UniProtKB - Q69YH5 (CDCA2_HUMAN)
Protein
Cell division cycle-associated protein 2
Gene
CDCA2
Organism
Homo sapiens (Human)
Status
Functioni
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.2 Publications
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- chromosome segregation Source: Ensembl
- positive regulation of protein dephosphorylation Source: MGI
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q69YH5 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle-associated protein 2Alternative name(s): Recruits PP1 onto mitotic chromatin at anaphase protein Short name: Repo-Man |
Gene namesi | Name:CDCA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184661.13 |
HGNCi | HGNC:14623, CDCA2 |
MIMi | 618785, gene |
neXtProti | NX_Q69YH5 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- chromosome Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 393 – 395 | VTF → ATA: Abolishes interaction with PPP1CC but not subcellular location. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 157313 |
OpenTargetsi | ENSG00000184661 |
PharmGKBi | PA26275 |
Miscellaneous databases
Pharosi | Q69YH5, Tbio |
Polymorphism and mutation databases
BioMutai | CDCA2 |
DMDMi | 308153420 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287695 | 1 – 1023 | Cell division cycle-associated protein 2Add BLAST | 1023 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 98 | PhosphoserineCombined sources | 1 | |
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Modified residuei | 210 | PhosphoserineCombined sources | 1 | |
Modified residuei | 291 | PhosphoserineCombined sources | 1 | |
Modified residuei | 309 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 412 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 437 | PhosphoserineCombined sources | 1 | |
Modified residuei | 591 | PhosphoserineCombined sources | 1 | |
Modified residuei | 614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 710 | PhosphoserineCombined sources | 1 | |
Modified residuei | 756 | PhosphoserineCombined sources | 1 | |
Cross-linki | 762 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 936 | PhosphoserineCombined sources | 1 | |
Modified residuei | 977 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1000 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by CDK1. May regulate its subcellular location.1 Publication
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q69YH5 |
jPOSTi | Q69YH5 |
MassIVEi | Q69YH5 |
MaxQBi | Q69YH5 |
PaxDbi | Q69YH5 |
PeptideAtlasi | Q69YH5 |
PRIDEi | Q69YH5 |
ProteomicsDBi | 66154 [Q69YH5-1] 66155 [Q69YH5-2] |
PTM databases
iPTMneti | Q69YH5 |
PhosphoSitePlusi | Q69YH5 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000184661, Expressed in testis and 135 other tissues |
ExpressionAtlasi | Q69YH5, baseline and differential |
Genevisiblei | Q69YH5, HS |
Organism-specific databases
HPAi | ENSG00000184661, Group enriched (lymphoid tissue, testis) |
Interactioni
Subunit structurei
Interacts with PPP1CC.
1 PublicationProtein-protein interaction databases
BioGRIDi | 127593, 28 interactors |
ELMi | Q69YH5 |
IntActi | Q69YH5, 20 interactors |
MINTi | Q69YH5 |
STRINGi | 9606.ENSP00000328228 |
Miscellaneous databases
RNActi | Q69YH5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q69YH5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 389 – 449 | PP1-bindingAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 533 – 575 | Lys-richAdd BLAST | 43 |
