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Entry version 104 (12 Aug 2020)
Sequence version 2 (18 Mar 2008)
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Protein

Dynein heavy chain 17, axonemal

Gene

Dnah17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1831 – 1838ATPSequence analysis8
Nucleotide bindingi2112 – 2119ATPSequence analysis8
Nucleotide bindingi2439 – 2446ATPSequence analysis8
Nucleotide bindingi2785 – 2792ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 17, axonemalCurated
Alternative name(s):
Axonemal beta dynein heavy chain 17
Ciliary dynein heavy chain 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah17Imported
Synonyms:Dnahc17, Kiaa3028
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917176, Dnah17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003237501 – 4481Dynein heavy chain 17, axonemalAdd BLAST4481

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q69Z23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69Z23

PRoteomics IDEntifications database

More...
PRIDEi
Q69Z23

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69Z23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69Z23

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101915

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q69Z23, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q69Z23

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati521 – 569Kelch 1Add BLAST49
Repeati1533 – 1566TPR 1Add BLAST34
Repeati1688 – 1722TPR 2Add BLAST35
Repeati2229 – 2275Kelch 2Add BLAST47
Repeati2782 – 2834Kelch 3Add BLAST53
Repeati4138 – 4173TPR 3Add BLAST36
Repeati4272 – 4321Kelch 4Add BLAST50
Repeati4339 – 4385Kelch 5Add BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1792StemBy similarityAdd BLAST1792
Regioni1793 – 2014AAA 1By similarityAdd BLAST222
Regioni2074 – 2295AAA 2By similarityAdd BLAST222
Regioni2401 – 2649AAA 3By similarityAdd BLAST249
Regioni2747 – 2996AAA 4By similarityAdd BLAST250
Regioni3011 – 3297StalkBy similarityAdd BLAST287
Regioni3389 – 3616AAA 5By similarityAdd BLAST228
Regioni3826 – 4059AAA 6By similarityAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili759 – 826Sequence analysisAdd BLAST68
Coiled coili3011 – 3071Sequence analysisAdd BLAST61
Coiled coili3241 – 3293Sequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69Z23

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q69Z23

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676, PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69Z23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDLRIDYLE TVSSVLLKFK ADKWGKLIGA EENMALLTEF FDKIDNPVLV
60 70 80 90 100
LTLNAAGMII PCLGFPESLK SKGVYFIKMK PENITKDNYK THLIYGDISP
110 120 130 140 150
TTVDQLIAVV EEVLYSLLNQ SENMDGWPRV VSEDIVKQVH RLKNEMFVMG
160 170 180 190 200
GKIKGKTLLP IPEHLGSLDG TLDSMERIPS SMDNSLLHSI ETIIIDWSHQ
210 220 230 240 250
IRDVLSKDSA QALLDGLHPL PRVEFEFWDA RLMNLQCIHE QLNRPKVNKI
260 270 280 290 300
VEILEKAKSC YWPALQNVYM NVTQGLKEAN GIVLYLKPLR ILLEEMEQAD
310 320 330 340 350
FTMLPSFIVK VLSTICFIWA TSEHYNTPSR VIVILREFCN QIIEMTRTYL
360 370 380 390 400
SPDEVLKGLQ GEIEEVLGNI SLSVSVLKGL FQAYDFCCAN MKLFFKDRPP
410 420 430 440 450
VPWEFPSSLA FSRMNSFFHR VQTIEDLYKT AIEFLKLEKI ELGGVWGNIL
460 470 480 490 500
GNLVTQIYDE VFELVKVFAE CKYDPLDPGD SSFDDDYSDF ETKIQDLDRR
510 520 530 540 550
LATIFCQAFD DCNCMESSAK LLYMCGGLLE RPLILVEVVP RYSVMLEMFN
560 570 580 590 600
TELDNAKLMY DAQMAASADG QIPPIHKNMS PVSGQLKWSL ELQERLEVSM
610 620 630 640 650
KYLKHIEHPV MSSMEAKLIY DKYDEMMGLL QSCRMKKYQQ WVEGVDQDCH
660 670 680 690 700
FNLGQPLIQR DPFTSLIQVN FSKALVAVLR EVKYLNFQQQ KEIPESAEKL
710 720 730 740 750
FSENETFRKF VGNLELIVGW YNEIKTTVKD VEFPLIKSEL EAIDVKLLSA
760 770 780 790 800
ETTLFWNGEN VMEYIQEMRE MLYNLQNRIQ KAKQNVEGIT QAMQEWSANP
810 820 830 840 850
LFERKDNKKE ALLDLDGRVA NLNKRYAAVK EAGVRIQAMV VENAELFRAD
860 870 880 890 900
TTSQSWKDYV NYIDTVVLDE FDRFIRKSLN YLMDNMTMDE SIAPLFEIRM
910 920 930 940 950
ELDKDGLTYN PSLEMGDEAG FLSLIEGLIN DLYNVARLIP RLAKGRLNYK
960 970 980 990 1000
SDLEDITDLI EMREEVSSLV IGAMKVAEEY QDSFERYSYL WVDDLQEFMK
1010 1020 1030 1040 1050
NFLIFGHAPT PEELDTKTDD TIPKTPPTLA QFQQQIDSYE KLYEEVSSCE
1060 1070 1080 1090 1100
NTKVFHGWLQ CDCRPFKQTL LNTIKRWSFL FKRYLNNHVI NSLADLESFM
1110 1120 1130 1140 1150
NITRTALKKP LKEGDYDGLV EVMGHLMKVK ERQVATDSMF EPLKQTIELL
1160 1170 1180 1190 1200
KSYGEEMPEE IYLKLQELPE QWTNTKKLAI QVKQNVAPLQ ANEVNILRRK
1210 1220 1230 1240 1250
CQQFELKQHE FREKFRRDAP FSFSDPEPYK SLNKIYLLYG VMEALCKSAS
1260 1270 1280 1290 1300
LFEVTVPDYK QLKACHREVR LLKELWDMIV MVNTSIDDWK TTKWKDINVE
1310 1320 1330 1340 1350
QMDIDCKKFA KDVRSLDKEM KPWDAFVGLD NTVKNMITSL RAVSELQNPA
1360 1370 1380 1390 1400
IRDRHWQQLM QATQVKFEMS EETTLADLLQ LNLHKYEDEV RNIVDKAVKE
1410 1420 1430 1440 1450
SGMEKVLKTL DITWTTMEFE HELHPRTGTM MLKSDEVLVE TLEDNQVQLQ
1460 1470 1480 1490 1500
NLMMSKYLSH FLKEVTSWQQ KLSTADSVIS IWFEVQRTWS HLESIFIGSE
1510 1520 1530 1540 1550
DIRAQLPEDS KRFDAIDQEF KALMEDAVKT PNVVEATNKP DLYNKLENLK
1560 1570 1580 1590 1600
MSLAVCEKAL AEYLETKRLA FPRFYFVSSA DLLDILSNGN DPVEVSRHLS
1610 1620 1630 1640 1650
KLFDSLCKLK FRLDASGKPL KFGLGMYSKE DEFVDFDKEC DLSGQVEVWL
1660 1670 1680 1690 1700
NRVLDRMRAT LRHEIPEAVV TYEEKPREQW IFDYPAQIWW TTEVGLAFAR
1710 1720 1730 1740 1750
LEEGYENAIK DYNKKQISQL NALITLLIGN LTAGDRMKIM TICTIDVHAR
1760 1770 1780 1790 1800
DVVAKMITVE SSQAFTWQSQ LRHRWDEEKK HCFANICDAQ IKYSYEYLGN
1810 1820 1830 1840 1850
TPRLVITPLT DRCYITLTQS LHLIMGGAPA GPAGTGKTET TKDLGRALGT
1860 1870 1880 1890 1900
MVYVFNCSEQ MDYKSCGNIY KGLAQTGAWG CFDEFNRISV EVLSVIAVQV
1910 1920 1930 1940 1950
KCVQDAIRAK KKKFNFLGEI ISLVPTVGIF ITMNPGYAGR TELPENLKAL
1960 1970 1980 1990 2000
FRPCAMVVPD FELICEIMLV AEGFLDARLL ARKFITLYTL CKELLSKQDH
2010 2020 2030 2040 2050
YDWGLRAIKS VLVVAGSLKR GDPTRAEDQV LMRALRDFNI PKIVTDDLPV
2060 2070 2080 2090 2100
FMGLIGDLFP ALDVPRKRDL NFEKIIKQSI VELKLQAEDS FVLKVVQLEE
2110 2120 2130 2140 2150
LLQVRHSVFV IGNAGSGKSQ VLKSLNKTYQ NLKRKPVAVD LDPKAVTCDE
2160 2170 2180 2190 2200
LFGIINPATR EWKDGLFSTI MRDLANLTHE GPKWIVLDGD IDPMWIESLN
2210 2220 2230 2240 2250
TVMDDNKVLT LASNERIPLN RTMRLVFEIS HLRTATPATV SRAGILYINP
2260 2270 2280 2290 2300
ADLGWNPVVS SWIERRKVQS EKANLIILFD KYLPTCLDKL RIGFKRITPV
2310 2320 2330 2340 2350
PEITVIQTIL YLLECLLTEK NAPPDSPKEL YELYFVFACF WAFGGAMFQD
2360 2370 2380 2390 2400
QLIDYRVEFS KWWINEFKTI KLPSQGTIFD YYIDPETKKF LPWTDKVPNF
2410 2420 2430 2440 2450
ELDPDIPLQA SLVHTTETIR IRYFIDLLME KAWPVMLVGN AGTGKSVLMG
2460 2470 2480 2490 2500
DKLENLSTDD YLVQAVPFNF YTTSAMLQGV LEKPLEKKSG RNYGPPGTKK
2510 2520 2530 2540 2550
LIYFIDDMNM PEVDKYGTVA PHTLIRQHMD HRHWYDRQKL TLKDVHNCQY
2560 2570 2580 2590 2600
VACMNPTSGS FTIDPRLQRH FCVFAVSFPG QEALTSIYNT ILAQHLSFRS
2610 2620 2630 2640 2650
APLVIQRLSS HLVTAALALH QKVSATFLPT AIKFHYIFNL RDLSNIFQGI
2660 2670 2680 2690 2700
LFSTAEILKT PLDLVRLWLH EAERVYGDKM VDEKDQETLH RVTIASVKKF
2710 2720 2730 2740 2750
FDDLGEENLF AKPNIFCHFT QGIGDPKYFP VTDVAQLNKL LKDVLDSYNE
2760 2770 2780 2790 2800
VNAVMNLVLF EDAVAHICKI NRILESPRGN ALLVGVGGSG KQSLSRLAAY
2810 2820 2830 2840 2850
ISALDVFQIT LKKGYAIPDL KMDLATQYIK SAVKNVPSVF LMTDSQVAEE
2860 2870 2880 2890 2900
QFLVLINDLL ASGEIPGLFG DEDLENIISS MRPQVKSLGI ADTREACWKF
2910 2920 2930 2940 2950
FIEKVRRQLK VILCFSPVGS VLRVRARKFP AVVNCTAINW FHEWPEDALV
2960 2970 2980 2990 3000
SVSARFLEET EGIEPEVKTS ISLFMAYVHT TVNEMSKIYL TIERRYNYTT
3010 3020 3030 3040 3050
PKTFLEQIKL YQNLLAKKRM ELVAKIERLE NGLMKLQSTA SQVDDLKAKL
3060 3070 3080 3090 3100
AVQETELKQK NENADKLIQV VGVETEKVSK EKAIADEEEM KVEVINKNVT
3110 3120 3130 3140 3150
EKQKACETDL AKAEPALLAA QEALDTLNKN NLTELKSFGS PPDAVVNVTA
3160 3170 3180 3190 3200
AVMILTAPGG KIPKDKSWKA AKIMMGKVDT FLDSLKKFDK EHIPEACLKA
3210 3220 3230 3240 3250
FKPYQGNPTF DPEFIRSKST AAAGLCSWCI NIVRFYEVYC DVAPKRQALE
3260 3270 3280 3290 3300
EANAELAEAQ EKLSRIKNKI AELNANLSNL TSAFEKATAE KIKCQQEADA
3310 3320 3330 3340 3350
TNRVISLANR LVGGLASENV RWAESVENFK SQGVTLCGDV LLISAFVSYV
3360 3370 3380 3390 3400
GYFTKKYRNE LMEKFWIPYI NKLKVPIPIT EGLDPLTLLT DDADVATWNN
3410 3420 3430 3440 3450
QGLPSDRMST ENATILCNTE RWPLIVDAQL QGIKWIKNKY GSDLQAIRLG
3460 3470 3480 3490 3500
QKSYLDIIEQ AISAGDTLLI ENIGETVDPV LDPLLGRNTI KKGRFIKIGD
3510 3520 3530 3540 3550
KEVEYHPSFR LILHTKYFNP HYKPEMQAQC TLINFLVTRD GLEDQLLAAV
3560 3570 3580 3590 3600
VAKERPDLEQ LKANLTKSQN EFKIVLKELE DSLLARLSAA SGNFLGDTAL
3610 3620 3630 3640 3650
VENLETTKHT ANEIEEKVQE AKITEVKINE ARENYRPAAE RASLLYFILN
3660 3670 3680 3690 3700
DLNKINPIYQ FSLKAFNVVF EKAIQKTAPA DEVKQRVINL TDEITYSVYM
3710 3720 3730 3740 3750
YTARGLFERD KLIFLAQVTF QVLSMKKELN PVELDFLLRF PFKAGVVSPV
3760 3770 3780 3790 3800
DFLQHQSWGG IKALSEMDEF KNLDSDIEGS AKRWKKLVES EAPEKEIFPK
3810 3820 3830 3840 3850
EWKNKTALQK LCMVRCMRPD RMTYAVKNFV EEKMGSKFVE GRSVEFSKSY
3860 3870 3880 3890 3900
KESSPSTPIF FILSPGVDPL KDVEALGKKL GFTIDNGKLH NVSLGQGQEV
3910 3920 3930 3940 3950
VAENALDVAA EKGHWVILQV RGSLPQNIHL VARWLGILDK KVERYSSGSH
3960 3970 3980 3990 4000
EDYRVFISAE PAPTAETHII PQGILENAIK ITNEPPTGMY ANLHKALDLF
4010 4020 4030 4040 4050
TQDTLEMCTK EIEFKCILFA LCYFHAVVAE RRKFGAQGWN RSYPFNNGDL
4060 4070 4080 4090 4100
TISINVLYNY LEANSKVPWD DLRYLFGEIM YGGHITDDWD RRLCRTYLAE
4110 4120 4130 4140 4150
YIRVEMLEGE VLLAPGFQIP PNLDYKGYHE YIDENLPPES PYLYGLHPNA
4160 4170 4180 4190 4200
EIGFLTVTSE KLFRTVLEMQ PKETDSGAGT GVSREEKVGA VPVPEGSLGS
4210 4220 4230 4240 4250
EGSLGTIGLP GTGFQVKAVL DDILEKIPET FNMAEIMAKA AEKTPYVVVA
4260 4270 4280 4290 4300
FQECERMNIL TNEMRRSLKE LNLGLKGELT ITTDMEDLST ALFYDTVPDT
4310 4320 4330 4340 4350
WVARAYPSMM GLAAWYADLL QRIRELESWT TDFALPTTVW LAGFFNPQSF
4360 4370 4380 4390 4400
LTAIMQSMAR KNEWPLDKMC LSVEVTKKNR EDMTAPPREG SYVYGLFMEG
4410 4420 4430 4440 4450
ARWDTQTGVI AEARLKDLTP VMPVIFIKAI PVDRMETKNI YECPVYKTRI
4460 4470 4480
RGPTYVWTFN LKTKEKAAKW ILAAVALLLQ V
Length:4,481
Mass (Da):511,603
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA64E53D65671224E
GO
Isoform 2 (identifier: Q69Z23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3828-3852: NFVEEKMGSKFVEGRSVEFSKSYKE → EKTGIYHRQWETPQRVPGARTRGGS
     3853-4481: Missing.

Show »
Length:3,852
Mass (Da):440,772
Checksum:i8AA92062B8AC87E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q7P0E9Q7P0_MOUSE
Dynein heavy chain 17, axonemal
Dnah17 Dnahc17
4,453Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A520A2A520_MOUSE
Dynein heavy chain 17, axonemal
Dnah17 Dnahc17
4,459Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K3W4R0K3W4R0_MOUSE
Dynein heavy chain 17, axonemal
Dnah17
4,481Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0321163828 – 3852NFVEE…KSYKE → EKTGIYHRQWETPQRVPGAR TRGGS in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0321173853 – 4481Missing in isoform 2. 1 PublicationAdd BLAST629

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL591204 Genomic DNA No translation available.
AL591433 Genomic DNA No translation available.
Z83807 mRNA Translation: CAB06061.1
AK173343 mRNA Translation: BAD32621.1

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591204 Genomic DNA No translation available.
AL591433 Genomic DNA No translation available.
Z83807 mRNA Translation: CAB06061.1
AK173343 mRNA Translation: BAD32621.1

3D structure databases

SMRiQ69Z23
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101915

PTM databases

iPTMnetiQ69Z23
PhosphoSitePlusiQ69Z23

Proteomic databases

jPOSTiQ69Z23
PaxDbiQ69Z23
PRIDEiQ69Z23

Organism-specific databases

MGIiMGI:1917176, Dnah17

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
InParanoidiQ69Z23
PhylomeDBiQ69Z23

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q69Z23
RNActiQ69Z23, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH17_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69Z23
Secondary accession number(s): O08820
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: August 12, 2020
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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