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Entry version 113 (16 Oct 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Centrosomal protein of 170 kDa

Gene

Cep170

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in microtubule organization. Required for centriole subdistal appendage assembly.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 170 kDa
Short name:
Cep170
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep170
Synonyms:Kiaa0470
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918348 Cep170

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828881 – 1588Centrosomal protein of 170 kDaAdd BLAST1588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei141PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei363PhosphotyrosineBy similarity1
Modified residuei443PhosphoserineCombined sources1
Modified residuei463PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei498PhosphothreonineBy similarity1
Modified residuei568PhosphoserineBy similarity1
Modified residuei577PhosphoserineBy similarity1
Modified residuei628PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1
Modified residuei639PhosphothreonineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei718PhosphoserineBy similarity1
Modified residuei752PhosphothreonineBy similarity1
Modified residuei829PhosphoserineCombined sources1
Modified residuei870PhosphoserineBy similarity1
Modified residuei872PhosphoserineBy similarity1
Modified residuei906PhosphothreonineBy similarity1
Modified residuei912PhosphothreonineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei925PhosphoserineBy similarity1
Modified residuei950PhosphoserineBy similarity1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1012PhosphothreonineCombined sources1
Modified residuei1047PhosphothreonineBy similarity1
Modified residuei1048PhosphoserineBy similarity1
Modified residuei1102PhosphoserineCombined sources1
Modified residuei1104PhosphoserineBy similarity1
Modified residuei1122PhosphoserineBy similarity1
Modified residuei1123PhosphoserineBy similarity1
Modified residuei1135PhosphoserineBy similarity1
Modified residuei1150PhosphoserineCombined sources1
Modified residuei1155PhosphoserineCombined sources1
Modified residuei1188PhosphoserineBy similarity1
Modified residuei1195PhosphoserineBy similarity1
Modified residuei1200PhosphoserineBy similarity1
Modified residuei1229PhosphoserineCombined sources1
Modified residuei1231PhosphoserineBy similarity1
Modified residuei1241PhosphoserineBy similarity1
Modified residuei1260PhosphoserineBy similarity1
Modified residuei1270PhosphoserineBy similarity1
Modified residuei1362PhosphoserineBy similarity1
Modified residuei1521PhosphoserineCombined sources1
Modified residuei1522PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; probably by PLK1.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6A065

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6A065

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6A065

PeptideAtlas

More...
PeptideAtlasi
Q6A065

PRoteomics IDEntifications database

More...
PRIDEi
Q6A065

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6A065

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6A065

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6A065

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057335 Expressed in 235 organ(s), highest expression level in olfactory bulb

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6A065 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6A065 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCDC68 and CCDC120; leading to recruitment to centrosomes (By similarity).

Interacts with PLK1 (By similarity).

Interacts with NIN (PubMed:27565344).

Interacts with FHDC1 (PubMed:29742020).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
244244, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q6A065, 21 interactors

Molecular INTeraction database

More...
MINTi
Q6A065

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000059562

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6A065

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 73FHAPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni844 – 1588Targeting to microtubulesBy similarityAdd BLAST745
Regioni1103 – 1588Targeting to centrosomesBy similarityAdd BLAST486

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1467 – 1495Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP170 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410II6S Eukaryota
ENOG4110JY6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155103

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111524

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6A065

Identification of Orthologs from Complete Genome Data

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OMAi
MIWEPTE

Database of Orthologous Groups

More...
OrthoDBi
83451at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6A065