Phylogenomic databases
eggNOGi | ENOG502S079, Eukaryota |
GeneTreei | ENSGT00940000154352 |
HOGENOMi | CLU_011968_0_0_1 |
InParanoidi | Q69YH5 |
OMAi | RRTICTF |
OrthoDBi | 290017at2759 |
PhylomeDBi | Q69YH5 |
TreeFami | TF336000 |
Family and domain databases
InterProi | View protein in InterPro IPR033064, CDCA2 IPR029334, PP1-bd |
PANTHERi | PTHR21603:SF16, PTHR21603:SF16, 1 hit |
Pfami | View protein in Pfam PF15276, PP1_bind, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q69YH5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDANSKDKPP ETKESAMNNA GNASFILGTG KIVTPQKHAE LPPNPCTPDT
60 70 80 90 100
FKSPLNFSTV TVEQLGITPE SFVRNSAGKS SSYLKKCRRR SAVGARGSPE
110 120 130 140 150
TNHLIRFIAR QQNIKNARKS PLAQDSPSQG SPALYRNVNT LRERISAFQS
160 170 180 190 200
AFHSIKENEK MTGCLEFSEA GKESEMTDLT RKEGLSACQQ SGFPAVLSSK
210 220 230 240 250
RRRISYQRDS DENLTDAEGK VIGLQIFNID TDRACAVETS VDLSEISSKL
260 270 280 290 300
GSTQSGFLVE ESLPLSELTE TSNALKVADC VVGKGSSDAV SPDTFTAEVS
310 320 330 340 350
SDAVPDVRSP ATPACRRDLP TPKTFVLRSV LKKPSVKMCL ESLQEHCNNL
360 370 380 390 400
YDDDGTHPSL ISNLPNCCKE KEAEDEENFE APAFLNMRKR KRVTFGEDLS
410 420 430 440 450
PEVFDESLPA NTPLRKGGTP VCKKDFSGLS SLLLEQSPVP EPLPQPDFDD
460 470 480 490 500
KGENLENIEP LQVSFAVLSS PNKSSISETL SGTDTFSSSN NHEKISSPKV
510 520 530 540 550
GRITRTSNRR NQLVSVVEES VCNLLNTEVQ PCKEKKINRR KSQETKCTKR
560 570 580 590 600
ALPKKSQVLK SCRKKKGKGK KSVQKSLYGE RDIASKKPLL SPIPELPEVP
610 620 630 640 650
EMTPSIPSIR RLGSGYFSSN GKLEEVKTPK NPVKRKDLLR HDPDLHMHQG
660 670 680 690 700
YDKYDVSEFC SYIKSSSSLG NATSDEDPNT NIMNINENKN IPKAKNKSES
710 720 730 740 750
ENEPKAGTDS PVSCASVTEE RVASDSPKPA LTLQQGQEFS AGGQNAENLC
760 770 780 790 800
QFFKISPDLN IKCERKDDFL GAAEGKLQCN RLMPNSQKDC HCLGDVLIEN
810 820 830 840 850
TKESKSQSED LGRKPMESSS VVSCRDRKDR RRSMCYSDGR SLHLEKNGNH
860 870 880 890 900
TPSSSVGSSV EISLENSELF KDLSDAIEQT FQRRNSETKV RRSTRLQKDL
910 920 930 940 950
ENEGLVWISL PLPSTSQKAK RRTICTFDSS GFESMSPIKE TVSSRQKPQM
960 970 980 990 1000
APPVSDPENS QGPAAGSSDE PGKRRKSFCI STLANTKATS QFKGYRRRSS
1010 1020
LNGKGESSLT ALERIEHNGE RKQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PEI0 | E9PEI0_HUMAN | Cell division cycle-associated prot... | CDCA2 | 1,008 | Annotation score: |
Sequence cautioni
The sequence AAH36214 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC05374 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAH10577 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 662 | Y → D in BG354575 (PubMed:12188893).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032350 | 717 | V → ICombined sources3 PublicationsCorresponds to variant dbSNP:rs4872318Ensembl. | 1 | |
Natural variantiVAR_032351 | 884 | R → S1 PublicationCorresponds to variant dbSNP:rs3829009Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025598 | 68 | T → N in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_025599 | 69 – 1023 | Missing in isoform 2. 1 PublicationAdd BLAST | 955 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL833396 mRNA Translation: CAH10585.1 AL833627 mRNA Translation: CAH10577.1 Sequence problems. AC103779 Genomic DNA No translation available. BC036214 mRNA Translation: AAH36214.1 Different initiation. BC063651 mRNA Translation: AAH63651.1 BC085609 mRNA Translation: AAH85609.1 BC104451 mRNA Translation: AAI04452.1 BC104450 mRNA Translation: AAI04451.1 BG354575 mRNA No translation available. AK098670 mRNA Translation: BAC05374.1 Different initiation. |
