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Entry version 90 (16 Oct 2019)
Sequence version 1 (13 Sep 2004)
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Protein
Submitted name:

MKIAA0824 protein

Gene

Pcf11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA0824 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pcf11Imported
Synonyms:mKIAA0824Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919579 Pcf11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q69ZY3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69ZY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69ZY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69ZY3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 230CIDInterPro annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni34 – 104DisorderedSequence analysisAdd BLAST71
Regioni255 – 274DisorderedSequence analysisAdd BLAST20
Regioni353 – 736DisorderedSequence analysisAdd BLAST384
Regioni795 – 821DisorderedSequence analysisAdd BLAST27
Regioni1009 – 1028DisorderedSequence analysisAdd BLAST20
Regioni1374 – 1401DisorderedSequence analysisAdd BLAST28
Regioni1604 – 1641DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili296 – 323Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi62 – 85PolyampholyteSequence analysisAdd BLAST24
Compositional biasi382 – 405PolyampholyteSequence analysisAdd BLAST24
Compositional biasi406 – 426PolarSequence analysisAdd BLAST21
Compositional biasi427 – 454PolyampholyteSequence analysisAdd BLAST28
Compositional biasi465 – 532PolyampholyteSequence analysisAdd BLAST68
Compositional biasi562 – 596BasicSequence analysisAdd BLAST35
Compositional biasi622 – 659PolyampholyteSequence analysisAdd BLAST38
Compositional biasi685 – 714PolyampholyteSequence analysisAdd BLAST30
Compositional biasi795 – 814PolyampholyteSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2071 Eukaryota
ENOG410Y266 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290721

KEGG Orthology (KO)

