889 Expressed in 30 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

More...
CleanExi
HS_KRT40

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6A162 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6A162 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q53FW83EBI-10171697,EBI-10242473
Q5BKY63EBI-10171697,EBI-10243533
Q5W1503EBI-10171697,EBI-10248148
Q8N9J23EBI-10171697,EBI-10268244
Q96GB03EBI-10171697,EBI-10286297
Q9H6F03EBI-10171697,EBI-10307481
Q9NWL93EBI-10171697,EBI-10315054
ADAMTSL3P829873EBI-10171697,EBI-10221726
AENQ8WTP83EBI-10171697,EBI-8637627
AESQ081173EBI-10171697,EBI-717810
AKAP17AQ02040-33EBI-10171697,EBI-10222656
ALDH3B1P433533EBI-10171697,EBI-2558314
ANKRD36BP1Q96IX93EBI-10171697,EBI-744859
AP1M1Q9BXS55EBI-10171697,EBI-541426
AQP1P299723EBI-10171697,EBI-745213
AQP5P550643EBI-10171697,EBI-746103
ARMC7Q9H6L45EBI-10171697,EBI-742909
ARSIQ5FYB13EBI-10171697,EBI-10243706
ASMTLO956713EBI-10171697,EBI-743231
ATPAF2Q8N5M17EBI-10171697,EBI-1166928
AVPI1Q5T6863EBI-10171697,EBI-8640233
AXIN1O151693EBI-10171697,EBI-710484
BAHD1Q8TBE03EBI-10171697,EBI-742750
BARD1Q997283EBI-10171697,EBI-473181
BCAS2O759343EBI-10171697,EBI-1050106
BEX2Q9BXY83EBI-10171697,EBI-745073
BYSLQ138957EBI-10171697,EBI-358049
C10orf62Q5T6813EBI-10171697,EBI-744052
C11orf87Q6NUJ23EBI-10171697,EBI-6660291
C18orf45B2RAB73EBI-10171697,EBI-743338
C19orf57Q0VDD73EBI-10171697,EBI-741210
C19orf73Q9NVV23EBI-10171697,EBI-2859285
C1orf109Q9NX043EBI-10171697,EBI-8643161
C1orf216Q8TAB53EBI-10171697,EBI-747505
C2CD6Q53TS83EBI-10171697,EBI-739879
C5orf60A6NFR6-43EBI-10171697,EBI-10173955
C6orf226Q5I0X43EBI-10171697,EBI-10244057
C8orf48Q96LL43EBI-10171697,EBI-751596
CA6Q8N4G43EBI-10171697,EBI-10265475
CARD9Q9H2573EBI-10171697,EBI-751319
CATIPQ7Z7H33EBI-10171697,EBI-10258233
CBX8Q9HC525EBI-10171697,EBI-712912
CCDC112Q8NEF33EBI-10171697,EBI-745040
CCDC120Q96HB5-43EBI-10171697,EBI-10185348
CCDC146Q8IYE0-23EBI-10171697,EBI-10247802
CCDC185Q8N7155EBI-10171697,EBI-740814
CCDC198Q9NVL83EBI-10171697,EBI-10238351
CCDC26Q8TAB73EBI-10171697,EBI-10271580
CCER1Q8TC903EBI-10171697,EBI-746041
CCHCR1Q8TD31-35EBI-10171697,EBI-10175300
CCNG1P519593EBI-10171697,EBI-3905829
CD33P201383EBI-10171697,EBI-3906571
CDC20BQ86Y333EBI-10171697,EBI-10260504
CDK18Q070023EBI-10171697,EBI-746238
CDK5R1Q8N6193EBI-10171697,EBI-10266998
CEP57Q86XR83EBI-10171697,EBI-308614
CEP57L1Q8IYX83EBI-10171697,EBI-1104570
