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Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

Jmjd1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2146Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2148Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2276Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1657 – 1682C6-typeSequence analysisAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
Gene namesi
Name:Jmjd1c
Synonyms:Jhdm2c, Kiaa1380
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1918614 Jmjd1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343751 – 2350Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST2350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei191PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei294PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei324PhosphothreonineBy similarity1
Modified residuei420PhosphoserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei457PhosphoserineBy similarity1
Modified residuei458PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei471PhosphoserineCombined sources1
Modified residuei762PhosphoserineBy similarity1
Modified residuei1800PhosphoserineBy similarity1
Cross-linki1942Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ69ZK6
MaxQBiQ69ZK6
PaxDbiQ69ZK6
PRIDEiQ69ZK6

PTM databases

iPTMnetiQ69ZK6
PhosphoSitePlusiQ69ZK6

Expressioni

Gene expression databases

BgeeiENSMUSG00000037876 Expressed in 281 organ(s), highest expression level in pineal body
CleanExiMM_JMJD1C
ExpressionAtlasiQ69ZK6 baseline and differential
GenevisibleiQ69ZK6 MM

Interactioni

Protein-protein interaction databases

BioGridi224438, 3 interactors
IntActiQ69ZK6, 1 interactor
STRINGi10090.ENSMUSP00000056227

Structurei

3D structure databases

ProteinModelPortaliQ69ZK6
SMRiQ69ZK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2084 – 2308JmjCPROSITE-ProRule annotationAdd BLAST225

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1876 – 1880LXXLL motif5

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1657 – 1682C6-typeSequence analysisAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOGENOMiHOG000113130
HOVERGENiHBG079631
InParanoidiQ69ZK6
KOiK11449
TreeFamiTF324723

