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Protein

Protein phosphatase 1 regulatory subunit 26

Gene

Ppp1r26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation.1 Publication

Miscellaneous

Nude mice injected with Ppp1r26-expressing cells develop tumors within 2 weeks.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 26
Gene namesi
Name:Ppp1r26
Synonyms:Gm347, Kiaa0649
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2685193 Ppp1r26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092191 – 1163Protein phosphatase 1 regulatory subunit 26Add BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1111PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6A025
PRIDEiQ6A025

PTM databases

iPTMnetiQ6A025
PhosphoSitePlusiQ6A025

Expressioni

Gene expression databases

BgeeiENSMUSG00000035829 Expressed in 198 organ(s), highest expression level in blastocyst
CleanExiMM_GM347
GenevisibleiQ6A025 MM

Interactioni

Subunit structurei

Interacts with UTP20 and PPP1CA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042173

Structurei

3D structure databases

ProteinModelPortaliQ6A025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGYJ Eukaryota
ENOG4111MX8 LUCA
GeneTreeiENSGT00390000014118
HOGENOMiHOG000113155
HOVERGENiHBG094902
InParanoidiQ6A025
KOiK17565
OMAiFGKGVSW
OrthoDBiEOG091G01H8
PhylomeDBiQ6A025
TreeFamiTF331544

Family and domain databases

InterProiView protein in InterPro
IPR026130 PPP1R26
IPR031474 PPP1R26_N
PANTHERiPTHR15724 PTHR15724, 1 hit
PfamiView protein in Pfam
PF15740 PPP1R26_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLMNAPPVV ALQSRWEAFG QPRSFCLPDC FSEAKEDGSR ASVSARVQML
60 70 80 90 100
ISTLQRDEAA LGMGHERLTQ RGQRAERSRD TRLAPKPAVC KEQPEFPARG
110 120 130 140 150
LVANCSALEK DEAGRRSPLE LDSDSDDSVD RDIEEAIQEY LKARGGASEP
160 170 180 190 200
MSQGAPSIPE PAHSSTLPIP CPSQLTPGSG SVPVGASEDQ GSTSPASMSS
210 220 230 240 250
EDSFEQSIRA EIEQFLNEKR QHENPKCDGF VDKKSDPNNS PARLRGNRET
260 270 280 290 300
SARAALMGTC KEFIFRKPPR LTKMSTQQRN FQPKPTTEPE TPVSTKLTAH
310 320 330 340 350
RPEAAQSRGG VRRSMPARRS KRIRSSAPVH QASDSSSDDG IEEAIQLYQL
360 370 380 390 400
EKTRKEASGD PPLRGQLKEE SPGSAQPNAL PEAHRRPPSK KKLAVPKVID
410 420 430 440 450
TTQGVLHPDP LSRLLTDSRA SLPPGHAAAK SEAVCQASRL ADTSTELMCA
460 470 480 490 500
EAILDISKTI LPAPMEGSDR PPSRNPLFCP QPMPPRSEGD SSNIDSDDSI
510 520 530 540 550
EQEIRTFLAL KAQVGSPQPA QGPLSSPGPS GQPGIPKVPF AKTLDLPLVC
560 570 580 590 600
KRKRRGGGGS TTMPKKIREG RESTQDADHI QGKAQPGHDG WDPLGHNKIT
610 620 630 640 650
ETPGGEAEAK EQPVISRTVG LSDTHLPQGA LGKATEKESS EDKSSSLDSD
660 670 680 690 700
EDLDMAIKDL LRSKRKFKKR CRDPRASCKK VRFGSTETRC GEKPSNLPGD
710 720 730 740 750
WKDHRQQALR SCLPKCRGDN KDGPGRSPGS SVAEKAKMGG TGGEDATPAF
760 770 780 790 800
LLRRKSPEGA LPSTDTGASG HPPSASSPTS EDSAVDSDDS IELEIRRFLA
810 820 830 840 850
EKAKESIRNT EPQGGPAKPE MPCRKDPTLG LQPGVCTRSQ KARGTPQLAE
860 870 880 890 900
GRRGPERART QATGLLSQSG KGTLRAEQTA RLTTALGRSE PALPKNTCRN
910 920 930 940 950
SSAKASPPSR KSAHVHKDHS PQGSQTATAE SVFGQLPSCA KVGAEAGSAG
960 970 980 990 1000
GTFHLNYGSQ NLLTPNPGSQ ADLVLPWSDF AHQSRLSSPW VLNSGQGTVW
1010 1020 1030 1040 1050
TGVFRGEKEK GATSQAGAPP SLSSGPRKGL PFLSTQLFHF GKNVSWGGKQ
1060 1070 1080 1090 1100
TSLFSPNLGL PLQAPAFSAF RETQPGHNPV FGSPHLLMKD SGNWPSRKAQ
1110 1120 1130 1140 1150
GTLRQQDRRN SASEDKVLDL RYRHRVDREP QDQETLGSDA SEFSDTSMED
1160
GGSATVSSKG LKL
Length:1,163
Mass (Da):124,934
Last modified:November 13, 2007 - v2
Checksum:iE9B62E05D458C406
GO

