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Protein

Ras-associating and dilute domain-containing protein

Gene

Radil

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-associating and dilute domain-containing protein
Gene namesi
Name:Radil
Synonyms:Kiaa1849
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443088 Radil

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508041 – 1099Ras-associating and dilute domain-containing proteinAdd BLAST1099

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ69Z89
PeptideAtlasiQ69Z89
PRIDEiQ69Z89

PTM databases

iPTMnetiQ69Z89
PhosphoSitePlusiQ69Z89

Expressioni

Gene expression databases

BgeeiENSMUSG00000029576 Expressed in 187 organ(s), highest expression level in testis
CleanExiMM_D930005D10RIK
ExpressionAtlasiQ69Z89 baseline and differential
GenevisibleiQ69Z89 MM

Interactioni

Subunit structurei

Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family. Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ69Z89
SMRiQ69Z89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 193Ras-associatingPROSITE-ProRule annotationAdd BLAST104
Domaini302 – 377FHAAdd BLAST76
Domaini525 – 792DilutePROSITE-ProRule annotationAdd BLAST268
Domaini1000 – 1085PDZPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the RADIL family.Curated

Phylogenomic databases

eggNOGiENOG410IQUG Eukaryota
ENOG410ZVSZ LUCA
GeneTreeiENSGT00530000063674
HOGENOMiHOG000154069
HOVERGENiHBG079536
InParanoidiQ69Z89
OMAiYEVHPEI
OrthoDBiEOG091G00X4
PhylomeDBiQ69Z89
TreeFamiTF350641

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProiView protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69Z89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSIFLGLQ PSPSHWLKSS VVIHEDAPTM FYGTQLIMSP PTKNKLKRQS
60 70 80 90 100
QLLSTMLSRT LSYKYRDLDS TFCSLGASDD PSELSTQLSA PGVLKVFGDS
110 120 130 140 150
VCTGTHYKSV LATGSSSAQE LVKEALERYA LDPECAGQYV LCDVVGQAGD
160 170 180 190 200
SGQRWQAQCF RVFGDNEKPL LIQELWKPRE GLSRRFELRK KSDVEELASR
210 220 230 240 250
DVDTTTAGIN AQARRLQRIR AKGTPALTSE AAQSSPPTRL RRTVSETSLS
260 270 280 290 300
PAPSLPEAAQ RPEEPVPEAM RYSLYQCPHL LLLQGYSQQH DSLVYVLSKE
310 320 330 340 350
RHTVGQRTPS SKPSISLSAP DILPLHCTIR RHQSPEGGPA GTRLVLEPIT
360 370 380 390 400
GASVSVNFSE VGRNPVVLQH GDLLSLGLYY LLLFKDPGQA QPLPACALAR
410 420 430 440 450
LGAAPQSCRM CGAVLRARGA PSLPAAVVRR RSLLLEFEPD VEDTLLQRIM
460 470 480 490 500
TLIEPGGDDH KLTPAFLLCL CIQHSAMHFQ PGTFRHLLLK ISKRVRDTVW
510 520 530 540 550
EKTKELAEKQ AQLQEPISWA SFPMADLVPD LQHILFWMSN SIELLYFIQQ
560 570 580 590 600
KSPLYVQSME EELDVTGSKE SLFSCTLTAS EEAMAALEEV VLYAFQQCVY
610 620 630 640 650
YLSKCLYVCL PALLECPPFQ TERRESWRSG PALPEELRRV VSVFQATLDL
660 670 680 690 700
LQQLQMHPEV ASQMLAYLFF FSGTLLLNQV LDKGPSLSCF HWPRGVQVCA
710 720 730 740 750
RLQQFLEWAR SAGLGAPAER FFRKLSCTLH LLATPRAQLI QMSWATLRVT
760 770 780 790 800
FPALNPAQLH RLLTQYQLAS AMGPVSAWEP GAPDGPEAFQ SEDILESYEN
810 820 830 840 850
PPPIVLPSQG FQVDLEADCV EDSIYQHLLY IRHFLWGLRG QASPDSGPAQ
860 870 880 890 900
PESIEGLYHT IPEGHLEGHG CPLANRDPGR VAVETAPPHS LPVTGAPRAQ
910 920 930 940 950
GPPGRQPTRG DRRGSQAGSL HTDSSCMLTP PSTPLGLEPA GPSWPEPSGL
960 970 980 990 1000
CGRAVLDGQR NGPGGLPGAV LEGDAIQDAE PPAEASSPSS SAEDFCYVFM
1010 1020 1030 1040 1050
VELERGPSGL GMGLIDGMHT PLGAQGLYIQ TLLPGSPAAS DGRLSLGDQI
1060 1070 1080 1090
LEVNGSSLRG VSYMRAVDLI RHGGKKMRFL VAKSDMETAK KIRFRNPPS
Length:1,099
Mass (Da):120,355
Last modified:November 8, 2005 - v2
Checksum:iCB1940EFFD10BC0D
GO
Isoform 2 (identifier: Q69Z89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     1019-1099: HTPLGAQGLY...KKIRFRNPPS → VRTLGPQPST...AFPWNIPGSG

Note: No experimental confirmation available.
Show »
Length:1,050
Mass (Da):114,933
Checksum:i7B70A682FF777253
GO
Isoform 3 (identifier: Q69Z89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.

