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Entry version 127 (02 Jun 2021)
Sequence version 4 (27 Jul 2011)
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Protein

Inactive tyrosine-protein kinase PEAK1

Gene

Peak1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.

By similarity

Caution

Has been the subject of controversy surrounding its catalytic capabilities. Early characterization of PEAK1 gave a weak in vitro tyrosine kinase activity. The crystal structure indicates that the kinase-domain contains a closed nucleotide-binding cleft that in this conformation may deleteriously affect nucleotide bindin. Furthermore PEAK1 is devoid of nucleotide binding activity, as detected by a thermal-shift assay. So it seems probable that PEAK1 is an inactive kinase.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive tyrosine-protein kinase PEAK1Curated
Alternative name(s):
Pseudopodium-enriched atypical kinase 11 Publication
Sugen kinase 269
Tyrosine-protein kinase SgK269
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Peak1
Synonyms:Kiaa2002, Sgk269
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442366, Peak1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002505901 – 1735Inactive tyrosine-protein kinase PEAK1Add BLAST1735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei282PhosphoserineCombined sources1
Modified residuei537PhosphoserineBy similarity1
Modified residuei569PhosphoserineBy similarity1
Modified residuei584PhosphoserineBy similarity1
Modified residuei632PhosphotyrosineCombined sources1
Modified residuei638PhosphotyrosineCombined sources1
Modified residuei645PhosphoserineBy similarity1
Modified residuei662PhosphotyrosineBy similarity1
Modified residuei824PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei897PhosphoserineBy similarity1
Modified residuei1141PhosphothreonineCombined sources1
Modified residuei1177PhosphotyrosineBy similarity1
Modified residuei1363PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451). Phosphorylation at Tyr-662 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics. Phosphorylation at Tyr-1177 is essential for binding to SHC1.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q69Z38

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q69Z38

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q69Z38

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69Z38

PeptideAtlas

More...
PeptideAtlasi
Q69Z38

PRoteomics IDEntifications database

More...
PRIDEi
Q69Z38

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
287911

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69Z38

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69Z38

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q69Z38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000074305, Expressed in zygote and 262 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q69Z38, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69Z38, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with BCAR1 and CRK (By similarity).

Interacts with PRAG1 (By similarity).

Interacts (when phosphorylated at Tyr-1177) with SHC1 (via PID domain) (By similarity).

Found in a complex with PPP1CA, PPP1CC and SHC1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
232703, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q69Z38, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109901

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q69Z38, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q69Z38

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1302 – 1664Protein kinasePROSITE-ProRule annotationAdd BLAST363

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 66DisorderedSequence analysisAdd BLAST41
Regioni111 – 145DisorderedSequence analysisAdd BLAST35
Regioni324 – 410DisorderedSequence analysisAdd BLAST87
Regioni491 – 514DisorderedSequence analysisAdd BLAST24
Regioni537 – 580DisorderedSequence analysisAdd BLAST44
Regioni663 – 762DisorderedSequence analysisAdd BLAST100
Regioni800 – 919DisorderedSequence analysisAdd BLAST120
Regioni1019 – 1097DisorderedSequence analysisAdd BLAST79
Regioni1274 – 1300Required for homodimerizationBy similarityAdd BLAST27
Regioni1394 – 1445DisorderedSequence analysisAdd BLAST52
Regioni1659 – 1732Required for homodimerizationBy similarityAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 58Polar residuesSequence analysisAdd BLAST21
Compositional biasi324 – 391Polar residuesSequence analysisAdd BLAST68
Compositional biasi494 – 514Polar residuesSequence analysisAdd BLAST21
Compositional biasi562 – 580Polar residuesSequence analysisAdd BLAST19
Compositional biasi672 – 762Polar residuesSequence analysisAdd BLAST91
Compositional biasi816 – 859Polar residuesSequence analysisAdd BLAST44
Compositional biasi860 – 875Pro residuesSequence analysisAdd BLAST16
Compositional biasi876 – 906Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVUZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69Z38

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPPSCMI

Database of Orthologous Groups

More...
OrthoDBi
49921at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333340

