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Protein

Constitutive coactivator of PPAR-gamma-like protein 1

Gene

FAM120A

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm.By similarity1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 1
Alternative name(s):
Oxidative stress-associated Src activator
Protein FAM120A
Gene namesi
Name:FAM120A
Synonyms:Kiaa0183, Ossa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2446163 Fam120a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003637801 – 1112Constitutive coactivator of PPAR-gamma-like protein 1Add BLAST1112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei653PhosphothreonineBy similarity1
Modified residuei871Omega-N-methylarginineCombined sources1
Modified residuei882Omega-N-methylarginineCombined sources1
Modified residuei884Omega-N-methylarginineCombined sources1
Modified residuei930N6-acetyllysineCombined sources1
Modified residuei958PhosphoserineBy similarity1
Modified residuei980Omega-N-methylarginine; alternateCombined sources1
Modified residuei980Omega-N-methylated arginine; alternateBy similarity1
Modified residuei984Omega-N-methylarginineBy similarity1
Modified residuei1021PhosphoserineBy similarity1
Modified residuei1042PhosphoserineBy similarity1

Post-translational modificationi

Arg-980 is dimethylated, probably to asymmetric dimethylarginine.By similarity
Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ6A0A9
MaxQBiQ6A0A9
PaxDbiQ6A0A9
PeptideAtlasiQ6A0A9
PRIDEiQ6A0A9

PTM databases

iPTMnetiQ6A0A9
PhosphoSitePlusiQ6A0A9
SwissPalmiQ6A0A9

Expressioni

Tissue specificityi

Present in Purkinje cells in the cerebellum, and in cortical neurons (at protein level).1 Publication

Developmental stagei

Expressed in the developing brain at E12. Expression increases postnatally and is maintained at an adult level beyond 4 weeks after birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000038014 Expressed in 301 organ(s), highest expression level in conjunctival fornix
GenevisibleiQ6A0A9 MM

Interactioni

Subunit structurei

Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1 (By similarity). Interacts with PURA.By similarity1 Publication

Protein-protein interaction databases

BioGridi230005, 5 interactors
IntActiQ6A0A9, 11 interactors
MINTiQ6A0A9
STRINGi10090.ENSMUSP00000053877

Structurei

3D structure databases

SMRiQ6A0A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni339 – 403Interaction with YES1, SRC and FYNBy similarityAdd BLAST65
Regioni827 – 1112RNA bindingBy similarityAdd BLAST286

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE6R Eukaryota
ENOG410XPY7 LUCA
GeneTreeiENSGT00530000063168
HOGENOMiHOG000112430
HOVERGENiHBG050957
InParanoidiQ6A0A9
OMAiSNDSKMC
OrthoDBiEOG091G030W
PhylomeDBiQ6A0A9
TreeFamiTF328642

