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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

Pds5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Gene namesi
Name:Pds5a
Synonyms:Kiaa0648Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918771 Pds5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963421 – 1332Sister chromatid cohesion protein PDS5 homolog AAdd BLAST1332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei1096PhosphoserineBy similarity1
Modified residuei1145N6-acetyllysineCombined sources1
Modified residuei1174PhosphoserineCombined sources1
Modified residuei1194PhosphoserineBy similarity1
Modified residuei1207PhosphothreonineBy similarity1
Modified residuei1210N6-acetyllysineCombined sources1
Modified residuei1288N6-acetyllysineBy similarity1
Modified residuei1303PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6A026
MaxQBiQ6A026
PaxDbiQ6A026
PRIDEiQ6A026

PTM databases

iPTMnetiQ6A026
PhosphoSitePlusiQ6A026
SwissPalmiQ6A026

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6A026, 12 interactors
STRINGi10090.ENSMUSP00000031104

Structurei

3D structure databases

ProteinModelPortaliQ6A026
SMRiQ6A026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati392 – 428HEATSequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
HOGENOMiHOG000230672
HOVERGENiHBG108241
InParanoidiQ6A026

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6A026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT
60 70 80 90 100
FMDMDQDSED EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY
110 120 130 140 150
APEAPYTSHD KLKDIFLFIT RQLKGLEDTK SPQFNRYFYL LENLAWVKSY
160 170 180 190 200
NICFELEDCN EIFIQLFRTL FSVINNSHNT KVQMHMLDLM SSIIMEGDGV
210 220 230 240 250
TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA CIANFFNQVL
260 270 280 290 300
VLGRSSVSDL SEHVFDLIQE LFAIDPQLLL SVMPQLEFKL KSNDGEERLA
310 320 330 340 350
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL
360 370 380 390 400
MNHPDLAKDL TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG
410 420 430 440 450
FVRERTLDKR WRVRKEAMMG LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL
460 470 480 490 500
HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE ERMKCLYYLY ASLDPNAVKA
510 520 530 540 550
LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT IAKNLPDPGK
560 570 580 590 600
AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADVCVR EIARKLANPK
610 620 630 640 650
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS
660 670 680 690 700
PDSAIRSGLE LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI
710 720 730 740 750
FRNTGHKIET DLPQIRSTLI PILHQKAKRG TPHQAKQAVH CIHAIFSNKE
760 770 780 790 800
VQLAQIFEPL SRSLNADVPE QLITPLVSLG HISMLAPDQF ASPMKSVVAN
810 820 830 840 850
FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVYLLRL LVRWLLGMKN
860 870 880 890 900
NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ
910 920 930 940 950
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA
960 970 980 990 1000
IFALCAKDPV KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV
1010 1020 1030 1040 1050
VPYMIHLLAH DPDFTRSQDV DQLRDIKECL WFMLEVLMTK NENNSHAFMK
1060 1070 1080 1090 1100
KMAENIKLTR DAQSPDESKT NEKLYTVCDV ALCVINSKSA LCNADSPKDP
1110 1120 1130 1140 1150
VLPMKFFTQP EKDFCNDKSY ISEETRVLLL TGKPKPTGVL GTVNKPLSAT
1160 1170 1180 1190 1200
GRKPYVRSAG TETGSNINAN SELSPSAGSR SREQSSEASE TGVSENEENP
1210 1220 1230 1240 1250
VRIISVTPVK NIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQK
1260 1270 1280 1290 1300
PDEKVDESGP PAPSKPRRGR RPKSESQGNA TKNDDLNKPV SKGRKRAAGS
1310 1320 1330
QESLEAGNAK APKLQDGAKK AVPAERQIDL QR
Length:1,332
Mass (Da):150,327
Last modified:July 27, 2011 - v3
Checksum:i0D6473650AC9D89B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPI5E9QPI5_MOUSE
Sister chromatid cohesion protein P...
Pds5a
1,332Annotation score:
A0A0J9YV33A0A0J9YV33_MOUSE
Sister chromatid cohesion protein P...
Pds5a
140Annotation score:

Sequence cautioni

The sequence BAD32270 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti557K → E in BAD32270 (PubMed:15368895).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112263 Genomic DNA No translation available.
AK172992 Transcribed RNA Translation: BAD32270.1 Different initiation.
CCDSiCCDS39099.1
UniGeneiMm.278974
Mm.319516
Mm.406095

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112263 Genomic DNA No translation available.
AK172992 Transcribed RNA Translation: BAD32270.1 Different initiation.
CCDSiCCDS39099.1
UniGeneiMm.278974
Mm.319516
Mm.406095

3D structure databases

ProteinModelPortaliQ6A026
SMRiQ6A026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6A026, 12 interactors
STRINGi10090.ENSMUSP00000031104

PTM databases

iPTMnetiQ6A026
PhosphoSitePlusiQ6A026
SwissPalmiQ6A026

Proteomic databases

EPDiQ6A026
MaxQBiQ6A026
PaxDbiQ6A026
PRIDEiQ6A026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1918771 Pds5a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
HOGENOMiHOG000230672
HOVERGENiHBG108241
InParanoidiQ6A026

Miscellaneous databases

PROiPR:Q6A026
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDS5A_MOUSE
AccessioniPrimary (citable) accession number: Q6A026
Secondary accession number(s): E9Q656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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