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UniProtKB - Q69YH5 (CDCA2_HUMAN)

Entry version 127 (12 Aug 2020)
Sequence version 2 (05 Oct 2010)
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Protein

Cell division cycle-associated protein 2

Gene

CDCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q69YH5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle-associated protein 2
Alternative name(s):
Recruits PP1 onto mitotic chromatin at anaphase protein
Short name:
Repo-Man
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDCA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000184661.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:14623, CDCA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618785, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q69YH5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi393 – 395VTF → ATA: Abolishes interaction with PPP1CC but not subcellular location. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		157313

Open Targets

More...OpenTargetsi		ENSG00000184661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26275

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q69YH5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDCA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153420

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002876951 – 1023Cell division cycle-associated protein 2Add BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei98PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei312PhosphothreonineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei412PhosphothreonineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki762Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei936PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1
Modified residuei1000PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK1. May regulate its subcellular location.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q69YH5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q69YH5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q69YH5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q69YH5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q69YH5

PeptideAtlas

More...PeptideAtlasi		Q69YH5

PRoteomics IDEntifications database

More...PRIDEi		Q69YH5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66154 [Q69YH5-1]
66155 [Q69YH5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q69YH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q69YH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184661, Expressed in testis and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q69YH5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q69YH5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184661, Group enriched (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPP1CC.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127593, 28 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q69YH5

Protein interaction database and analysis system

More...IntActi		Q69YH5, 20 interactors

Molecular INTeraction database

More...MINTi		Q69YH5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000328228

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q69YH5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11023
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q69YH5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini389 – 449PP1-bindingAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi533 – 575Lys-richAdd BLAST43

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S079, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011968_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q69YH5

KEGG Orthology (KO)

More...KOi		K17590

Identification of Orthologs from Complete Genome Data

More...OMAi		RRTICTF

Database of Orthologous Groups

More...OrthoDBi		290017at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q69YH5

TreeFam database of animal gene trees

More...TreeFami		TF336000

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033064, CDCA2
IPR029334, PP1-bd

The PANTHER Classification System

More...PANTHERi		PTHR21603:SF16, PTHR21603:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15276, PP1_bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69YH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDANSKDKPP ETKESAMNNA GNASFILGTG KIVTPQKHAE LPPNPCTPDT 
        60         70         80         90        100
FKSPLNFSTV TVEQLGITPE SFVRNSAGKS SSYLKKCRRR SAVGARGSPE 
       110        120        130        140        150
TNHLIRFIAR QQNIKNARKS PLAQDSPSQG SPALYRNVNT LRERISAFQS 
       160        170        180        190        200
AFHSIKENEK MTGCLEFSEA GKESEMTDLT RKEGLSACQQ SGFPAVLSSK 
       210        220        230        240        250
RRRISYQRDS DENLTDAEGK VIGLQIFNID TDRACAVETS VDLSEISSKL 
       260        270        280        290        300
GSTQSGFLVE ESLPLSELTE TSNALKVADC VVGKGSSDAV SPDTFTAEVS 
       310        320        330        340        350
SDAVPDVRSP ATPACRRDLP TPKTFVLRSV LKKPSVKMCL ESLQEHCNNL 
       360        370        380        390        400
YDDDGTHPSL ISNLPNCCKE KEAEDEENFE APAFLNMRKR KRVTFGEDLS 
       410        420        430        440        450
PEVFDESLPA NTPLRKGGTP VCKKDFSGLS SLLLEQSPVP EPLPQPDFDD 
       460        470        480        490        500
KGENLENIEP LQVSFAVLSS PNKSSISETL SGTDTFSSSN NHEKISSPKV 
       510        520        530        540        550
GRITRTSNRR NQLVSVVEES VCNLLNTEVQ PCKEKKINRR KSQETKCTKR 
       560        570        580        590        600
ALPKKSQVLK SCRKKKGKGK KSVQKSLYGE RDIASKKPLL SPIPELPEVP 
       610        620        630        640        650
EMTPSIPSIR RLGSGYFSSN GKLEEVKTPK NPVKRKDLLR HDPDLHMHQG 
       660        670        680        690        700
YDKYDVSEFC SYIKSSSSLG NATSDEDPNT NIMNINENKN IPKAKNKSES 
       710        720        730        740        750
ENEPKAGTDS PVSCASVTEE RVASDSPKPA LTLQQGQEFS AGGQNAENLC 
       760        770        780        790        800
QFFKISPDLN IKCERKDDFL GAAEGKLQCN RLMPNSQKDC HCLGDVLIEN 
       810        820        830        840        850
TKESKSQSED LGRKPMESSS VVSCRDRKDR RRSMCYSDGR SLHLEKNGNH 
       860        870        880        890        900
TPSSSVGSSV EISLENSELF KDLSDAIEQT FQRRNSETKV RRSTRLQKDL 
       910        920        930        940        950
ENEGLVWISL PLPSTSQKAK RRTICTFDSS GFESMSPIKE TVSSRQKPQM 
       960        970        980        990       1000
APPVSDPENS QGPAAGSSDE PGKRRKSFCI STLANTKATS QFKGYRRRSS 
      1010       1020 
LNGKGESSLT ALERIEHNGE RKQ
Length:1,023
Mass (Da):112,676
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A073D6DD928B1E5
GO
Isoform 2 (identifier: Q69YH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: T → N
     69-1023: Missing.