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q69ZK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGPYSLNGY RVRVYRQDSA TQWFTGIITH HDLFTRTMIV MNDQVLEPQN
60 70 80 90 100
VDPSMVQMTF LDDVVHSLLK GENIGITSRR RSRASQNIST VHGHYTRAQA
110 120 130 140 150
NSPRPAMNSQ AAVPKQNTHQ QQQQRSIRPN KRKGSDSSIP DEEKMKEDKY
160 170 180 190 200
DCVSRGENPK GKNKHVVTKR RKPEEAEKRL SMKRLRTDNA SDASESSDAE
210 220 230 240 250
SSSKRVTETS SSEPMPEYEP KNKVTSKVNG EEGQSQAAEE AGEETLIDTR
260 270 280 290 300
PPWDQMQEDK NHNEGEKPKS TDSHLQDKMT LRSSEQATVA DHNSNDSVLQ
310 320 330 340 350
ECNVENQRTV ELLPKDRLVS RTPTPKCVTD IKNDTHSERA AQENLNTFGL
360 370 380 390 400
QTPENMDPNV SDSKHSNAKY LETAKQDCDQ SWVSDVVKVD LTQSSVTNAP
410 420 430 440 450
SGSDKRDTEK ERNHYVSYMS SLSAVSVTED QLHKRSPPPE TIKAKLTTSV
460 470 480 490 500
DTQKAKSSSS PEVVKPKITH SPDSVKSKAA YGNSQAVGER RLANKIEHEL
510 520 530 540 550
SRGSFHPVPT RGSALETTKS PLIIDKNEHF TVYRDPALIG SETGANHISP
560 570 580 590 600
FLSQHPFSLH SSSHRTCLNP GTHHPALTPG PHLLAGSTSQ TPLPTINTHP
610 620 630 640 650
LTSGPHHPVH HPHLLPTVLP GVPTASLLGG HPRLESAHAS SLSHLALAHQ
660 670 680 690 700
QQQQLLQHQS PHLLGQAHPS ASYNQLGLYP IIWQYPNGTH AYSGLGLPSS
710 720 730 740 750
KWVHPENAVN AEASLRRNSP SPWLHQPTPV TSADGIGLLS HIPVRPSSAE
760 770 780 790 800
PHRPHKITVH SSPPLTKTLA DHHKEELERK AFMEPLRSNA STSVKGDLDL
810 820 830 840 850
NRSQAGKDCH LHRHFVGPRP PQETGERLNK YKEEHRRILQ ESIDVAPFTT
860 870 880 890 900
KIKGHEVERE NYSRVVPSSS SPKSHAIKQD KDVDRSVSEI YKMKHSVPQS
910 920 930 940 950
LPQSNYFTTL SNSVVNEPPR SYPSKEVSNI YTEKQNNNLS ATANPQTHSF
960 970 980 990 1000
ISSLSKPPPL IKHQPESESL VGKIPDHLPH QSASHSVTTF RSDCRSPTHL
1010 1020 1030 1040 1050
TVSSTNALRS MPALHRAPVF HPPIHHSLER KESSYSSLSP PTLTPVMPVN
1060 1070 1080 1090 1100
AGGKVQESQK PPTLIPEPKD SQSNFKNSSD QSLTEMWRSN NNLNREKAEW
1110 1120 1130 1140 1150
PVEKSSGKSQ AAVASVIVRP PSSTKVDSVP SVPLASKDRV CERSSSGANK
1160 1170 1180 1190 1200
TDYLKPEAGE TGRIILPNVN LESAHVKSEK NFEAVSQGNV PVSVMSAVNV
1210 1220 1230 1240 1250
VSTTKADVFT SAATTTSVSS LSSAETSYSL SNTISASTPF ECTSSKSVVS
1260 1270 1280 1290 1300
QAVAQAKDCT VSTAVPGTLA CSKTGSAVQP GSGFSGTTDF IHLKKHKAAL
1310 1320 1330 1340 1350
AAAQFKNSSV SEAELNTVRN QTVAASLPLD STMTCTASNK AISVGNGPAA
1360 1370 1380 1390 1400
QSSQPNYHTK LKKAWLTRHS EEDKNTNKME NSGNSVSEII KPCSVNLIAS
1410 1420 1430 1440 1450
TSNDIENRAD GRVAVDKYGR DEKVSRRKAK RTYESGSESG DSDESESKSE
1460 1470 1480 1490 1500
QRTKRQPKPT YKKKQNDLQK RKGEVEEDSK PNGVLSRSAK DKSKLKLQNS
1510 1520 1530 1540 1550
NSAGVPRSVL KDWRKVKKLK QTGESFLQDD SCCEIGPNLQ KCRECRLIRS
1560 1570 1580 1590 1600
KKGEESTHSP VFCRFYYFRR LSFSKNGVVR IDGFSSPDQY DDEAMSLWTH
1610 1620 1630 1640 1650
ENYEDDEVDV ETSKYILDII GDKFCQLVTS EKTALSWVKK DAKIAWKRAV
1660 1670 1680 1690 1700
RGVREMCDAC EATLFNVHWV CRKCGFVACL DCYKAKERKS SRDKELYAWM
1710 1720 1730 1740 1750
KCVKGQPHDH KHLMLTQIIP GSVLTDLLDA MHILREKYGI KSHCHCTNRQ
1760 1770 1780 1790 1800
NLQGGNVPTM NGVSQVLQNV LHHSNKTSVS LPESQQQNSP QKSQTNGNSS
1810 1820 1830 1840 1850
PGSASTDSRL TPPESQSPLH WLADLAEQKS REEKQENKEF TLEREIKEDG
1860 1870 1880 1890 1900
DQDASDSPNG STSPPASQSN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP
1910 1920 1930 1940 1950
VYSMGTSSGK GGRTMPNILD DIIASVVENK IPPNKTSKIN IKSEPNEEPK
1960 1970 1980 1990 2000
ESSLPATDES NKSYRDIPHS WICDQHILWL KDYKNSNNWK LFKECWKQGQ
2010 2020 2030 2040 2050
PAVVSGVHKK MNISLWKAES ISLDFGDHQA DLLNCKDSIV SNANVKEFWD
2060 2070 2080 2090 2100
GFEEVSKRQK NKGGETVVLK LKDCPSGEDF KAMMPTRYED FLRCLPLPEY
2110 2120 2130 2140 2150
CNPEGKFNLA SHLPGFFVRP DLGPRLCSAY GVAAAKDHDI GTTNLHIEAS
2160 2170 2180 2190 2200
DVVNVLVYVG IAKGNGVLSK AGILKKFEEE ELDDVLRKRL KDSSEIPGAL
2210 2220 2230 2240 2250
WHIYAGKDVD KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNRKLRQRLL
2260 2270 2280 2290 2300
EEYGVRACTL IQFLGDAIVL PAGTLHQVQN FHSCVQVTED FVSPEHLVQS
2310 2320 2330 2340 2350
FHLTQELRLL KEEINYDDKL QVKNILYHAV KEMVRALKMH EDEVEDMEDT
Length:2,350
Mass (Da):260,639
Last modified:July 27, 2011 - v3
Checksum:iB17F6FAEB48FBE73
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZM1G3UZM1_MOUSE
Probable JmjC domain-containing his...
Jmjd1c
2,531Annotation score:
A0A0A0MQ98A0A0A0MQ98_MOUSE
Probable JmjC domain-containing his...
Jmjd1c
2,530Annotation score:
G3UYW3G3UYW3_MOUSE
Probable JmjC domain-containing his...
Jmjd1c
744Annotation score:

