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Entry version 114 (12 Aug 2020)
Sequence version 1 (13 Sep 2004)
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Protein

Transmembrane protein 200B

Gene

TMEM200B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q69YZ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 200B
Alternative name(s):
Transmembrane protein TTMA
Two transmembrane domain-containing family member B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM200B
Synonyms:TTMB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000253304.1

Human Gene Nomenclature Database

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HGNCi
HGNC:33785, TMEM200B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q69YZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000253304

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406350

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q69YZ2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM200B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736342

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003171541 – 307Transmembrane protein 200BAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q69YZ2

PeptideAtlas

More...
PeptideAtlasi
Q69YZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q69YZ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66175

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q69YZ2, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69YZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69YZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000253304, Expressed in uterus and 198 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69YZ2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000253304, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
134353, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q69YZ2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428544

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q69YZ2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 49Arg-richAdd BLAST37
Compositional biasi159 – 237Pro-richAdd BLAST79
Compositional biasi298 – 301Poly-Gly4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4823, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_948489_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69YZ2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAEPESW

Database of Orthologous Groups

More...
OrthoDBi
1246267at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q69YZ2

TreeFam database of animal gene trees

More...
TreeFami
TF332635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018787, DUF2371_TMEM200

The PANTHER Classification System

More...
PANTHERi
PTHR31815, PTHR31815, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10177, DUF2371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q69YZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAGSPEECG EVRRSPEGRV SRLGRRLGRR RRPRSPPEPL RVRARLRLRS
60 70 80 90 100
PSGAFAALGA LVVLVGMGIA VAGYWPHRAG APGSRAANAS SPQMSELRRE
110 120 130 140 150
GRGGGRAHGP HERLRLLGPV IMGVGLFVFI CANTLLYENR DLETRRLRQG
160 170 180 190 200
VLRAQALRPP DGPGWDCALL PSPGPRSPRA VGCAEPEIWD PSPRRGTSPV
210 220 230 240 250
PSVRSLRSEP ANPRLGLPAL LNSYPLKGPG LPPPWGPRTQ TGHVIITVQP
260 270 280 290 300
SGSCIEHSKS LDLGLGELLL GAPAARDCAH RSWPRLDRLS LGGYAKLGGG

GDLGARV
Length:307
Mass (Da):32,750
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8F7D986A0A773A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL110282 mRNA Translation: CAH10727.1
BC064375 mRNA Translation: AAH64375.2
BC064538 mRNA Translation: AAH64538.1
BC082989 mRNA Translation: AAH82989.1
BC110336 mRNA Translation: AAI10337.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30658.1

NCBI Reference Sequences

More...
RefSeqi
NP_001003682.1, NM_001003682.3
NP_001165339.1, NM_001171868.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000420504; ENSP00000428544; ENSG00000253304
ENST00000521452; ENSP00000428459; ENSG00000253304

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
399474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:399474

UCSC genome browser

More...
UCSCi
uc001brn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110282 mRNA Translation: CAH10727.1
BC064375 mRNA Translation: AAH64375.2
BC064538 mRNA Translation: AAH64538.1
BC082989 mRNA Translation: AAH82989.1
BC110336 mRNA Translation: AAI10337.1
CCDSiCCDS30658.1
RefSeqiNP_001003682.1, NM_001003682.3
NP_001165339.1, NM_001171868.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi134353, 1 interactor
IntActiQ69YZ2, 1 interactor
STRINGi9606.ENSP00000428544

PTM databases

GlyGeniQ69YZ2, 1 site
iPTMnetiQ69YZ2
PhosphoSitePlusiQ69YZ2

Polymorphism and mutation databases

BioMutaiTMEM200B
DMDMi74736342

Proteomic databases

PaxDbiQ69YZ2
PeptideAtlasiQ69YZ2
PRIDEiQ69YZ2
ProteomicsDBi66175

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
55485, 28 antibodies

Genome annotation databases

EnsembliENST00000420504; ENSP00000428544; ENSG00000253304
ENST00000521452; ENSP00000428459; ENSG00000253304
GeneIDi399474
KEGGihsa:399474
UCSCiuc001brn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
399474
EuPathDBiHostDB:ENSG00000253304.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM200B
HGNCiHGNC:33785, TMEM200B
HPAiENSG00000253304, Low tissue specificity
neXtProtiNX_Q69YZ2
OpenTargetsiENSG00000253304
PharmGKBiPA162406350

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4823, Eukaryota
GeneTreeiENSGT00530000063698
HOGENOMiCLU_948489_0_0_1
InParanoidiQ69YZ2
OMAiCAEPESW
OrthoDBi1246267at2759
PhylomeDBiQ69YZ2
TreeFamiTF332635

Enzyme and pathway databases

PathwayCommonsiQ69YZ2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
399474, 9 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM200B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
399474
PharosiQ69YZ2, Tdark

Protein Ontology

More...
PROi
PR:Q69YZ2
RNActiQ69YZ2, protein

Gene expression databases

BgeeiENSG00000253304, Expressed in uterus and 198 other tissues
GenevisibleiQ69YZ2, HS

Family and domain databases

InterProiView protein in InterPro
IPR018787, DUF2371_TMEM200
PANTHERiPTHR31815, PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177, DUF2371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT200B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69YZ2
Secondary accession number(s): Q6P2G8, Q6P2Q5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 13, 2004
Last modified: August 12, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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