More...
KOi
K14400

Database of Orthologous Groups

More...
OrthoDBi
321518at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818 CTD_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00582 RPR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391 CID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q69ZY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RHCRRHFVSV EKEAPAAAGS GRRFPVRLRR FFPEVPPGSS PIPPPWSACG
60 70 80 90 100
EAAAAGDPGS EAEASEGRRG VERLQLRRRR TSEGGRGAMS EQTPAQAGAA
110 120 130 140 150
GAREDACRDY QSSLEDLTFN SKPHINMLTI LAEENLPFAK EIVSLIEAQT
160 170 180 190 200
AKAPSSEKLP VMYLMDSIVK NVGREYLTAF TKNLVATFIC VFEKVDENTR
210 220 230 240 250
KSLFKLRSTW DEIFPLKKLY ALDVRVNSLD PAWPIKPLPP NVNTSSIHVN
260 270 280 290 300
PKFLNKSPDE PSTPGTVVSS PSISTPPIVP DIQKNLTQEQ LIRQQLLAKQ
310 320 330 340 350
KQLLELQQKK LELELEQAKA QLAVSLSVQQ ETANLGPGSV PSKLHVPQIP
360 370 380 390 400
TMAVKTPHQV PVQPDKSRAG PSLQMQDLKG TNRDPRLNRM SQHSSHGKEQ
410 420 430 440 450
SHRKEFVMNT INQSDIKTSK NVPSEKLNSS KQEKSKSGER ITKKELDQLD
460 470 480 490 500
SKSKSKSKSP SPLKNKLSHT KDLKNQDSES MRLSDMSKRD PRLKKHLQDK
510 520 530 540 550
AEGKDEDVKE KRKTAEKKEK DEHMKSSEHR VIGSRSKIIN GIVQKQDMVT
560 570 580 590 600
EELEKQGTKP GRSSTRKRSR SRSPKSRSPI IHSPKRRDRR SPKRRQRSMS
610 620 630 640 650
PNLAPKAGKM RQSGLKQSHM EEFPPPSREE RNIKRSAKQD VRDPRRLKKM
660 670 680 690 700
DEDRPQETAG QHSMKSGGDP KENIENWQSS KSAKRWKSGW EENKSLQQGD
710 720 730 740 750
EHSKPPHLRH RESWSSTKGI LSPRAPKQQH RLSVDANLQI PKELTLASKR
760 770 780 790 800
ELLQKTSERL ASGEITQDEF LVVVHQIRQL FQYQEGVREE QRSPFNDRFP
810 820 830 840 850
LKRPRYEDSD KPFVDGPASR FAGLDTNQRL TALAEDRPLF DGPGRPSVTR
860 870 880 890 900
DGPAKMIFEG PNKLSPRIDG PPTPGSLRFD GSPGQMGGGG PMRFEGPQGQ
910 920 930 940 950
LGGGCPLRFE GPPGPVGTPL RFEGPIGQGG GGGFRFEGSP SLRFEGSTGG
960 970 980 990 1000
LRFEGPGGQP VGGLRFEGHR GQPVGGLRFE GPHGQPVGSL RFDNPRGQPV
1010 1020 1030 1040 1050
GGLRFEGGHG PSGAAIRFDG PHGQPGGGGG IRFEGPLLQQ GVGMRFEGPH
1060 1070 1080 1090 1100
GQSVAGLRFE GHNQLGGNLR FEGPHGQPGV GIRFEGPIVQ QGGGMRFEGP
1110 1120 1130 1140 1150
VPGGGLRIEG PLGQGGPRFE GCHSLRFDGQ PGQPSLLPRF DGLHGQPGPR
1160 1170 1180 1190 1200
FERTGQPGPQ RFDGPPGQQV QPRFDGVPQR FDGPQHQQAS RFDIPLGLQG
1210 1220 1230 1240 1250
TRFDNHPSQR IESFNHSGPY NDPPGNTFNV PSQGLQFQRH EQIFDTPQGP
1260 1270 1280 1290 1300
NFNGPHGPGN QNFPNPINRA SGHYFDEKNL QSSQFGNFGN LPTPISVGNI
1310 1320 1330 1340 1350
QASQQVLTGV AQPVAFGQGQ QFLPVHPQNP GAFIQNPSGG LPKAYPDNHL
1360 1370 1380 1390 1400
SQVDVNELFS KLLKTGILKL SQPDSATAQV TEAVAQPPPE EDEDQNEDQD
1410 1420 1430 1440 1450
VPDLTNFTIE ELKQRYDSVI NRLYTGIQCY SCGMRFTTSQ TDVYADHLDW
1460 1470 1480 1490 1500
HYRQNRTEKD VSRKVTHRRW YYSLTDWIEF EEIADLEERA KSQFFEKVHE
1510 1520 1530 1540 1550
EVVLKTQEAA KEKEFQSVPA GPAGAVESCE ICQEQFEQYW DEEEEEWHLK
1560 1570 1580 1590 1600
NAIRVDGKIY HPSCYEDYQN TSSFDCTPSP SKTPVENPLN IMLNIVKNEL
1610 1620 1630 1640
QEPCESPKVK EEQIDAPPAC SEESVATPTE IKTESDTVES V
Length:1,641
Mass (Da):182,205
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC25347AA8C94B9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173035 mRNA Translation: BAD32313.1

NCBI Reference Sequences

More...
RefSeqi
NP_083354.3, NM_029078.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74737

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74737

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173035 mRNA Translation: BAD32313.1
RefSeqiNP_083354.3, NM_029078.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ69ZY3
PhosphoSitePlusiQ69ZY3

Proteomic databases

PRIDEiQ69ZY3

Genome annotation databases

GeneIDi74737
KEGGimmu:74737

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51585
MGIiMGI:1919579 Pcf11

Phylogenomic databases

eggNOGiKOG2071 Eukaryota
ENOG410Y266 LUCA
HOGENOMiHOG000290721
KOiK14400
OrthoDBi321518at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pcf11 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ69ZY3 MM

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ69ZY3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69ZY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 16, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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