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Protein

Cytochrome P450 4X1

Gene

Cyp4x1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi452Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4X1 (EC:1.14.14.1)
Alternative name(s):
CYPIVX1
Gene namesi
Name:Cyp4x1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1932403 Cyp4x1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004216831 – 507Cytochrome P450 4X1Add BLAST507

Proteomic databases

EPDiQ6A152
MaxQBiQ6A152
PaxDbiQ6A152
PRIDEiQ6A152

PTM databases

iPTMnetiQ6A152
PhosphoSitePlusiQ6A152

Expressioni

Tissue specificityi

Expressed in brain and aorta. In the brain, expressed in the Purkinje cells of the cerebellum, pyramidal neurons in the dentate gyrus of the hippocampus, cortical forebrain neurons and those of brain stem nuclei (at protein level). In addition to neurons, also expressed in cerebral vascular endothelial cells (at protein level). Also expressed in epithelial cells of the choroid plexus (at protein level). Hardly detectable in heart, lung, kidney and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000047155 Expressed in 97 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ6A152 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059545

Structurei

3D structure databases

ProteinModelPortaliQ6A152
SMRiQ6A152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ6A152
KOiK07428
OMAiYPCAFPC
OrthoDBiEOG091G06KN
PhylomeDBiQ6A152
TreeFamiTF105088

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6A152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEASWLETRW ARPLHLALVF CLALVLMQAM KLYLRRQRLL RDLSPFPGPP
60 70 80 90 100
AHWLLGHQKF LQEDNMETLD EIVKKHPCAF PCWVGPFQAF FYIYDPDYAK
110 120 130 140 150
IFLSRTDPKM QYLHQLLTPC IGRGLLNLDG PRWFQHRCLL TPAFHQDILK
160 170 180 190 200
PCVDTMAHSV KVMLDKWEKM WTTQETTIEV FEHINLMTLD IIMKCAFGQE
210 220 230 240 250
TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL SPKGHCFQEL
260 270 280 290 300
GKVIHQYTEK IIQDRKKILK NQVKQDDTQT SQIFLDIVLS AQAEDERAFS
310 320 330 340 350
DADLRAEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD
360 370 380 390 400
GSSITWEQLD EMSYTTMCIK ETLRLIPPVP SISRELSKPL TLPDGHSLPA
410 420 430 440 450
GMTVVLSIWG LHHNPAVWND PKVFDPLRFT KENSDQRHPC AFLPFSSGPR
460 470 480 490 500
NCIGQQFAML ELKVAIALIL LHFQVAPDLT RPPAFSSHTV LRPKHGIYLH

LKKLLEC
Length:507
Mass (Da):58,557
Last modified:September 13, 2004 - v1
Checksum:i11A2FAAA650F705A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A9Y7A2A9Y7_MOUSE
Cytochrome P450 4X1
Cyp4x1
481Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9R → G in BAC30028 (PubMed:16141072).Curated1
Sequence conflicti110M → T in AAI13126 (PubMed:15489334).Curated1
Sequence conflicti188T → A in AAI13126 (PubMed:15489334).Curated1
Sequence conflicti327L → P in AAI13126 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786769 mRNA Translation: CAH10751.1
AL645473 Genomic DNA No translation available.
BC113125 mRNA Translation: AAI13126.1
AK038526 mRNA Translation: BAC30028.1
CCDSiCCDS18488.1
RefSeqiNP_001003947.1, NM_001003947.1
UniGeneiMm.215544

Genome annotation databases

EnsembliENSMUST00000051400; ENSMUSP00000059545; ENSMUSG00000047155
GeneIDi81906
KEGGimmu:81906
UCSCiuc008uep.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786769 mRNA Translation: CAH10751.1
AL645473 Genomic DNA No translation available.
BC113125 mRNA Translation: AAI13126.1
AK038526 mRNA Translation: BAC30028.1
CCDSiCCDS18488.1
RefSeqiNP_001003947.1, NM_001003947.1
UniGeneiMm.215544

3D structure databases

ProteinModelPortaliQ6A152
SMRiQ6A152
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059545

PTM databases

iPTMnetiQ6A152
PhosphoSitePlusiQ6A152

Proteomic databases

EPDiQ6A152
MaxQBiQ6A152
PaxDbiQ6A152
PRIDEiQ6A152

Protocols and materials databases

DNASUi81906
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051400; ENSMUSP00000059545; ENSMUSG00000047155
GeneIDi81906
KEGGimmu:81906
UCSCiuc008uep.1 mouse

Organism-specific databases

CTDi260293
MGIiMGI:1932403 Cyp4x1

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ6A152
KOiK07428
OMAiYPCAFPC
OrthoDBiEOG091G06KN
PhylomeDBiQ6A152
TreeFamiTF105088

Miscellaneous databases

PROiPR:Q6A152
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047155 Expressed in 97 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ6A152 baseline and differential

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP4X1_MOUSE
AccessioniPrimary (citable) accession number: Q6A152
Secondary accession number(s): Q2HJC6, Q8BYS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: September 13, 2004
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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