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UniProtKB - Q69ZN6 (GNPTA_MOUSE)

Entry version 114 (16 Oct 2019)
Sequence version 2 (07 Mar 2006)
Previous versions | rss
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Protein

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Gene

Gnptab

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.By similarity

Miscellaneous

Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are most likely involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi449CalciumPROSITE-ProRule annotation1
Metal bindingi464CalciumPROSITE-ProRule annotation1
Metal bindingi467CalciumPROSITE-ProRule annotation1
Metal bindingi516CalciumPROSITE-ProRule annotation1
Metal bindingi531CalciumPROSITE-ProRule annotation1
Metal bindingi534CalciumPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi997 – 1008PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC:2.7.8.17By similarity)
Alternative name(s):
GlcNAc-1-phosphotransferase subunits alpha/beta
Stealth protein GNPTAB
UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Cleaved into the following 2 chains:
N-acetylglucosamine-1-phosphotransferase subunit alpha
N-acetylglucosamine-1-phosphotransferase subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gnptab
Synonyms:Gnpta, Kiaa1208
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3643902 Gnptab

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei1194 – 1214HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe retinal degeneration, growth retardation and secretory cell lesions. Mice are smaller with a reduced mean body weight and length, along with a reduction in total tissue mass and lean body mass. They show elevated levels of serum lysosomal enzymes, cartilage defects, and display cytoplasmic alterations in secretory cells of several exocrine glands.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002250101 – 907N-acetylglucosamine-1-phosphotransferase subunit alphaAdd BLAST907
ChainiPRO_0000225011908 – 1235N-acetylglucosamine-1-phosphotransferase subunit betaAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi438 ↔ 461PROSITE-ProRule annotation
Disulfide bondi452 ↔ 468PROSITE-ProRule annotation
Disulfide bondi505 ↔ 528PROSITE-ProRule annotation
Disulfide bondi519 ↔ 535PROSITE-ProRule annotation
Glycosylationi614N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi988N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1108N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The alpha- and beta-subunits are generated by a proteolytic cleavage by MBTPS1 protease at the Lys-907-Asp-908 bond.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei907 – 908Cleavage; by MBTPS1By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q69ZN6

PeptideAtlas

More...PeptideAtlasi		Q69ZN6

PRoteomics IDEntifications database

More...PRIDEi		Q69ZN6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q69ZN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q69ZN6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q69ZN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000035311 Expressed in 272 organ(s), highest expression level in cleaving embryo

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q69ZN6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q69ZN6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hexamer of two alpha, two beta and two gamma (GNPTG) subunits; disulfide-linked. The alpha and/or the beta subunits of the enzyme constitute the catalytic subunits.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000020251

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q69ZN6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati438 – 473LNR 1Add BLAST36
Repeati505 – 545LNR 2Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini700 – 810DMAP-interactionAdd BLAST111
Domaini984 – 1019EF-handPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi480 – 485Poly-Gly6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DMAP-interaction domain mediates substrate recognition. It specifically recognizes a conformation-dependent protein determinant present in acid hydrolases.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the stealth family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEF9 Eukaryota
ENOG410XYNB LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006747

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007474

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q69ZN6

KEGG Orthology (KO)

More...KOi		K08239

Identification of Orthologs from Complete Genome Data

More...OMAi		TLIMFTV

Database of Orthologous Groups

More...OrthoDBi		851009at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q69ZN6

TreeFam database of animal gene trees

More...TreeFami		TF324175

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010506 DMAP1-bd
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR041536 GNPTAB_reg
IPR035993 Notch-like_dom_sf
IPR000800 Notch_dom
IPR031358 Stealth_CR1
IPR021520 Stealth_CR2
IPR031357 Stealth_CR3
IPR031356 Stealth_CR4

