Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger CCHC domain-containing protein 2

Gene

Zcchc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1119 – 1136CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 2
Gene namesi
Name:Zcchc2
Synonyms:Kiaa1744
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444114 Zcchc2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509501 – 1166Zinc finger CCHC domain-containing protein 2Add BLAST1166

Proteomic databases

PaxDbiQ69ZB8
PRIDEiQ69ZB8

PTM databases

iPTMnetiQ69ZB8
PhosphoSitePlusiQ69ZB8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038866 Expressed in 231 organ(s), highest expression level in secondary oocyte
CleanExiMM_ZCCHC2
ExpressionAtlasiQ69ZB8 baseline and differential
GenevisibleiQ69ZB8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113974

Structurei

3D structure databases

ProteinModelPortaliQ69ZB8
SMRiQ69ZB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 72Pro-richAdd BLAST66
Compositional biasi783 – 964Pro-richAdd BLAST182

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1119 – 1136CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IZZC Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiHOG000155766
HOVERGENiHBG108762
InParanoidiQ69ZB8
KOiK22700
OMAiSMEASQQ
OrthoDBiEOG091G01BF
PhylomeDBiQ69ZB8
TreeFamiTF335574

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69ZB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRMKLPPKS THPSEPPPDA EEPEADARPG AKAPLRRRRD CRPPPPPTGL
60 70 80 90 100
PRGPPPPPSP PRGLEPPVAS GPTAGAGMPG GGGHAAALRE QERVYEWFGL
110 120 130 140 150
VLGSAQRLEF MCGLLDLCNP LELRFLGSCL EDLARKDYHY LRDSEAKANG
160 170 180 190 200
LSDPGSLADF REPAVRSRLI VYLALLGSEN REAAGRLHRL LPQVDAVLRS
210 220 230 240 250
LRATRAEGSR GSVEDEPSGD GEQDAEKDGP GPEGSGCAKL GTGGGLGFRA
260 270 280 290 300
QEELLLLFTM ASLHPAFSFH QRVTLREHLE RLRSALRVEP EDAEVEPSNF
310 320 330 340 350
AGSRAQNDSA CGDYIQSNET GLVEQAQIPP DGLTVAPHRA QREAVHIEKI
360 370 380 390 400
MLKGVQRKRA DKYWEYTFKV NWSDLSVTTV TKTHQELQEF LLKLPKEFSS
410 420 430 440 450
ESFDKTILKA LNQGSLRREE RRHPDLEPIL RQLFSTSPQA FLQSHKVRSF
460 470 480 490 500
FRSISSESQH NFNNLQSSLK TSKILEHLKE DSSEASSQEE DVLQHTIIHK
510 520 530 540 550
KHAGKSPALN VATSCSPLDG LTMQYAEQNG IVDWRNQGCA AIQHSEHCVS
560 570 580 590 600
SADQHSAEKR SLSSGNKKKG KPQVEKEKVK KTEDRLNSRI NGIRLSAPQH
610 620 630 640 650
VHGSTVKDMN LDIGSGHDTC GETSSESYSS PSSPRHDGRE SLESEEEKDR
660 670 680 690 700
DSDSNSEDSV NPSSARFSGY GSVAQTIAVK PPAETVSLGT EDGNLLEAAL
710 720 730 740 750
TSHKYPHIPF MPTLHCVTHN GAQKSQVVIP SPKSADGKTL GMLVPNAVAI
760 770 780 790 800
SAVMESSNSA PVGILGPAAS GESEKHLELL ASPLPLPSTF LPHSSAPALQ
810 820 830 840 850
LTLQSLKLQP PQGSSDSCPV SIPPQPTGSL SIGSPNTAFI PVHNPGSFPG
860 870 880 890 900
SPVATTDPIT KSAPQVVGLN QMVPQIEGNT GTVPQPSNVK VVLPAAGLSA
910 920 930 940 950
AQPPASFPFP GSPQAASALP TQNSSALNAA TSAQPASTGI SPSQSTVPPA
960 970 980 990 1000
VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT IVPPQQMGPC
1010 1020 1030 1040 1050
GSCGRRCSCG TNGNLQLNSY YYPNPMPGPM YRLPSFFTLP SICNGSYLNQ
1060 1070 1080 1090 1100
AHQSNGNQLP FFLPQTPYAN GLVHDPVMGS QASYGMQQMA GFGRLYPVYP
1110 1120 1130 1140 1150
APNVVANTSG SGPKKNGNVS CYNCGVSGHY AQDCKQSSME ANQQGTYRLR
1160
YAPPLPPSND TLDSAD
Length:1,166
Mass (Da):124,517
Last modified:April 8, 2008 - v3
Checksum:iBBE1E89BC7EED4E6
GO
Isoform 2 (identifier: Q69ZB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1146-1166: TYRLRYAPPLPPSNDTLDSAD → NPTNSQRTCF

