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Entry version 129 (05 Jun 2019)
Sequence version 2 (20 May 2008)
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Protein

Attractin-like protein 1

Gene

Atrnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in melanocortin signaling pathways that regulate energy homeostasis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Attractin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atrnl1
Synonyms:Alp, Atrnl, Kiaa0534
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147749 Atrnl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini52 – 1229ExtracellularSequence analysisAdd BLAST1178
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1230 – 1250HelicalSequence analysisAdd BLAST21
Topological domaini1251 – 1378CytoplasmicSequence analysisAdd BLAST128

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are grossly normal with no alterations of pigmentation, central nervous system pathology or body weight. In contrast, constitutive expression of Atrnl1 in mice lacking Atrn display normal, agouti-banded hairs and significantly delayed onset of spongiform neurodegeneration, indicating that overexpression of Atrnl1 compensates for loss of Atrn.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 51Sequence analysisAdd BLAST51
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033465152 – 1378Attractin-like protein 1Add BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi62 ↔ 78By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 89By similarity
Disulfide bondi92 ↔ 118By similarity
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi210 ↔ 220By similarity
Disulfide bondi214 ↔ 232By similarity
Disulfide bondi234 ↔ 243By similarity
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi703N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi775 ↔ 871By similarity
Glycosylationi777N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1013 ↔ 1021By similarity
Disulfide bondi1015 ↔ 1027By similarity
Disulfide bondi1030 ↔ 1039By similarity
Disulfide bondi1042 ↔ 1056By similarity
Disulfide bondi1059 ↔ 1068By similarity
Disulfide bondi1061 ↔ 1075By similarity
Disulfide bondi1077 ↔ 1087By similarity
Disulfide bondi1090 ↔ 1105By similarity
Glycosylationi1156N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6A051

PeptideAtlas

More...
PeptideAtlasi
Q6A051

PRoteomics IDEntifications database

More...
PRIDEi
Q6A051

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6A051

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, heart, lung, kidney and liver. In the central nervous system, it is highly expressed in the dentate gyrus, CA1-3 regions of the hippocampus, and the ventral taenia tecta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054843 Expressed in 243 organ(s), highest expression level in vas deferens

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6A051 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MC4R.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230494, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000076514

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 90EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini92 – 208CUBPROSITE-ProRule annotationAdd BLAST117
Domaini206 – 244EGF-like 2PROSITE-ProRule annotationAdd BLAST39
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati315 – 364Kelch 1Add BLAST50
Repeati366 – 414Kelch 2Add BLAST49
Repeati426 – 474Kelch 3Add BLAST49
Repeati479 – 530Kelch 4Add BLAST52
Repeati532 – 590Kelch 5Add BLAST59
Repeati591 – 637Kelch 6Add BLAST47
Domaini613 – 656PSI 1Add BLAST44
Domaini665 – 708PSI 2Add BLAST44
Domaini714 – 759PSI 3Add BLAST46
Domaini754 – 872C-type lectinPROSITE-ProRule annotationAdd BLAST119
Domaini888 – 938PSI 4Add BLAST51
Domaini941 – 1011PSI 5Add BLAST71
Domaini1013 – 1058Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1059 – 1107Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1287 – 1324Interaction with MC4R1 PublicationAdd BLAST38

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1388 Eukaryota
ENOG410XRW4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155790