CEP57L1Q8IYX8-23EBI-10171697,EBI-10181988
CFAP206Q8IYR05EBI-10171697,EBI-749051
CHCHD2Q9Y6H13EBI-10171697,EBI-2321769
CHCHD3Q9NX633EBI-10171697,EBI-743375
CHIC2Q9UKJ53EBI-10171697,EBI-741528
CLEC18AA5D8T83EBI-10171697,EBI-10173491
CNTFP264413EBI-10171697,EBI-1050897
COL8A1P276583EBI-10171697,EBI-747133
COMTP21964-23EBI-10171697,EBI-10200977
COX5AP206743EBI-10171697,EBI-715032
CREB5Q02930-35EBI-10171697,EBI-10192698
CTSZQ9UBR23EBI-10171697,EBI-8636823
CWF19L2Q2TBE03EBI-10171697,EBI-5453285
CYCSP999996EBI-10171697,EBI-446479
CYTH4Q8WWE83EBI-10171697,EBI-10277443
DAAM2Q6DCB03EBI-10171697,EBI-10249414
DCDC2BA2VCK23EBI-10171697,EBI-10173222
DCXO436023EBI-10171697,EBI-8646694
DDX6P261963EBI-10171697,EBI-351257
DLGAP2Q9P1A63EBI-10171697,EBI-1753397
DMRT3Q9NQL95EBI-10171697,EBI-9679045
DOCK2Q926085EBI-10171697,EBI-448771
DOCK8Q8NF503EBI-10171697,EBI-2548605
DTNBO609413EBI-10171697,EBI-740402
EIF4E2O605733EBI-10171697,EBI-398610
ELA2BQ6ISP93EBI-10171697,EBI-10250477
ELOAQ142413EBI-10171697,EBI-742350
EXOC3-AS1Q8N2X63EBI-10171697,EBI-749333
FAM107AO95990-33EBI-10171697,EBI-10192902
FAM124BQ9H5Z63EBI-10171697,EBI-741626
FAM214AQ32MH53EBI-10171697,EBI-2866142
FAM27E3Q08E933EBI-10171697,EBI-2602739
FAM71CQ8NEG03EBI-10171697,EBI-752049
FAM74A6Q5TZK35EBI-10171697,EBI-10247271
FAM90A1Q86YD75EBI-10171697,EBI-6658203
FARS2O953635EBI-10171697,EBI-2513774
FASLGP480233EBI-10171697,EBI-495538
FBF1Q8TES7-63EBI-10171697,EBI-10244131
FBXL18Q96D163EBI-10171697,EBI-744419
FBXO34Q9NWN33EBI-10171697,EBI-719816
FBXW5Q969U63EBI-10171697,EBI-741068
FKBP1BP681063EBI-10171697,EBI-6693977
FLJ23584Q9H5C53EBI-10171697,EBI-7226406
FNDC11Q9BVV23EBI-10171697,EBI-744935
FOXB1Q998533EBI-10171697,EBI-3916225
FRG1Q143313EBI-10171697,EBI-2515248
GAD1A0A0S2Z4D93EBI-10171697,EBI-16430771
GATA2P237693EBI-10171697,EBI-2806671
GATAD2AQ86YP4-33EBI-10171697,EBI-10261080
GEMP550403EBI-10171697,EBI-744104
GFOD1Q9NXC23EBI-10171697,EBI-8799578
GGNQ86UU53EBI-10171697,EBI-10259069
GNAI2P048993EBI-10171697,EBI-353997
GNG5P632183EBI-10171697,EBI-10220734
GOLGA6L2Q8N9W4-23EBI-10171697,EBI-10268729
GPATCH2LQ9NWQ43EBI-10171697,EBI-5666657
GTF3C5Q9Y5Q83EBI-10171697,EBI-1045409
GUCD1Q96NT33EBI-10171697,EBI-8293751
HAUS1Q96CS23EBI-10171697,EBI-2514791
HBA2P699053EBI-10171697,EBI-714680
HBZP020083EBI-10171697,EBI-719843
HCKP086313EBI-10171697,EBI-346340
HDAC4P565243EBI-10171697,EBI-308629
HEL-S-90nV9HWJ53EBI-10171697,EBI-10330335
HGSO149646EBI-10171697,EBI-740220
HOXA1P496393EBI-10171697,EBI-740785
HSPA12BQ96MM63EBI-10171697,EBI-10291310
HSPD1P108093EBI-10171697,EBI-352528
ING5Q8WYH83EBI-10171697,EBI-488533
INPP5DQ928353EBI-10171697,EBI-1380477
IQUBQ8NA543EBI-10171697,EBI-10220600
ISCUQ9H1K13EBI-10171697,EBI-1047335
ITGB5L7RT223EBI-10171697,EBI-10178729
JOSD1Q150405EBI-10171697,EBI-2510602
KAT5Q929933EBI-10171697,EBI-399080
KCTD9Q7L2733EBI-10171697,EBI-4397613
KIFC3Q9BVG83EBI-10171697,EBI-2125614
KLHL38Q2WGJ63EBI-10171697,EBI-6426443
KPNA2P522923EBI-10171697,EBI-349938
KRT2P3590810EBI-10171697,EBI-1247312
KRT20P359003EBI-10171697,EBI-742094
KRT4P190135EBI-10171697,EBI-2371606
KRT5P136475EBI-10171697,EBI-702187
KRT6AP0253813EBI-10171697,EBI-702198
KRT6CP486685EBI-10171697,EBI-2564105
KRT71Q3SY845EBI-10171697,EBI-2952676
KRT72Q14CN43EBI-10171697,EBI-1221280
KRT8P057875EBI-10171697,EBI-297852
KRT81Q145337EBI-10171697,EBI-739648
LAGE3Q146575EBI-10171697,EBI-1052105
LCE3EQ5T5B03EBI-10171697,EBI-10245456
LENG1Q96BZ85EBI-10171697,EBI-726510
LHX4A0A0S2Z5S93EBI-10171697,EBI-16429099
LIMS2Q7Z4I7-53EBI-10171697,EBI-10257651
LIN37Q96GY33EBI-10171697,EBI-748884
LMF2Q9BU233EBI-10171697,EBI-10298556
LMO1P258003EBI-10171697,EBI-8639312
LMO2P257913EBI-10171697,EBI-739696
LMO4P619683EBI-10171697,EBI-2798728
LRCH4O754273EBI-10171697,EBI-718707
MAB21L2Q9Y5863EBI-10171697,EBI-6659161
MAGOHBQ96A723EBI-10171697,EBI-746778
MAPKBP1O603363EBI-10171697,EBI-947402
MARK4Q6IPE93EBI-10171697,EBI-10250211
MED8Q96G25-23EBI-10171697,EBI-10286267
METTL17Q9H7H03EBI-10171697,EBI-749353
METTL17Q9H7H0-23EBI-10171697,EBI-11098807
MFAP1P550813EBI-10171697,EBI-1048159
MGC13033Q4ZG743EBI-10171697,EBI-10241963
MOB3CQ70IA83EBI-10171697,EBI-9679267
MOBPQ138753EBI-10171697,EBI-10230628
MOSP005403EBI-10171697,EBI-1757866
MRPL11Q9Y3B73EBI-10171697,EBI-5453723
MTA1Q133303EBI-10171697,EBI-714236
MXI1P50539-33EBI-10171697,EBI-10211940
MXI1P50539-43EBI-10171697,EBI-16436111
NAPRTQ6XQN6-23EBI-10171697,EBI-10254820
NDEL1Q9GZM83EBI-10171697,EBI-928842
NEK6Q9HC983EBI-10171697,EBI-740364
NFKBIDQ8NI383EBI-10171697,EBI-10271199
NINJ1Q929823EBI-10171697,EBI-2802124
NPBWR2P481463EBI-10171697,EBI-10210114
NPPBP168603EBI-10171697,EBI-747044
NR1D2Q6NSM03EBI-10171697,EBI-10250949
NXF1Q9UBU93EBI-10171697,EBI-398874
OPCMLA8K0Y03EBI-10171697,EBI-10174172
OTUB2Q9BWI93EBI-10171697,EBI-10300896
PDLIM5Q96HC43EBI-10171697,EBI-751267
PHF21AQ96BD53EBI-10171697,EBI-745085
PIGSQ96S523EBI-10171697,EBI-2908273
PIMREGQ9BSJ66EBI-10171697,EBI-2568609
PIN1Q135263EBI-10171697,EBI-714158
PKD2Q135633EBI-10171697,EBI-7813714
POLDIP3Q8WUT13EBI-10171697,EBI-10276663
POLLQ9UGP5-23EBI-10171697,EBI-10320765
POP5Q969H63EBI-10171697,EBI-366525
PPP1R18Q6NYC83EBI-10171697,EBI-2557469
PRAM1Q96QH23EBI-10171697,EBI-2860740
PRKAA1Q131313EBI-10171697,EBI-1181405
PRKAB2O437415EBI-10171697,EBI-1053424
PRPF31Q8WWY36EBI-10171697,EBI-1567797
PSMA1P257863EBI-10171697,EBI-359352
PSMC5P621953EBI-10171697,EBI-357745
PTGER3P43115-123EBI-10171697,EBI-10234038
PTPMT1Q8WUK03EBI-10171697,EBI-7199479
RAB3IL1Q8TBN03EBI-10171697,EBI-743796
RAB3IPQ96QF03EBI-10171697,EBI-747844
RAC1P630003EBI-10171697,EBI-413628
RASSF5Q8WWW03EBI-10171697,EBI-367390
RBM41Q96IZ53EBI-10171697,EBI-740773
RCOR3Q9P2K33EBI-10171697,EBI-743428
RECKQ6P9E23EBI-10171697,EBI-10253121
RNF213Q63HN8-63EBI-10171697,EBI-10248548
RNF6A0A0S2Z4G93EBI-10171697,EBI-16428950
RPL11P629133EBI-10171697,EBI-354380
RSPH14Q9UHP63EBI-10171697,EBI-748350
RTP5Q14D333EBI-10171697,EBI-10217913
RWDD2BP570605EBI-10171697,EBI-724442
RXRBA0A0S2Z4M53EBI-10171697,EBI-16436147
RXRBP28702-33EBI-10171697,EBI-16429492
RYDENQ9NUL53EBI-10171697,EBI-10313866
SCOCQ9UIL13EBI-10171697,EBI-2686537
SEMA4CQ9C0C43EBI-10171697,EBI-10303490
SETD5Q9C0A6-23EBI-10171697,EBI-10303449
SFRS2Q6NXQ03EBI-10171697,EBI-10251550
SH2D4AQ9H7885EBI-10171697,EBI-747035
SHC3Q925295EBI-10171697,EBI-79084
SLC25A10Q9UBX33EBI-10171697,EBI-750394
SLIRPQ9GZT33EBI-10171697,EBI-1050793
SLU7O953913EBI-10171697,EBI-750559
SMARCE1Q969G35EBI-10171697,EBI-455078
SMCO4Q9NRQ53EBI-10171697,EBI-8640191
SNAI1O958633EBI-10171697,EBI-1045459
SNRPBP14678-23EBI-10171697,EBI-372475
SNW1Q135733EBI-10171697,EBI-632715
SPEF1Q9Y4P93EBI-10171697,EBI-740053
SPG7Q9UQ903EBI-10171697,EBI-717201
SSX2BQ163853EBI-10171697,EBI-2210673
SSX2IPQ9Y2D83EBI-10171697,EBI-2212028
SYT6Q5T7P8-23EBI-10171697,EBI-10246152
TBC1D22BQ9NU193EBI-10171697,EBI-8787464
TCEA2Q155603EBI-10171697,EBI-710310
TCHPQ9BT923EBI-10171697,EBI-740781
TEAD4A0A0S2Z4F23EBI-10171697,EBI-16429215
TEAD4Q155615EBI-10171697,EBI-747736
THAP7Q9BT493EBI-10171697,EBI-741350
TIE1P355903EBI-10171697,EBI-2256865
TMEM231Q9H6L23EBI-10171697,EBI-10307654
TMSB4XQ0P5Q03EBI-10171697,EBI-10226570
TNIP3Q96KP64EBI-10171697,EBI-2509913
TNNT1P138053EBI-10171697,EBI-726527
TRAF4Q9BUZ45EBI-10171697,EBI-3650647
TRIM42Q8IWZ53EBI-10171697,EBI-5235829
TROAPQ128153EBI-10171697,EBI-2349743
