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Entry version 138 (07 Oct 2020)
Sequence version 2 (15 Jan 2008)
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Protein

Keratin, type I cytoskeletal 40

Gene

KRT40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in late hair differentiation.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei338Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q6A162

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 40
Alternative name(s):
Cytokeratin-40
Short name:
CK-40
Keratin-40
Short name:
K40
Type I hair keratin Ka36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT40
Synonyms:KA36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204889.10

Human Gene Nomenclature Database

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HGNCi
HGNC:26707, KRT40

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616679, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6A162

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
125115

Open Targets

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OpenTargetsi
ENSG00000204889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA147357651

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q6A162, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRT40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166218814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148571 – 431Keratin, type I cytoskeletal 40Add BLAST431

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1314

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6A162

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6A162

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6A162

PeptideAtlas

More...
PeptideAtlasi
Q6A162

PRoteomics IDEntifications database

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PRIDEi
Q6A162

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
66176

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6A162

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6A162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During differentiation of the hair, it is one of the last keratins expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000204889, Expressed in adenohypophysis and 44 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6A162, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6A162, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204889, Tissue enhanced (pituitary gland, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6A162
With#Exp.IntAct
ACSF3 [Q4G176]3EBI-10171697,EBI-10714818
ADAMTS1 [Q9UHI8]3EBI-10171697,EBI-2511802
ADAMTSL3 [P82987]3EBI-10171697,EBI-10221726