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231727

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6A051

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNVGTLS

Database of Orthologous Groups

More...
OrthoDBi
49565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6A051

TreeFam database of animal gene trees

More...
TreeFami
TF321873

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03597 CLECT_attractin_like, 1 hit
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034011 Attractin-like_CTLD
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR015915 Kelch-typ_b-propeller
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF07974 EGF_2, 1 hit
PF00053 Laminin_EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF01437 PSI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00042 CUB, 1 hit
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 1 hit
SM00423 PSI, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6A051-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPGVRARSG APQPASPVLW RARPAGGGGA SSWLLLDGNS WLLCYGFLYL
60 70 80 90 100
ALYAQVSQSK PCERTGSCFS GRCVNSTCLC DPGWVGDQCQ HCQGRFKLTE
110 120 130 140 150
PSGYLTDGPI NYKYKTKCTW LIEGYPNAVL RLRFNHFATE CSWDHMYVYD
160 170 180 190 200
GDSIYAPLVA VLSGLIVPEV RGNETVPEVV TTSGYALLHF FSDAAYNLTG
210 220 230 240 250
FNIFYSINSC PNNCSGHGKC TTSVSVASQV YCECDKYWKG EACDIPYCKA
260 270 280 290 300
NCGSPDHGYC DLTGEKLCVC NDSWQGPDCS LNVPSTESYW ILPNVKPFSP
310 320 330 340 350
SVGRASHKAV LHGKFMWVIG GYTFNYSSFQ MVLNYNLESS IWNVGAVSRG
360 370 380 390 400
PLQRYGHSLA LYQENIFMYG GRMETSDGNV TDELWVFNVR SQSWSTKTPT
410 420 430 440 450
VLGHSQQYAV EGHSAHIMEL DSRDVVMIVI FGYSAIYGYT SSIQEYHISS
460 470 480 490 500
NTWLVPETKG AIVQGGYGHT SVYDEVTKSI YVHGGYKALP GNKYGLVDDL
510 520 530 540 550
YKYEVNTRTW TILKESGFAR YLHSAVLING AMLIFGGNTH NDTSLSNGAK
560 570 580 590 600
CFSADFLAYD IACDEWKTLP KPNLHRDVNR FGHSAVVING SMYIFGGFSS
610 620 630 640 650
VLLNDILVYK PPNCKAFRDE ELCRNAGPGI KCVWNKNHCE SWESGNTNNI
660 670 680 690 700
LRAKCPPKTA ATDDRCYRYA DCASCTANTN GCQWCDDKKC ISASSNCSTS
710 720 730 740 750
VRNYTKCHIR NEQICNKLTS CKSCSLNLNC QWDQRQQECQ ALPAHLCGEG
760 770 780 790 800
WNHVGDACLR INSSRESYDN AKLYCYNLSG NLASLTTSKE VEFVLDEIQK
810 820 830 840 850
FTQQKVSPWV GLRKINISYW GWEDMSPFTN TSLQWLPGEP NDSGFCAYLE
860 870 880 890 900
RAAVAGLKAN PCTSMADGLV CEKPVVSPNQ NARPCKKPCS LRTSCANCTS
910 920 930 940 950
SGMECMWCSS TKRCVDSNAY IISFPYGQCL EWQTATCSPQ NCSGLRTCGQ
960 970 980 990 1000
CLEQPGCGWC NDPSNTGRGY CIEGSSRGPM KLAGVHNSDV VLDTSLCPKE
1010 1020 1030 1040 1050
KNYEWSFIQC PACQCNGHST CINNNVCEQC KNLTTGRQCQ ECMPGYYGDP
1060 1070 1080 1090 1100
TNGGQCTACT CGGHANVCHL HTGKCFCTTK GIKGDQCQLC DSENRYVGNP
1110 1120 1130 1140 1150
LRGTCYYSLL IDYQFTFSLL QEDDRHHTAI NFIANPEQSN KNLDISINAS
1160 1170 1180 1190 1200
NNFNLNITWS VGSTGGTISG EETPIVSKTN IKEYRDSFSY EKFNFRSNPN
1210 1220 1230 1240 1250
ITFYVYVSNF SWPIKIQIAF SQHNTIMDLV QFFVTFFSCF LSLLLVAAVV
1260 1270 1280 1290 1300
WKIKQTCWAS RRREQLLRER QQMASRPFAS VDVALEVGAE QTDFLRGPLE
1310 1320 1330 1340 1350
GAPKPIAIEP CAGNRAAVLT VFLCLPRGSS GAPPPGQSGL AIASALIDIS
1360 1370
QQKPSDNKDK TSGVRNRKHL STRQGTCV
Length:1,378
Mass (Da):152,467
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28E9AE30440E32A7
GO
Isoform 2 (identifier: Q6A051-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1094: CDSEN → YCQFF
     1095-1378: Missing.

