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Protein

PWWP domain-containing protein 2A

Gene

Pwwp2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein 2A
Gene namesi
Name:Pwwp2a
Synonyms:Kiaa1935
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918052 Pwwp2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113641 – 730PWWP domain-containing protein 2AAdd BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ69Z61
PeptideAtlasiQ69Z61
PRIDEiQ69Z61

PTM databases

iPTMnetiQ69Z61
PhosphoSitePlusiQ69Z61

Expressioni

Gene expression databases

BgeeiENSMUSG00000044950 Expressed in 232 organ(s), highest expression level in pes
CleanExiMM_PWWP2A
ExpressionAtlasiQ69Z61 baseline and differential
GenevisibleiQ69Z61 MM

Interactioni

Subunit structurei

Interacts with H2A.Z/H2AFZ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054154

Structurei

3D structure databases

ProteinModelPortaliQ69Z61
SMRiQ69Z61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini630 – 690PWWPPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni396 – 547Interaction with the H2A.Z/H2AFZBy similarityAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 126Pro-richAdd BLAST102
Compositional biasi220 – 266Pro-richAdd BLAST47
Compositional biasi533 – 607Ser-richAdd BLAST75

Phylogenomic databases

eggNOGiENOG410IXQI Eukaryota
ENOG4111IWH LUCA
GeneTreeiENSGT00530000063940
HOGENOMiHOG000060329
HOVERGENiHBG108311
InParanoidiQ69Z61
OMAiSEVQDTN
OrthoDBiEOG091G08LI
PhylomeDBiQ69Z61
TreeFamiTF331271

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69Z61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAAEAAA TAASPGEGGA GEAEPELEPI PGSEAGTPLP VTATEAAVPD
60 70 80 90 100
GEADGRQSAP QADEQPLPPP PPPPPPGELA DSSEAEEAKP PEPAAVPVSP
110 120 130 140 150
PEQPPAAPEQ PEDAPRPPPA PALVPPAGGD SAVSHLIPGS EVRVTLDHII
160 170 180 190 200
EDALVVSFRL GEKLFSGVLM DLSKRFGPHG IPVTVFPKRE YKDKPDAMQL
210 220 230 240 250
QSTTFQEGIE VKQEVNGAVP DDLSPVPPPE RLWASKPPPL FHEGAPYPPP
260 270 280 290 300
LFIRDTYNQS IPQPPPRKIK RPKRKMYREE PTSIMNAIKL RPRQVLCDKC
310 320 330 340 350
KNSVVAEKKE IRKGSSDSSR YEDKKRRNDS VATVNKKLKT DHKVDGKNQN
360 370 380 390 400
ESQRRNTVVR VSSIAHSRGR VVKVSAQANT SKAQLNTKKV LQSKNMDHAK
410 420 430 440 450
AREVLKIAKE KAQKKQSETS TSKTAHAKVH FTRRYQSPSS GSLPPRVRLK
460 470 480 490 500
PQRYRNEEND SSLKTGLEKI RSGKLAPKPQ SRCTSTRSAG EAPSEKPSPS
510 520 530 540 550
EGPEESAGEV QDTSRVRVPG EQEELRMLGK KGSKSSISVY LTLNQETSDS
560 570 580 590 600
SSASVCSIDS MDDLKSSNSE CSSSESFVFP PGCMHAPSAS STSTSFSSKE
610 620 630 640 650
ENSLRNSLKM KIFSKNVSKC ITPDGRTICV GDIVWAKIYG FPWWPARILT
660 670 680 690 700
ITVSRKDNGL LARQEARISW FASPTTSSLA LSQLSPFLEN FQLRFNKKRK
710 720 730
GLYRRAITEA AKAAKQLTPE VRALLTQFET
Length:730
Mass (Da):79,388
Last modified:November 13, 2007 - v2
Checksum:iEC3F67CC6CCC1D6D
GO
Isoform 2 (identifier: Q69Z61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-529: Missing.
     530-572: KKGSKSSISV...DLKSSNSECS → LNKWQLLHQT...LTVKRAAQRH
     573-730: Missing.