AEN [Q8WTP8]3EBI-10171697,EBI-8637627
AGXT [P21549]3EBI-10171697,EBI-727098
AKAP17A - isoform 3 [Q02040-3]3EBI-10171697,EBI-10222656
ALDH3B1 [P43353]3EBI-10171697,EBI-2558314
ANKRD36BP1 [Q96IX9]3EBI-10171697,EBI-744859
AP1M1 [Q9BXS5]6EBI-10171697,EBI-541426
AQP1 [P29972]3EBI-10171697,EBI-745213
AQP5 [P55064]3EBI-10171697,EBI-746103
ARMC7 [Q9H6L4]6EBI-10171697,EBI-742909
ARSI [Q5FYB1]3EBI-10171697,EBI-10243706
ASMTL [O95671]3EBI-10171697,EBI-743231
ATPAF2 [Q8N5M1]7EBI-10171697,EBI-1166928
AVPI1 [Q5T686]3EBI-10171697,EBI-8640233
AXIN1 [O15169]3EBI-10171697,EBI-710484
BAHD1 [Q8TBE0]3EBI-10171697,EBI-742750
BARD1 [Q99728]3EBI-10171697,EBI-473181
BCAS2 [O75934]3EBI-10171697,EBI-1050106
BEX2 [Q9BXY8]3EBI-10171697,EBI-745073
BYSL [Q13895]8EBI-10171697,EBI-358049
C10orf62 [Q5T681]3EBI-10171697,EBI-744052
C11orf87 [Q6NUJ2]3EBI-10171697,EBI-6660291
C18orf45 [B2RAB7]3EBI-10171697,EBI-743338
C19orf57 [Q0VDD7]3EBI-10171697,EBI-741210
C19orf73 [Q9NVV2]3EBI-10171697,EBI-2859285
C1orf109 [Q9NX04]3EBI-10171697,EBI-8643161
C1orf216 [Q8TAB5]3EBI-10171697,EBI-747505
C2CD6 [Q53TS8]3EBI-10171697,EBI-739879
C2orf68 [Q2NKX9]3EBI-10171697,EBI-11603468
C4orf45 [Q96LM5]3EBI-10171697,EBI-12020542
C5orf60 - isoform 4 [A6NFR6-4]3EBI-10171697,EBI-10173955
C6orf226 [Q5I0X4]3EBI-10171697,EBI-10244057
C8orf48 [Q96LL4]3EBI-10171697,EBI-751596
CA6 [Q8N4G4]3EBI-10171697,EBI-10265475
CARD9 [Q9H257]3EBI-10171697,EBI-751319
CATIP [Q7Z7H3]3EBI-10171697,EBI-10258233
CBX8 [Q9HC52]6EBI-10171697,EBI-712912
CCDC112 [Q8NEF3]3EBI-10171697,EBI-745040
CCDC116 [Q8IYX3]3EBI-10171697,EBI-744311
CCDC120 - isoform 4 [Q96HB5-4]4EBI-10171697,EBI-10185348
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-10171697,EBI-10247802
CCDC185 [Q8N715]6EBI-10171697,EBI-740814
CCDC198 [Q9NVL8]3EBI-10171697,EBI-10238351
CCDC26 [Q8TAB7]3EBI-10171697,EBI-10271580
CCER1 [Q8TC90]3EBI-10171697,EBI-746041
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-10171697,EBI-10175300
CCNG1 [P51959]3EBI-10171697,EBI-3905829
CD33 [P20138]3EBI-10171697,EBI-3906571
CDC20B [Q86Y33]3EBI-10171697,EBI-10260504
CDK18 [Q07002]3EBI-10171697,EBI-746238
CDK5R1 [Q8N619]3EBI-10171697,EBI-10266998
CEP57 [Q86XR8]3EBI-10171697,EBI-308614
CEP57L1 [Q8IYX8]3EBI-10171697,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-10171697,EBI-10181988
CFAP206 [Q8IYR0]6EBI-10171697,EBI-749051
CHCHD2 [Q9Y6H1]3EBI-10171697,EBI-2321769
CHCHD3 [Q9NX63]3EBI-10171697,EBI-743375
CHIC2 [Q9UKJ5]3EBI-10171697,EBI-741528
CLEC18A [A5D8T8]3EBI-10171697,EBI-10173491
CNNM3 [Q8NE01]3EBI-10171697,EBI-741032
CNTF [P26441]3EBI-10171697,EBI-1050897
COL8A1 [P27658]3EBI-10171697,EBI-747133
COMT - isoform Soluble [P21964-2]3EBI-10171697,EBI-10200977