Sequence cautioni

The sequence BAD32271 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172993 mRNA Translation: BAD32271.1 Different initiation.
BC070440 mRNA Translation: AAH70440.1
AL772249 Genomic DNA No translation available.
CCDSiCCDS15836.1
RefSeqiNP_001005420.1, NM_001005420.1
XP_006498089.1, XM_006498026.3
XP_006498090.1, XM_006498027.2
XP_006498092.1, XM_006498029.3
XP_011237395.1, XM_011239093.1
XP_017173526.1, XM_017318037.1
UniGeneiMm.330095

Genome annotation databases

EnsembliENSMUST00000040324; ENSMUSP00000042173; ENSMUSG00000035829
ENSMUST00000189694; ENSMUSP00000139546; ENSMUSG00000035829
GeneIDi241289
KEGGimmu:241289
UCSCiuc008iye.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172993 mRNA Translation: BAD32271.1 Different initiation.
BC070440 mRNA Translation: AAH70440.1
AL772249 Genomic DNA No translation available.
CCDSiCCDS15836.1
RefSeqiNP_001005420.1, NM_001005420.1
XP_006498089.1, XM_006498026.3
XP_006498090.1, XM_006498027.2
XP_006498092.1, XM_006498029.3
XP_011237395.1, XM_011239093.1
XP_017173526.1, XM_017318037.1
UniGeneiMm.330095

3D structure databases

ProteinModelPortaliQ6A025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042173

PTM databases

iPTMnetiQ6A025
PhosphoSitePlusiQ6A025

Proteomic databases

PaxDbiQ6A025
PRIDEiQ6A025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040324; ENSMUSP00000042173; ENSMUSG00000035829
ENSMUST00000189694; ENSMUSP00000139546; ENSMUSG00000035829
GeneIDi241289
KEGGimmu:241289
UCSCiuc008iye.1 mouse

Organism-specific databases

CTDi9858
MGIiMGI:2685193 Ppp1r26
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGYJ Eukaryota
ENOG4111MX8 LUCA
GeneTreeiENSGT00390000014118
HOGENOMiHOG000113155
HOVERGENiHBG094902
InParanoidiQ6A025
KOiK17565
OMAiFGKGVSW
OrthoDBiEOG091G01H8
PhylomeDBiQ6A025
TreeFamiTF331544

Miscellaneous databases

PROiPR:Q6A025
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035829 Expressed in 198 organ(s), highest expression level in blastocyst
CleanExiMM_GM347
GenevisibleiQ6A025 MM

Family and domain databases

InterProiView protein in InterPro
IPR026130 PPP1R26
IPR031474 PPP1R26_N
PANTHERiPTHR15724 PTHR15724, 1 hit
PfamiView protein in Pfam
PF15740 PPP1R26_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR26_MOUSE
AccessioniPrimary (citable) accession number: Q6A025
Secondary accession number(s): Q6NS64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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