CCDSi | CCDS6049.1 [Q69YH5-1] |
RefSeqi | NP_001304835.1, NM_001317906.1 NP_001304836.1, NM_001317907.1 NP_689775.2, NM_152562.3 [Q69YH5-1] |
Genome annotation databases
Ensembli | ENST00000330560; ENSP00000328228; ENSG00000184661 [Q69YH5-1] |
GeneIDi | 157313 |
KEGGi | hsa:157313 |
UCSCi | uc003xep.2, human [Q69YH5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL833396 mRNA Translation: CAH10585.1 AL833627 mRNA Translation: CAH10577.1 Sequence problems. AC103779 Genomic DNA No translation available. BC036214 mRNA Translation: AAH36214.1 Different initiation. BC063651 mRNA Translation: AAH63651.1 BC085609 mRNA Translation: AAH85609.1 BC104451 mRNA Translation: AAI04452.1 BC104450 mRNA Translation: AAI04451.1 BG354575 mRNA No translation available. AK098670 mRNA Translation: BAC05374.1 Different initiation. |
CCDSi | CCDS6049.1 [Q69YH5-1] |
RefSeqi | NP_001304835.1, NM_001317906.1 NP_001304836.1, NM_001317907.1 NP_689775.2, NM_152562.3 [Q69YH5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5INB | X-ray | 1.30 | B | 383-423 | [»] | |
5IOH | X-ray | 2.57 | B/D | 383-441 | [»] | |
5SW9 | X-ray | 2.85 | B | 581-601 | [»] | |
SMRi | Q69YH5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127593, 28 interactors |
ELMi | Q69YH5 |
IntActi | Q69YH5, 20 interactors |
MINTi | Q69YH5 |
STRINGi | 9606.ENSP00000328228 |
PTM databases
iPTMneti | Q69YH5 |
PhosphoSitePlusi | Q69YH5 |
Polymorphism and mutation databases
BioMutai | CDCA2 |
DMDMi | 308153420 |
Proteomic databases
EPDi | Q69YH5 |
jPOSTi | Q69YH5 |
MassIVEi | Q69YH5 |
MaxQBi | Q69YH5 |
PaxDbi | Q69YH5 |
PeptideAtlasi | Q69YH5 |
PRIDEi | Q69YH5 |
ProteomicsDBi | 66154 [Q69YH5-1] 66155 [Q69YH5-2] |
Protocols and materials databases
Antibodypediai | 10001, 125 antibodies |
Genome annotation databases
Ensembli | ENST00000330560; ENSP00000328228; ENSG00000184661 [Q69YH5-1] |
GeneIDi | 157313 |
KEGGi | hsa:157313 |
UCSCi | uc003xep.2, human [Q69YH5-1] |
Organism-specific databases
CTDi | 157313 |
DisGeNETi | 157313 |
EuPathDBi | HostDB:ENSG00000184661.13 |
GeneCardsi | CDCA2 |
HGNCi | HGNC:14623, CDCA2 |
HPAi | ENSG00000184661, Group enriched (lymphoid tissue, testis) |
MIMi | 618785, gene |
neXtProti | NX_Q69YH5 |
OpenTargetsi | ENSG00000184661 |
PharmGKBi | PA26275 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S079, Eukaryota |
GeneTreei | ENSGT00940000154352 |
HOGENOMi | CLU_011968_0_0_1 |
InParanoidi | Q69YH5 |
OMAi | RRTICTF |
OrthoDBi | 290017at2759 |
PhylomeDBi | Q69YH5 |
TreeFami | TF336000 |
Enzyme and pathway databases
PathwayCommonsi | Q69YH5 |
Miscellaneous databases
BioGRID-ORCSi | 157313, 24 hits in 837 CRISPR screens |
ChiTaRSi | CDCA2, human |
GenomeRNAii | 157313 |
Pharosi | Q69YH5, Tbio |
PROi | PR:Q69YH5 |
RNActi | Q69YH5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184661, Expressed in testis and 135 other tissues |
ExpressionAtlasi | Q69YH5, baseline and differential |
Genevisiblei | Q69YH5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033064, CDCA2 IPR029334, PP1-bd |
PANTHERi | PTHR21603:SF16, PTHR21603:SF16, 1 hit |
Pfami | View protein in Pfam PF15276, PP1_bind, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDCA2_HUMAN | |
Accessioni | Q69YH5Primary (citable) accession number: Q69YH5 Secondary accession number(s): Q3SX74 Q8N7C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations