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Entry version 86 (12 Aug 2020)
Sequence version 1 (13 Sep 2004)
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Protein
Submitted name:

MKIAA1461 protein

Gene

Mbd5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA1461 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mbd5Imported
Synonyms:mKIAA1461Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2138934, Mbd5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69ZJ2, MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 106MBDInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni224 – 298DisorderedSequence analysisAdd BLAST75
Regioni354 – 375DisorderedSequence analysisAdd BLAST22
Regioni477 – 546DisorderedSequence analysisAdd BLAST70
Regioni619 – 667DisorderedSequence analysisAdd BLAST49
Regioni1055 – 1081DisorderedSequence analysisAdd BLAST27
Regioni1605 – 1632DisorderedSequence analysisAdd BLAST28
Regioni1728 – 1753DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 261PolarSequence analysisAdd BLAST15
Compositional biasi281 – 296PolarSequence analysisAdd BLAST16
Compositional biasi355 – 371Pro-richSequence analysisAdd BLAST17
Compositional biasi480 – 496PolarSequence analysisAdd BLAST17
Compositional biasi522 – 537PolarSequence analysisAdd BLAST16
Compositional biasi619 – 659PolarSequence analysisAdd BLAST41
Compositional biasi1055 – 1080PolarSequence analysisAdd BLAST26
Compositional biasi1617 – 1632PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q69ZJ2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037385, MBD5/MBD6
IPR001739, Methyl_CpG_DNA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR16112, PTHR16112, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00391, MBD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50982, MBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q69ZJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RPPCSVIDGY HLIADIFGAP KQTQKMNGGK ECDGGDKEGG LAAIQVPVGW
60 70 80 90 100
QRRVDHNGVL YISPSGSLLS CLDQVKTYLL TDGTCKCGLE CPLILPKVFN
110 120 130 140 150
FDPGAAVKQR TAEDVKADDD VTKLCIHKRK IIAVATLHQS MEAPHPSLVL
160 170 180 190 200
TSPGGGTNAT PVVPSRAATP RSVRNKSHEG ITNSVMPECK NPFKLMTGSS
210 220 230 240 250
NAMGRLYMQD LPGSQQQELH PVYPRQRLGS SEHGQKSPFR GSHGGLPSPA
260 270 280 290 300
SSGSQIYGDG SISPRTDPLG SPDVFTRNNP GFHGAPNSSP IHLNRTPLSP
310 320 330 340 350
PSVMLHGSPV QSSCAMAGRT NIPLSPTLTT KSPVMKKPMC NFSTNMEIPR
360 370 380 390 400
AMFHHKPPQG PPPPPPPSCA LQKKPLTSEK DPLGILDPIP SKPVNQNPII
410 420 430 440 450
INPTSFHSNV HSQVPVMNVS MPPAVVPLPS NLPLPTVKPG HMNHGSHVQR
460 470 480 490 500
IQHSASTSLS PSPVTSPVHM MGTGIGRIEA SPQRSRSSST SSDHGNFMMP
510 520 530 540 550
PVGPQATCSG IKVPPRSPRS TIGSPRPSMP SSPSTKSDGH HQYKDIPNPL
560 570 580 590 600
IAGMSNVLNT PSSAAFPTAP AGNGSVKSQP GLLGMPLNQI LNQHNAASFP
610 620 630 640 650
ASSLLSAAAK AQLANQNKLA GNNSSSSNNS GAVASSGNTE GHSTLNTMFP
660 670 680 690 700
PTANMLLPTG EGQSGRAALR DKLMSQQKDS LRKRKQPPTT VLSLLRQSQM
710 720 730 740 750
