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Entry version 114 (10 Feb 2021)
Sequence version 2 (13 Nov 2007)
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Protein

Fanconi-associated nuclease 1

Gene

Fan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (PubMed:24981866). Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (By similarity). Also has endonuclease activity toward 5'-flaps (PubMed:24981866).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity, Mg2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi837Magnesium or manganese 2By similarity1
Metal bindingi963Magnesium or manganese 1By similarity1
Metal bindingi963Magnesium or manganese 2By similarity1
Metal bindingi978Magnesium or manganese 1By similarity1
Metal bindingi979Magnesium or manganese 1; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri41 – 69UBZ4-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6783310, Fanconi Anemia Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi-associated nuclease 1By similarity (EC:3.1.21.-1 Publication, EC:3.1.4.11 Publication)
Alternative name(s):
FANCD2/FANCI-associated nuclease 1By similarity
Short name:
mFAN11 Publication
Myotubularin-related protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fan1Imported
Synonyms:Kiaa10181 Publication, Mtmr15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045266, Fan1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112251 – 1020Fanconi-associated nuclease 1Add BLAST1020

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated and degraded during mitotic exit by the APC/C-Cdh1 complex.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q69ZT1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69ZT1

PeptideAtlas

More...
PeptideAtlasi
Q69ZT1

PRoteomics IDEntifications database

More...
PRIDEi
Q69ZT1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69ZT1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69ZT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033458, Expressed in quadriceps femoris and 54 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FANCD2 (when monoubiquitinated).

Interacts with FANCI, MLH1, MLH3 and PMS2.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
236987, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130012

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q69ZT1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q69ZT1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini898 – 1010VRR-NUCAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili673 – 737Sequence analysisAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi14 – 22D-box9
Motifi212 – 214KEN box3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBZ4-type zinc finger specifically binds monoubiquitinated FANCD2.By similarity
The KEN box and D-box are required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated ubiquitination.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAN1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 69UBZ4-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2143, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005116_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69ZT1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQTCPLD

Database of Orthologous Groups

More...
OrthoDBi
1003565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q69ZT1

TreeFam database of animal gene trees

More...
TreeFami
TF312870

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1350.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033315, Fan1-like
IPR006642, Rad18_UBZ4
IPR011856, tRNA_endonuc-like_dom_sf
IPR014883, VRR_NUC

The PANTHER Classification System

More...
PANTHERi
PTHR15749, PTHR15749, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08774, VRR_NUC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00990, VRR_NUC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51908, ZF_UBZ4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q69ZT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSQRKSPDQ KRPRRSLSTS KTAKSQCHSI TSYFNSAPPA KLACSTCHKM
60 70 80 90 100
VPRYDLIRHL DESCANNGVG DDVQVEPAQA GLMSPTVPTS DLPSGPLENV
110 120 130 140 150
TPQKLSPPKR SLISVQCGSK LGIQQQTSPY FKDALVSKDQ NELPNQSVEI
160 170 180 190 200
MPLGSLTSKL SRRYLNAKKS LAKNEGLASQ CPQTSPSTPG TSLTDNCPEM
210 220 230 240 250
EDKDEVLNSS QKENIYSCAP LKEENASEQK VKNNKITGDE SQKASCGEPA
260 270 280 290 300
LTPASAEHAS ILLSSDSTLV SNTKSSPGDT LVKQESARRA DVGLAEPLEV
310 320 330 340 350
RSHKEVQMTF DAAAKTLVSG EAESNGPTDV DMSDMTTWSN NQELVREAGS
360 370 380 390 400
VLHCPLEQGS SCGGPSETAQ LALSHPYYLR SFLVVLQALL GNEEDMKLFD
410 420 430 440 450
EQEKAIITRF YQLSASGQKL YVRLFQRKLT WIKMSKLEYE EIASDLTPVV
460 470 480 490 500
EELKDSGFLQ TESELQELSD VLELLSAPEL KALAKTFHLV SPGGQKQQLV
510 520 530 540 550
DAFHKLAKQR SVCTWGKTQP GIRAVILKRA KDLAGRSLRV CKGPRAVFAR
560 570 580 590 600
ILLLFSLTDS MEDEEAACGG QGQLSTVLLV NLGRMEFPQY TICRKTQIFR
610 620 630 640 650
DREDLIRYAA AAHMLSDISA AMASGNWEDA KELARSAKRD WEQLKSHPSL
660 670 680 690 700
RYHEALPPFL RCFTVGWIYT RISSRAVEVL ERLHMYEEAV KELENLLSQK
710 720 730 740 750
IYCPDSRGRW WDRLALNLHQ HLKRLEEAIR CIREGLADPH VRTGHRLSLY
760 770 780 790 800
QRAVRLRESP SCRKYKHLFS RLPEVAVGDV KHVTITGRLC PQHGMGKSVF
810 820 830 840 850
VMESGDGANP TTVLCSVEEL ALGYYRQSGF DQGIHGEGST FSTLCGLLLW
860 870 880 890 900
DIIFMDGIPD VFRNAYQASP LDLLTDSFFA SREQALEARL QLIHSAPAES
910 920 930 940 950
LRAWVGEAWQ AQQGRVASLV SWDRFTSLQQ AQDLVSCLGG PVLSGVCRRL
960 970 980 990 1000
AADFRHCRGG LPDLVVWNSQ SHHCKLVEVK GPSDRLSCKQ MIWLYELQKL
1010 1020
GADVEVCHVV AVGAKSKGLG
Length:1,020
Mass (Da):112,925
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA887731CD19DBF93
GO
Isoform 2 (identifier: Q69ZT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     728-743: AIRCIREGLADPHVRT → VLAAYPAAYLVLNGKL
     744-1020: Missing.

Show »
Length:743
Mass (Da):82,316
Checksum:iCD2E7516C695D88D
GO
Isoform 3 (identifier: Q69ZT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-468: ESELQEL → GTVRRRT
     469-1020: Missing.

Show »
Length:468
Mass (Da):51,103
Checksum:i7607F809E2A3E5F2
GO
Isoform 4 (identifier: Q69ZT1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-469: ASGQKLYVRL...QTESELQELS → GTFGLLAFRA...GPFKTSSCAW
     470-1020: Missing.

Show »
Length:469
Mass (Da):50,415
Checksum:i74205382B373310F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029431415 – 469ASGQK…LQELS → GTFGLLAFRASSSGLCAMGG PVSSLMTTTRSHCGSTAGWL SVSRRGPFKTSSCAW in isoform 4. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_029432462 – 468ESELQEL → GTVRRRT in isoform 3. 1 Publication7
Alternative sequenceiVSP_029433469 – 1020Missing in isoform 3. 1 PublicationAdd BLAST552
Alternative sequenceiVSP_029434470 – 1020Missing in isoform 4. 1 PublicationAdd BLAST551
Alternative sequenceiVSP_029435728 – 743AIRCI…PHVRT → VLAAYPAAYLVLNGKL in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_029436744 – 1020Missing in isoform 2. 1 PublicationAdd BLAST277

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK077918 mRNA Translation: BAC37062.1
AC129199 Genomic DNA No translation available.
AC139849 Genomic DNA No translation available.
BC116270 mRNA Translation: AAI16271.1
BC116271 mRNA Translation: AAI16272.1
AK173087 mRNA Translation: BAD32365.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52265.1 [Q69ZT1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_808561.2, NM_177893.3 [Q69ZT1-1]
XP_006541021.1, XM_006540958.3 [Q69ZT1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000163289; ENSMUSP00000130012; ENSMUSG00000033458 [Q69ZT1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
330554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:330554

UCSC genome browser

More...
UCSCi
uc009hge.1, mouse [Q69ZT1-2]
uc009hgf.2, mouse [Q69ZT1-3]
uc012fmp.1, mouse [Q69ZT1-1]
uc029wgg.1, mouse [Q69ZT1-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077918 mRNA Translation: BAC37062.1
AC129199 Genomic DNA No translation available.
AC139849 Genomic DNA No translation available.
BC116270 mRNA Translation: AAI16271.1
BC116271 mRNA Translation: AAI16272.1
AK173087 mRNA Translation: BAD32365.1
CCDSiCCDS52265.1 [Q69ZT1-1]
RefSeqiNP_808561.2, NM_177893.3 [Q69ZT1-1]
XP_006541021.1, XM_006540958.3 [Q69ZT1-1]

3D structure databases

SMRiQ69ZT1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi236987, 1 interactor
STRINGi10090.ENSMUSP00000130012

PTM databases

iPTMnetiQ69ZT1
PhosphoSitePlusiQ69ZT1

Proteomic databases

EPDiQ69ZT1
PaxDbiQ69ZT1
PeptideAtlasiQ69ZT1
PRIDEiQ69ZT1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22515, 108 antibodies

Genome annotation databases

EnsembliENSMUST00000163289; ENSMUSP00000130012; ENSMUSG00000033458 [Q69ZT1-1]
GeneIDi330554
KEGGimmu:330554
UCSCiuc009hge.1, mouse [Q69ZT1-2]
uc009hgf.2, mouse [Q69ZT1-3]
uc012fmp.1, mouse [Q69ZT1-1]
uc029wgg.1, mouse [Q69ZT1-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22909
MGIiMGI:3045266, Fan1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG2143, Eukaryota
GeneTreeiENSGT00390000018637
HOGENOMiCLU_005116_3_0_1
InParanoidiQ69ZT1
OMAiFQTCPLD
OrthoDBi1003565at2759
PhylomeDBiQ69ZT1
TreeFamiTF312870

Enzyme and pathway databases

ReactomeiR-MMU-6783310, Fanconi Anemia Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
330554, 0 hits in 17 CRISPR screens

Protein Ontology

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PROi
PR:Q69ZT1
RNActiQ69ZT1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000033458, Expressed in quadriceps femoris and 54 other tissues

Family and domain databases

Gene3Di3.40.1350.10, 1 hit
InterProiView protein in InterPro
IPR033315, Fan1-like
IPR006642, Rad18_UBZ4
IPR011856, tRNA_endonuc-like_dom_sf
IPR014883, VRR_NUC
PANTHERiPTHR15749, PTHR15749, 1 hit
PfamiView protein in Pfam
PF08774, VRR_NUC, 1 hit
SMARTiView protein in SMART
SM00990, VRR_NUC, 1 hit
PROSITEiView protein in PROSITE
PS51908, ZF_UBZ4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAN1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69ZT1
Secondary accession number(s): Q14B88, Q8BVK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 10, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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