COX5A [P20674]3EBI-10171697,EBI-715032
CREB5 - isoform 3 [Q02930-3]6EBI-10171697,EBI-10192698
CRY2 [Q49AN0]3EBI-10171697,EBI-2212355
CTSZ [Q9UBR2]3EBI-10171697,EBI-8636823
CWF19L2 [Q2TBE0]3EBI-10171697,EBI-5453285
CYCS [P99999]6EBI-10171697,EBI-446479
CYTH4 [Q8WWE8]3EBI-10171697,EBI-10277443
DAAM2 [Q6DCB0]3EBI-10171697,EBI-10249414
DCDC2B [A2VCK2]3EBI-10171697,EBI-10173222
DCX [O43602]3EBI-10171697,EBI-8646694
DDX6 [P26196]3EBI-10171697,EBI-351257
DHX57 [Q6P158]3EBI-10171697,EBI-1051531
DLGAP2 [Q9P1A6]4EBI-10171697,EBI-1753397
DMRT3 [Q9NQL9]6EBI-10171697,EBI-9679045
DOCK2 [Q92608]6EBI-10171697,EBI-448771
DOCK8 [Q8NF50]3EBI-10171697,EBI-2548605
DTNB [O60941]3EBI-10171697,EBI-740402
EIF4E2 [O60573]3EBI-10171697,EBI-398610
ELA2B [Q6ISP9]3EBI-10171697,EBI-10250477
ELOA [Q14241]3EBI-10171697,EBI-742350
ENKD1 [Q9H0I2]3EBI-10171697,EBI-744099
EXOC3-AS1 [Q8N2X6]3EBI-10171697,EBI-749333
FADS2 - isoform 3 [O95864-3]3EBI-10171697,EBI-12057609
FAM107A - isoform 3 [O95990-3]3EBI-10171697,EBI-10192902
FAM124B [Q9H5Z6]3EBI-10171697,EBI-741626
FAM214A [Q32MH5]3EBI-10171697,EBI-2866142
FAM27E3 [Q08E93]3EBI-10171697,EBI-2602739
FAM71C [Q8NEG0]3EBI-10171697,EBI-752049
FAM74A6 [Q5TZK3]3EBI-10171697,EBI-10247271
FAM90A1 [Q86YD7]6EBI-10171697,EBI-6658203
FARS2 [O95363]6EBI-10171697,EBI-2513774
FASLG [P48023]3EBI-10171697,EBI-495538
FBF1 - isoform 6 [Q8TES7-6]3EBI-10171697,EBI-10244131
FBXL18 [Q96D16]3EBI-10171697,EBI-744419
FBXO34 [Q9NWN3]3EBI-10171697,EBI-719816
FBXW5 [Q969U6]3EBI-10171697,EBI-741068
FEZF1 [A0PJY2]3EBI-10171697,EBI-11988727
FKBP1B [P68106]3EBI-10171697,EBI-6693977
FLJ23584 [Q9H5C5]3EBI-10171697,EBI-7226406
FNDC11 [Q9BVV2]3EBI-10171697,EBI-744935
FOXB1 [Q99853]3EBI-10171697,EBI-3916225
FRG1 [Q14331]3EBI-10171697,EBI-2515248
GAD1 [A0A0S2Z4D9]3EBI-10171697,EBI-16430771
GADD45GIP1 [Q8TAE8]3EBI-10171697,EBI-372506
GATA2 [P23769]3EBI-10171697,EBI-2806671
GATAD2A - isoform 3 [Q86YP4-3]3EBI-10171697,EBI-10261080
GEM [P55040]3EBI-10171697,EBI-744104
GFOD1 [Q9NXC2]3EBI-10171697,EBI-8799578
GGN [Q86UU5]3EBI-10171697,EBI-10259069
GNAI2 [P04899]3EBI-10171697,EBI-353997
GNE - isoform 2 [Q9Y223-2]3EBI-10171697,EBI-11975289
GNG5 [P63218]3EBI-10171697,EBI-10220734
GOLGA6L2 - isoform 2 [Q8N9W4-2]3EBI-10171697,EBI-10268729
GPATCH2L [Q9NWQ4]3EBI-10171697,EBI-5666657
GTF3C5 [Q9Y5Q8]3EBI-10171697,EBI-1045409
GUCD1 [Q96NT3]3EBI-10171697,EBI-8293751
HAPLN2 [Q9GZV7]3EBI-10171697,EBI-11956675
HAUS1 [Q96CS2]3EBI-10171697,EBI-2514791
HBA2 [P69905]3EBI-10171697,EBI-714680
HBZ [P02008]3EBI-10171697,EBI-719843
HCK [P08631]3EBI-10171697,EBI-346340
HCK - isoform 2 [P08631-2]3EBI-10171697,EBI-9834454
HDAC4 [P56524]3EBI-10171697,EBI-308629