Family and domain databases

InterProiView protein in InterPro
IPR026784 Coact_PPARg
IPR029060 PIN-like_dom_sf
PANTHERiPTHR15976 PTHR15976, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A0A9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA
60 70 80 90 100
DNCLHRLYGG FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL
110 120 130 140 150
EKARLHEWVK RQGNERQTAQ QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL
160 170 180 190 200
ALIRFHVKVA QSIEDHHQEV IGFCRENGFH GLVAYDSDYA LCNIPYYFSA
210 220 230 240 250
HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL GNHILPDEDL
260 270 280 290 300
ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIHDTSDLD
310 320 330 340 350
AIAKDVFQHS QSRTDDKVIR FKRAVGYYSA TSKPMPFHPP HYLARPNPFG
360 370 380 390 400
MPGMVPPYVP PQMLNIPQTS LQAKPAVPQV PSPGGTPGQA PYPYSLSEPA
410 420 430 440 450
LTLDTSGKNL TEQNSYSNIP HEGKHTPLYE RSSPINLAQS GSPNHVDSAY
460 470 480 490 500
FPGSSTSSSS DNDEGGGGAT NHISGNKIGW EKTGSHAEPL ARGDPGDQVK
510 520 530 540 550
VEGSSTASSG SQLAEGKGSH MGTVQPIPCL LSMPTRNHMD ITTPPLPPVA
560 570 580 590 600
PEVLRVAEHR HKKGLMYPYI FHILTKGEIK IAVSIEDEAN KDLPPAALLY
610 620 630 640 650
RPVRQYVYGV LFSLAESRKK TERLAFRKNR LPPEFSPLII KEWAAYKGKS
660 670 680 690 700
PQTPELVEAL AFREWTCPNL KRLWLGKAVE DKNRRMRAFL ACMRSDTPAM
710 720 730 740 750
LNPANVPTHL MVLCCVLRYM VQWPGARILR RQELDAFLAQ ALSPKLYEPD
760 770 780 790 800
QLQELKIDNL DPRGIQLSAL FMSGVDMALF ANDACGQPIP WEHCCPWMYF
810 820 830 840 850
DGKLFQSKLL KASREKTPLI DLCDGQAEQA AKVEKMRQSI LEGLSFSRQN
860 870 880 890 900
HPLPFPPPPA LPFYPASVYP RHFGPVPPSQ GRGRGFAGVC GFGGHYGETV
910 920 930 940 950
ATGPYRAFRV TAASGHCGAF SGSDSSRTSK SQGGVQPIPS QGGKLEIAGT
960 970 980 990 1000
VVGHWAGSRR GRGGRGPFPL QVVSVGGPAR GRPRGVISTP VIRTFGRGGR
1010 1020 1030 1040 1050
YYGRGYKSQG AIQGRPPYAA SAEEVAKELK SKSGESKSSA VSLAENGVMA
1060 1070 1080 1090 1100
EEKPVPQLNG STGDPRVPSH SESALNNDSK PCNTNPHLNA LSTDSACRRE
1110
AALEAAVLNK EE
Length:1,112
Mass (Da):121,646
Last modified:February 10, 2009 - v2
Checksum:i5B9086869336B9D6
GO

Sequence cautioni

The sequence BAD32187 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172909 mRNA Translation: BAD32187.1 Different initiation.
BC010304 mRNA Translation: AAH10304.1
BC042582 mRNA Translation: AAH42582.1
BC158134 mRNA Translation: AAI58135.1
CCDSiCCDS49259.1
RefSeqiNP_001028440.2, NM_001033268.2
UniGeneiMm.426571

Genome annotation databases

EnsembliENSMUST00000060805; ENSMUSP00000053877; ENSMUSG00000038014
GeneIDi218236
KEGGimmu:218236
UCSCiuc007qio.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172909 mRNA Translation: BAD32187.1 Different initiation.
BC010304 mRNA Translation: AAH10304.1
BC042582 mRNA Translation: AAH42582.1
BC158134 mRNA Translation: AAI58135.1
CCDSiCCDS49259.1
RefSeqiNP_001028440.2, NM_001033268.2
UniGeneiMm.426571

3D structure databases

SMRiQ6A0A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230005, 5 interactors
IntActiQ6A0A9, 11 interactors
MINTiQ6A0A9
STRINGi10090.ENSMUSP00000053877

PTM databases

iPTMnetiQ6A0A9
PhosphoSitePlusiQ6A0A9
SwissPalmiQ6A0A9

Proteomic databases

EPDiQ6A0A9
MaxQBiQ6A0A9
PaxDbiQ6A0A9
PeptideAtlasiQ6A0A9
PRIDEiQ6A0A9

Protocols and materials databases

DNASUi218236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060805; ENSMUSP00000053877; ENSMUSG00000038014
GeneIDi218236
KEGGimmu:218236
UCSCiuc007qio.1 mouse

Organism-specific databases

CTDi23196
MGIiMGI:2446163 Fam120a
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE6R Eukaryota
ENOG410XPY7 LUCA
GeneTreeiENSGT00530000063168
HOGENOMiHOG000112430
HOVERGENiHBG050957
InParanoidiQ6A0A9
OMAiSNDSKMC
OrthoDBiEOG091G030W
PhylomeDBiQ6A0A9
TreeFamiTF328642

Miscellaneous databases

ChiTaRSiFam120a mouse
PROiPR:Q6A0A9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038014 Expressed in 301 organ(s), highest expression level in conjunctival fornix
GenevisibleiQ6A0A9 MM

Family and domain databases

InterProiView protein in InterPro
IPR026784 Coact_PPARg
IPR029060 PIN-like_dom_sf
PANTHERiPTHR15976 PTHR15976, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF120A_MOUSE
AccessioniPrimary (citable) accession number: Q6A0A9
Secondary accession number(s): A0PJK6, B3DFJ0, Q91Z16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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