Sequence cautioni

The sequence AAH68318 differs from that shown. Aberrant splicing.Curated
The sequence AAH68318 differs from that shown. Reason: Frameshift at position 1075.Curated
The sequence BAC36783 differs from that shown. Reason: Erroneous termination at position 2326. Translated as Leu.Curated
The sequence BAC38410 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD32440 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1506P → S in AAH68318 (PubMed:15489334).Curated1
Sequence conflicti1715L → P in BAD32440 (PubMed:15368895).Curated1
Sequence conflicti2189R → I in BAD32440 (PubMed:15368895).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173162 mRNA Translation: BAD32440.1 Different initiation.
AC155712 Genomic DNA No translation available.
AC156272 Genomic DNA No translation available.
AK077400 mRNA Translation: BAC36783.1 Sequence problems.
AK082106 mRNA Translation: BAC38410.1 Different initiation.
AK085500 mRNA Translation: BAC39458.1
BC068318 mRNA Translation: AAH68318.1 Sequence problems.
CCDSiCCDS56708.1
RefSeqiNP_001229325.1, NM_001242396.1
XP_006513104.1, XM_006513041.2
XP_006513105.1, XM_006513042.3
UniGeneiMm.23846

Genome annotation databases

EnsembliENSMUST00000173689; ENSMUSP00000133700; ENSMUSG00000037876
ENSMUST00000230394; ENSMUSP00000154840; ENSMUSG00000116315
GeneIDi108829
KEGGimmu:108829
UCSCiuc007fls.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173162 mRNA Translation: BAD32440.1 Different initiation.
AC155712 Genomic DNA No translation available.
AC156272 Genomic DNA No translation available.
AK077400 mRNA Translation: BAC36783.1 Sequence problems.
AK082106 mRNA Translation: BAC38410.1 Different initiation.
AK085500 mRNA Translation: BAC39458.1
BC068318 mRNA Translation: AAH68318.1 Sequence problems.
CCDSiCCDS56708.1
RefSeqiNP_001229325.1, NM_001242396.1
XP_006513104.1, XM_006513041.2
XP_006513105.1, XM_006513042.3
UniGeneiMm.23846

3D structure databases

ProteinModelPortaliQ69ZK6
SMRiQ69ZK6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224438, 3 interactors
IntActiQ69ZK6, 1 interactor
STRINGi10090.ENSMUSP00000056227

PTM databases

iPTMnetiQ69ZK6
PhosphoSitePlusiQ69ZK6

Proteomic databases

EPDiQ69ZK6
MaxQBiQ69ZK6
PaxDbiQ69ZK6
PRIDEiQ69ZK6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173689; ENSMUSP00000133700; ENSMUSG00000037876
ENSMUST00000230394; ENSMUSP00000154840; ENSMUSG00000116315
GeneIDi108829
KEGGimmu:108829
UCSCiuc007fls.2 mouse

Organism-specific databases

CTDi221037
MGIiMGI:1918614 Jmjd1c
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00530000063039
HOGENOMiHOG000113130
HOVERGENiHBG079631
InParanoidiQ69ZK6
KOiK11449
TreeFamiTF324723

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiJmjd1c mouse
PROiPR:Q69ZK6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037876 Expressed in 281 organ(s), highest expression level in pineal body
CleanExiMM_JMJD1C
ExpressionAtlasiQ69ZK6 baseline and differential
GenevisibleiQ69ZK6 MM

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJHD2C_MOUSE
AccessioniPrimary (citable) accession number: Q69ZK6
Secondary accession number(s): E9QMM8
, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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