Note: No experimental confirmation available.
Show »
Length:1,094
Mass (Da):120,880
Checksum:iB434DCA9C4887A50
GO
Isoform 3 (identifier: Q6A051-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-561: MEPGVRARSG...FSADFLAYDI → MGWWTTSISTKSTPGL
     1012-1057: Missing.

Note: No experimental confirmation available.
Show »
Length:787
Mass (Da):87,278
Checksum:iC09A4BBA53620B9F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32245 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47F → S in AAT99560 (Ref. 1) Curated1
Sequence conflicti851R → K in AAH50020 (PubMed:15489334).Curated1
Sequence conflicti983A → V in BAD32245 (PubMed:15368895).Curated1
Sequence conflicti1191E → D in AAH50020 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0337201 – 561MEPGV…LAYDI → MGWWTTSISTKSTPGL in isoform 3. 1 PublicationAdd BLAST561
Alternative sequenceiVSP_0337211012 – 1057Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0337221090 – 1094CDSEN → YCQFF in isoform 2. 1 Publication5
Alternative sequenceiVSP_0337231095 – 1378Missing in isoform 2. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY688677 mRNA Translation: AAT99560.1
AK172967 mRNA Translation: BAD32245.1 Different initiation.
AK050882 mRNA Translation: BAC34442.1
AK147492 mRNA Translation: BAE27947.1
BC030872 mRNA Translation: AAH30872.1
BC050020 mRNA Translation: AAH50020.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS29928.1 [Q6A051-1]

NCBI Reference Sequences

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RefSeqi
NP_852080.3, NM_181415.4 [Q6A051-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000077282; ENSMUSP00000076514; ENSMUSG00000054843 [Q6A051-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
226255

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:226255

UCSC genome browser

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UCSCi
uc008iai.2 mouse [Q6A051-1]
uc008iaj.1 mouse [Q6A051-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688677 mRNA Translation: AAT99560.1
AK172967 mRNA Translation: BAD32245.1 Different initiation.
AK050882 mRNA Translation: BAC34442.1
AK147492 mRNA Translation: BAE27947.1
BC030872 mRNA Translation: AAH30872.1
BC050020 mRNA Translation: AAH50020.1
CCDSiCCDS29928.1 [Q6A051-1]
RefSeqiNP_852080.3, NM_181415.4 [Q6A051-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi230494, 1 interactor
STRINGi10090.ENSMUSP00000076514

PTM databases

PhosphoSitePlusiQ6A051

Proteomic databases

PaxDbiQ6A051
PeptideAtlasiQ6A051
PRIDEiQ6A051

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077282; ENSMUSP00000076514; ENSMUSG00000054843 [Q6A051-1]
GeneIDi226255
KEGGimmu:226255
UCSCiuc008iai.2 mouse [Q6A051-1]
uc008iaj.1 mouse [Q6A051-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26033
MGIiMGI:2147749 Atrnl1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1388 Eukaryota
ENOG410XRW4 LUCA
GeneTreeiENSGT00940000155790
HOGENOMiHOG000231727
InParanoidiQ6A051
OMAiWNVGTLS
OrthoDBi49565at2759
PhylomeDBiQ6A051
TreeFamiTF321873

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Atrnl1 mouse

Protein Ontology

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PROi
PR:Q6A051

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054843 Expressed in 243 organ(s), highest expression level in vas deferens
GenevisibleiQ6A051 MM

Family and domain databases

CDDicd03597 CLECT_attractin_like, 1 hit
cd00041 CUB, 1 hit
Gene3Di2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR034011 Attractin-like_CTLD
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR015915 Kelch-typ_b-propeller
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF07974 EGF_2, 1 hit
PF00053 Laminin_EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF01437 PSI, 2 hits
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00042 CUB, 1 hit
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 1 hit
SM00423 PSI, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRN1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6A051
Secondary accession number(s): Q3UHB0
, Q68HV2, Q80VI3, Q8BKS4, Q8K0P5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 5, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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