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Entry version 81 (05 Jun 2019)
Sequence version 2 (06 Mar 2007)
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Protein

Sterile alpha motif domain-containing protein 9-like

Gene

Samd9l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 9-like
Short name:
SAM domain-containing protein 9-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Samd9l
Synonyms:Kiaa2005
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1343184 Samd9l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice die of white blood cells proliferation that accumulate in the bone marrow and interfere with the production of normal blood cells.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002794991 – 1561Sterile alpha motif domain-containing protein 9-likeAdd BLAST1561

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q69Z37

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q69Z37

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q69Z37

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69Z37

PRoteomics IDEntifications database

More...
PRIDEi
Q69Z37

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69Z37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69Z37

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EEA1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q150752EBI-8784283,EBI-298113From Homo sapiens.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q69Z37, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112688

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 79SAMPROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IETT Eukaryota
ENOG41124X3 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154250

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69Z37

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q69Z37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGQVTQPKL IKDWTKEHVR KWVTEDLNIV EKYAQILFKE EVTGMVLQEL
60 70 80 90 100
TEEDLREMGL PRGPALLIKR MYNKLISSPE SHNQDSRELN DKKLSTKEQQ
110 120 130 140 150
TKTKNEEENS VSSNSDHGLR ETGQNEEQEP SLTKENMLGD VVTKDMEDNK
160 170 180 190 200
PKPEQMSCTP YPFDSFCDVK QYIEHSILRV AETGPLNLID PIHEFKAFTN
210 220 230 240 250
TKKATEEDIK MKFSNETFRF AAACMNSRTN GTIHFGVKDK PHGEIVGVQV
260 270 280 290 300
TSKDIFVNHF NTMITKYFED SEISEARACI REPRFVEVLL QNNTQSNRFV
310 320 330 340 350
IEVDVIPRHS ICQEKYFYIM MQSSTGKTWK QSKDTSLFVR EGASSKNILG
360 370 380 390 400
NPNQRDREFK KFLEDLKMWT ASRKAAEEEL RMVTKKESEG LKLSKLLTRH
410 420 430 440 450
QGSLDESYYD WYILVTNTCA PTQLEHLEFI KEMKLFAVLD FDPYSHIKGV
460 470 480 490 500
VKAYRESRIA NLHLPSHYEE KTTIAEKIST LKLYEQPSWI FCNGRVDLSC
510 520 530 540 550
QPLEPHLWQR DRASGVRRLI SFLTDENIIV KGKVLVVFLL LSPIENQKDP
560 570 580 590 600
LIETFCAFYQ VFNGMDNMLC ICVNSAIYQQ WSDLLQVRLE IKDDLAKHSI
610 620 630 640 650
STLNIELVNN TILKLKSVIQ SSRRFLPSCG SSSVILEKMD EDIMSALEIL
660 670 680 690 700
CENECKDTDI EKDESQFLEF KKSREEHFYR GGRVSWWNFY FSSENYSSAF
710 720 730 740 750
VKRDSFEELT TLIQQCADSP KPVFVKVINL YHHPGCGGTT LAMHVLWDLK
760 770 780 790 800
QKFRCAVLKN KATDFVEIGE QVSKLMSYKA TSHEDFIPVL LLVDDFEEQE
810 820 830 840 850
NAYILQNAIN AFIAEKGLRY EKTLVIILNC MRSQNPDESA KLANSISLKY
860 870 880 890 900
QLSPKEQRAF EAKLQEIEKE HKNCENFYSF MILKGNFDTT YIKNVVKNTL
910 920 930 940 950
KDLDAKSRRA QLISYLALLN SYVTDSTISV SQCEIFLGIT YTKKYGKPET
960 970 980 990 1000
VEKNMGTYST LLIRTEVSDY GRYTGIRIIH PLIATHCLKE LEMSYRMDKC
1010 1020 1030 1040 1050
QIALNMLEEN VLYDSGLGRD KFKYDVQTLL LTRQRKEHGA ETDTLFSPLI
1060 1070 1080 1090 1100
EELQNEETEK VLIAGSDRFP QNAFICQALA RHFYIKEKNF STALVWANLA
1110 1120 1130 1140 1150
KRKAPKNSYI SDTLGQVYKS ELNSGWEVAE KASKAFKESQ NQSDSKDYGT
1160 1170 1180 1190 1200
EAWSPQNSQR RYDTFNTAGF FGEIEVGLDT IQLLQLTPLF HKENEISKES
1210 1220 1230 1240 1250
MAEFLSGKGT ILSDPKGEYC VVLSKFTSLL QNLHSDLERC FHFFGDYMGF
1260 1270 1280 1290 1300
LKPRNTPKEL TELLLSKKVS RCFKKYVELF CHLDTNLVQG KEDLLLQKEN
1310 1320 1330 1340 1350
CRKRIQAWRA DTFSGLLEYL NPNHKEANNI ENIVGNYTFL LQDILNKQLS
1360 1370 1380 1390 1400
KVLTKDIQNF ILANIILSCL KPSSKYILPF STLKKKLREV LQIVGLTHSY
1410 1420 1430 1440 1450
PDPYFLACLL FWPENKELDE DSTLIEKYVS SLNRSFRRQY KHMCRSRQPS
1460 1470 1480 1490 1500
TLFYLGQKKG LNSLVHKAEI ERYFSEVQDS NSFWHSGVVW EKREVKDLLR
1510 1520 1530 1540 1550
LLDGQAEGKL ISLEYGTEAK IKIPVTSVYS APLRSGRNIE RVSFYLGFSI
1560
EGPLAYGIKV I
Length:1,561
Mass (Da):180,203
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC510ABEBDF226ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PX59E9PX59_MOUSE
Sterile alpha motif domain-containi...
Samd9l
1,579Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GX63V9GX63_MOUSE
Sterile alpha motif domain-containi...
Samd9l
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32607 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173329 Transcribed RNA Translation: BAD32607.1 Different initiation.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173329 Transcribed RNA Translation: BAD32607.1 Different initiation.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ69Z37, 2 interactors
STRINGi10090.ENSMUSP00000112688

PTM databases

iPTMnetiQ69Z37
PhosphoSitePlusiQ69Z37

Proteomic databases

EPDiQ69Z37
jPOSTiQ69Z37
MaxQBiQ69Z37
PaxDbiQ69Z37
PRIDEiQ69Z37

Organism-specific databases

MGIiMGI:1343184 Samd9l

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IETT Eukaryota
ENOG41124X3 LUCA
HOGENOMiHOG000154250
InParanoidiQ69Z37

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Samd9l mouse

Protein Ontology

More...
PROi
PR:Q69Z37

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAM9L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69Z37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: June 5, 2019
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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