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Protein

RNA-binding protein MEX3B

Gene

Mex3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri550 – 590RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • GTPase activating protein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of cell-cell adhesion Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • protein localization to cell cortex Source: MGI

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MEX3B
Alternative name(s):
RING finger and KH domain-containing protein 3
Gene namesi
Name:Mex3b
Synonyms:Kiaa2009, Rkhd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918252 Mex3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787851 – 601RNA-binding protein MEX3BAdd BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei320PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-494 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ69Z36
PaxDbiQ69Z36
PRIDEiQ69Z36

PTM databases

iPTMnetiQ69Z36
PhosphoSitePlusiQ69Z36

Expressioni

Gene expression databases

CleanExiMM_MEX3B

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082168

Structurei

3D structure databases

ProteinModelPortaliQ69Z36
SMRiQ69Z36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 159KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini192 – 253KH 2PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 32Poly-GlyAdd BLAST20

Domaini

Binds RNA through its KH domains.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri550 – 590RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ69Z36
PhylomeDBiQ69Z36

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q69Z36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSSLFADLE RNGSGGGGGG GGGGGGGGSG GGETLDDQRA LQLALDQLSL
60 70 80 90 100
LGLDSDEGAS LYDSEPRKKS VNMTECVPVP SSEHVAEIVG RQGGSGRDGD
110 120 130 140 150
RRGFSISPTP SLEPWLPGCK IKALRAKTNT YIKTPVRGEE PVFVVTGRKE
160 170 180 190 200
DVAMARREII SAAEHFSMIR ASRNKNTALN GAVPGPPNLP GQTTIQVRVP
210 220 230 240 250
YRVVGLVVGP KGATIKRIQQ QTHTYIVTPS RDKEPVFEVT GMPENVDRAR
260 270 280 290 300
EEIEAHIALR TGGIIELTDE NDFHANGTDV GFDLHHGSGG SGPGSLWSKP
310 320 330 340 350
TPSITPTPGR KPFSSYRNDS SSSLGSASTD SYFGGGTSGS AAATSRLADY
360 370 380 390 400
SPPSPALSFA HNGNNNNNGN GYTYTAGEAS VPSPDGGPEL QPTFDPAPAP
410 420 430 440 450
PPGTPLLWAQ FERSPGGGSA APVSSSCSSS ASSSASSSSV VFPGGGASST
460 470 480 490 500
PSNANLGLLV HRRLHPGTSC PRLSPPLHMA TGAGEHHLAR RVRSDPGGGG
510 520 530 540 550
LAYAAYANGL GTQLPGLPSS DTSGSSSSSS SSSSSSSSSS GLRRKGSRDC
560 570 580 590 600
SVCFESEVIA ALVPCGHNLF CMECANRICE KSEPECPVCH TAVTQAIRIF

S
Length:601
Mass (Da):61,781
Last modified:February 20, 2007 - v2
Checksum:i77CC73DB8DB2F08B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WJD6F8WJD6_MOUSE
RNA-binding protein MEX3B
Mex3b
576Annotation score:

Sequence cautioni

The sequence BAD32608 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173330 Transcribed RNA Translation: BAD32608.1 Different initiation.
BC031512 mRNA Translation: AAH31512.1
BC067199 mRNA Translation: AAH67199.1
BC108401 mRNA Translation: AAI08402.1
UniGeneiMm.306789

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173330 Transcribed RNA Translation: BAD32608.1 Different initiation.
BC031512 mRNA Translation: AAH31512.1
BC067199 mRNA Translation: AAH67199.1
BC108401 mRNA Translation: AAI08402.1
UniGeneiMm.306789

3D structure databases

ProteinModelPortaliQ69Z36
SMRiQ69Z36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082168

PTM databases

iPTMnetiQ69Z36
PhosphoSitePlusiQ69Z36

Proteomic databases

MaxQBiQ69Z36
PaxDbiQ69Z36
PRIDEiQ69Z36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1918252 Mex3b
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ69Z36
PhylomeDBiQ69Z36

Miscellaneous databases

PROiPR:Q69Z36
SOURCEiSearch...

Gene expression databases

CleanExiMM_MEX3B

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEX3B_MOUSE
AccessioniPrimary (citable) accession number: Q69Z36
Secondary accession number(s): Q2VPR1, Q6NX84, Q8K2G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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