Cyp4x1

Functionⁱ

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	452	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

aromatase activity Source: UniProtKB-EC
heme binding Source: InterPro
iron ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 4X1 (EC:1.14.14.1) Alternative name(s): CYPIVX1
Gene namesⁱ	Name:Cyp4x1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1932403 Cyp4x1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	14 – 34	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000421683	1 – 507	Cytochrome P450 4X1Add BLAST		507

Proteomic databases

EPDⁱ	Q6A152
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6A152
PaxDbⁱ	Q6A152
PRIDEⁱ	Q6A152

PTM databases

iPTMnetⁱ	Q6A152
PhosphoSitePlusⁱ	Q6A152

Expressionⁱ

Tissue specificityⁱ

Expressed in brain and aorta. In the brain, expressed in the Purkinje cells of the cerebellum, pyramidal neurons in the dentate gyrus of the hippocampus, cortical forebrain neurons and those of brain stem nuclei (at protein level). In addition to neurons, also expressed in cerebral vascular endothelial cells (at protein level). Also expressed in epithelial cells of the choroid plexus (at protein level). Hardly detectable in heart, lung, kidney and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000047155 Expressed in 97 organ(s), highest expression level in substantia nigra
ExpressionAtlasⁱ	Q6A152 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000059545

STRINGⁱ

10090.ENSMUSP00000059545

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6A152
SMRⁱ	Q6A152
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0157 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140829
HOGENOMⁱ	HOG000233833
HOVERGENⁱ	HBG000182
InParanoidⁱ	Q6A152
KEGG Orthology (KO) More...KOⁱ	K07428
OMAⁱ	YPCAFPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06KN
PhylomeDBⁱ	Q6A152
TreeFamⁱ	TF105088

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6A152-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEASWLETRW ARPLHLALVF CLALVLMQAM KLYLRRQRLL RDLSPFPGPP 
        60         70         80         90        100
AHWLLGHQKF LQEDNMETLD EIVKKHPCAF PCWVGPFQAF FYIYDPDYAK 
       110        120        130        140        150
IFLSRTDPKM QYLHQLLTPC IGRGLLNLDG PRWFQHRCLL TPAFHQDILK 
       160        170        180        190        200
PCVDTMAHSV KVMLDKWEKM WTTQETTIEV FEHINLMTLD IIMKCAFGQE 
       210        220        230        240        250
TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL SPKGHCFQEL 
       260        270        280        290        300
GKVIHQYTEK IIQDRKKILK NQVKQDDTQT SQIFLDIVLS AQAEDERAFS 
       310        320        330        340        350
DADLRAEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD 
       360        370        380        390        400
GSSITWEQLD EMSYTTMCIK ETLRLIPPVP SISRELSKPL TLPDGHSLPA 
       410        420        430        440        450
GMTVVLSIWG LHHNPAVWND PKVFDPLRFT KENSDQRHPC AFLPFSSGPR 
       460        470        480        490        500
NCIGQQFAML ELKVAIALIL LHFQVAPDLT RPPAFSSHTV LRPKHGIYLH 

LKKLLEC

Length:507

Mass (Da):58,557

Last modified:September 13, 2004 - v1

Checksum:ⁱ11A2FAAA650F705A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2A9Y7	A2A9Y7_MOUSE		Cytochrome P450 4X1 Cytochrome P450 4X1	Cyp4x1	481	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	9	R → G in BAC30028 (PubMed:16141072).Curated	1
Sequence conflictⁱ	110	M → T in AAI13126 (PubMed:15489334).Curated	1
Sequence conflictⁱ	188	T → A in AAI13126 (PubMed:15489334).Curated	1
Sequence conflictⁱ	327	L → P in AAI13126 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ786769 mRNA Translation: CAH10751.1 AL645473 Genomic DNA No translation available. BC113125 mRNA Translation: AAI13126.1 AK038526 mRNA Translation: BAC30028.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18488.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001003947.1, NM_001003947.1
UniGeneⁱ	Mm.215544

Genome annotation databases

Ensemblⁱ	ENSMUST00000051400; ENSMUSP00000059545; ENSMUSG00000047155
GeneIDⁱ	81906
KEGGⁱ	mmu:81906
UCSC genome browser More...UCSCⁱ	uc008uep.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6A152	Cytochrome P450 4X1		MOUSE		481	UniRef100_Q6A152

Protein	Similar proteins		Species	Score	Length	Source
Q6A152	Cytochrome P450 4X1		RAT		507	UniRef90_Q6A152
Cytochrome P450 4X1		MOUSE		481
Uncharacterized protein		NEOLE		601
cytochrome P450 4X1 isoform X1		MESAU		505
Cytochrome P450 4X1		CRIGR		495
+6

Protein	Similar proteins		Species	Score	Length	Source
Q6A152	Cytochrome P450 4X1		HUMAN		509	UniRef50_Q8N118
Cytochrome P450 4X1		RAT		507
Uncharacterized protein		MANLE		510
Uncharacterized protein		PANPA		509
Uncharacterized protein		MACFA		509
+193

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ786769 mRNA Translation: CAH10751.1 AL645473 Genomic DNA No translation available. BC113125 mRNA Translation: AAI13126.1 AK038526 mRNA Translation: BAC30028.1
CCDSⁱ	CCDS18488.1
RefSeqⁱ	NP_001003947.1, NM_001003947.1
UniGeneⁱ	Mm.215544

3D structure databases

ProteinModelPortalⁱ	Q6A152
SMRⁱ	Q6A152
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000059545

STRINGⁱ

10090.ENSMUSP00000059545

PTM databases

iPTMnetⁱ	Q6A152
PhosphoSitePlusⁱ	Q6A152

Proteomic databases

EPDⁱ	Q6A152
MaxQBⁱ	Q6A152
PaxDbⁱ	Q6A152
PRIDEⁱ	Q6A152

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	81906
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000051400; ENSMUSP00000059545; ENSMUSG00000047155
GeneIDⁱ	81906
KEGGⁱ	mmu:81906
UCSCⁱ	uc008uep.1 mouse

Organism-specific databases

CTDⁱ	260293
MGIⁱ	MGI:1932403 Cyp4x1

Phylogenomic databases

eggNOGⁱ	KOG0157 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00900000140829
HOGENOMⁱ	HOG000233833
HOVERGENⁱ	HBG000182
InParanoidⁱ	Q6A152
KOⁱ	K07428
OMAⁱ	YPCAFPC
OrthoDBⁱ	EOG091G06KN
PhylomeDBⁱ	Q6A152
TreeFamⁱ	TF105088

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6A152
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000047155 Expressed in 97 organ(s), highest expression level in substantia nigra
ExpressionAtlasⁱ	Q6A152 baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP4X1_MOUSE
Accessionⁱ	Q6A152Primary (citable) accession number: Q6A152 Secondary accession number(s): Q2HJC6, Q8BYS0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2013
	Last sequence update:	September 13, 2004
	Last modified:	November 7, 2018
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6A152 (CP4X1_MOUSE)

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Cytochrome P450 4X1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