UniProtKB - Q69ZF7 (CNNM4_MOUSE)
Protein
Metal transporter CNNM4
Gene
Cnnm4
Organism
Mus musculus (Mouse)
Status
Functioni
Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.By similarity2 Publications
Miscellaneous
Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.
GO - Molecular functioni
- magnesium ion transmembrane transporter activity Source: MGI
- sodium ion transmembrane transporter activity Source: MGI
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- enamel mineralization Source: MGI
- magnesium ion homeostasis Source: MGI
- magnesium ion transport Source: MGI
- metal ion homeostasis Source: MGI
- response to stimulus Source: UniProtKB-KW
- visual perception Source: UniProtKB-KW
Keywordsi
Biological process | Biomineralization, Ion transport, Sensory transduction, Transport, Vision |
Names & Taxonomyi
Protein namesi | Recommended name: Metal transporter CNNM4Alternative name(s): Ancient conserved domain-containing protein 4 Short name: mACDP4 Cyclin-M4 |
Gene namesi | Name:Cnnm4 Synonyms:Acdp4, Kiaa1592 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2151060, Cnnm4 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- basolateral plasma membrane Source: MGI
- plasma membrane Source: GO_Central
Other locations
- dendrite Source: MGI
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
- neuronal cell body Source: MGI
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 175 | ExtracellularSequence analysisAdd BLAST | 175 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 237 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Intramembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 261 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 290 | ExtracellularSequence analysis | 8 | |
Transmembranei | 291 – 313 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 314 – 771 | CytoplasmicSequence analysisAdd BLAST | 458 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295766 | 1 – 771 | Metal transporter CNNM4Add BLAST | 771 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 657 | PhosphoserineBy similarity | 1 | |
Modified residuei | 661 | PhosphoserineCombined sources | 1 | |
Modified residuei | 766 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q69ZF7 |
jPOSTi | Q69ZF7 |
MaxQBi | Q69ZF7 |
PaxDbi | Q69ZF7 |
PeptideAtlasi | Q69ZF7 |
PRIDEi | Q69ZF7 |
PTM databases
GlyConnecti | 2511, 5 N-Linked glycans (1 site) |
GlyGeni | Q69ZF7, 1 site |
iPTMneti | Q69ZF7 |
PhosphoSitePlusi | Q69ZF7 |
Expressioni
Tissue specificityi
Cornea, retina, teeth (at protein level). In the retina it is predominantly localized to the outer plexiform layer, inner plexiform layer and ganglion cell layer. In the tooth strongest expression is observed in the cell body of the ameloblasts. Expressed at high levels in the gastrointestinal tract and testis.4 Publications
Gene expression databases
Bgeei | ENSMUSG00000037408, Expressed in spermatocyte and 122 other tissues |
Genevisiblei | Q69ZF7, MM |
Interactioni
Subunit structurei
Interacts with COX11.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000121317 |
Miscellaneous databases
RNActi | Q69ZF7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 175 – 355 | CNNM transmembranePROSITE-ProRule annotationAdd BLAST | 181 | |
Domaini | 374 – 435 | CBS 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 442 – 508 | CBS 2PROSITE-ProRule annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the ACDP family.Curated
Keywords - Domaini
CBS domain, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2118, Eukaryota |
GeneTreei | ENSGT00940000156317 |
HOGENOMi | CLU_011310_1_1_1 |
InParanoidi | Q69ZF7 |
OMAi | FMIRNDA |
OrthoDBi | 1446644at2759 |
PhylomeDBi | Q69ZF7 |
TreeFami | TF101012 |
Family and domain databases
InterProi | View protein in InterPro IPR000644, CBS_dom IPR018490, cNMP-bd-like IPR002550, CNNM |