Show »
Length:1,155
Mass (Da):123,322
Checksum:i23220B79AF4B214D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSQ9A0A087WSQ9_MOUSE
Zinc finger CCHC domain-containing ...
Zcchc2
758Annotation score:
A0A087WPY9A0A087WPY9_MOUSE
Zinc finger CCHC domain-containing ...
Zcchc2
257Annotation score:
A0A087WRA5A0A087WRA5_MOUSE
Zinc finger CCHC domain-containing ...
Zcchc2
79Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0137211146 – 1166TYRLR…LDSAD → NPTNSQRTCF in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173248 mRNA Translation: BAD32526.1
AK037100 mRNA Translation: BAC29703.1
BC055760 mRNA Translation: AAH55760.1
CCDSiCCDS48335.1 [Q69ZB8-1]
CCDS48336.1 [Q69ZB8-2]
RefSeqiNP_001116147.1, NM_001122675.1 [Q69ZB8-2]
NP_001116148.1, NM_001122676.1 [Q69ZB8-1]
UniGeneiMm.210188

Genome annotation databases

EnsembliENSMUST00000118196; ENSMUSP00000113974; ENSMUSG00000038866 [Q69ZB8-1]
ENSMUST00000119166; ENSMUSP00000113128; ENSMUSG00000038866 [Q69ZB8-2]
GeneIDi227449
KEGGimmu:227449
UCSCiuc007cgq.3 mouse [Q69ZB8-2]
uc007cgt.3 mouse [Q69ZB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173248 mRNA Translation: BAD32526.1
AK037100 mRNA Translation: BAC29703.1
BC055760 mRNA Translation: AAH55760.1
CCDSiCCDS48335.1 [Q69ZB8-1]
CCDS48336.1 [Q69ZB8-2]
RefSeqiNP_001116147.1, NM_001122675.1 [Q69ZB8-2]
NP_001116148.1, NM_001122676.1 [Q69ZB8-1]
UniGeneiMm.210188

3D structure databases

ProteinModelPortaliQ69ZB8
SMRiQ69ZB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113974

PTM databases

iPTMnetiQ69ZB8
PhosphoSitePlusiQ69ZB8

Proteomic databases

PaxDbiQ69ZB8
PRIDEiQ69ZB8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118196; ENSMUSP00000113974; ENSMUSG00000038866 [Q69ZB8-1]
ENSMUST00000119166; ENSMUSP00000113128; ENSMUSG00000038866 [Q69ZB8-2]
GeneIDi227449
KEGGimmu:227449
UCSCiuc007cgq.3 mouse [Q69ZB8-2]
uc007cgt.3 mouse [Q69ZB8-1]

Organism-specific databases

CTDi54877
MGIiMGI:2444114 Zcchc2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IZZC Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiHOG000155766
HOVERGENiHBG108762
InParanoidiQ69ZB8
KOiK22700
OMAiSMEASQQ
OrthoDBiEOG091G01BF
PhylomeDBiQ69ZB8
TreeFamiTF335574

Miscellaneous databases

ChiTaRSiZcchc2 mouse
PROiPR:Q69ZB8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038866 Expressed in 231 organ(s), highest expression level in secondary oocyte
CleanExiMM_ZCCHC2
ExpressionAtlasiQ69ZB8 baseline and differential
GenevisibleiQ69ZB8 MM

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZCHC2_MOUSE
AccessioniPrimary (citable) accession number: Q69ZB8
Secondary accession number(s): Q7TNF1, Q8CB08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again