TSC22D4Q8IV543EBI-10171697,EBI-10261521
TSGA10IPQ3SY003EBI-10171697,EBI-10241197
TSHZ3Q63HK53EBI-10171697,EBI-9053916
TTC23Q5W5X93EBI-10171697,EBI-6447954
TTC25Q96NG33EBI-10171697,EBI-1046387
TTLL10Q6ZVT03EBI-10171697,EBI-7844656
TXLNAP402225EBI-10171697,EBI-359793
TXN2Q997573EBI-10171697,EBI-2932492
TXNDC5Q86UY05EBI-10171697,EBI-2825190
TYK2P295973EBI-10171697,EBI-1383454
TYRO3Q064183EBI-10171697,EBI-3951628
UACAQ9BZF93EBI-10171697,EBI-350510
UBASH3AP570753EBI-10171697,EBI-2105393
USHBP1Q8N6Y03EBI-10171697,EBI-739895
USP2O756045EBI-10171697,EBI-743272
USP21Q9UK803EBI-10171697,EBI-373242
UTP14CQ08E773EBI-10171697,EBI-10225961
UTP23Q9BRU93EBI-10171697,EBI-5457544
UXTQ9UBK93EBI-10171697,EBI-357355
WDR25Q64LD23EBI-10171697,EBI-744560
WT1P195443EBI-10171697,EBI-2320534
WT1-ASQ062503EBI-10171697,EBI-10223946
ZBTB16Q055168EBI-10171697,EBI-711925
ZBTB24O431673EBI-10171697,EBI-744471
ZC2HC1CQ53FD03EBI-10171697,EBI-740767
ZFABQ9Y2603EBI-10171697,EBI-750052
ZFHX3Q15911-23EBI-10171697,EBI-10237226
ZFP2Q6ZN575EBI-10171697,EBI-7236323
ZFP69BQ9UJL93EBI-10171697,EBI-10322364
ZFYVE21Q9BQ243EBI-10171697,EBI-2849569
ZFYVE26Q68DK2-55EBI-10171697,EBI-8656416
ZGPATQ8N5A53EBI-10171697,EBI-3439227
ZGPATQ8N5A5-26EBI-10171697,EBI-10183064
ZMAT2Q96NC03EBI-10171697,EBI-2682299
ZNF101Q8IZC73EBI-10171697,EBI-5278328
ZNF124Q159733EBI-10171697,EBI-2555767
ZNF138P52744-23EBI-10171697,EBI-10213071
ZNF165Q53Z403EBI-10171697,EBI-10186058
ZNF20P170243EBI-10171697,EBI-717634
ZNF202O951255EBI-10171697,EBI-751960
ZNF230Q9UIE03EBI-10171697,EBI-1105361
ZNF250P15622-35EBI-10171697,EBI-10177272
ZNF26P170313EBI-10171697,EBI-2841331
ZNF266Q145845EBI-10171697,EBI-7115319
ZNF286AQ9HBT8-23EBI-10171697,EBI-10310244
ZNF317Q96PQ6-43EBI-10171697,EBI-10292528
ZNF329Q86UD43EBI-10171697,EBI-7233259
ZNF337Q9Y3M93EBI-10171697,EBI-714987
ZNF417Q8TAU35EBI-10171697,EBI-740727
ZNF439Q8NDP45EBI-10171697,EBI-747580
ZNF446Q9NWS9-25EBI-10171697,EBI-740232
ZNF488Q96MN93EBI-10171697,EBI-948288
ZNF564Q8TBZ83EBI-10171697,EBI-10273713
ZNF569Q5MCW43EBI-10171697,EBI-4395687
ZNF581Q9P0T45EBI-10171697,EBI-745520
ZNF587Q96SQ55EBI-10171697,EBI-6427977
ZNF625Q96I273EBI-10171697,EBI-4395587
ZNF655Q8N7203EBI-10171697,EBI-625509
ZNF688A0A0S2Z5X43EBI-10171697,EBI-16429014
ZNF697Q8N5083EBI-10171697,EBI-10265733
ZNF702PQ9H9633EBI-10171697,EBI-10309738
ZNF792Q3KQV33EBI-10171697,EBI-10240849
ZNF844Q08AG55EBI-10171697,EBI-10225757
ZSCAN21Q9Y5A63EBI-10171697,EBI-10281938