Show »
Length:533
Mass (Da):57,864
Checksum:iFED2FB9B56B99F6D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YKW0Z4YKW0_MOUSE
PWWP domain-containing protein 2A
Pwwp2a
455Annotation score:

Sequence cautioni

The sequence BAB29417 differs from that shown. Reason: Frameshift at position 704.Curated
The sequence BAD32583 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM20715 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173S → A in BAE42348 (PubMed:16141072).Curated1
Sequence conflicti335N → K in BAE42348 (PubMed:16141072).Curated1
Sequence conflicti521E → D in BAB29417 (PubMed:16141072).Curated1
Isoform 2 (identifier: Q69Z61-2)
Sequence conflicti510C → Y in BAE42348 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029549491 – 529Missing in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_029550530 – 572KKGSK…NSECS → LNKWQLLHQTVTSPAAPLQC LTDHCGFRLGALKLTVKRAA QRH in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_029551573 – 730Missing in isoform 2. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173305 mRNA Translation: BAD32583.1 Different initiation.
AL732633 Genomic DNA Translation: CAM20714.1
AL732633 Genomic DNA Translation: CAM20715.1 Sequence problems.
AK014534 mRNA Translation: BAB29417.1 Frameshift.
AK171257 mRNA Translation: BAE42348.1
CCDSiCCDS48773.1 [Q69Z61-2]
CCDS48774.1 [Q69Z61-1]
RefSeqiNP_001157703.1, NM_001164231.1 [Q69Z61-2]
NP_081833.1, NM_027557.1 [Q69Z61-1]
UniGeneiMm.397449
Mm.475270

Genome annotation databases

EnsembliENSMUST00000061070; ENSMUSP00000054154; ENSMUSG00000044950 [Q69Z61-1]
ENSMUST00000094294; ENSMUSP00000091852; ENSMUSG00000044950 [Q69Z61-2]
GeneIDi70802
KEGGimmu:70802
UCSCiuc007imu.2 mouse [Q69Z61-1]
uc007imv.2 mouse [Q69Z61-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173305 mRNA Translation: BAD32583.1 Different initiation.
AL732633 Genomic DNA Translation: CAM20714.1
AL732633 Genomic DNA Translation: CAM20715.1 Sequence problems.
AK014534 mRNA Translation: BAB29417.1 Frameshift.
AK171257 mRNA Translation: BAE42348.1
CCDSiCCDS48773.1 [Q69Z61-2]
CCDS48774.1 [Q69Z61-1]
RefSeqiNP_001157703.1, NM_001164231.1 [Q69Z61-2]
NP_081833.1, NM_027557.1 [Q69Z61-1]
UniGeneiMm.397449
Mm.475270

3D structure databases

ProteinModelPortaliQ69Z61
SMRiQ69Z61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054154

PTM databases

iPTMnetiQ69Z61
PhosphoSitePlusiQ69Z61

Proteomic databases

PaxDbiQ69Z61
PeptideAtlasiQ69Z61
PRIDEiQ69Z61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061070; ENSMUSP00000054154; ENSMUSG00000044950 [Q69Z61-1]
ENSMUST00000094294; ENSMUSP00000091852; ENSMUSG00000044950 [Q69Z61-2]
GeneIDi70802
KEGGimmu:70802
UCSCiuc007imu.2 mouse [Q69Z61-1]
uc007imv.2 mouse [Q69Z61-2]

Organism-specific databases

CTDi114825
MGIiMGI:1918052 Pwwp2a
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IXQI Eukaryota
ENOG4111IWH LUCA
GeneTreeiENSGT00530000063940
HOGENOMiHOG000060329
HOVERGENiHBG108311
InParanoidiQ69Z61
OMAiSEVQDTN
OrthoDBiEOG091G08LI
PhylomeDBiQ69Z61
TreeFamiTF331271

Miscellaneous databases

ChiTaRSiPwwp2a mouse
PROiPR:Q69Z61
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044950 Expressed in 232 organ(s), highest expression level in pes
CleanExiMM_PWWP2A
ExpressionAtlasiQ69Z61 baseline and differential
GenevisibleiQ69Z61 MM

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPWP2A_MOUSE
AccessioniPrimary (citable) accession number: Q69Z61
Secondary accession number(s): A2AJK9
, A2AJL0, Q3TBG3, Q9CUT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 12, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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