HDAC4 - isoform 2 [P56524-2]3EBI-10171697,EBI-11953488
HEL-S-90n [V9HWJ5]3EBI-10171697,EBI-10330335
HGS [O14964]6EBI-10171697,EBI-740220
HOXA1 [P49639]3EBI-10171697,EBI-740785
HOXB9 [P17482]3EBI-10171697,EBI-745290
HOXC8 [P31273]3EBI-10171697,EBI-1752118
HSD3B7 [Q9H2F3]3EBI-10171697,EBI-3918847
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-10171697,EBI-12056251
HSPA12B [Q96MM6]3EBI-10171697,EBI-10291310
HSPD1 [P10809]3EBI-10171697,EBI-352528
ING5 [Q8WYH8]3EBI-10171697,EBI-488533
INO80B [Q9C086]3EBI-10171697,EBI-715611
INPP5D [Q92835]3EBI-10171697,EBI-1380477
IQUB [Q8NA54]3EBI-10171697,EBI-10220600
ISCU [Q9H1K1]3EBI-10171697,EBI-1047335
ITGB4 - isoform Beta-4A [P16144-2]3EBI-10171697,EBI-11051601
ITGB5 [L7RT22]3EBI-10171697,EBI-10178729
JOSD1 [Q15040]6EBI-10171697,EBI-2510602
KANK2 [Q63ZY3]3EBI-10171697,EBI-2556193
KAT5 [Q92993]3EBI-10171697,EBI-399080
KCTD9 [Q7L273]3EBI-10171697,EBI-4397613
KDM1A [O60341]3EBI-10171697,EBI-710124
KIFC3 [Q9BVG8]3EBI-10171697,EBI-2125614
KLHL38 [Q2WGJ6]3EBI-10171697,EBI-6426443
KPNA2 [P52292]3EBI-10171697,EBI-349938
KRT2 [P35908]11EBI-10171697,EBI-1247312
KRT20 [P35900]3EBI-10171697,EBI-742094
KRT4 [P19013]7EBI-10171697,EBI-2371606
KRT5 [P13647]6EBI-10171697,EBI-702187
KRT6A [P02538]14EBI-10171697,EBI-702198
KRT6B [P04259]3EBI-10171697,EBI-740907
KRT6C [P48668]6EBI-10171697,EBI-2564105
KRT71 [Q3SY84]6EBI-10171697,EBI-2952676
KRT72 [Q14CN4]3EBI-10171697,EBI-1221280
KRT75 [O95678]3EBI-10171697,EBI-2949715
KRT76 [Q01546]3EBI-10171697,EBI-2952745
KRT8 [P05787]6EBI-10171697,EBI-297852
KRT81 [Q14533]8EBI-10171697,EBI-739648
KRT82 [Q9NSB4]3EBI-10171697,EBI-1045341
KRT83 [P78385]3EBI-10171697,EBI-10221390
KRT85 [P78386]3EBI-10171697,EBI-1049371
KRT86 [O43790]3EBI-10171697,EBI-9996498
LAGE3 [Q14657]6EBI-10171697,EBI-1052105
LCE3E [Q5T5B0]3EBI-10171697,EBI-10245456
LENG1 [Q96BZ8]6EBI-10171697,EBI-726510
LHX4 [A0A0S2Z5S9]3EBI-10171697,EBI-16429099
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-10171697,EBI-10257651
LIN37 [Q96GY3]3EBI-10171697,EBI-748884
LMF2 [Q9BU23]3EBI-10171697,EBI-10298556
LMO1 [P25800]3EBI-10171697,EBI-8639312
LMO2 [P25791]3EBI-10171697,EBI-739696
LMO4 [P61968]3EBI-10171697,EBI-2798728
LRCH4 [O75427]3EBI-10171697,EBI-718707
MAB21L2 [Q9Y586]3EBI-10171697,EBI-6659161
MAGOHB [Q96A72]3EBI-10171697,EBI-746778
MAPKBP1 [O60336]3EBI-10171697,EBI-947402
MARK4 [Q6IPE9]3EBI-10171697,EBI-10250211
MED8 - isoform 2 [Q96G25-2]3EBI-10171697,EBI-10286267
METTL17 [Q9H7H0]4EBI-10171697,EBI-749353
METTL17 - isoform 2 [Q9H7H0-2]3EBI-10171697,EBI-11098807
MFAP1 [P55081]3EBI-10171697,EBI-1048159
MGC13033 [Q4ZG74]3EBI-10171697,EBI-10241963
MID2 - isoform 2 [Q9UJV3-2]3EBI-10171697,EBI-10172526