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q69Z38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACNTFTEH VWKPGECKNC FKPKSLHQLP PDSEKTPITH GSGKTNANHS
60 70 80 90 100
NNHRVRSTGN FRPPVAKKPT IAVKPTMMVA DGQSVCGELS IQEHCENKPV
110 120 130 140 150
ILGWNQNKTS LSQKPLNNNS EGDAEGFGSD PQQCANNDSA QKISNNNNGL
160 170 180 190 200
TEVLKEIAGL EATPPVRGNE TNARETFLGR INDCYKRSLE RKIPPSCMTG
210 220 230 240 250
SMKDSQGKHV ILSGSAEVIS NEGGRFCYPE FSSGEESEED VLFSNMEEEH
260 270 280 290 300
ESWDESDEEL LAMEIRMRGQ PRFANFRANT LSPVRFFVSK KWNTIPLRNK
310 320 330 340 350
SLQRICAVDY DDSYDEILNG YEENSGVSYG QGSVQSTISS DCTSPGSSFT
360 370 380 390 400
EESRSETASS LSQKVCNGGI SPGNPGNSKD IAETESNFES PPGNNEEKDE
410 420 430 440 450
SLTSKSSVKV PETHKAVLAL RLQEKDGKIA VHTEKPESKA STDIAGQAVT
460 470 480 490 500
ISLVPVEEQT KPYRVVNLEQ PLCKPYTVVD VSAAMASEHL GRPKIKGSSS
510 520 530 540 550
TPNSPVTSPA LTPGQINAHL KKSSAIRYQE VWTSSTSPRQ KIPKIELSTG
560 570 580 590 600
GPGPNVPPRK NCHKSAPTSP TATNISSKTI PVKSPNLSEI KFNSYNNAGM
610 620 630 640 650
PPFPIIIHDE PSYARSSKNA IKVPIVINPN AYDNLAIYKS FLGTSGELSV
660 670 680 690 700
KEKTTSVISH TYEEIETESK VSDSTPSKLT DCPQAKGFSN STERKRGSVA
710 720 730 740 750
QKVQEFNNCL NRGQSSPQRS YSSTHSSPAK IQRPTQEPAG KTEGAQGSQV
760 770 780 790 800
PGSSSNSTRE KASAVLCQIV ASIQPPQTPP EAPQSSPKAC SVEELYAVPP
810 820 830 840 850
DADTTKSIPK NPPVRPKSLF TSQSSGEGEA HQTTESPTAK IQKDPSTKPV
860 870 880 890 900
TSPPSKLVTS AQSEPPPPFP PPRSTSSPYH ASNLLQRHFT NWTKPTSPTR
910 920 930 940 950
STEAESILHS EGSRRAADAK PKRWISFKSF FRRRKTDEEE EKEKEREKGK
960 970 980 990 1000
LVGLDGTVIH MLPPPPVQRH HWFTEAKGEA SEKPAIVFMY RCDPDQGHLS
1010 1020 1030 1040 1050
VDQSKAGAEK GRAEEVLLRN SEEKKSSYLP SQIPDKACSR VTHEVAGELS
1060 1070 1080 1090 1100
PRDPRTPAGK QDGTSVTPTL PPPDLEREEE KDDTLDPTDV SPCSATYSNL
1110 1120 1130 1140 1150
GQSRAAMIPP KHPRHPKGAV DDAIAFGEKT DQEGLNASQP TPPPLPKKMI
1160 1170 1180 1190 1200
RANTEPISKD LQKAMESSLC VMANPTYDID PNWDASSAGS SISYELKGLD
1210 1220 1230 1240 1250
VESYESLERP LHKERPVPSA ANSISSLATL SVKDRFSNSM ESLSSRRGLS
1260 1270 1280 1290 1300
YRQTRSIQKP QRQALYRGLD NREEVVGKLR SLHTDALKRL AVKCEDLFMA
1310 1320 1330 1340 1350
GQKDQLRFGV DSWSDFRLTS DKPCCEAGDA VYYTASYAKD PLSNYAVKIC
1360 1370 1380 1390 1400
KSKAKESQQY YHSLAVRQSL PVHFNIQQDC GHFLAEVPSR LLPWEDPDAP
1410 1420 1430 1440 1450
EKAEDGTEDS EEEGKAETLG GNPEPCSETE PSQKENQRVT NRKQRSHVVV
1460 1470 1480 1490 1500
ITREVPHLTV ADFVRDSLAH HGNSPDLYER QVCLLLLQLC SGLEHLKPYH
1510 1520 1530 1540 1550
VTHCDLRLEN LLLVQHQPGG AAQGPSPADP CPTLACPTRL IVSNFSQAKQ
1560 1570 1580 1590 1600
KSHLVDPQIL RDQSRLAPEI ITATQYKKCD EFQTGILIYE MLHLPNPFDE
1610 1620 1630 1640 1650
NPELKEKEYT RTDLPRIPLR SPYSWGLQQL ASCLLNPNPS ERILISDAKG
1660 1670 1680 1690 1700
ILQCLLWGPR EDLFQIFTTS ATLAQKNALL QNWLDIKRTL LMIKFAEKSL
1710 1720 1730
DREGGISLED WLCAQYLAFA TTDSLSYIVK ILQYR
Length:1,735
Mass (Da):191,097
Last modified:July 27, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99A629E9061A0BF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQ01A0A087WQ01_MOUSE
Inactive tyrosine-protein kinase PE...
Peak1
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQ82A0A087WQ82_MOUSE
Inactive tyrosine-protein kinase PE...
Peak1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560K → R in BAC33490 (PubMed:16141072).Curated1
Sequence conflicti965 – 991PPVQR…VFMYR → SSPAPSLVHRGQRRGQREAC YSLHVQV in BAC33490 (PubMed:16141072).CuratedAdd BLAST27
Sequence conflicti1026 – 1039SSYLP…DKACS → GDPVKMSLNGELCD in BAD32606 (PubMed:15368895).CuratedAdd BLAST14
Sequence conflicti1085L → S in BAD32606 (PubMed:15368895).Curated1
Sequence conflicti1534 – 1536LAC → PTR in AAH26466 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC157474 Genomic DNA No translation available.
AC159819 Genomic DNA No translation available.
AC160935 Genomic DNA No translation available.
AK048912 mRNA Translation: BAC33490.1
AK173328 mRNA Translation: BAD32606.1
BC026466 mRNA Translation: AAH26466.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52804.1

