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Protein

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Gene

Prex1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity).By similarity1 Publication

GO - Molecular functioni

  • phospholipid binding Source: MGI
  • Rac guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Short name:
P-Rex1
Short name:
PtdIns(3,4,5)-dependent Rac exchanger 1
Gene namesi
Name:Prex1
Synonyms:Kiaa1415
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3040696 Prex1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926741 – 1650Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinAdd BLAST1650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314PhosphoserineBy similarity1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1186PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ69ZK0
PaxDbiQ69ZK0
PeptideAtlasiQ69ZK0
PRIDEiQ69ZK0

PTM databases

iPTMnetiQ69ZK0
PhosphoSitePlusiQ69ZK0

Expressioni

Gene expression databases

BgeeiENSMUSG00000039621 Expressed in 236 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_BC067047
ExpressionAtlasiQ69ZK0 baseline and differential
GenevisibleiQ69ZK0 MM

Interactioni

Subunit structurei

Interacts preferentially with RAC2 (PubMed:16243036). Interacts with RAC1 (PubMed:16243036). Interacts with AUTS2 (PubMed:25533347).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ69ZK0, 3 interactors
STRINGi10090.ENSMUSP00000037180

Structurei

3D structure databases

ProteinModelPortaliQ69ZK0
SMRiQ69ZK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 235DHPROSITE-ProRule annotationAdd BLAST192
Domaini266 – 387PHPROSITE-ProRule annotationAdd BLAST122
Domaini416 – 491DEP 1PROSITE-ProRule annotationAdd BLAST76
Domaini518 – 592DEP 2PROSITE-ProRule annotationAdd BLAST75
Domaini620 – 698PDZPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1469 – 1472Poly-Pro4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITRX Eukaryota
ENOG410Z6ZS LUCA
GeneTreeiENSGT00930000150835
HOGENOMiHOG000115690
HOVERGENiHBG053677
InParanoidiQ69ZK0
KOiK12365
OMAiMPQYEFR
OrthoDBiEOG091G00MJ
PhylomeDBiQ69ZK0
TreeFamiTF328639

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.10.10.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50186 DEP, 2 hits
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69ZK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAPGSGGGD GGGDPGGDGA HPDARGPVSG PCAAARDSER QLRLRLCVLN
60 70 80 90 100
EILGTERDYV GTLRFLQSAF LQRIRQNVAD SVEKGLTEEN VKVLFSNIED
110 120 130 140 150
ILEVHKDFLA ALEYCLHPEP QSQHELGNVF LKFKDKFCVY EEYCSNHEKA
160 170 180 190 200
LRLLVELNKV PAVRAFLLSC MLLGGRKTTD IPLEGYLLSP IQRICKYPLL
210 220 230 240 250
LKELAKRTPG KHPDHTAVQS ALQAMKTVCS NINETKRQME KLEALEQLQS
260 270 280 290 300
HIEGWEGSNL TDICTELLLQ GNLLKISAGN IQERAFFLFD NLLVYCKRKS
310 320 330 340 350
RVTGSKKSTK RTKSINGSLY IFRGRINTEV MEVENVEDGT ADYHSNGYTV
360 370 380 390 400
TNGWKIHNTA KNKWFVCMAK TAEEKQKWLD ALIREREQRE SLKLGMERDA
410 420 430 440 450
YVMIAEKGEK LYHMMMSKKV NLIKDRRRKL STVPKCFLGN EFVAWLLEIG
460 470 480 490 500
EISKTEEGVN LGQALLENGI IHHVSDKHQF KNEQVMYRFR YDDGTYKARS
510 520 530 540 550
ELEDIMSKGV RLYCRLHSLY APVIKDRDYH LKTYKSVVPG SKLVDWLLAQ
560 570 580 590 600
GDCQTREEAV ALGVGLCNNG FMHHVLEKSE FKDESQYFRF HADEEMEGTS
610 620 630 640 650
SKNKQLRNDF KLVENILAKR LLIPPQEDDY GFDLEEKNKA VVVKSVQRGS
660 670 680 690 700
LAEMAGLQAG RKIYSINEDL VFLRPFSEVE TILNQFFCSR RPLRLLVATK
710 720 730 740 750
AKETIKVPDH PEALSFQIRG TAPPCVFAVG RGSEAVAAGL CAGQCILKVN
760 770 780 790 800
GTSVANDGAL EVLEHFQAFR NHREEALGLY QWVYHSHEDA QLARASQGAP
810 820 830 840 850
DEDPQEDDQP DSALPLLSLG PQLSLHEDSA VVSLTLDNVH LEHGVVYEYM
860 870 880 890 900
STAGAKCHVL EKIVEPRGCF RLAAKILEAF AVDDSIFVQN CGRLMAMSSA
910 920 930 940 950
IVTMSHYEFH NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQASLEPH
960 970 980 990 1000
PLCGLDFCPT NCHVNLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG
1010 1020 1030 1040 1050
LNPMAYTQHC ITTMAAPSWK CSPAVDEDSQ GQGLNDSSYG SASGAPSQQD
1060 1070 1080 1090 1100
RGLSFLLKQE DREIQDAYLQ LFTKLDVALK EMKQYVTQIN RLLSTITEPT
1110 1120 1130 1140 1150
SAAPAPCDPS LVEETSSSPP VSEESEVDRT DHSGIKKVCF KVSEDEQEDS
1160 1170 1180 1190 1200
GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG SGDELPCDMR
1210 1220 1230 1240 1250
IPSDKQDKLH GCLEHLFNQV DSIHALLKGP VMSRAFEETR HFPMKHSWQE
1260 1270 1280 1290 1300
FKQKEECTVR GRNLIQISIQ EDPWNLPSSI RTLVDNIQQY VEDGKNQLLL
1310 1320 1330 1340 1350
ALLKCTDTEL QLRRDAVFCQ ALVAAVCTFS EQLLAALDYR YNNNGEYEES
1360 1370 1380 1390 1400
SRDASRKWLE QVAATGVLLH WQSLLAPASV KEERTMLEDI WVTLSELDNV
1410 1420 1430 1440 1450
TFSFKQLDEN SVANTNVFYH IEGSRQALKV VFYLDGFHFS RLPSRLEGGA
1460 1470 1480 1490 1500
SLRLHTVLFT KALESVEGPP PPGNQAAEEL QQEINAQSLE KVQQYYRKLR
1510 1520 1530 1540 1550
AFYLERSNLP TDAGATAVKI DQLIRPINAL DELYRLMKTF VHPKAGAAGS
1560 1570 1580 1590 1600
LGAGLIPVSS ELCYRLGACQ ITMCGTGMQR STLSVSLEQA AILARSHGLL
1610 1620 1630 1640 1650
PKCVMQATDI MRKQGPRVEI LAKNLRIKDP MPQGAPRLYQ LCQPPVDGDL
Length:1,650
Mass (Da):184,935
Last modified:June 26, 2007 - v2
Checksum:iEB1C0140126209FC
GO
Isoform 2 (identifier: Q69ZK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1188: Missing.

Show »
Length:462
Mass (Da):51,898
Checksum:i3C66B9F7533B4546
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HPV9I7HPV9_MOUSE
Phosphatidylinositol 3,4,5-trisphos...
Prex1
1,480Annotation score:

Sequence cautioni

The sequence BAD32446 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1575G → V in AAH57617 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264361 – 1188Missing in isoform 2. 1 PublicationAdd BLAST1188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173168 mRNA Translation: BAD32446.1 Different initiation.
AL591884 Genomic DNA Translation: CAM16778.1
AL591884, AL732357 Genomic DNA Translation: CAM16779.1
AL732357, AL591884 Genomic DNA Translation: CAM22699.1
AK090301 mRNA Translation: BAC41161.1
BC057617 mRNA Translation: AAH57617.1
CCDSiCCDS38334.1 [Q69ZK0-1]
RefSeqiNP_808450.2, NM_177782.3 [Q69ZK0-1]
UniGeneiMm.34420

Genome annotation databases

EnsembliENSMUST00000036719; ENSMUSP00000037180; ENSMUSG00000039621 [Q69ZK0-1]
ENSMUST00000109246; ENSMUSP00000104869; ENSMUSG00000039621 [Q69ZK0-2]
GeneIDi277360
KEGGimmu:277360
UCSCiuc008nym.1 mouse [Q69ZK0-2]
uc008nyn.1 mouse [Q69ZK0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173168 mRNA Translation: BAD32446.1 Different initiation.
AL591884 Genomic DNA Translation: CAM16778.1
AL591884, AL732357 Genomic DNA Translation: CAM16779.1
AL732357, AL591884 Genomic DNA Translation: CAM22699.1
AK090301 mRNA Translation: BAC41161.1
BC057617 mRNA Translation: AAH57617.1
CCDSiCCDS38334.1 [Q69ZK0-1]
RefSeqiNP_808450.2, NM_177782.3 [Q69ZK0-1]
UniGeneiMm.34420

3D structure databases

ProteinModelPortaliQ69ZK0
SMRiQ69ZK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ69ZK0, 3 interactors
STRINGi10090.ENSMUSP00000037180

PTM databases

iPTMnetiQ69ZK0
PhosphoSitePlusiQ69ZK0

Proteomic databases

EPDiQ69ZK0
PaxDbiQ69ZK0
PeptideAtlasiQ69ZK0
PRIDEiQ69ZK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036719; ENSMUSP00000037180; ENSMUSG00000039621 [Q69ZK0-1]
ENSMUST00000109246; ENSMUSP00000104869; ENSMUSG00000039621 [Q69ZK0-2]
GeneIDi277360
KEGGimmu:277360
UCSCiuc008nym.1 mouse [Q69ZK0-2]
uc008nyn.1 mouse [Q69ZK0-1]

Organism-specific databases

CTDi57580
MGIiMGI:3040696 Prex1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ITRX Eukaryota
ENOG410Z6ZS LUCA
GeneTreeiENSGT00930000150835
HOGENOMiHOG000115690
HOVERGENiHBG053677
InParanoidiQ69ZK0
KOiK12365
OMAiMPQYEFR
OrthoDBiEOG091G00MJ
PhylomeDBiQ69ZK0
TreeFamiTF328639

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

PROiPR:Q69ZK0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039621 Expressed in 236 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_BC067047
ExpressionAtlasiQ69ZK0 baseline and differential
GenevisibleiQ69ZK0 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.10.10.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50186 DEP, 2 hits
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPREX1_MOUSE
AccessioniPrimary (citable) accession number: Q69ZK0
Secondary accession number(s): A2A5U1, Q6PFD4, Q8BN08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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