Show »
Length:68
Mass (Da):7,241
Checksum:i93DB1640A846E0C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEI0E9PEI0_HUMAN
Cell division cycle-associated prot...
CDCA2
1,008Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36214 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC05374 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAH10577 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti662Y → D in BG354575 (PubMed:12188893).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032350717V → ICombined sources3 PublicationsCorresponds to variant dbSNP:rs4872318Ensembl.1
Natural variantiVAR_032351884R → S1 PublicationCorresponds to variant dbSNP:rs3829009Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02559868T → N in isoform 2. 1 Publication1
Alternative sequenceiVSP_02559969 – 1023Missing in isoform 2. 1 PublicationAdd BLAST955

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL833396 mRNA Translation: CAH10585.1
AL833627 mRNA Translation: CAH10577.1 Sequence problems.
AC103779 Genomic DNA No translation available.
BC036214 mRNA Translation: AAH36214.1 Different initiation.
BC063651 mRNA Translation: AAH63651.1
BC085609 mRNA Translation: AAH85609.1
BC104451 mRNA Translation: AAI04452.1
BC104450 mRNA Translation: AAI04451.1
BG354575 mRNA No translation available.
AK098670 mRNA Translation: BAC05374.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6049.1 [Q69YH5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001304835.1, NM_001317906.1
NP_001304836.1, NM_001317907.1
NP_689775.2, NM_152562.3 [Q69YH5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000330560; ENSP00000328228; ENSG00000184661 [Q69YH5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		157313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:157313

UCSC genome browser

More...UCSCi		uc003xep.2, human [Q69YH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833396 mRNA Translation: CAH10585.1
AL833627 mRNA Translation: CAH10577.1 Sequence problems.
AC103779 Genomic DNA No translation available.
BC036214 mRNA Translation: AAH36214.1 Different initiation.
BC063651 mRNA Translation: AAH63651.1
BC085609 mRNA Translation: AAH85609.1
BC104451 mRNA Translation: AAI04452.1
BC104450 mRNA Translation: AAI04451.1
BG354575 mRNA No translation available.
AK098670 mRNA Translation: BAC05374.1 Different initiation.
CCDSiCCDS6049.1 [Q69YH5-1]
RefSeqiNP_001304835.1, NM_001317906.1
NP_001304836.1, NM_001317907.1
NP_689775.2, NM_152562.3 [Q69YH5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5INBX-ray1.30B383-423[»]
5IOHX-ray2.57B/D383-441[»]
5SW9X-ray2.85B581-601[»]
SMRiQ69YH5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127593, 28 interactors
ELMiQ69YH5
IntActiQ69YH5, 20 interactors
MINTiQ69YH5
STRINGi9606.ENSP00000328228

PTM databases

iPTMnetiQ69YH5
PhosphoSitePlusiQ69YH5

Polymorphism and mutation databases

BioMutaiCDCA2
DMDMi308153420

Proteomic databases

EPDiQ69YH5
jPOSTiQ69YH5
MassIVEiQ69YH5
MaxQBiQ69YH5
PaxDbiQ69YH5
PeptideAtlasiQ69YH5
PRIDEiQ69YH5
ProteomicsDBi66154 [Q69YH5-1]
66155 [Q69YH5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10001, 125 antibodies

Genome annotation databases

EnsembliENST00000330560; ENSP00000328228; ENSG00000184661 [Q69YH5-1]
GeneIDi157313
KEGGihsa:157313
UCSCiuc003xep.2, human [Q69YH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		157313
DisGeNETi157313
EuPathDBiHostDB:ENSG00000184661.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDCA2
HGNCiHGNC:14623, CDCA2
HPAiENSG00000184661, Group enriched (lymphoid tissue, testis)
MIMi618785, gene
neXtProtiNX_Q69YH5
OpenTargetsiENSG00000184661
PharmGKBiPA26275

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S079, Eukaryota
GeneTreeiENSGT00940000154352
HOGENOMiCLU_011968_0_0_1
InParanoidiQ69YH5
KOiK17590
OMAiRRTICTF
OrthoDBi290017at2759
PhylomeDBiQ69YH5
TreeFamiTF336000

Enzyme and pathway databases

PathwayCommonsiQ69YH5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		157313, 24 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDCA2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		157313
PharosiQ69YH5, Tbio

Protein Ontology

More...PROi		PR:Q69YH5
RNActiQ69YH5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184661, Expressed in testis and 135 other tissues
ExpressionAtlasiQ69YH5, baseline and differential
GenevisibleiQ69YH5, HS

Family and domain databases

InterProiView protein in InterPro
IPR033064, CDCA2
IPR029334, PP1-bd
PANTHERiPTHR21603:SF16, PTHR21603:SF16, 1 hit
PfamiView protein in Pfam
PF15276, PP1_bind, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDCA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69YH5
Secondary accession number(s): Q3SX74
, Q4G0W0, Q5RKN0, Q69YI4, Q6P464, Q8N7C1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 5, 2010
Last modified: August 12, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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