Family and domain databases

Conserved Domains Database

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CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026644 CEP170
IPR029300 CEP170_C
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15715:SF17 PTHR15715:SF17, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15308 CEP170_C, 1 hit
PF00498 FHA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240 FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6A065-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA
60 70 80 90 100
SMDEHLVKDL GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVR
110 120 130 140 150
GEMRVPEEAL KHEKFTIQLQ LSQKSSESEL PKSASAKGTD SKVEAAAEVQ
160 170 180 190 200
PRATEALKSE EKPMDVSAMP RGTPLYGQPS WWGDAEEDEQ RAFKANGKPE
210 220 230 240 250
GKSQEAGASG CSTEAKHVEG QSAAASEEAL FPFCREPSYF EIPTKEFQQP
260 270 280 290 300
SQIAESTIHE IPTKDTPSSH TAGAGHASFT IEFDDSTPGK VTIRDHVTKF
310 320 330 340 350
TSDQRHKSKK ASPGTQDLPG IQTGMMAPEN KVADWLAQNN PPQMVWERTE
360 370 380 390 400
EDSKSIKSDV PVYLKRLKGN KHDDGTQSDS ENAGAHRRCS KRATLEEHLR
410 420 430 440 450
RHHSEQKKKA QSTEKHQEQA ATSSTHHRGG HGVPHGKLLK QKSEEPSVSL
460 470 480 490 500
PFLQTALLRS SGSLGHRPSQ EMDVMLKNQA TSASSEKDND DDQSDKGTYT
510 520 530 540 550
IELENPNSEE VEARKMIDKV FGVDDNQDYN RPIINEKHKG LIKDWALNSA
560 570 580 590 600
AVVMEERKPL STPGFHNSEE AISSSGSKRW VSQWASLAAN HTRHDPEERL
610 620 630 640 650
MELSATVENE TDTGDAGVSL RSTSCTTSLA SQGERKRRTL PQLPNEEKLL
660 670 680 690 700
ESSRAKVVPQ RSEIGEKQDT ELQEKEAQVY QSEKHDADRG LSKMSRAVNG
710 720 730 740 750
ESPKTGGDGK ALLHSGSSSS KEKSETEKET SLVKQTLAKM QQQEQKEQAQ
760 770 780 790 800
WTPTKFPSKN ALGHIDKCRE ESSKQESQLL EKVSGHSTSK GDRVIQNESK
810 820 830 840 850
RRKAEEIPKC QASKGDKKES SKSLVRQGSF TIDKPSSNIP IELIPHINKQ
860 870 880 890 900
NSSVPTALAL TSASRLRERS DSLDTDSSMD TTLILKDTEA VMAFLEAKLR
910 920 930 940 950
EDNNKTDEGP DTPSYNRDNS ISPESDVDTA STISLVTGET ERKSTQKRKS
960 970 980 990 1000
FTSLYKDRCS TSSPSKDVTK SGSREKIEKK AKSRSADIGA RADGRKFVQS
1010 1020 1030 1040 1050
SGRIRQPSID LTDDDQTSSV PHSAISDIMS SDQETYSCKS HGRTPLTSAD
1060 1070 1080 1090 1100
EHNIHSKLEG GKATKSKTSP VASGSTSKST TLPRPRPTRT SLLRRARLGE
1110 1120 1130 1140 1150
ASDSELADAD KASVASEVST TSSTSKPPTG RRTISRIDLL AQPRRTRLGS
1160 1170 1180 1190 1200
LSARSDSEAT ISRSSASART AEAVIRSGAR LVPSDKLSPR TRANSISRLS
1210 1220 1230 1240 1250
DSKVKSMSST HGSPSVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS
1260 1270 1280 1290 1300
PALKTTRMQS TGSAMPASSS FKHRIKEQED YIRDWTAHRE EIARISQDLA
1310 1320 1330 1340 1350
LIAREINDVA GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REEVGDLHGE
1360 1370 1380 1390 1400
MHKLVDRVFD ESLNFRKIPP LVHSKTPEGN NGRSVDSRPQ PAEHPDHLTI
1410 1420 1430 1440 1450
TRRRTWSRDE VMGDNLLLSS VFQFSRKIRQ SIDKTAGKIR ILFKDKDRNW
1460 1470 1480 1490 1500
DDIENKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQVI NAMIDPDGTL
1510 1520 1530 1540 1550
EALNNMGFPN AILPSPPKQK SSPVNNHSSP SQTPALCPPE TRALHPAAAG
1560 1570 1580
VAAAASTEFE NAESEADFSI HFNRFNPDGE EEDVTVHE
Length:1,588
Mass (Da):175,050
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7140E6F82AF93A7
GO
Isoform 2 (identifier: Q6A065-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-236: CSTEAKHVEGQSAAASEEALFPFCRE → KNTSVAVASNSYWASIYSLNKSHSTL
     237-1588: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):26,206
Checksum:i316C395EA550A7AA
GO
Isoform 3 (identifier: Q6A065-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1257: Missing.
     1344-1353: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,531
Checksum:i92A5A8D7B504F9E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BX26H7BX26_MOUSE
Centrosomal protein of 170 kDa
Cep170
1,578Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YX99A0A0A6YX99_MOUSE
Centrosomal protein of 170 kDa
Cep170
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXK7A0A0A6YXK7_MOUSE
Centrosomal protein of 170 kDa
Cep170
787Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YVZ3A0A0A6YVZ3_MOUSE
Centrosomal protein of 170 kDa
Cep170
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXT4A0A0A6YXT4_MOUSE
Centrosomal protein of 170 kDa
Cep170
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWV9A0A0A6YWV9_MOUSE
Centrosomal protein of 170 kDa
Cep170
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXR9A0A0A6YXR9_MOUSE
Centrosomal protein of 170 kDa
Cep170
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242431 – 1257Missing in isoform 3. 1 PublicationAdd BLAST1257
Alternative sequenceiVSP_024244211 – 236CSTEA…PFCRE → KNTSVAVASNSYWASIYSLN KSHSTL in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_024245237 – 1588Missing in isoform 2. 1 PublicationAdd BLAST1352
Alternative sequenceiVSP_0242461344 – 1353Missing in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK016937 mRNA Translation: BAB30507.2
AK078541 mRNA Translation: BAC37328.1
AC113311 Genomic DNA No translation available.
BC054781 mRNA Translation: AAH54781.1
BC057019 mRNA Translation: AAH57019.1
AK172953 mRNA Translation: BAD32231.1