Note: No experimental confirmation available.
Show »
Length:830
Mass (Da):90,912
Checksum:iBCF3809A5A03323C
GO
Isoform 4 (identifier: Q69Z89-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     485-1079: Missing.

Note: No experimental confirmation available.
Show »
Length:475
Mass (Da):52,088
Checksum:i2943CB51E311CF77
GO
Isoform 5 (identifier: Q69Z89-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:1,070
Mass (Da):117,251
Checksum:iA411CD5FAB5290A4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWJ9D3YWJ9_MOUSE
Ras-associating and dilute domain-c...
Radil
1,093Annotation score:
D3YYI1D3YYI1_MOUSE
Ras-associating and dilute domain-c...
Radil
107Annotation score:
D3YUE9D3YUE9_MOUSE
Ras-associating and dilute domain-c...
Radil
80Annotation score:

Sequence cautioni

The sequence BAC38904 differs from that shown. Reason: Frameshift at position 985.Curated
The sequence BAD32555 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti575C → S in BAC37675 (PubMed:16141072).Curated1
Sequence conflicti909R → Q in BAC38904 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0161001 – 269Missing in isoform 3. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_0161011 – 29Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_016102485 – 1079Missing in isoform 4. 1 PublicationAdd BLAST595
Alternative sequenceiVSP_0161031019 – 1099HTPLG…RNPPS → VRTLGPQPSTPPTPTPCFCR LILYSVSTVEASERCPDCLM GLPLGALMEPSAFPWNIPGS G in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173277 mRNA Translation: BAD32555.1 Different initiation.
AK038570 mRNA Translation: BAC30049.1
AK052964 mRNA Translation: BAC35223.1
AK079539 mRNA Translation: BAC37675.1
AK083410 mRNA Translation: BAC38904.1 Frameshift.
BC056483 mRNA Translation: AAH56483.1
CCDSiCCDS19827.1 [Q69Z89-5]
CCDS80453.1 [Q69Z89-1]
RefSeqiNP_001297681.1, NM_001310752.1 [Q69Z89-1]
NP_848817.2, NM_178702.4 [Q69Z89-5]
XP_006504749.1, XM_006504686.2 [Q69Z89-3]
UniGeneiMm.33766

Genome annotation databases

EnsembliENSMUST00000063635; ENSMUSP00000064539; ENSMUSG00000029576 [Q69Z89-5]
ENSMUST00000085758; ENSMUSP00000082910; ENSMUSG00000029576 [Q69Z89-1]
ENSMUST00000110784; ENSMUSP00000106411; ENSMUSG00000029576 [Q69Z89-3]
GeneIDi231858
KEGGimmu:231858
UCSCiuc009ais.2 mouse [Q69Z89-1]
uc009aiu.2 mouse [Q69Z89-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173277 mRNA Translation: BAD32555.1 Different initiation.
AK038570 mRNA Translation: BAC30049.1
AK052964 mRNA Translation: BAC35223.1
AK079539 mRNA Translation: BAC37675.1
AK083410 mRNA Translation: BAC38904.1 Frameshift.
BC056483 mRNA Translation: AAH56483.1
CCDSiCCDS19827.1 [Q69Z89-5]
CCDS80453.1 [Q69Z89-1]
RefSeqiNP_001297681.1, NM_001310752.1 [Q69Z89-1]
NP_848817.2, NM_178702.4 [Q69Z89-5]
XP_006504749.1, XM_006504686.2 [Q69Z89-3]
UniGeneiMm.33766

3D structure databases

ProteinModelPortaliQ69Z89
SMRiQ69Z89
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ69Z89
PhosphoSitePlusiQ69Z89

Proteomic databases

PaxDbiQ69Z89
PeptideAtlasiQ69Z89
PRIDEiQ69Z89

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063635; ENSMUSP00000064539; ENSMUSG00000029576 [Q69Z89-5]
ENSMUST00000085758; ENSMUSP00000082910; ENSMUSG00000029576 [Q69Z89-1]
ENSMUST00000110784; ENSMUSP00000106411; ENSMUSG00000029576 [Q69Z89-3]
GeneIDi231858
KEGGimmu:231858
UCSCiuc009ais.2 mouse [Q69Z89-1]
uc009aiu.2 mouse [Q69Z89-4]

Organism-specific databases

CTDi55698
MGIiMGI:2443088 Radil
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IQUG Eukaryota
ENOG410ZVSZ LUCA
GeneTreeiENSGT00530000063674
HOGENOMiHOG000154069
HOVERGENiHBG079536
InParanoidiQ69Z89
OMAiYEVHPEI
OrthoDBiEOG091G00X4
PhylomeDBiQ69Z89
TreeFamiTF350641

Miscellaneous databases

PROiPR:Q69Z89
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029576 Expressed in 187 organ(s), highest expression level in testis
CleanExiMM_D930005D10RIK
ExpressionAtlasiQ69Z89 baseline and differential
GenevisibleiQ69Z89 MM

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProiView protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRADIL_MOUSE
AccessioniPrimary (citable) accession number: Q69Z89
Secondary accession number(s): Q8BNL0
, Q8C549, Q8C6X2, Q8CAL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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