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Protein

Actin-binding LIM protein 3

Gene

Ablim3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 3
Short name:
abLIM-3
Alternative name(s):
Actin-binding LIM protein family member 3
Gene namesi
Name:Ablim3
Synonyms:Kiaa0843
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2442582 Ablim3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757031 – 682Actin-binding LIM protein 3Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei277PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1
Modified residuei286PhosphoserineBy similarity1
Modified residuei290PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphotyrosineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei388PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1
Modified residuei502PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei542PhosphothreonineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1
Modified residuei630Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ69ZX8
PaxDbiQ69ZX8
PeptideAtlasiQ69ZX8
PRIDEiQ69ZX8

PTM databases

iPTMnetiQ69ZX8
PhosphoSitePlusiQ69ZX8

Expressioni

Tissue specificityi

Expressed in heart, brain, lung and liver. In the brain, highly expressed in the olfactory bulb. In the hippocampus, expressed selectively in the CA2 and CA3 fields. In the cerebellum, expressed in internal granular cells.1 Publication

Developmental stagei

At 15.5 dpc, expressed in skeletal muscle. Down-regulated in adult skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000032735 Expressed in 205 organ(s), highest expression level in telencephalon
CleanExiMM_ABLIM3
GenevisibleiQ69ZX8 MM

Interactioni

Subunit structurei

Directly interacts with F-actin and ABRA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi235467, 1 interactor
IntActiQ69ZX8, 1 interactor
STRINGi10090.ENSMUSP00000041243

Structurei

3D structure databases

ProteinModelPortaliQ69ZX8
SMRiQ69ZX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 80LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini80 – 140LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini149 – 208LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini208 – 268LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini614 – 682HPPROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ69ZX8
KOiK07520
OMAiTLERYSY
OrthoDBiEOG091G025W
PhylomeDBiQ69ZX8
TreeFamiTF318042

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028449 ABLIM3
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF0 PTHR24213:SF0, 1 hit
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q69ZX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTSIPYQQS PYSPRGGSNV IQCYRCGDTC KGEVVRVHNN HFHIRCFTCQ
60 70 80 90 100
VCGCGLAQSG FFFKNQEYIC TQDYQQLYGT RCDSCRDFIT GEVISALGRT
110 120 130 140 150
YHPKCFVCSL CRKPFPIGDK VTFSGKECVC QTCSQSMTSS KPIKIRGPSH
160 170 180 190 200
CAGCKEEIKH GQSLLALDKQ WHVSCFKCQT CSVILTGEYI SKDGVPYCES
210 220 230 240 250
DYHSQFGIKC ETCDRYISGR VLEAGGKHYH PTCARCVRCH QMFTEGEEMY
260 270 280 290 300
LTGSEVWHPI CKQAARAEKK LKHRRTSETS ISPPGSSIGS PNRVICAKVD
310 320 330 340 350
NEILNYKDLA ALPKVKSIYE VQRPDLISYE PHSRYTSDEM LERCGYGESL
360 370 380 390 400
GTLSPYSQDI YENLDLRQRR ASSPGYIDSP TYSRQGMSPT FSRSPHYYRS
410 420 430 440 450
GPESGRSSPY HSQLDVRSST PTSYQAPKHF HIPAGESNIY RKPPIYKRHG
460 470 480 490 500
DLSTATKSKT SEDISQASKY SPAYSPDPYY ASESEYWTYH GSPKVPRARR
510 520 530 540 550
FSSGGEEEDF DRSMHKLQSG IGRLILKEEM KARSSSYADP WTPPRSSTSS
560 570 580 590 600
REALHTTGYE MSFNGSPRSH YLADSDPLIS KSASLPAYRR NGLHRTPSAD
610 620 630 640 650
LFHYDSMNAV NWGMREYKIY PYELLLVTTR GRNRLPKDVD RTRLERHLSQ
660 670 680
EEFYQVFGMT ISEFERLALW KRNELKKQAR LF
Length:682
Mass (Da):77,630
Last modified:December 7, 2004 - v2
Checksum:i44E7E59BD850F9CE
GO

Sequence cautioni

The sequence BAD32318 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381T → I in AAH60275 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173040 mRNA Translation: BAD32318.1 Different initiation.
BC060275 mRNA Translation: AAH60275.1
BC094229 mRNA Translation: AAH94229.1
CCDSiCCDS37839.1
RefSeqiNP_001157963.1, NM_001164491.1
NP_941051.2, NM_198649.3
UniGeneiMm.329478

Genome annotation databases

EnsembliENSMUST00000049378; ENSMUSP00000041243; ENSMUSG00000032735
ENSMUST00000166783; ENSMUSP00000125836; ENSMUSG00000032735
GeneIDi319713
KEGGimmu:319713
UCSCiuc008fct.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173040 mRNA Translation: BAD32318.1 Different initiation.
BC060275 mRNA Translation: AAH60275.1
BC094229 mRNA Translation: AAH94229.1
CCDSiCCDS37839.1
RefSeqiNP_001157963.1, NM_001164491.1
NP_941051.2, NM_198649.3
UniGeneiMm.329478

3D structure databases

ProteinModelPortaliQ69ZX8
SMRiQ69ZX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi235467, 1 interactor
IntActiQ69ZX8, 1 interactor
STRINGi10090.ENSMUSP00000041243

PTM databases

iPTMnetiQ69ZX8
PhosphoSitePlusiQ69ZX8

Proteomic databases

MaxQBiQ69ZX8
PaxDbiQ69ZX8
PeptideAtlasiQ69ZX8
PRIDEiQ69ZX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049378; ENSMUSP00000041243; ENSMUSG00000032735
ENSMUST00000166783; ENSMUSP00000125836; ENSMUSG00000032735
GeneIDi319713
KEGGimmu:319713
UCSCiuc008fct.2 mouse

Organism-specific databases

CTDi22885
MGIiMGI:2442582 Ablim3
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ69ZX8
KOiK07520
OMAiTLERYSY
OrthoDBiEOG091G025W
PhylomeDBiQ69ZX8
TreeFamiTF318042

Miscellaneous databases

PROiPR:Q69ZX8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032735 Expressed in 205 organ(s), highest expression level in telencephalon
CleanExiMM_ABLIM3
GenevisibleiQ69ZX8 MM

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028449 ABLIM3
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF0 PTHR24213:SF0, 1 hit
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiABLM3_MOUSE
AccessioniPrimary (citable) accession number: Q69ZX8
Secondary accession number(s): Q52KR1, Q6PAI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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