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Entry version 119 (31 Jul 2019)
Sequence version 2 (10 Aug 2010)
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Protein

E3 ubiquitin-protein ligase HECTD1

Gene

Hectd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:22431752). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (PubMed:22431752). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells impairs their emigration and is consequently essential for the correct development of the cranial neural folds and neural tube closure (PubMed:17442300, PubMed:22431752).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2587Glycyl thioester intermediatePROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: InterPro
  • ubiquitin protein ligase activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HECTD1 (EC:2.3.2.261 Publication)
Alternative name(s):
HECT domain-containing protein 1
HECT-type E3 ubiquitin transferase HECTD1
Protein open mind
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hectd1
Synonyms:Kiaa1131, Opm
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2384768 Hectd1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Perinatal lethality, exencephaly, impaired neural fold elevation, abnormal head mesenchyme morphology and defects in eye and cranial vault morphology (PubMed:17442300, PubMed:22431752). Cranial mesenchyme (CM) cells are larger, have an abnormal shape and an abnormal emigration (PubMed:22431752). It is likely that the increased motility of CM cells results in the exencephaly phenotype (PubMed:22431752).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2587C → G: Loss of activity. No effect on binding to HSP90AA1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003961271 – 2618E3 ubiquitin-protein ligase HECTD1Add BLAST2618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei632PhosphoserineBy similarity1
Modified residuei641PhosphoserineCombined sources1
Modified residuei1389PhosphoserineCombined sources1
Modified residuei1493PhosphoserineBy similarity1
Modified residuei1572PhosphoserineCombined sources1
Modified residuei1777PhosphoserineBy similarity1
Modified residuei2323PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q69ZR2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q69ZR2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q69ZR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69ZR2

PeptideAtlas

More...
PeptideAtlasi
Q69ZR2

PRoteomics IDEntifications database

More...
PRIDEi
Q69ZR2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69ZR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69ZR2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q69ZR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed throughout early development of the embryo.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035247 Expressed in 274 organ(s), highest expression level in ear

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q69ZR2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69ZR2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IGSF1 (By similarity).

Interacts (via N-terminus) with HSP90AA1 (PubMed:22431752).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000136449

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q69ZR2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati396 – 425ANK 1Sequence analysisAdd BLAST30
Repeati427 – 456ANK 2Sequence analysisAdd BLAST30
Repeati460 – 492ANK 3Sequence analysisAdd BLAST33
Repeati580 – 613ANK 4Sequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1271 – 1343MIB/HERC2PROSITE-ProRule annotationAdd BLAST73
Domaini2156 – 2618HECTPROSITE-ProRule annotationAdd BLAST463

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2034 – 2108K-boxBy similarityAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi496 – 499Poly-LysSequence analysis4
Compositional biasi1355 – 1654Ser-richPROSITE-ProRule annotationAdd BLAST300
Compositional biasi1750 – 1757Poly-GluSequence analysis8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4276 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156572

