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Protein

Rho GTPase-activating protein 23

Gene

Arhgap23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 23
Alternative name(s):
Rho-type GTPase-activating protein 23
Gene namesi
Name:Arhgap23
Synonyms:Kiaa1501
ORF Names:MNCb-1301
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3697726 Arhgap23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804721 – 1483Rho GTPase-activating protein 23Add BLAST1483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei361PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei421PhosphoserineBy similarity1
Modified residuei515PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei607PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei652PhosphothreonineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Cross-linki850Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ69ZH9
PeptideAtlasiQ69ZH9
PRIDEiQ69ZH9

PTM databases

iPTMnetiQ69ZH9
PhosphoSitePlusiQ69ZH9

Expressioni

Gene expression databases

BgeeiENSMUSG00000049807
ExpressionAtlasiQ69ZH9 baseline and differential
GenevisibleiQ69ZH9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103227

Structurei

3D structure databases

ProteinModelPortaliQ69ZH9
SMRiQ69ZH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 155PDZPROSITE-ProRule annotationAdd BLAST85
Domaini684 – 804PHPROSITE-ProRule annotationAdd BLAST121
Domaini901 – 1093Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi183 – 273Pro-richAdd BLAST91
Compositional biasi1421 – 1424Poly-Gly4

Phylogenomic databases

eggNOGiENOG410IQ9B Eukaryota
ENOG410YY7B LUCA
GeneTreeiENSGT00920000148945
HOGENOMiHOG000049125
HOVERGENiHBG093896
InParanoidiQ69ZH9
KOiK20315

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGVAFCLVG IPPRPEPRPP QLPLGPRDGC SSGRPLPWPG PRTLLLRKSL
60 70 80 90 100
QDGFGFTLRH FIVYPPESAV HCILKEEENG GRGGGPSPRH RLEPMDTIFV
110 120 130 140 150
KNVKDGGPAH RAGLRTGDRL VKVNGESIIG KTYSQVIGLI QNSDDTLELS
160 170 180 190 200
IMPKDEDILQ LAYSQDAYLK GNEPYSGEAR SIPEPPPLCY PRKTYAPPTR
210 220 230 240 250
APAWATMVPE PISALPPDPR SPAAWSDPGS RVPSATRAHL DNSSLGMSQP
260 270 280 290 300
RPSPGAFPHL PSESRTPRAF PEPGSRVLPS RLECQQALSH WLSNQIPRRA
310 320 330 340 350
GERRCPAMPP RARSASQDRL EDVTTHHPWP CSTSQDALSQ LGQEGWHRAR
360 370 380 390 400
SDDYLSRATR SAEALGPGAL VSPRLERCGW ASQRPSARTS ACPSRDLTQA
410 420 430 440 450
PPPSGLQGLD DIGYIGYRSY SPSFQRRTGL LHALSFRDSP FGGLPTFSLA
460 470 480 490 500
QSPASFPPEA SEPPRVVRPD PSTRALEPPA EDHRDEVVLR QKPPTGRKVQ
510 520 530 540 550
LTPARQMNLG FGDESPEPEA RGERLGRKVA PLATTEDSLA SIPFIDEPTS
560 570 580 590 600
PSIDLQAKHV PASAVVSSAM NSAPVLGTSP SSPTFTFALS RHYSQDCSSI
610 620 630 640 650
KAGRRSSYLL AITTERSKSC DDGLNTFRDE GRVLRRLPSR VPSLRVLRSF
660 670 680 690 700
FTDGSLDSWG TSEDADAPSK RHSTSDLSDA TFSDIRREGW LYYKQILTKK
710 720 730 740 750
GKKAGGGLRQ WKRVYAVLRA RSLSLSKERR EPGPAAAGAA AAGAGEDEAA
760 770 780 790 800
PVCIGSCLVD ISYSETKRRH VFRLTTADFC EYLFQAEDRD DMLGWIRAIR
810 820 830 840 850
ENSRAEGEDP GCANQALISK KLNDYRKVSH SSGPKADSSP KGSRGLGGLK
860 870 880 890 900
SEFLKQTAVR GLRTQEQPPG SKEDSVAAPK TPWGINIIKK NKKAAPRAFG
910 920 930 940 950
IRLEECQPAT ENQRVPLIVA ACCRIVEARG LESTGIYRVP GNNAVVSSLQ
960 970 980 990 1000
EQLNRGPSDI NLQDERWQDL NVISSLLKAF FRKLPEPLFT DDKYNDFIEA
1010 1020 1030 1040 1050
NRIEDSRERM KTLRKLIRDL PGHYYETLKF LVGHLKTIAD HSEKNKMEPR
1060 1070 1080 1090 1100
NLALVFGPTL VRTSEDNMTD MVTHMPDRYK IVETLIQHSD WFFSDDEDKG
1110 1120 1130 1140 1150
ERTPVDDKEP QSVPNIEYLL PNIGRTVPPS DPGSDSTTCS SAKSKGSWVP
1160 1170 1180 1190 1200
KKEPYAREML AISFISAVNR KRKKRREARG LGSSTDDDSE QEAHKAAVGT
1210 1220 1230 1240 1250
QEPPEGQLPG PAAEEAPGRL SPPTAPDERP AADTRSIVSG YSTLSTMDRS
1260 1270 1280 1290 1300
VCSGTGGRRA GAGDEADDER SELSHVETDT EGGAGPGGRL SRRPSFSSHH
1310 1320 1330 1340 1350
LMPCDTLARR RLSRSRAEAE GPGAGTARAC PRGPEPPGSA SSSSQESLRP
1360 1370 1380 1390 1400
PAAAPALGSR PSRVEALRLR LRGTADDMLA VRLRRPLSPE TRRRRSSWRR
1410 1420 1430 1440 1450
HTVVVQSPLT DLNFNEWKEL GGGGPQESVG VRPHSDNKDS GLSSLESTKA
1460 1470 1480
RASSAASLPS GDLGALQGLP QRRSAAARLH QCL
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,483
Mass (Da):161,832
Last modified:March 20, 2007 - v2
Checksum:i652088C6725EC9BE
GO
Isoform 2 (identifier: Q69ZH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1158: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):34,361
Checksum:iA85DCB18697C48C9
GO

Sequence cautioni

The sequence BAC37556 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1462 – 1464DLG → EPR in BAC37556 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0237101 – 1158Missing in isoform 2. 1 PublicationAdd BLAST1158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041572 mRNA Translation: BAA95056.1
AL596088 Genomic DNA No translation available.
AK173187 mRNA Translation: BAD32465.1
AK079135 mRNA Translation: BAC37556.1 Different initiation.
RefSeqiNP_067468.2, NM_021493.2
UniGeneiMm.394118

Genome annotation databases

EnsembliENSMUST00000093940; ENSMUSP00000091472; ENSMUSG00000049807 [Q69ZH9-2]
GeneIDi58996
KEGGimmu:58996
UCSCiuc007lec.1 mouse [Q69ZH9-1]
uc007led.1 mouse [Q69ZH9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRHG23_MOUSE
AccessioniPrimary (citable) accession number: Q69ZH9
Secondary accession number(s): Q8BNY7, Q9JJD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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