Pfami | View protein in Pfam PF00571, CBS, 1 hit PF01595, DUF21, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits PS51846, CNNM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q69ZF7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPGGGGGRR DGWPARGRLL LAALLLLWTR AASGQSSPQQ SVILGMRLAS
60 70 80 90 100
CNKSCGMNPD GIIFVSEGST VNLRLYGHSL GDISSNLISF TEVDDAEAVH
110 120 130 140 150
NSTNCLELTK DLVVQRLVNV SRGNTSGMLV VITKFLRRSE NMKLYALCTR
160 170 180 190 200
PRADGPWTRW TDKDSLLFMV EEHGRFLPLW LHILLVMVLL VLSGIFSGLN
210 220 230 240 250
LGLMALDPME LRIVQNCGTE KERKYARKIE PIRRKGNYLL CSLLLGNVLV
260 270 280 290 300
NTSLTILLDN LIGSGIMAVA SSTIGIVIFG EILPQALCSR HGLAVGANTI
310 320 330 340 350
VLTKVFMLLT FPLSFPISKL LDFVLGQEIR TVYNREKLME MLKVTEPYND
360 370 380 390 400
LVKEELNMIQ GALELRTKTV EDIMTQLHDC FMIRSDAILD FNTMSEIMES
410 420 430 440 450
GYTRIPVFED EQSNIVDILY VKDLAFVDPD DCTPLKTITR FYNHPVHFVF
460 470 480 490 500
HDTKLDAMLE EFKKGKSHLA IVQKVNNEGE GDPFYEVLGL VTLEDVIEEI
510 520 530 540 550
IKSEILDESD MYTDNRTRKR VSVKNKRDFS AFKDTDNELK VKISPQLLLA
560 570 580 590 600
AHRFLATEVP QFSPSLMSEK ILLRLLKYPD VIQELRFNEH NRYCVRHYLY
610 620 630 640 650
TRNKPADCFV LILQGKVEVE AGKENMKFET GAFSYYGTMA LSVAPPDRSP
660 670 680 690 700
ALPTPLSRSA SLSYPDRNTD LTSTSLAGSN QFGSCILGQY VSDFSVRALT
710 720 730 740 750
DLQYIKITRQ QYQNGLMASR MDNSPQPTFD GCATCSENFM ERPELPPVDE
760 770
TTTLLNERNS LLHRASEEET I
Sequence cautioni
The sequence AAF86375 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD32487 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173209 mRNA Translation: BAD32487.1 Different initiation. AF216963 mRNA Translation: AAF86375.1 Different initiation. |
CCDSi | CCDS14879.2 |
RefSeqi | NP_291048.2, NM_033570.2 |
Genome annotation databases
Ensembli | ENSMUST00000153128; ENSMUSP00000121317; ENSMUSG00000037408 |
GeneIDi | 94220 |
KEGGi | mmu:94220 |
UCSCi | uc007aqg.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173209 mRNA Translation: BAD32487.1 Different initiation. AF216963 mRNA Translation: AAF86375.1 Different initiation. |
CCDSi | CCDS14879.2 |
RefSeqi | NP_291048.2, NM_033570.2 |
3D structure databases
SMRi | Q69ZF7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000121317 |
PTM databases
GlyConnecti | 2511, 5 N-Linked glycans (1 site) |
GlyGeni | Q69ZF7, 1 site |
iPTMneti | Q69ZF7 |
PhosphoSitePlusi | Q69ZF7 |
Proteomic databases
EPDi | Q69ZF7 |
jPOSTi | Q69ZF7 |
MaxQBi | Q69ZF7 |
PaxDbi | Q69ZF7 |
PeptideAtlasi | Q69ZF7 |
PRIDEi | Q69ZF7 |
Protocols and materials databases
Antibodypediai | 17482, 145 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000153128; ENSMUSP00000121317; ENSMUSG00000037408 |
GeneIDi | 94220 |
KEGGi | mmu:94220 |
UCSCi | uc007aqg.2, mouse |
Organism-specific databases
CTDi | 26504 |
MGIi | MGI:2151060, Cnnm4 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2118, Eukaryota |
GeneTreei | ENSGT00940000156317 |
HOGENOMi | CLU_011310_1_1_1 |
InParanoidi | Q69ZF7 |
OMAi | FMIRNDA |
OrthoDBi | 1446644at2759 |
PhylomeDBi | Q69ZF7 |
TreeFami | TF101012 |
Miscellaneous databases
BioGRID-ORCSi | 94220, 1 hit in 19 CRISPR screens |
ChiTaRSi | Cnnm4, mouse |
PROi | PR:Q69ZF7 |
RNActi | Q69ZF7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037408, Expressed in spermatocyte and 122 other tissues |
Genevisiblei | Q69ZF7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000644, CBS_dom IPR018490, cNMP-bd-like IPR002550, CNNM |
Pfami | View protein in Pfam PF00571, CBS, 1 hit PF01595, DUF21, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits PS51846, CNNM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNNM4_MOUSE | |
Accessioni | Q69ZF7Primary (citable) accession number: Q69ZF7 Secondary accession number(s): Q9JIM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families