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Entry version 113 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

Jmjd1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2146Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2148Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2276Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1657 – 1682C6-typeSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Jmjd1c
Synonyms:Jhdm2c, Kiaa1380
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918614 Jmjd1c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343751 – 2350Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST2350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei135PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei191PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei294PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei324PhosphothreonineBy similarity1
Modified residuei420PhosphoserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei457PhosphoserineBy similarity1
Modified residuei458PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei471PhosphoserineCombined sources1
Modified residuei762PhosphoserineBy similarity1
Modified residuei1800PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1942Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q69ZK6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q69ZK6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69ZK6

PRoteomics IDEntifications database

More...
PRIDEi
Q69ZK6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69ZK6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69ZK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037876 Expressed in 281 organ(s), highest expression level in pineal body

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q69ZK6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69ZK6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
224438, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q69ZK6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000133700

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q69ZK6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2084 – 2308JmjCPROSITE-ProRule annotationAdd BLAST225

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1876 – 1880LXXLL motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1657 – 1682C6-typeSequence analysisAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1356 Eukaryota
ENOG410XTAA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113130

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69ZK6

KEGG Orthology (KO)

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KOi
K11449

Database of Orthologous Groups

More...
OrthoDBi
1185631at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324723

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003347 JmjC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02373 JmjC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00558 JmjC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51184 JMJC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q69ZK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGPYSLNGY RVRVYRQDSA TQWFTGIITH HDLFTRTMIV MNDQVLEPQN
60 70 80 90 100
VDPSMVQMTF LDDVVHSLLK GENIGITSRR RSRASQNIST VHGHYTRAQA
110 120 130 140 150
NSPRPAMNSQ AAVPKQNTHQ QQQQRSIRPN KRKGSDSSIP DEEKMKEDKY
160 170 180 190 200
DCVSRGENPK GKNKHVVTKR RKPEEAEKRL SMKRLRTDNA SDASESSDAE
210 220 230 240 250
SSSKRVTETS SSEPMPEYEP KNKVTSKVNG EEGQSQAAEE AGEETLIDTR
260 270 280 290 300
PPWDQMQEDK NHNEGEKPKS TDSHLQDKMT LRSSEQATVA DHNSNDSVLQ
310 320 330 340 350
ECNVENQRTV ELLPKDRLVS RTPTPKCVTD IKNDTHSERA AQENLNTFGL
360 370 380 390 400
QTPENMDPNV SDSKHSNAKY LETAKQDCDQ SWVSDVVKVD LTQSSVTNAP
410 420 430 440 450
SGSDKRDTEK ERNHYVSYMS SLSAVSVTED QLHKRSPPPE TIKAKLTTSV
460 470 480 490 500
DTQKAKSSSS PEVVKPKITH SPDSVKSKAA YGNSQAVGER RLANKIEHEL
510 520 530 540 550
SRGSFHPVPT RGSALETTKS PLIIDKNEHF TVYRDPALIG SETGANHISP
560 570 580 590 600
FLSQHPFSLH SSSHRTCLNP GTHHPALTPG PHLLAGSTSQ TPLPTINTHP
610 620 630 640 650
LTSGPHHPVH HPHLLPTVLP GVPTASLLGG HPRLESAHAS SLSHLALAHQ
660 670 680 690 700
QQQQLLQHQS PHLLGQAHPS ASYNQLGLYP IIWQYPNGTH AYSGLGLPSS
710 720 730 740 750
KWVHPENAVN AEASLRRNSP SPWLHQPTPV TSADGIGLLS HIPVRPSSAE
760 770 780 790 800
PHRPHKITVH SSPPLTKTLA DHHKEELERK AFMEPLRSNA STSVKGDLDL
810 820 830 840 850
NRSQAGKDCH LHRHFVGPRP PQETGERLNK YKEEHRRILQ ESIDVAPFTT
860 870 880 890 900
KIKGHEVERE NYSRVVPSSS SPKSHAIKQD KDVDRSVSEI YKMKHSVPQS
910 920 930 940 950
LPQSNYFTTL SNSVVNEPPR SYPSKEVSNI YTEKQNNNLS ATANPQTHSF
960 970 980 990 1000
ISSLSKPPPL IKHQPESESL VGKIPDHLPH QSASHSVTTF RSDCRSPTHL
1010 1020 1030 1040 1050
TVSSTNALRS MPALHRAPVF HPPIHHSLER KESSYSSLSP PTLTPVMPVN
1060 1070 1080 1090 1100
AGGKVQESQK PPTLIPEPKD SQSNFKNSSD QSLTEMWRSN NNLNREKAEW
1110 1120 1130 1140 1150
PVEKSSGKSQ AAVASVIVRP PSSTKVDSVP SVPLASKDRV CERSSSGANK
1160 1170 1180 1190 1200
TDYLKPEAGE TGRIILPNVN LESAHVKSEK NFEAVSQGNV PVSVMSAVNV
1210 1220 1230 1240 1250
VSTTKADVFT SAATTTSVSS LSSAETSYSL SNTISASTPF ECTSSKSVVS
1260 1270 1280 1290 1300
QAVAQAKDCT VSTAVPGTLA CSKTGSAVQP GSGFSGTTDF IHLKKHKAAL
1310 1320 1330 1340 1350
AAAQFKNSSV SEAELNTVRN QTVAASLPLD STMTCTASNK AISVGNGPAA
1360 1370 1380 1390 1400
QSSQPNYHTK LKKAWLTRHS EEDKNTNKME NSGNSVSEII KPCSVNLIAS
1410 1420 1430 1440 1450
TSNDIENRAD GRVAVDKYGR DEKVSRRKAK RTYESGSESG DSDESESKSE
1460 1470 1480 1490 1500
QRTKRQPKPT YKKKQNDLQK RKGEVEEDSK PNGVLSRSAK DKSKLKLQNS
1510 1520 1530 1540 1550
NSAGVPRSVL KDWRKVKKLK QTGESFLQDD SCCEIGPNLQ KCRECRLIRS
1560 1570 1580 1590 1600
KKGEESTHSP VFCRFYYFRR LSFSKNGVVR IDGFSSPDQY DDEAMSLWTH
1610 1620 1630 1640 1650
ENYEDDEVDV ETSKYILDII GDKFCQLVTS EKTALSWVKK DAKIAWKRAV
1660 1670 1680 1690 1700
RGVREMCDAC EATLFNVHWV CRKCGFVACL DCYKAKERKS SRDKELYAWM
1710 1720 1730 1740 1750
KCVKGQPHDH KHLMLTQIIP GSVLTDLLDA MHILREKYGI KSHCHCTNRQ
1760 1770 1780 1790 1800
NLQGGNVPTM NGVSQVLQNV LHHSNKTSVS LPESQQQNSP QKSQTNGNSS
1810 1820 1830 1840 1850
PGSASTDSRL TPPESQSPLH WLADLAEQKS REEKQENKEF TLEREIKEDG
1860 1870 1880 1890 1900
DQDASDSPNG STSPPASQSN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP
1910 1920 1930 1940 1950
VYSMGTSSGK GGRTMPNILD DIIASVVENK IPPNKTSKIN IKSEPNEEPK
1960 1970 1980 1990 2000
ESSLPATDES NKSYRDIPHS WICDQHILWL KDYKNSNNWK LFKECWKQGQ
2010 2020 2030 2040 2050
PAVVSGVHKK MNISLWKAES ISLDFGDHQA DLLNCKDSIV SNANVKEFWD
2060 2070 2080 2090 2100
GFEEVSKRQK NKGGETVVLK LKDCPSGEDF KAMMPTRYED FLRCLPLPEY
2110 2120 2130 2140 2150
CNPEGKFNLA SHLPGFFVRP DLGPRLCSAY GVAAAKDHDI GTTNLHIEAS
2160 2170 2180 2190 2200
DVVNVLVYVG IAKGNGVLSK AGILKKFEEE ELDDVLRKRL KDSSEIPGAL
2210 2220 2230 2240 2250
WHIYAGKDVD KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNRKLRQRLL
2260 2270 2280 2290 2300
EEYGVRACTL IQFLGDAIVL PAGTLHQVQN FHSCVQVTED FVSPEHLVQS
2310 2320 2330 2340 2350
FHLTQELRLL KEEINYDDKL QVKNILYHAV KEMVRALKMH EDEVEDMEDT
Length:2,350
Mass (Da):260,639
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB17F6FAEB48FBE73
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZM1G3UZM1_MOUSE
Probable JmjC domain-containing his...
Jmjd1c
2,531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQ98A0A0A0MQ98_MOUSE
Probable JmjC domain-containing his...
Jmjd1c
2,530Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYW3G3UYW3_MOUSE
Probable JmjC domain-containing his...
Jmjd1c
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH68318 differs from that shown. Aberrant splicing.Curated
The sequence AAH68318 differs from that shown. Reason: Frameshift.Curated
The sequence BAC36783 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC38410 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD32440 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1506P → S in AAH68318 (PubMed:15489334).Curated1
Sequence conflicti1715L → P in BAD32440 (PubMed:15368895).Curated1
Sequence conflicti2189R → I in BAD32440 (PubMed:15368895).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173162 mRNA Translation: BAD32440.1 Different initiation.
AC155712 Genomic DNA No translation available.
AC156272 Genomic DNA No translation available.
AK077400 mRNA Translation: BAC36783.1 Sequence problems.
AK082106 mRNA Translation: BAC38410.1 Different initiation.
AK085500 mRNA Translation: BAC39458.1
BC068318 mRNA Translation: AAH68318.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56708.1