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06464 DMAP_binding, 1 hit
PF18440 GlcNAc-1_reg, 1 hit
PF00066 Notch, 2 hits
PF17101 Stealth_CR1, 1 hit
PF11380 Stealth_CR2, 1 hit
PF17102 Stealth_CR3, 1 hit
PF17103 Stealth_CR4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01137 DMAP_binding, 1 hit
SM00004 NL, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90193 SSF90193, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50258 LNR, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69ZN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLKLLQRQT YTCLSHRYGL YVCFVGVVVT IVSAFQFGEV VLEWSRDQYH 
        60         70         80         90        100
VLFDSYRDNI AGKSFQNRLC LPMPIDVVYT WVNGTDLELL KELQQVREHM 
       110        120        130        140        150
EEEQRAMRET LGKNTTEPTK KSEKQLECLL THCIKVPMLV LDPPLPANCT 
       160        170        180        190        200
LKDLPTLYPS FHAASDMFNV AKPKNPSTNV SVVVFDTTKD VEDAHAGPFK 
       210        220        230        240        250
GGSKQMVWRA YLTTDKEAPG LVLMQGLAFL SGFPPTFKET SQLKTKLPEK 
       260        270        280        290        300
LSSKIKLLRL YSEASVALLK LNNPKGFQEL NKQTKKNMTI DGKELTISPA 
       310        320        330        340        350
YLLWDLSAIS QSKQDEDVSA SRFEDNEELR YSLRSIERHA PWVRNIFIVT 
       360        370        380        390        400
NGQIPSWLNL DNPRVTIVTH QDIFQNLSHL PTFSSPAIES HIHRIEGLSQ 
       410        420        430        440        450
KFIYLNDDVM FGKDVWPDDF YSHSKGQKVY LTWPVPNCAE GCPGSWIKDG 
       460        470        480        490        500
YCDKACNNSA CDWDGGDCSG NTAGNRFVAG GGGTGNIGAG QHWQFGGGIN 
       510        520        530        540        550
TISYCNQGCA NSWLADKFCD QACNVLSCGF DAGDCGQDHF HELYKVTLLP 
       560        570        580        590        600
NQTHYVVPKG EYLSYFSFAN IARRGVEGTY SDNPIIRHAS IANKWKTIHL 
       610        620        630        640        650
IMHSGMNATT IYFNLTLQNA NDEEFKIQIA VEVDTREAPK LNSTTQKAYE 
       660        670        680        690        700
SLVSPVTPLP QADVPFEDVP KEKRFPKIRR HDVNATGRFQ EEVKIPRVNI 
       710        720        730        740        750
SLLPKEAQVR LSNLDLQLER GDITLKGYNL SKSALLRSFL GNSLDTKIKP 
       760        770        780        790        800
QARTDETKGN LEVPQENPSH RRPHGFAGEH RSERWTAPAE TVTVKGRDHA 
       810        820        830        840        850
LNPPPVLETN ARLAQPTLGV TVSKENLSPL IVPPESHLPK EEESDRAEGN 
       860        870        880        890        900
AVPVKELVPG RRLQQNYPGF LPWEKKKYFQ DLLDEEESLK TQLAYFTDSK 
       910        920        930        940        950
HTGRQLKDTF ADSLRYVNKI LNSKFGFTSR KVPAHMPHMI DRIVMQELQD 
       960        970        980        990       1000
MFPEEFDKTS FHKVRHSEDM QFAFSYFYYL MSAVQPLNIS QVFHEVDTDQ 
      1010       1020       1030       1040       1050
SGVLSDREIR TLATRIHDLP LSLQDLTGLE HMLINCSKML PANITQLNNI 
      1060       1070       1080       1090       1100
PPTQEAYYDP NLPPVTKSLV TNCKPVTDKI HKAYKDKNKY RFEIMGEEEI 
      1110       1120       1130       1140       1150
AFKMIRTNVS HVVGQLDDIR KNPRKFVCLN DNIDHNHKDA RTVKAVLRDF 
      1160       1170       1180       1190       1200
YESMFPIPSQ FELPREYRNR FLHMHELQEW RAYRDKLKFW THCVLATLII 
      1210       1220       1230 
FTIFSFFAEQ IIALKRKIFP RRRIHKEASP DRIRV
Length:1,235
Mass (Da):140,984
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i683038D0FDB673FF
GO
Isoform 2 (identifier: Q69ZN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-67: DQYHVLFDSYRDNIAGKSFQN → MGSTSASWASLSPSSRLSSSE

