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UniProtKB - Q69Z28 (ATS16_MOUSE)

Entry version 123 (02 Dec 2020)
Sequence version 2 (16 Aug 2005)
Previous versions | rss
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 16

Gene

Adamts16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi247Zinc; in inhibited formBy similarity1
Metal bindingi431Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei432PROSITE-ProRule annotation1
Metal bindingi435Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi441Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...MEROPSi		M12.026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 16 (EC:3.4.24.-)
Short name:
ADAM-TS 16
Short name:
ADAM-TS16
Short name:
ADAMTS-16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adamts16
Synonyms:Kiaa2029
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2429637, Adamts16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002919621 – 277By similarityAdd BLAST257
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029197278 – 1222A disintegrin and metalloproteinase with thrombospondin motifs 16Add BLAST945

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi364 ↔ 415By similarity
Disulfide bondi390 ↔ 397By similarity
Disulfide bondi409 ↔ 488By similarity
Disulfide bondi448 ↔ 472By similarity
Disulfide bondi516 ↔ 541By similarity
Disulfide bondi527 ↔ 548By similarity
Disulfide bondi536 ↔ 567By similarity
Disulfide bondi561 ↔ 572By similarity
Disulfide bondi596 ↔ 633By similarity
Disulfide bondi600 ↔ 638By similarity
Disulfide bondi611 ↔ 623By similarity
Glycosylationi739N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi825N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi833N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi903N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q69Z28

PRoteomics IDEntifications database

More...PRIDEi		Q69Z28

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q69Z28, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q69Z28

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q69Z28

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000049538, Expressed in efferent duct and 134 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q69Z28, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		234828, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000079041

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q69Z28, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q69Z28

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini288 – 493Peptidase M12BPROSITE-ProRule annotationAdd BLAST206
Domaini494 – 583DisintegrinAdd BLAST90
Domaini584 – 639TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini872 – 920TSP type-1 2PROSITE-ProRule annotationAdd BLAST49
Domaini925 – 985TSP type-1 3PROSITE-ProRule annotationAdd BLAST61
Domaini986 – 1046TSP type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini1049 – 1113TSP type-1 5PROSITE-ProRule annotationAdd BLAST65
Domaini1125 – 1179TSP type-1 6PROSITE-ProRule annotationAdd BLAST55
Domaini1184 – 1221PLACPROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni745 – 871SpacerAdd BLAST127

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi245 – 253Cysteine switchBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi640 – 744Cys-richAdd BLAST105

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3538, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000660_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q69Z28

Identification of Orthologs from Complete Genome Data

More...OMAi		DFHMDLK

Database of Orthologous Groups

More...OrthoDBi		125522at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q69Z28

