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UniProtKB - Q69FE3 (Q69FE3_HUMAN)
Protein
Interleukin-1 receptor-associated kinase 4
Gene
IRAK4
Organism
Homo sapiens (Human)
Status
Functioni
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.
UniRule annotationCatalytic activityi
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 213 | ATPUniRule annotation | 1 | |
Active sitei | 311 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 313 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 313 – 315 | ATPUniRule annotation | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- interleukin-1 receptor binding Source: Ensembl
- magnesium ion binding Source: InterPro
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- cytokine-mediated signaling pathway Source: Ensembl
- innate immune response Source: UniProtKB-UniRule
- JNK cascade Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProt
- positive regulation of smooth muscle cell proliferation Source: Ensembl
Keywordsi
Molecular function | Kinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Biological process | Immunity, Innate immunityUniRule annotation |
Ligand | ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-1 receptor-associated kinase 4UniRule annotation (EC:2.7.11.1UniRule annotation) |
Gene namesi | Name:IRAK4Imported ORF Names:hCG_39494Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000198001 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000198001, Expressed in monocyte and 196 other tissues |
Interactioni
Subunit structurei
Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
UniRule annotationGO - Molecular functioni
- interleukin-1 receptor binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q69FE3, 1 interactor |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 186 – 454 | Protein kinaseInterPro annotationAdd BLAST | 269 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 396 – 416 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_000288_21_15_1 |
OMAi | WHQRCLI |
OrthoDBi | 684563at2759 |
Family and domain databases
CDDi | cd08793, Death_IRAK4, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR017428, IRAK4 IPR037970, IRAK4_Death IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF038189, IRAK4, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q69FE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ
60 70 80 90 100
FHIRRFEALL QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL
110 120 130 140 150
LPDAVPKTAN TLPSKEAITV QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS
160 170 180 190 200
SSPENKSLEV SDTRFHSFSF YELKNVTNNF DERPISVGGN KMGEGGFGVV
210 220 230 240 250
YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC QHENLVELLG
260 270 280 290 300
FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
310 320 330 340 350
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG
360 370 380 390 400
TTAYMAPEAL RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK
410 420 430 440 450
EEIEDEEKTI EDYIDKKMND ADSTSVEAMY SVASQCLHEK KNKRPDIKKV
460
QQLLQEMTAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY340962 mRNA Translation: AAR02358.1 AY340963 mRNA Translation: AAR02359.1 AY730682 mRNA Translation: AAX22228.1 KU178631 mRNA Translation: ALQ34089.1 CH471111 Genomic DNA Translation: EAW57867.1 |
RefSeqi | NP_001107654.1, NM_001114182.2 NP_057207.2, NM_016123.3 XP_005269000.1, XM_005268943.3 XP_005269001.1, XM_005268944.4 XP_005269002.1, XM_005268945.4 XP_006719501.1, XM_006719438.3 XP_011536733.1, XM_011538431.2 XP_011536734.1, XM_011538432.1 XP_011536735.1, XM_011538433.2 XP_016874879.1, XM_017019390.1 |
Genome annotation databases
GeneIDi | 51135 |
KEGGi | hsa:51135 |
MANE-Selecti | ENST00000613694.5; ENSP00000479889.3; NM_016123.4; NP_057207.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY340962 mRNA Translation: AAR02358.1 AY340963 mRNA Translation: AAR02359.1 AY730682 mRNA Translation: AAX22228.1 KU178631 mRNA Translation: ALQ34089.1 CH471111 Genomic DNA Translation: EAW57867.1 |
RefSeqi | NP_001107654.1, NM_001114182.2 NP_057207.2, NM_016123.3 XP_005269000.1, XM_005268943.3 XP_005269001.1, XM_005268944.4 XP_005269002.1, XM_005268945.4 XP_006719501.1, XM_006719438.3 XP_011536733.1, XM_011538431.2 XP_011536734.1, XM_011538432.1 XP_011536735.1, XM_011538433.2 XP_016874879.1, XM_017019390.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q69FE3, 1 interactor |
Protocols and materials databases
Antibodypediai | 696, 786 antibodies from 42 providers |
DNASUi | 51135 |
Genome annotation databases
GeneIDi | 51135 |
KEGGi | hsa:51135 |
MANE-Selecti | ENST00000613694.5; ENSP00000479889.3; NM_016123.4; NP_057207.2 |
Organism-specific databases
CTDi | 51135 |
PharmGKBi | PA134914577 |
VEuPathDBi | HostDB:ENSG00000198001 |
Phylogenomic databases
HOGENOMi | CLU_000288_21_15_1 |
OMAi | WHQRCLI |
OrthoDBi | 684563at2759 |
Miscellaneous databases
BioGRID-ORCSi | 51135, 17 hits in 1075 CRISPR screens |
ChiTaRSi | IRAK4, human |
GenomeRNAii | 51135 |
Gene expression databases
Bgeei | ENSG00000198001, Expressed in monocyte and 196 other tissues |
Family and domain databases
CDDi | cd08793, Death_IRAK4, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR017428, IRAK4 IPR037970, IRAK4_Death IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF038189, IRAK4, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q69FE3_HUMAN | |
Accessioni | Q69FE3Primary (citable) accession number: Q69FE3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |