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Protein

MORC family CW-type zinc finger protein 2A

Gene

Morc2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri490 – 544CW-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 2A
Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 1
Gene namesi
Name:Morc2aImported
Synonyms:Kiaa0852Imported, Zcwcc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921772 Morc2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482431 – 1030MORC family CW-type zinc finger protein 2AAdd BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei737PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei834PhosphothreonineCombined sources1
Modified residuei854PhosphoserineCombined sources1
Modified residuei859PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ69ZX6
MaxQBiQ69ZX6
PaxDbiQ69ZX6
PeptideAtlasiQ69ZX6
PRIDEiQ69ZX6

PTM databases

iPTMnetiQ69ZX6
PhosphoSitePlusiQ69ZX6

Expressioni

Tissue specificityi

Expressed in the axons and Schwann cells of peripheral nerves.1 Publication

Gene expression databases

BgeeiENSMUSG00000034543 Expressed in 241 organ(s), highest expression level in dorsal pancreas
CleanExiMM_MORC2A
ExpressionAtlasiQ69ZX6 baseline and differential
GenevisibleiQ69ZX6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091087

Structurei

3D structure databases

ProteinModelPortaliQ69ZX6
SMRiQ69ZX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili285 – 362Sequence analysisAdd BLAST78
Coiled coili555 – 583Sequence analysisAdd BLAST29
Coiled coili738 – 775Sequence analysisAdd BLAST38
Coiled coili966 – 1011Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi601 – 724Pro-richSequence analysisAdd BLAST124

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri490 – 544CW-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000060084
HOVERGENiHBG056877
InParanoidiQ69ZX6
OMAiCNSYQTR
OrthoDBiEOG091G02B6
PhylomeDBiQ69ZX6
TreeFamiTF329118

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q69ZX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI
60 70 80 90 100
YAERREDLRG GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY
110 120 130 140 150
GNGLKSGSMR IGKDFILFTK KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW
160 170 180 190 200
NARTREPITD NVEKFAIETE LVYKYSPFHT EEQVMNQFMK IPGNSGTLVI
210 220 230 240 250
IFNLKLMDNG EPELDIISNP KDIQMAETSP EGTKPERRSF RAYAAVLYID
260 270 280 290 300
PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR
310 320 330 340 350
IAEEKAREAE SKARTLEVRM GGDLTRDSRV MLRQVQNTAI TLRREADVKK
360 370 380 390 400
RIKDAKQRAL KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ
410 420 430 440 450
LEGGMACGGV VGVVDVPYLV LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY
460 470 480 490 500
WKDIAIAQRG IIKFWDEFGY LSANWNQPPS SELRFKRRRA MEIPTTIQCD
510 520 530 540 550
LCLKWRTLPF QLSSVETDYP DTWVCSMNPD PEQDRCEASE QKQKVPLGTL
560 570 580 590 600
KKDPKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR
610 620 630 640 650
PIEEPVRRPQ RPRSPPLPAV IKNAPSRPPS IQTPRPSTQL RKTSVISLPK
660 670 680 690 700
PPTTAARGET STSRLLQPTE APRKPANPPI KTVPRPTPPV HTPPLSLIPS
710 720 730 740 750
SKSLREVPAQ KAIKTPVVKK PEPPVKQSVA TSGRKRSLAV SDEEEAEEEA
760 770 780 790 800
EKRRERCKRG KLAVKEEKKE ANELSDSAGE DHPAELRKAQ KDKGLHVEVR
810 820 830 840 850
VNREWYTGRV TAVEVGKNAV RWKVKFDYVP TDTTPRDRWV EKGSEDVRLM
860 870 880 890 900
KPPSPEHQSP DTQQEGGEEE EAMVARQAVA LPEPSTSDGL PIEPDTTATS
910 920 930 940 950
PSHETIDLLV QILRNCLRYF LPPSFPISKK ELSVMNSEEL ISFPLKEYFK
960 970 980 990 1000
QYEVGLQNLC HSYQSRADSR AKASEESLRT SEKKLRETEE KLQKLRTNIV
1010 1020 1030
ALLQKVQEDI DINTDDELDA YIEDLITKGD
Length:1,030
Mass (Da):117,330
Last modified:September 5, 2006 - v2
Checksum:i0EDD2D09F11C80A2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QNQ8Q5QNQ8_MOUSE
MORC family CW-type zinc finger pro...
Morc2a
102Annotation score:

Sequence cautioni

The sequence BAD32320 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173042 mRNA Translation: BAD32320.1 Different initiation.
AL691413 Genomic DNA No translation available.
BC063082 mRNA Translation: AAH63082.1
CCDSiCCDS48741.1
RefSeqiNP_001152760.1, NM_001159288.1
XP_011242078.1, XM_011243776.2
UniGeneiMm.139127

Genome annotation databases

EnsembliENSMUST00000093389; ENSMUSP00000091087; ENSMUSG00000034543
ENSMUST00000096441; ENSMUSP00000094176; ENSMUSG00000034543
GeneIDi74522
KEGGimmu:74522
UCSCiuc007htm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173042 mRNA Translation: BAD32320.1 Different initiation.
AL691413 Genomic DNA No translation available.
BC063082 mRNA Translation: AAH63082.1
CCDSiCCDS48741.1
RefSeqiNP_001152760.1, NM_001159288.1
XP_011242078.1, XM_011243776.2
UniGeneiMm.139127

3D structure databases

ProteinModelPortaliQ69ZX6
SMRiQ69ZX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091087

PTM databases

iPTMnetiQ69ZX6
PhosphoSitePlusiQ69ZX6

Proteomic databases

EPDiQ69ZX6
MaxQBiQ69ZX6
PaxDbiQ69ZX6
PeptideAtlasiQ69ZX6
PRIDEiQ69ZX6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093389; ENSMUSP00000091087; ENSMUSG00000034543
ENSMUST00000096441; ENSMUSP00000094176; ENSMUSG00000034543
GeneIDi74522
KEGGimmu:74522
UCSCiuc007htm.1 mouse

Organism-specific databases

CTDi74522
MGIiMGI:1921772 Morc2a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000060084
HOVERGENiHBG056877
InParanoidiQ69ZX6
OMAiCNSYQTR
OrthoDBiEOG091G02B6
PhylomeDBiQ69ZX6
TreeFamiTF329118

Enzyme and pathway databases

ReactomeiR-MMU-75105 Fatty acyl-CoA biosynthesis

Miscellaneous databases

ChiTaRSiMorc2a mouse
PROiPR:Q69ZX6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034543 Expressed in 241 organ(s), highest expression level in dorsal pancreas
CleanExiMM_MORC2A
ExpressionAtlasiQ69ZX6 baseline and differential
GenevisibleiQ69ZX6 MM

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOR2A_MOUSE
AccessioniPrimary (citable) accession number: Q69ZX6
Secondary accession number(s): Q5QNQ7, Q6P547
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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