MOB3C [Q70IA8]3EBI-10171697,EBI-9679267
MOBP [Q13875]3EBI-10171697,EBI-10230628
MOS [P00540]3EBI-10171697,EBI-1757866
MRPL11 [Q9Y3B7]3EBI-10171697,EBI-5453723
MRRF [Q96E11]3EBI-10171697,EBI-2855755
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-10171697,EBI-10699187
MTA1 [Q13330]4EBI-10171697,EBI-714236
MXI1 - isoform 3 [P50539-3]3EBI-10171697,EBI-10211940
MXI1 - isoform 4 [P50539-4]3EBI-10171697,EBI-16436111
MYPOP [Q86VE0]3EBI-10171697,EBI-2858213
NAPRT - isoform 2 [Q6XQN6-2]3EBI-10171697,EBI-10254820
NDEL1 [Q9GZM8]3EBI-10171697,EBI-928842
NEK6 [Q9HC98]3EBI-10171697,EBI-740364
NEK6 - isoform 4 [Q9HC98-4]3EBI-10171697,EBI-11750983
NFKBID [Q8NI38]3EBI-10171697,EBI-10271199
NINJ1 [Q92982]3EBI-10171697,EBI-2802124
NPBWR2 [P48146]3EBI-10171697,EBI-10210114
NPPB [P16860]3EBI-10171697,EBI-747044
NR1D2 [Q6NSM0]3EBI-10171697,EBI-10250949
NXF1 [Q9UBU9]3EBI-10171697,EBI-398874
OIP5 [O43482]3EBI-10171697,EBI-536879
OPCML [A8K0Y0]3EBI-10171697,EBI-10174172
OTUB2 [Q9BWI9]3EBI-10171697,EBI-10300896
PDLIM5 [Q96HC4]3EBI-10171697,EBI-751267
PHF1 [O43189]3EBI-10171697,EBI-530034
PHF21A [Q96BD5]3EBI-10171697,EBI-745085
PHLDA1 [A2BDE7]3EBI-10171697,EBI-14084211
PIGS [Q96S52]3EBI-10171697,EBI-2908273
PIMREG [Q9BSJ6]6EBI-10171697,EBI-2568609
PIN1 [Q13526]3EBI-10171697,EBI-714158
PKD2 [Q13563]3EBI-10171697,EBI-7813714
POLDIP3 [Q8WUT1]3EBI-10171697,EBI-10276663
POLL - isoform 2 [Q9UGP5-2]3EBI-10171697,EBI-10320765
POP5 [Q969H6]3EBI-10171697,EBI-366525
PPP1R18 [Q6NYC8]3EBI-10171697,EBI-2557469
PRAM1 [Q96QH2]3EBI-10171697,EBI-2860740
PRKAA1 [Q13131]3EBI-10171697,EBI-1181405
PRKAB2 [O43741]6EBI-10171697,EBI-1053424
PRPF18 [Q99633]3EBI-10171697,EBI-2798416
PRPF31 [Q8WWY3]6EBI-10171697,EBI-1567797
PSMA1 [P25786]3EBI-10171697,EBI-359352
PSMB1 [P20618]3EBI-10171697,EBI-372273
PSMC5 [P62195]5EBI-10171697,EBI-357745
PTGER3 - isoform 12 [P43115-12]3EBI-10171697,EBI-10234038
PTPMT1 [Q8WUK0]3EBI-10171697,EBI-7199479
RAB3IL1 [Q8TBN0]3EBI-10171697,EBI-743796
RAB3IP [Q96QF0]3EBI-10171697,EBI-747844
RAC1 [P63000]3EBI-10171697,EBI-413628
RASSF5 [Q8WWW0]3EBI-10171697,EBI-367390
RBM41 [Q96IZ5]3EBI-10171697,EBI-740773
RCOR3 [Q9P2K3]3EBI-10171697,EBI-743428
RECK [Q6P9E2]3EBI-10171697,EBI-10253121
RGS8 - isoform 2 [P57771-2]3EBI-10171697,EBI-12058229
RNF213 - isoform 4 [Q63HN8-6]3EBI-10171697,EBI-10248548
RNF6 [A0A0S2Z4G9]3EBI-10171697,EBI-16428950
RPL11 [P62913]3EBI-10171697,EBI-354380
RSPH14 [Q9UHP6]3EBI-10171697,EBI-748350
RTP5 [Q14D33]3EBI-10171697,EBI-10217913
RWDD2B [P57060]6EBI-10171697,EBI-724442
RXRB [A0A0S2Z4M5]3EBI-10171697,EBI-16436147
RXRB - isoform 2 [P28702-3]3EBI-10171697,EBI-16429492
SCAND1 [P57086]3EBI-10171697,EBI-745846
SCOC [Q9UIL1]3EBI-10171697,EBI-2686537
SEMA4C [Q9C0C4]3EBI-10171697,EBI-10303490
SETD5 - isoform 2 [Q9C0A6-2]3EBI-10171697,EBI-10303449
SFRS2 [Q6NXQ0]3EBI-10171697,EBI-10251550
SH2D4A [Q9H788]6EBI-10171697,EBI-747035
SHC3 [Q92529]6EBI-10171697,EBI-79084
SHFL [Q9NUL5]3EBI-10171697,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-10171697,EBI-11955083
SLC23A1 - isoform 3 [Q9UHI7-3]3EBI-10171697,EBI-11998660
SLC25A10 [Q9UBX3]3EBI-10171697,EBI-750394
SLIRP [Q9GZT3]3EBI-10171697,EBI-1050793
SLU7 [O95391]3EBI-10171697,EBI-750559
SMARCE1 [Q969G3]6EBI-10171697,EBI-455078
SMCO4 [Q9NRQ5]3EBI-10171697,EBI-8640191
SNAI1 [O95863]4EBI-10171697,EBI-1045459
SNRPB - isoform SM-B [P14678-2]3EBI-10171697,EBI-372475
SNW1 [Q13573]3EBI-10171697,EBI-632715
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-10171697,EBI-11995806
SPEF1 [Q9Y4P9]3EBI-10171697,EBI-740053
SPG7 [Q9UQ90]3EBI-10171697,EBI-717201
SSX2B [Q16385]3EBI-10171697,EBI-2210673
SSX2IP [Q9Y2D8]3EBI-10171697,EBI-2212028
SUOX [P51687]3EBI-10171697,EBI-3921347
SYT6 - isoform 2 [Q5T7P8-2]3EBI-10171697,EBI-10246152
TACO1 [Q9BSH4]3EBI-10171697,EBI-747797
TBC1D21 [Q8IYX1]3EBI-10171697,EBI-12018146
TBC1D22B [Q9NU19]4EBI-10171697,EBI-8787464
TCEA2 [Q15560]3EBI-10171697,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-10171697,EBI-11955057
TCHP [Q9BT92]3EBI-10171697,EBI-740781
TEAD4 [A0A0S2Z4F2]3EBI-10171697,EBI-16429215
TEAD4 [Q15561]6EBI-10171697,EBI-747736
THAP7 [Q9BT49]3EBI-10171697,EBI-741350
TIE1 [P35590]3EBI-10171697,EBI-2256865
TLE5 [Q08117]3EBI-10171697,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-10171697,EBI-11741437
TMEM231 [Q9H6L2]3EBI-10171697,EBI-10307654
TMSB4X [Q0P5Q0]3EBI-10171697,EBI-10226570
TNIP3 [Q96KP6]4EBI-10171697,EBI-2509913
TNNT1 [P13805]3EBI-10171697,EBI-726527
TRAF4 [Q9BUZ4]6EBI-10171697,EBI-3650647
TRIM42 [Q8IWZ5]3EBI-10171697,EBI-5235829
TROAP [Q12815]3EBI-10171697,EBI-2349743
TSC22D4 [Q8IV54]3EBI-10171697,EBI-10261521
TSGA10IP [Q3SY00]3EBI-10171697,EBI-10241197
TSHZ3 [Q63HK5]3EBI-10171697,EBI-9053916
TTC23 [Q5W5X9]3EBI-10171697,EBI-6447954
TTC25 [Q96NG3]3EBI-10171697,EBI-1046387
TTC9C [Q8N5M4]3EBI-10171697,EBI-2851213
TTLL10 [Q6ZVT0]3EBI-10171697,EBI-7844656
TXLNA [P40222]6EBI-10171697,EBI-359793
TXN2 [Q99757]3EBI-10171697,EBI-2932492
TXNDC5 [Q86UY0]3EBI-10171697,EBI-2825190
TYK2 [P29597]3EBI-10171697,EBI-1383454
TYRO3 [Q06418]3EBI-10171697,EBI-3951628
UACA [Q9BZF9]3EBI-10171697,EBI-350510
UBASH3A [P57075]3EBI-10171697,EBI-2105393
USHBP1 [Q8N6Y0]3EBI-10171697,EBI-739895
USP2 [O75604]6EBI-10171697,EBI-743272
USP21 [Q9UK80]3EBI-10171697,EBI-373242
UTP14C [Q08E77]3EBI-10171697,EBI-10225961
UTP23 [Q9BRU9]3EBI-10171697,EBI-5457544
UXT [Q9UBK9]3EBI-10171697,EBI-357355
VEZF1 [Q14119]3EBI-10171697,EBI-11980193
WDR25 [Q64LD2]3EBI-10171697,EBI-744560
WT1 [P19544]4EBI-10171697,EBI-2320534
WT1-AS [Q06250]3EBI-10171697,EBI-10223946
ZBTB16 [Q05516]9EBI-10171697,EBI-711925
ZBTB24 [O43167]3EBI-10171697,EBI-744471
ZBTB42 [B2RXF5]3EBI-10171697,EBI-12287587
ZC2HC1C [Q53FD0]3EBI-10171697,EBI-740767
ZFAB [Q9Y260]3EBI-10171697,EBI-750052
ZFHX3 - isoform B [Q15911-2]3EBI-10171697,EBI-10237226
ZFP1 [Q6P2D0]3EBI-10171697,EBI-2555749
ZFP2 [Q6ZN57]6EBI-10171697,EBI-7236323
ZFP69B [Q9UJL9]3EBI-10171697,EBI-10322364
ZFYVE21 [Q9BQ24]3EBI-10171697,EBI-2849569
ZFYVE26 - isoform 5 [Q68DK2-5]6EBI-10171697,EBI-8656416
ZGPAT [Q8N5A5]3EBI-10171697,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]6EBI-10171697,EBI-10183064
ZMAT2 [Q96NC0]3EBI-10171697,EBI-2682299
ZNF101 [Q8IZC7]3EBI-10171697,EBI-5278328
ZNF124 [Q15973]3EBI-10171697,EBI-2555767
ZNF138 - isoform 2 [P52744-2]3EBI-10171697,EBI-10213071
ZNF165 [Q53Z40]3EBI-10171697,EBI-10186058
ZNF17 [P17021]3EBI-10171697,EBI-1105334
ZNF20 [P17024]3EBI-10171697,EBI-717634
ZNF202 [O95125]6EBI-10171697,EBI-751960
ZNF230 [Q9UIE0]3EBI-10171697,EBI-1105361
ZNF250 - isoform 3 [P15622-3]6EBI-10171697,EBI-10177272
ZNF26 [P17031]3EBI-10171697,EBI-2841331
ZNF266 [Q14584]5EBI-10171697,EBI-7115319
ZNF286A - isoform 2 [Q9HBT8-2]3EBI-10171697,EBI-10310244
ZNF317 - isoform 4 [Q96PQ6-4]3EBI-10171697,EBI-10292528
ZNF319 [Q9P2F9]3EBI-10171697,EBI-11993110
ZNF329 [Q86UD4]3EBI-10171697,EBI-7233259
ZNF337 [Q9Y3M9]3EBI-10171697,EBI-714987
ZNF408 [Q9H9D4]3EBI-10171697,EBI-347633
ZNF410 - isoform 3 [Q86VK4-3]3EBI-10171697,EBI-11741890
ZNF417 [Q8TAU3]6EBI-10171697,EBI-740727
ZNF438 [Q7Z4V0]3EBI-10171697,EBI-11962468
ZNF439 [Q8NDP4]6EBI-10171697,EBI-747580
ZNF446 - isoform 2 [Q9NWS9-2]6EBI-10171697,EBI-740232
ZNF488 [Q96MN9]3EBI-10171697,EBI-948288
ZNF564 [Q8TBZ8]3EBI-10171697,EBI-10273713
ZNF569 [Q5MCW4]3EBI-10171697,EBI-4395687
ZNF575 [Q86XF7]3EBI-10171697,EBI-14069183
ZNF580 [Q9UK33]3EBI-10171697,EBI-746277
ZNF581 [Q9P0T4]6EBI-10171697,EBI-745520
ZNF587 [Q96SQ5]6EBI-10171697,EBI-6427977
ZNF625 [Q96I27]3EBI-10171697,EBI-4395587
ZNF655 [Q8N720]3EBI-10171697,EBI-625509
ZNF688 [A0A0S2Z5X4]3EBI-10171697,EBI-16429014
ZNF697 [Q8N508]3EBI-10171697,EBI-10265733
ZNF702P [Q9H963]3EBI-10171697,EBI-10309738
ZNF76 [P36508]3EBI-10171697,EBI-7254550
ZNF792 [Q3KQV3]3EBI-10171697,EBI-10240849
ZNF844 [Q08AG5]6EBI-10171697,EBI-10225757
ZSCAN21 [Q9Y5A6]3EBI-10171697,EBI-10281938
Q53FW83EBI-10171697,EBI-10242473
Q5BKY63EBI-10171697,EBI-10243533
Q5W1503EBI-10171697,EBI-10248148
Q8N9J23EBI-10171697,EBI-10268244
Q96GB03EBI-10171697,EBI-10286297
Q9H6F03EBI-10171697,EBI-10307481
Q9NWL93EBI-10171697,EBI-10315054