DSSAAPKPGP DLLRKHGQGS FPISSMSQLL QSMSCQSSHL SSNSTPGCGG
760 770 780 790 800
SNTALPCSAN QLHFPDPNMN STVLQNSLTQ SIPLRGEAVH CHNANTNFVH
810 820 830 840 850
SNSPVPNHHL AGLINQIQAS GNCGMLSQSG MALGNSLHPN PPQSRISTSS
860 870 880 890 900
TPVIPNSIVS SYNQTSSEAG GSSLPSSIAI AGSNHPAITK TTSVLQDGVI
910 920 930 940 950
VTTAAGNPLQ SQLPIGSDFP FVGQEHALHF PSNSTANNHL PHPLNPSLLS
960 970 980 990 1000
SLPISLPVNQ QHLLNQNLLN ILQPSAGEGK SEINLHPLGF LNPNVNAALA
1010 1020 1030 1040 1050
FLSGDVDGQV LQPVHFQLLA ALLQNQAQAA AMLPLPSFNL TISDLLQPQN
1060 1070 1080 1090 1100
TPLPLLTQMT APPDRLPSNQ SDNSRADTLL GSPLGNPLAG SDTTFNPLLL
1110 1120 1130 1140 1150
PAVTGASGLM ALNPQLLGGV LNSASANTAI HPEVSIATSS QATTTTTTTS
1160 1170 1180 1190 1200
SAVAALTVST LGGTAVVSMA ETLLNISNNA GNPPGPAKLN SNSMVPQLLN
1210 1220 1230 1240 1250
PLLGTGLLGD ISSINNSLNN HQLTHLQSLL NSNQMFPPNQ QPQQHLLQGH
1260 1270 1280 1290 1300
QNLQAFQGQP TVPCPANNNP MACLFQNFQV RMQGDAALLN KRISTQPGLT
1310 1320 1330 1340 1350
TLPENPNLAL PHFQDTPCEL QPRIDLGQPM KDGLVMGGQG DASVDAIYKA
1360 1370 1380 1390 1400
VVDAASKGMQ VVITTAVNST TQISPIPALS AMSAFTASIG DPLNLSSAVS
1410 1420 1430 1440 1450
AVIHGRNMGG VDHDGRLRNA RGARLPKNID HGKNSSEGDG FECFKSASCH
1460 1470 1480 1490 1500
TSRKQWDGEQ SPRGERNRWK YEEFLDHPGH IHSSPCHERP NNVSTLPFLA
1510 1520 1530 1540 1550
GEQHPILLPP RNCQGDKILE ENFRYNNYKR TMMSFKERLE STVERCTHIN
1560 1570 1580 1590 1600
GNRPRQSRGF GELLGTAKQD LVLEGQSPGS SNSLESSLVK DYIHYNGDFN
1610 1620 1630 1640 1650
AKTINGCVPS PSDAKSISSE DDLRNPDSPS SHELIHYRPR TFNVGDLVWG
1660 1670 1680 1690 1700
QIKGLTSWPG KFIREDDVHN SCQQSPEEGK VEPEKLKTLT EGLEAYSRVR
1710 1720 1730 1740 1750
KRSRKSGKLN NHLEAAIHEA MSELDKMSGT VHQIPQGDRQ MRPPKPKRRK

ISR
Length:1,753
Mass (Da):186,329
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD2B05318DAADBAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173176 mRNA Translation: BAD32454.1

NCBI Reference Sequences

More...
RefSeqi
NP_084200.1, NM_029924.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109241

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173176 mRNA Translation: BAD32454.1
RefSeqiNP_084200.1, NM_029924.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi109241

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55777
MGIiMGI:2138934, Mbd5

Phylogenomic databases

PhylomeDBiQ69ZJ2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
109241, 1 hit in 22 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mbd5, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ69ZJ2, MM

Family and domain databases

InterProiView protein in InterPro
IPR037385, MBD5/MBD6
IPR001739, Methyl_CpG_DNA-bd
PANTHERiPTHR16112, PTHR16112, 1 hit
SMARTiView protein in SMART
SM00391, MBD, 1 hit
PROSITEiView protein in PROSITE
PS50982, MBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ69ZJ2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69ZJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: August 12, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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