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Entry version 116 (07 Apr 2021)
Sequence version 1 (13 Sep 2004)
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Protein

Neuropilin

Gene

nrp1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi193CalciumUniRule annotation1
Metal bindingi207CalciumUniRule annotation1
Metal bindingi248CalciumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, Heparin-bindingARBA annotation, ReceptorUniRule annotation
Biological processAngiogenesisARBA annotation, DifferentiationUniRule annotationARBA annotation, NeurogenesisUniRule annotationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NeuropilinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nrp1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030519-2, nrp1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei857 – 882HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500427002020 – 923NeuropilinSequence analysisAdd BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 52UniRule annotation
Disulfide bondi80 ↔ 102UniRule annotation
Disulfide bondi145 ↔ 171UniRule annotation
Disulfide bondi204 ↔ 226UniRule annotation
Disulfide bondi273 ↔ 422UniRule annotation
Disulfide bondi429 ↔ 581UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, Glycoprotein, Heparan sulfateARBA annotation, Proteoglycan

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 139CUBInterPro annotationAdd BLAST115
Domaini145 – 263CUBInterPro annotationAdd BLAST119
Domaini273 – 422F5/8 type CInterPro annotationAdd BLAST150
Domaini429 – 581F5/8 type CInterPro annotationAdd BLAST153
Domaini642 – 811MAMInterPro annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni587 – 624DisorderedSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46806:SF4, PTHR46806:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036960, Neuropilin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q69DB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHCGLVLILF TGIFLIVSAL KNDKCGDNIR ITSANYLTSP GYPVSYYPSQ
60 70 80 90 100
KCIWVITAPG PNQRILINFN PHFDLEDREC KYDYVEVRDG VDENGQLVGK
110 120 130 140 150
YCGKIAPSPV VSSGNQLFIK FVSDYETHGA GFSIRYEIFK TGPECSRNFT
160 170 180 190 200
SSSGVIKSPG FPEKYPNNLD CTFMIFAPKM SEIVLEFESF ELEPDTQPPA
210 220 230 240 250
GVFCRYDRLE IWDGFPGVGP YIGRYCGQNT PGRIISYTGT LAMTINTDSA
260 270 280 290 300
IAKEGFSANF TVLERTVPDD FDCTEPLGME TGEIHSDQIM ASSQYSNSWS
310 320 330 340 350
AERSRLNNPE NGWTPLEDTN KEGIQVDLGF LRFVSAIGTQ GAISQETKKK
360 370 380 390 400
YYVKEYKVDV SSNGEDWITI KDGPKQKLFQ GNTNPTDVVK AKFPKPTLTR
410 420 430 440 450
YPRIRPINWE TGIALRFEVY GCKISEYPCS GMLGMVSGLI TDSQITVSSH
460 470 480 490 500
IERTWVSENA RLMTSRSGWM LLPQSQPYAD EWLQIDLAEE KLVKGLIIQG
510 520 530 540 550
GKHRDNKVFM KKFRLGYSNN GSDWKLAMDA TGNKPKIFEG NLNYDTPALR
560 570 580 590 600
TMEPVLTRFV RIYPDRGTPA GMGLRLELLG CEMEVPTVPP TTPAASTTPS
610 620 630 640 650
DECDDDQANC HSGTGDGYDQ TGGTTATETI REMSTIPAFL WFACDFGWAN
660 670 680 690 700
DPSFCGWISE DSGFRWQIQS SGTPTLNTGP NMDHTGGSGN FIYTLATGAQ
710 720 730 740 750
ETEVARLVSP SVSGQDSDLC LSFWYHMFGS HIGTLHIKQR RETSQGSADV
760 770 780 790 800
LLWTVSGHQG NRWREGRVLI PHSNKPYQVI IESVVERKSW GDIAVDDIKI
810 820 830 840 850
LDNVNMADCK DPDVPAEPIQ PEDNINEIMV DITDFPDIVE NPDIGGAGNM
860 870 880 890 900
LKTLDPILIT IIAMSALGVF LGAICGVVLY CACSHSGMSD RNLSALENYN
910 920
FELVDGVKLK KDKLNSQNSY SEA
Length:923
Mass (Da):102,304
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22D6B1EAB49F39C4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY351910 mRNA Translation: AAR11552.1

NCBI Reference Sequences

More...
RefSeqi
NP_852474.2, NM_181497.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
353246

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY351910 mRNA Translation: AAR11552.1
RefSeqiNP_852474.2, NM_181497.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi353246

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
353246
ZFINiZDB-GENE-030519-2, nrp1a

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR46806:SF4, PTHR46806:SF4, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit
PIRSFiPIRSF036960, Neuropilin, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit
SUPFAMiSSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ69DB8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69DB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: April 7, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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