Show »
Length:1,189
Mass (Da):135,245
Checksum:iAE2B3A97DA5EBAA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXC6D3YXC6_MOUSE
N-acetylglucosamine-1-phosphotransf...
Gnptab
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJ30D6RJ30_MOUSE
N-acetylglucosamine-1-phosphotransf...
Gnptab
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z1C3D3Z1C3_MOUSE
N-acetylglucosamine-1-phosphotransf...
Gnptab
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32410 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32779 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti444G → S in BAE24503 (PubMed:16141072).Curated1
Sequence conflicti707A → V in BAE32779 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173401 – 46Missing in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_01734147 – 67DQYHV…KSFQN → MGSTSASWASLSPSSRLSSS E in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK173132 mRNA Translation: BAD32410.1 Different initiation.
AK140867 mRNA Translation: BAE24503.1
AK154710 mRNA Translation: BAE32779.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24110.1 [Q69ZN6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001004164.2, NM_001004164.2 [Q69ZN6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000020251; ENSMUSP00000020251; ENSMUSG00000035311 [Q69ZN6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		432486

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:432486

UCSC genome browser

More...UCSCi		uc007grk.1 mouse [Q69ZN6-1]
uc011xlg.1 mouse [Q69ZN6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173132 mRNA Translation: BAD32410.1 Different initiation.
AK140867 mRNA Translation: BAE24503.1
AK154710 mRNA Translation: BAE32779.1 Different initiation.
CCDSiCCDS24110.1 [Q69ZN6-1]
RefSeqiNP_001004164.2, NM_001004164.2 [Q69ZN6-1]

3D structure databases

SMRiQ69ZN6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020251

PTM databases

iPTMnetiQ69ZN6
PhosphoSitePlusiQ69ZN6
SwissPalmiQ69ZN6

Proteomic databases

PaxDbiQ69ZN6
PeptideAtlasiQ69ZN6
PRIDEiQ69ZN6

Genome annotation databases

EnsembliENSMUST00000020251; ENSMUSP00000020251; ENSMUSG00000035311 [Q69ZN6-1]
GeneIDi432486
KEGGimmu:432486
UCSCiuc007grk.1 mouse [Q69ZN6-1]
uc011xlg.1 mouse [Q69ZN6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79158
MGIiMGI:3643902 Gnptab

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG410IEF9 Eukaryota
ENOG410XYNB LUCA
GeneTreeiENSGT00390000006747
HOGENOMiHOG000007474
InParanoidiQ69ZN6
KOiK08239
OMAiTLIMFTV
OrthoDBi851009at2759
PhylomeDBiQ69ZN6
TreeFamiTF324175

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gnptab mouse

Protein Ontology

More...PROi		PR:Q69ZN6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000035311 Expressed in 272 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ69ZN6 baseline and differential
GenevisibleiQ69ZN6 MM

Family and domain databases

InterProiView protein in InterPro
IPR010506 DMAP1-bd
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR041536 GNPTAB_reg
IPR035993 Notch-like_dom_sf
IPR000800 Notch_dom
IPR031358 Stealth_CR1
IPR021520 Stealth_CR2
IPR031357 Stealth_CR3
IPR031356 Stealth_CR4
PfamiView protein in Pfam
PF06464 DMAP_binding, 1 hit
PF18440 GlcNAc-1_reg, 1 hit
PF00066 Notch, 2 hits
PF17101 Stealth_CR1, 1 hit
PF11380 Stealth_CR2, 1 hit
PF17102 Stealth_CR3, 1 hit
PF17103 Stealth_CR4, 1 hit
SMARTiView protein in SMART
SM01137 DMAP_binding, 1 hit
SM00004 NL, 2 hits
SUPFAMiSSF90193 SSF90193, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50258 LNR, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNPTA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69ZN6
Secondary accession number(s): Q3U3K6, Q3US34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 16, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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