NCBI Reference Sequences

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RefSeqi
NP_001229325.1, NM_001242396.1
XP_006513104.1, XM_006513041.2
XP_006513105.1, XM_006513042.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000173689; ENSMUSP00000133700; ENSMUSG00000037876
ENSMUST00000230394; ENSMUSP00000154840; ENSMUSG00000116315

Database of genes from NCBI RefSeq genomes

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GeneIDi
108829

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:108829

UCSC genome browser

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UCSCi
uc007fls.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173162 mRNA Translation: BAD32440.1 Different initiation.
AC155712 Genomic DNA No translation available.
AC156272 Genomic DNA No translation available.
AK077400 mRNA Translation: BAC36783.1 Sequence problems.
AK082106 mRNA Translation: BAC38410.1 Different initiation.
AK085500 mRNA Translation: BAC39458.1
BC068318 mRNA Translation: AAH68318.1 Sequence problems.
CCDSiCCDS56708.1
RefSeqiNP_001229325.1, NM_001242396.1
XP_006513104.1, XM_006513041.2
XP_006513105.1, XM_006513042.3

3D structure databases

SMRiQ69ZK6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi224438, 4 interactors
IntActiQ69ZK6, 1 interactor
STRINGi10090.ENSMUSP00000133700

PTM databases

iPTMnetiQ69ZK6
PhosphoSitePlusiQ69ZK6

Proteomic databases

EPDiQ69ZK6
MaxQBiQ69ZK6
PaxDbiQ69ZK6
PRIDEiQ69ZK6

Genome annotation databases

EnsembliENSMUST00000173689; ENSMUSP00000133700; ENSMUSG00000037876
ENSMUST00000230394; ENSMUSP00000154840; ENSMUSG00000116315
GeneIDi108829
KEGGimmu:108829
UCSCiuc007fls.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221037
MGIiMGI:1918614 Jmjd1c

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1356 Eukaryota
ENOG410XTAA LUCA
GeneTreeiENSGT00940000158210
HOGENOMiHOG000113130
InParanoidiQ69ZK6
KOiK11449
OrthoDBi1185631at2759
TreeFamiTF324723

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Jmjd1c mouse

Protein Ontology

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PROi
PR:Q69ZK6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000037876 Expressed in 281 organ(s), highest expression level in pineal body
ExpressionAtlasiQ69ZK6 baseline and differential
GenevisibleiQ69ZK6 MM

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJHD2C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69ZK6
Secondary accession number(s): E9QMM8
, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 113 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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