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125917, 381 interactors

Protein interaction database and analysis system

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IntActi
Q6A162, 374 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366984

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6A162, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6A162

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 400IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 89HeadAdd BLAST89
Regioni90 – 124Coil 1AAdd BLAST35
Regioni125 – 135Linker 1Add BLAST11
Regioni136 – 236Coil 1BAdd BLAST101
Regioni237 – 252Linker 12Add BLAST16
Regioni253 – 396Coil 2Add BLAST144
Regioni397 – 431TailAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502SHG0, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_8_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6A162

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
IPLVCPD

Database of Orthologous Groups

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OrthoDBi
798081at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6A162

TreeFam database of animal gene trees

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TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

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PANTHERi
PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6A162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSDCSSTHC SPESCGTASG CAPASSCSVE TACLPGTCAT SRCQTPSFLS
60 70 80 90 100
RSRGLTGCLL PCYFTGSCNS PCLVGNCAWC EDGVFTSNEK ETMQFLNDRL
110 120 130 140 150
ASYLEKVRSL EETNAELESR IQEQCEQDIP MVCPDYQRYF NTIEDLQQKI
160 170 180 190 200
LCTKAENSRL AVQLDNCKLA TDDFKSKYES ELSLRQLLEA DISSLHGILE
210 220 230 240 250
ELTLCKSDLE AHVESLKEDL LCLKKNHEEE VNLLREQLGD RLSVELDTAP
260 270 280 290 300
TLDLNRVLDE MRCQCETVLA NNRREAEEWL AVQTEELNQQ QLSSAEQLQG
310 320 330 340 350
CQMEILELKR TASALEIELQ AQQSLTESLE CTVAETEAQY SSQLAQIQCL
360 370 380 390 400
IDNLENQLAE IRCDLERQNQ EYQVLLDVKA RLEGEINTYW GLLDSEDSRL
410 420 430
SCSPCSTTCT SSNTCEPCSA YVICTVENCC L
Length:431
Mass (Da):48,139
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD57C5153D50E7D41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1C2G3V1C2_HUMAN
Keratin, type I cytoskeletal 40
KRT40 KA36, hCG_1643846
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241R → C in CAH10353 (PubMed:15617563).Curated1
Sequence conflicti349C → R in CAH10353 (PubMed:15617563).Curated1
Sequence conflicti408T → I in CAH10353 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03807837T → A. Corresponds to variant dbSNP:rs1510069Ensembl.1
Natural variantiVAR_03807985F → S1 PublicationCorresponds to variant dbSNP:rs17843015Ensembl.1
Natural variantiVAR_038080102S → N. Corresponds to variant dbSNP:rs1510068Ensembl.1
Natural variantiVAR_038081153T → M. Corresponds to variant dbSNP:rs9908304Ensembl.1
Natural variantiVAR_049787235R → H. Corresponds to variant dbSNP:rs2010027Ensembl.1
Natural variantiVAR_049788265C → Y1 PublicationCorresponds to variant dbSNP:rs721957Ensembl.1
Natural variantiVAR_049789286E → D. Corresponds to variant dbSNP:rs721958Ensembl.1
Natural variantiVAR_049790303M → T. Corresponds to variant dbSNP:rs9908389Ensembl.1
Natural variantiVAR_049791406S → L. Corresponds to variant dbSNP:rs16968862Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ786658 mRNA Translation: CAH10353.1
BC130396 mRNA Translation: AAI30397.1
BC150174 mRNA Translation: AAI50175.1
BC150191 mRNA Translation: AAI50192.1
BK004055 mRNA Translation: DAA04488.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42320.1

NCBI Reference Sequences

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RefSeqi
NP_872303.2, NM_182497.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000377755; ENSP00000366984; ENSG00000204889
ENST00000398486; ENSP00000381500; ENSG00000204889
ENST00000576967; ENSP00000459621; ENSG00000262845
ENST00000610983; ENSP00000479080; ENSG00000262845

Database of genes from NCBI RefSeq genomes

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GeneIDi
125115

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:125115

UCSC genome browser

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UCSCi
uc010cxh.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786658 mRNA Translation: CAH10353.1
BC130396 mRNA Translation: AAI30397.1
BC150174 mRNA Translation: AAI50175.1
BC150191 mRNA Translation: AAI50192.1
BK004055 mRNA Translation: DAA04488.1
CCDSiCCDS42320.1
RefSeqiNP_872303.2, NM_182497.3

3D structure databases

SMRiQ6A162
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125917, 381 interactors
IntActiQ6A162, 374 interactors
STRINGi9606.ENSP00000366984

PTM databases

iPTMnetiQ6A162
SwissPalmiQ6A162

Polymorphism and mutation databases

BioMutaiKRT40
DMDMi166218814

Proteomic databases

CPTACiCPTAC-1314
jPOSTiQ6A162
MassIVEiQ6A162
PaxDbiQ6A162
PeptideAtlasiQ6A162
PRIDEiQ6A162
ProteomicsDBi66176

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28766, 60 antibodies

The DNASU plasmid repository

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DNASUi
125115

Genome annotation databases

EnsembliENST00000377755; ENSP00000366984; ENSG00000204889
ENST00000398486; ENSP00000381500; ENSG00000204889
ENST00000576967; ENSP00000459621; ENSG00000262845
ENST00000610983; ENSP00000479080; ENSG00000262845
GeneIDi125115
KEGGihsa:125115
UCSCiuc010cxh.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
125115
DisGeNETi125115
EuPathDBiHostDB:ENSG00000204889.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT40
HGNCiHGNC:26707, KRT40
HPAiENSG00000204889, Tissue enhanced (pituitary gland, skin)
MIMi616679, gene
neXtProtiNX_Q6A162
OpenTargetsiENSG00000204889
PharmGKBiPA147357651

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SHG0, Eukaryota
GeneTreeiENSGT00940000161968
HOGENOMiCLU_012560_8_0_1
InParanoidiQ6A162
KOiK07604
OMAiIPLVCPD
OrthoDBi798081at2759
PhylomeDBiQ6A162
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiQ6A162
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
125115, 2 hits in 861 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
125115
PharosiQ6A162, Tdark

Protein Ontology

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PROi
PR:Q6A162
RNActiQ6A162, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204889, Expressed in adenohypophysis and 44 other tissues
ExpressionAtlasiQ6A162, baseline and differential
GenevisibleiQ6A162, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6A162
Secondary accession number(s): Q6IFU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 7, 2020
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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