NCBI Reference Sequences

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RefSeqi
XP_006497000.1, XM_006496937.3 [Q6A065-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000192961; ENSMUSP00000142271; ENSMUSG00000057335 [Q6A065-2]
ENSMUST00000194727; ENSMUSP00000141793; ENSMUSG00000057335 [Q6A065-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
545389

UCSC genome browser

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UCSCi
uc007dub.1 mouse [Q6A065-3]
uc007duc.1 mouse [Q6A065-1]
uc007dug.2 mouse [Q6A065-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016937 mRNA Translation: BAB30507.2
AK078541 mRNA Translation: BAC37328.1
AC113311 Genomic DNA No translation available.
BC054781 mRNA Translation: AAH54781.1
BC057019 mRNA Translation: AAH57019.1
AK172953 mRNA Translation: BAD32231.1
RefSeqiXP_006497000.1, XM_006496937.3 [Q6A065-1]

3D structure databases

SMRiQ6A065
ModBaseiSearch...

Protein-protein interaction databases

BioGridi244244, 37 interactors
IntActiQ6A065, 21 interactors
MINTiQ6A065
STRINGi10090.ENSMUSP00000059562

PTM databases

iPTMnetiQ6A065
PhosphoSitePlusiQ6A065
SwissPalmiQ6A065

Proteomic databases

EPDiQ6A065
jPOSTiQ6A065
PaxDbiQ6A065
PeptideAtlasiQ6A065
PRIDEiQ6A065

Genome annotation databases

EnsembliENSMUST00000192961; ENSMUSP00000142271; ENSMUSG00000057335 [Q6A065-2]
ENSMUST00000194727; ENSMUSP00000141793; ENSMUSG00000057335 [Q6A065-1]
GeneIDi545389
UCSCiuc007dub.1 mouse [Q6A065-3]
uc007duc.1 mouse [Q6A065-1]
uc007dug.2 mouse [Q6A065-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9859
MGIiMGI:1918348 Cep170

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410II6S Eukaryota
ENOG4110JY6 LUCA
GeneTreeiENSGT00940000155103
HOGENOMiHOG000111524
InParanoidiQ6A065
OMAiMIWEPTE
OrthoDBi83451at2759
PhylomeDBiQ6A065

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cep170 mouse

Protein Ontology

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PROi
PR:Q6A065

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000057335 Expressed in 235 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiQ6A065 baseline and differential
GenevisibleiQ6A065 MM

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR026644 CEP170
IPR029300 CEP170_C
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR15715:SF17 PTHR15715:SF17, 1 hit
PfamiView protein in Pfam
PF15308 CEP170_C, 1 hit
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE170_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6A065
Secondary accession number(s): Q7TQD9, Q8BJW2, Q9D3Z0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 16, 2019
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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