NCBI Reference Sequences

More...
RefSeqi
NP_766512.2, NM_172924.3
XP_006511230.1, XM_006511167.3
XP_006511231.1, XM_006511168.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061552; ENSMUSP00000109901; ENSMUSG00000074305

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
244895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:244895

UCSC genome browser

More...
UCSCi
uc009psz.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157474 Genomic DNA No translation available.
AC159819 Genomic DNA No translation available.
AC160935 Genomic DNA No translation available.
AK048912 mRNA Translation: BAC33490.1
AK173328 mRNA Translation: BAD32606.1
BC026466 mRNA Translation: AAH26466.1
CCDSiCCDS52804.1
RefSeqiNP_766512.2, NM_172924.3
XP_006511230.1, XM_006511167.3
XP_006511231.1, XM_006511168.3

3D structure databases

SMRiQ69Z38
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232703, 5 interactors
IntActiQ69Z38, 3 interactors
STRINGi10090.ENSMUSP00000109901

PTM databases

iPTMnetiQ69Z38
PhosphoSitePlusiQ69Z38
SwissPalmiQ69Z38

Proteomic databases

EPDiQ69Z38
jPOSTiQ69Z38
MaxQBiQ69Z38
PaxDbiQ69Z38
PeptideAtlasiQ69Z38
PRIDEiQ69Z38
ProteomicsDBi287911

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
7598, 210 antibodies

The DNASU plasmid repository

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DNASUi
244895

Genome annotation databases

EnsembliENSMUST00000061552; ENSMUSP00000109901; ENSMUSG00000074305
GeneIDi244895
KEGGimmu:244895
UCSCiuc009psz.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79834
MGIiMGI:2442366, Peak1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG502QVUZ, Eukaryota
GeneTreeiENSGT00940000157591
HOGENOMiCLU_002882_0_0_1
InParanoidiQ69Z38
OMAiLPPSCMI
OrthoDBi49921at2759
TreeFamiTF333340

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
244895, 2 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Peak1, mouse

Protein Ontology

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PROi
PR:Q69Z38
RNActiQ69Z38, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000074305, Expressed in zygote and 262 other tissues
ExpressionAtlasiQ69Z38, baseline and differential
GenevisibleiQ69Z38, MM

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEAK1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69Z38
Secondary accession number(s): E9QKY2, Q8BX56, Q8R365
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 127 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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