TreeFam database of animal gene trees

More...TreeFami		TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 5 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF08686, PLAC, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00209, TSP1, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69Z28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESRGCAALW VLLLAQVSEQ QTPACALGLA AAASGSPEDP QPPPFSGSSW 
        60         70         80         90        100
LETGEYDLVS AYEVDHRGDY VSHDIMHYQR RRRRRAVTQP GGDALHLRLK 
       110        120        130        140        150
GPRHDLHLDL KAASNLMAPG FMVQTLGKGG TKSVQMFPPE ENCFYQGSLR 
       160        170        180        190        200
SQGNSSVALS TCQGLLGMIR TKDTDYFLKP LPPHLTSKLN RSAQGDSPSH 
       210        220        230        240        250
VLYKRSTERQ APRENEVLMI TRKRDLARPH LHHDNFHLGP SQKQHFCGRR 
       260        270        280        290        300
KKYMPQPPND DLYILPDEYK PSSRHKRSLL KSHRNEELNV ETLVVVDRKM 
       310        320        330        340        350
MQSHGHENIT TYVLTILNMV SALFKDGTIG GNINIVIVGL ILLEDEQPGL 
       360        370        380        390        400
AISHHADHTL TSFCQWQSGL MGKDGTRHDH AILLTGLDIC SWKNEPCDTL 
       410        420        430        440        450
GFAPISGMCS KYRSCTVNED SGLGLAFTIA HESGHNFGMV HDGEGNMCKK 
       460        470        480        490        500
SEGNIMSPTL AGRNGVFSWS SCSRQYLHKF LSTAQAICLA DQPKPVKEYK 
       510        520        530        540        550
YPEKLPGQLY DANTQCKWQF GEKAKLCMLD FRKDICKALW CHRIGRKCET 
       560        570        580        590        600
KFMPAAEGTL CGQDMWCRGG QCVKYGDEGP KPTHGHWSDW SPWSPCSRTC 
       610        620        630        640        650
GGGISHRDRL CTNPRPSHGG KFCQGSTRTL KLCNSQRCPL DSVDFRAAQC 
       660        670        680        690        700
AEYNSKRFRG WLYKWKPYTQ LEDQDLCKLY CIAEGFDFFF SLSNKVKDGT 
       710        720        730        740        750
PCSEDSRNVC IDGMCERVGC DNVLGSDATE DSCGVCKGNN SDCVTHRGLY 
       760        770        780        790        800
SKHHSTNQYY HMVTIPSGAR SIHIYETNIS TSYISVRNSL KRYYLNGHWS 
       810        820        830        840        850
VDWPGRYKFS GATFNYKRSY KEPENLTSPG PTNETLIVEL LFQGRNPGVA 
       860        870        880        890        900
WEFSLPRSGA KKTPAAQPSY SWAIVRSECS VSCGGGKMNS KAGCYRDLKV 
       910        920        930        940        950
PVNASFCNPK TRPVTGLVPC KVSPCPSSWS VGNWSVCSRT CGGGTQSRPV 
       960        970        980        990       1000
RCTRRAHYRD ESIPASLCPQ PEPPIHQACN SQSCPPAWST GPWAECSRTC 
      1010       1020       1030       1040       1050
GKGWRKRTVA CKSTNPSARA QLLHDTACTS EPKPRTHEIC LLKRCHKHKK 
      1060       1070       1080       1090       1100
LQWLVSAWSQ CSVTCQGGTQ QRVLRCAEKY ISGKYRELAS KKCLHLPKPD 
      1110       1120       1130       1140       1150
LELERACGLI PCPKHPPFDA SGSPRGSWFA SPWSQCTASC GGGVQRRTVQ 
      1160       1170       1180       1190       1200
CLLRGQPASD CFLHEKPETS SACNTHFCPI AEKRGTFCKD LFHWCYLVPQ 
      1210       1220 
HGMCGHRFYS KQCCNTCSKS NL
Length:1,222
Mass (Da):136,282
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A95FB40A8F15083
GO
Isoform 2 (identifier: Q69Z28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     886-900: GKMNSKAGCYRDLKV → DRQCQTGRGHLEISS
     901-1222: Missing.

Show »
Length:900
Mass (Da):100,680
Checksum:i590BE2B0E73740FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGS8D6RGS8_MOUSE
A disintegrin and metalloproteinase...
Adamts16
684Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014991886 – 900GKMNS…RDLKV → DRQCQTGRGHLEISS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_014992901 – 1222Missing in isoform 2. 1 PublicationAdd BLAST322

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK173338 mRNA Translation: BAD32616.1
BC034739 mRNA Translation: AAH34739.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36723.1 [Q69Z28-1]

NCBI Reference Sequences

More...RefSeqi		NP_742050.2, NM_172053.3 [Q69Z28-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000080145; ENSMUSP00000079041; ENSMUSG00000049538 [Q69Z28-1]
ENSMUST00000109694; ENSMUSP00000105316; ENSMUSG00000049538 [Q69Z28-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		271127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:271127

UCSC genome browser

More...UCSCi		uc007rcz.1, mouse [Q69Z28-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173338 mRNA Translation: BAD32616.1
BC034739 mRNA Translation: AAH34739.1
CCDSiCCDS36723.1 [Q69Z28-1]
RefSeqiNP_742050.2, NM_172053.3 [Q69Z28-1]

3D structure databases

SMRiQ69Z28
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234828, 1 interactor
STRINGi10090.ENSMUSP00000079041

Protein family/group databases

MEROPSiM12.026

PTM databases

GlyGeniQ69Z28, 9 sites
iPTMnetiQ69Z28
PhosphoSitePlusiQ69Z28

Proteomic databases

PaxDbiQ69Z28
PRIDEiQ69Z28

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		59056, 38 antibodies

Genome annotation databases

EnsembliENSMUST00000080145; ENSMUSP00000079041; ENSMUSG00000049538 [Q69Z28-1]
ENSMUST00000109694; ENSMUSP00000105316; ENSMUSG00000049538 [Q69Z28-2]
GeneIDi271127
KEGGimmu:271127
UCSCiuc007rcz.1, mouse [Q69Z28-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		170690
MGIiMGI:2429637, Adamts16

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000159433
HOGENOMiCLU_000660_1_0_1
InParanoidiQ69Z28
OMAiDFHMDLK
OrthoDBi125522at2759
PhylomeDBiQ69Z28
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-MMU-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		271127, 0 hits in 17 CRISPR screens

Protein Ontology

More...PROi		PR:Q69Z28
RNActiQ69Z28, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000049538, Expressed in efferent duct and 134 other tissues
GenevisibleiQ69Z28, MM

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF08686, PLAC, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 6 hits
SUPFAMiSSF82895, SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS16_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69Z28
Secondary accession number(s): Q8K206
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: December 2, 2020
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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