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000018061

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q69ZR2

Database for complete collections of gene phylogenies

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PhylomeDBi
Q69ZR2

TreeFam database of animal gene trees

More...
TreeFami
TF323674

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR041200 FKBP3_BTHB
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR012919 SUN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF18410 BTHB, 1 hit
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF07738 Sad1_UNC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00119 HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF159034 SSF159034, 1 hit
SSF48371 SSF48371, 1 hit
SSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q69ZR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP
60 70 80 90 100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK
110 120 130 140 150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF
160 170 180 190 200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH
210 220 230 240 250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP
260 270 280 290 300
SSACKPGRST TGAPSAAADS KLSNQVSTIV SLLSTLCRGS PLVTHDLLRS
310 320 330 340 350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP
360 370 380 390 400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAAFEV NFMDDVGQTL
410 420 430 440 450
LNWASAFGTQ EMVEFLCERG ADVNRGQRSS SLHYAACFGR PQVAKTLLRH
460 470 480 490 500
GANPDLRDED GKTPLDKARE RGHSEVVAIL QSPGDWMCPV NKGDDKKKKD
510 520 530 540 550
TNKDEEECNE PRGDPEMAPL YLKRLLPVFA QTFQHTMLPS IRKASLALIR
560 570 580 590 600
KMIHFCSEAL LKEVCDSDVG HNLPTTLVEI TATVLDQEDD DDGHLLALQI
610 620 630 640 650
IRDLVDKGGD IFLDQLARLG VISKVSALAG PSSDDENEEE SKPEKEDEPQ
660 670 680 690 700
EDAKELQQGK PYHWRDWSII RGRDCLYIWS DAAALELSNG SNGWFRFILD
710 720 730 740 750
GKLATMYSSG SPEGGSDSSE SRSEFLEKLQ RARGQVKPST SSQPILSAPG
760 770 780 790 800
PTKLTVGNWS LTCLKEGEIA IHNSDGQQAT ILKEDLPGFV FESNRGTKHS
810 820 830 840 850
FTAETSLGSE FVTGWTGKRG RKLKSKLEKT KQKVRTMARD LYDDHFKAVE
860 870 880 890 900
SMPRGVVVTL RNIATQLESS WELHTNRQCI EGENTWRDLM KTALENLIVL
910 920 930 940 950
LKDENTISPY EMCSSGLVQA LLTVLNNVSI FRATKQKQNE VLVERINVFK
960 970 980 990 1000
TAFSESEDDE SYSRPAVALI RKLIAVLESI ERLPLHLYDT PGSTYNLQIL
1010 1020 1030 1040 1050
TRRLRFRLER APGETSLIDR TGRMLKMEPL ATVESLEQYL LKMVAKQWYD
1060 1070 1080 1090 1100
FDRSSFVFVR KLREGQNFIF RHQHDFDENG IIYWIGTNAK TAYEWVNPAA
1110 1120 1130 1140 1150
YGLVVVTSSE GRNLPYGRLE DILSRDNSAL NCHSNDDKNA WFAIDLGVWV
1160 1170 1180 1190 1200
IPSAYTLRHA RGYGRSALRN WVFQVSKDGQ NWTSLYTHVD DCSLNEPGST
1210 1220 1230 1240 1250
ATWPLDPAKD EKQGWRHVRL KQMGKNASGQ THYLSLSGFE LYGTVNGVCE
1260 1270 1280 1290 1300
DQLGKAAKEA EANLRRQRRL VRSQVLKYMV PGARVIRGLD WKWRDQDGSP
1310 1320 1330 1340 1350
QGEGTVTGEL HNGWIDVTWD AGGSNSYRMG AEGKFDLKLA PGYDPDTVAS
1360 1370 1380 1390 1400
PKPVSSTVSG TTQSWSSLVK NNCPDKTSAA AGSSSRKGSS SSVCSVASSS
1410 1420 1430 1440 1450
DISLASTKTE RRSEIVMEHS IVSGADVHEP IVVLSSAENV PQTEVGSSSS
1460 1470 1480 1490 1500
ASTSTLTAET GSENAERKLG PDSSVRAPGE SSAISMGIVS VSSPDVSSVS
1510 1520 1530 1540 1550
ELTNKEAASQ RPLSSSASNR LSVSSLLAAG APMSSSASVP NLSSRETSSL
1560 1570 1580 1590 1600
ESFVRRVANI ARTNATNNMN LSRSSSDNNT NTLGRNVMST ATSPLMGAQS
1610 1620 1630 1640 1650
FPNLTTPGTT STVTMSTSSV TSSSNVATAT TVLSVGQSLS NTLTTSLTST
1660 1670 1680 1690 1700
SSESDTGQEA EYSLYDFLDS CRASTLLAEL DDDEDLPEPD EEDDENEDDN
1710 1720 1730 1740 1750
QEDQEYEEVM ILRRPSLQRR AGSRSDVTHH VVTSQLPQVP SGAGSRPVGE
1760 1770 1780 1790 1800
QEEEEYETKG GRRRAWDDDY VLKRQFSALV PAFDPRPGRT NVQQTTDLEI
1810 1820 1830 1840 1850
PPPGTPHSEL LEEVECTPSP RLALTLKVTG LGTTREVELP LTNFRSTIFY
1860 1870 1880 1890 1900
YVQKLLQLSC NGNVKSDKLR RIWEPTYTIM YREMKDSDKE KENGKMGCWS
1910 1920 1930 1940 1950
IEHVEQYLGT DELPKNDLIT YLQKNADAAF LRHWKLTGTN KSIRKNRNCS
1960 1970 1980 1990 2000
QLIAAYKDFC EHGTKSGLNQ GAISSLQSSD ILNLTKEQPQ AKAGNGQSPC
2010 2020 2030 2040 2050
GVEDVLQLLR ILYIVASDPY SRISQEDGDE QPQFTFPPDE FTSKKITTKI
2060 2070 2080 2090 2100
LQQIEEPLAL ASGALPDWCE QLTSKCPFLI PFETRQLYFT CTAFGASRAI
2110 2120 2130 2140 2150
VWLQNRREAT VERTRTTSSV RRDDPGEFRV GRLKHERVKV PRGESLMEWA
2160 2170 2180 2190 2200
ENVMQIHADR KSVLEVEFLG EEGTGLGPTL EFYALVAAEF QRTDLGTWLC
2210 2220 2230 2240 2250
DDNFPDDESR HVDLGGGLKP PGYYVQRSCG LFTAPFPQDS DELERITKLF
2260 2270 2280 2290 2300
HFLGIFLAKC IQDNRLVDLP ISKPFFKLMC MGDIKSNMSK LIYESRGDRD
2310 2320 2330 2340 2350
LHCTESQSEA STEEGHDSLS VGSFEEDSKS EFILDPPKPK PPAWFNGILT
2360 2370 2380 2390 2400
WEDFELVNPH RARFLKEIKD LAIKRRQILG NKSLSEDEKN TKLQELVLRN
2410 2420 2430 2440 2450
PSGSGPPLSI EDLGLNFQFC PSSRIYGFTA VDLKPSGEDE MITMDNAEEY
2460 2470 2480 2490 2500
VDLMFDFCMH TGIQKQMEAF RGNVDGFNKV FPMEKLSSFS HEEVQMILCG
2510 2520 2530 2540 2550
NQSPSWAAED IINYTEPKLG YTRDSPGFLR FVRVLCGMSS DERKAFLQFT
2560 2570 2580 2590 2600
TGCSTLPPGG LANLHPRLTV VRKVDATDAS YPSVNTCVHY LKLPEYSSEE
2610
IMRERLLAAT MEKGFHLN
Length:2,618
Mass (Da):290,086
Last modified:August 10, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A06C9F973B11AFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIE5F8WIE5_MOUSE
E3 ubiquitin-protein ligase HECTD1
Hectd1
2,610Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1070F → S in BAD32384 (PubMed:15368895).Curated1
Sequence conflicti2472 – 2474Missing in BAD32384 (PubMed:15368895).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC159644 Genomic DNA No translation available.
AC157213 Genomic DNA No translation available.
AK173106 mRNA Translation: BAD32384.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000179265; ENSMUSP00000136449; ENSMUSG00000035247

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159644 Genomic DNA No translation available.
AC157213 Genomic DNA No translation available.
AK173106 mRNA Translation: BAD32384.1

3D structure databases

SMRiQ69ZR2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136449

PTM databases

iPTMnetiQ69ZR2
PhosphoSitePlusiQ69ZR2
SwissPalmiQ69ZR2

Proteomic databases

EPDiQ69ZR2
jPOSTiQ69ZR2
MaxQBiQ69ZR2
PaxDbiQ69ZR2
PeptideAtlasiQ69ZR2
PRIDEiQ69ZR2

Genome annotation databases

EnsembliENSMUST00000179265; ENSMUSP00000136449; ENSMUSG00000035247

Organism-specific databases

MGIiMGI:2384768 Hectd1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG4276 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000156572
HOGENOMiHOG000018061
InParanoidiQ69ZR2
PhylomeDBiQ69ZR2
TreeFamiTF323674

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Hectd1 mouse

Protein Ontology

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PROi
PR:Q69ZR2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035247 Expressed in 274 organ(s), highest expression level in ear
ExpressionAtlasiQ69ZR2 baseline and differential
GenevisibleiQ69ZR2 MM

Family and domain databases

CDDicd00078 HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR041200 FKBP3_BTHB
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR012919 SUN_dom
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF18410 BTHB, 1 hit
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF07738 Sad1_UNC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00119 HECTc, 1 hit
SUPFAMiSSF159034 SSF159034, 1 hit
SSF48371 SSF48371, 1 hit
SSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHECD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69ZR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: July 31, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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