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125917, 313 interactors

Protein interaction database and analysis system

More...
IntActi
Q6A162, 376 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6A162

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6A162

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 400IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 89HeadAdd BLAST89
Regioni90 – 124Coil 1AAdd BLAST35
Regioni125 – 135Linker 1Add BLAST11
Regioni136 – 236Coil 1BAdd BLAST101
Regioni237 – 252Linker 12Add BLAST16
Regioni253 – 396Coil 2Add BLAST144
Regioni397 – 431TailAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFTS Eukaryota
ENOG41119VC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230975

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG013015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6A162

KEGG Orthology (KO)

More...
KOi
K07604

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDNVENQ

Database of Orthologous Groups

More...
OrthoDBi
798081at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6A162

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR002957 Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6A162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSDCSSTHC SPESCGTASG CAPASSCSVE TACLPGTCAT SRCQTPSFLS
60 70 80 90 100
RSRGLTGCLL PCYFTGSCNS PCLVGNCAWC EDGVFTSNEK ETMQFLNDRL
110 120 130 140 150
ASYLEKVRSL EETNAELESR IQEQCEQDIP MVCPDYQRYF NTIEDLQQKI
160 170 180 190 200
LCTKAENSRL AVQLDNCKLA TDDFKSKYES ELSLRQLLEA DISSLHGILE
210 220 230 240 250
ELTLCKSDLE AHVESLKEDL LCLKKNHEEE VNLLREQLGD RLSVELDTAP
260 270 280 290 300
TLDLNRVLDE MRCQCETVLA NNRREAEEWL AVQTEELNQQ QLSSAEQLQG
310 320 330 340 350
CQMEILELKR TASALEIELQ AQQSLTESLE CTVAETEAQY SSQLAQIQCL
360 370 380 390 400
IDNLENQLAE IRCDLERQNQ EYQVLLDVKA RLEGEINTYW GLLDSEDSRL
410 420 430
SCSPCSTTCT SSNTCEPCSA YVICTVENCC L
Length:431
Mass (Da):48,139
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD57C5153D50E7D41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1C2G3V1C2_HUMAN
Keratin, type I cytoskeletal 40
KRT40 KA36, hCG_1643846
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241R → C in CAH10353 (PubMed:15617563).Curated1
Sequence conflicti349C → R in CAH10353 (PubMed:15617563).Curated1
Sequence conflicti408T → I in CAH10353 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03807837T → A. Corresponds to variant dbSNP:rs1510069Ensembl.1
Natural variantiVAR_03807985F → S1 PublicationCorresponds to variant dbSNP:rs17843015Ensembl.1
Natural variantiVAR_038080102S → N. Corresponds to variant dbSNP:rs1510068Ensembl.1
Natural variantiVAR_038081153T → M. Corresponds to variant dbSNP:rs9908304Ensembl.1
Natural variantiVAR_049787235R → H. Corresponds to variant dbSNP:rs2010027Ensembl.1
Natural variantiVAR_049788265C → Y1 PublicationCorresponds to variant dbSNP:rs721957Ensembl.1
Natural variantiVAR_049789286E → D. Corresponds to variant dbSNP:rs721958Ensembl.1
Natural variantiVAR_049790303M → T. Corresponds to variant dbSNP:rs9908389Ensembl.1
Natural variantiVAR_049791406S → L. Corresponds to variant dbSNP:rs16968862Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ786658 mRNA Translation: CAH10353.1
BC130396 mRNA Translation: AAI30397.1
BC150174 mRNA Translation: AAI50175.1
BC150191 mRNA Translation: AAI50192.1
BK004055 mRNA Translation: DAA04488.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42320.1

NCBI Reference Sequences

More...
RefSeqi
NP_872303.2, NM_182497.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.534929

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377755; ENSP00000366984; ENSG00000204889
ENST00000398486; ENSP00000381500; ENSG00000204889
ENST00000576967; ENSP00000459621; ENSG00000262845
ENST00000610983; ENSP00000479080; ENSG00000262845

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
125115

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:125115

UCSC genome browser

More...
UCSCi
uc010cxh.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786658 mRNA Translation: CAH10353.1
BC130396 mRNA Translation: AAI30397.1
BC150174 mRNA Translation: AAI50175.1
BC150191 mRNA Translation: AAI50192.1
BK004055 mRNA Translation: DAA04488.1
CCDSiCCDS42320.1
RefSeqiNP_872303.2, NM_182497.3
UniGeneiHs.534929

3D structure databases

ProteinModelPortaliQ6A162
SMRiQ6A162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125917, 313 interactors
IntActiQ6A162, 376 interactors

PTM databases

iPTMnetiQ6A162
SwissPalmiQ6A162

Polymorphism and mutation databases

BioMutaiKRT40
DMDMi166218814

Proteomic databases

jPOSTiQ6A162
PaxDbiQ6A162
PeptideAtlasiQ6A162
PRIDEiQ6A162
ProteomicsDBi66176

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
125115
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377755; ENSP00000366984; ENSG00000204889
ENST00000398486; ENSP00000381500; ENSG00000204889
ENST00000576967; ENSP00000459621; ENSG00000262845
ENST00000610983; ENSP00000479080; ENSG00000262845
GeneIDi125115
KEGGihsa:125115
UCSCiuc010cxh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
125115
EuPathDBiHostDB:ENSG00000204889.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT40
HGNCiHGNC:26707 KRT40
MIMi616679 gene
neXtProtiNX_Q6A162
OpenTargetsiENSG00000204889
PharmGKBiPA147357651

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFTS Eukaryota
ENOG41119VC LUCA
GeneTreeiENSGT00940000161968
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ6A162
KOiK07604
OMAiIDNVENQ
OrthoDBi798081at2759
PhylomeDBiQ6A162
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
125115

Protein Ontology

More...
PROi
PR:Q6A162

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204889 Expressed in 30 organ(s), highest expression level in adenohypophysis
CleanExiHS_KRT40
ExpressionAtlasiQ6A162 baseline and differential
GenevisibleiQ6A162 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C40_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6A162
Secondary accession number(s): Q6IFU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 16, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again