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Entry version 105 (08 May 2019)
Sequence version 1 (13 Sep 2004)
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Protein

Striated muscle preferentially expressed protein kinase

Gene

speg

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1283ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1372Proton acceptorBy similarity1
Binding sitei2711ATPPROSITE-ProRule annotation1
Active sitei2801Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1261 – 1269ATPPROSITE-ProRule annotation9
Nucleotide bindingi2688 – 2696ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Striated muscle preferentially expressed protein kinase (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:speg
Synonyms:apeg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-3230 spega

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343401 – 2995Striated muscle preferentially expressed protein kinaseAdd BLAST2995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 93PROSITE-ProRule annotation
Disulfide bondi639 ↔ 691PROSITE-ProRule annotation
Disulfide bondi861 ↔ 912PROSITE-ProRule annotation
Disulfide bondi2345 ↔ 2397PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q696W0

PRoteomics IDEntifications database

More...
PRIDEi
Q696W0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in striated muscle.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000032236

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q696W0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 109Ig-like 1Add BLAST83
Domaini613 – 701Ig-like 2Add BLAST89
Domaini714 – 802Ig-like 3Add BLAST89
Domaini840 – 930Ig-like 4Add BLAST91
Domaini937 – 1035Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini1135 – 1224Ig-like 5Add BLAST90
Domaini1255 – 1505Protein kinase 1PROSITE-ProRule annotationAdd BLAST251
Domaini2323 – 2413Ig-like 6Add BLAST91
Domaini2420 – 2513Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini2682 – 2934Protein kinase 2PROSITE-ProRule annotationAdd BLAST253

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1571 – 1576Poly-Ser6
Compositional biasi2274 – 2277Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG0613 Eukaryota
ENOG410XQFD LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154379

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q696W0

KEGG Orthology (KO)

More...
KOi
K08809

Database of Orthologous Groups

More...
OrthoDBi
12436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q696W0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015726 Ser/Thr_kin_striated-sp
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR47633:SF3 PTHR47633:SF3, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 6 hits
PF00069 Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 7 hits
SM00408 IGc2, 6 hits
SM00220 S_TKc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q696W0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKVTEEKRH SSSMNSSTVE TSFIAAPPVF LRKLKWAAVA AGCDVRLRVC
60 70 80 90 100
VGGNPRPTLH WYHNDDPLVI DHEDYDGLWI RDCQQADGGL YTCVAVNHLG
110 120 130 140 150
EARTSAVLAV LDLEEDSNST EDESAEPHVS MEMKEQFMPP QGEAINSQPT
160 170 180 190 200
GRGRAMLSHI PSDGLVVERE MRALGSRAPG LQEPLSPGRG QLDFKTSEAT
210 220 230 240 250
PFVQTQPPHK AQASITKSDV DATIDSTATK IKGTKTAMNG AEVSIKSSKI
260 270 280 290 300
TGSHQSGGLQ DPSSIQTPKV SQASSKILDR VRAFEEQSHN SNMPKVSSRL
310 320 330 340 350
SWGFNRTSSC NSEDETCKAG KFQANTKSDV ALKRSFFKQK ASSLEEQSTY
360 370 380 390 400
VQKNFQSKLS EELHRIKKLV GKSNIKKAFS MEQLTQTDKQ SSVSTESVPT
410 420 430 440 450
QVIQKSEETG KHFTNLKAVP DAKERWTTLP KEQSSRLPKI NLADKTKQPE
460 470 480 490 500
NETPPEMNEN QENNSKPTQL LDGQVLNEKV SFIPGQCSPM LPRTNVSRKW
510 520 530 540 550
PKSPAQPMVK DGLVQAPQKP PRLLESISTP PTPFKMTIPT IVVENKPVDE
560 570 580 590 600
ELDQKEGQIM RQNRDALDDF HTSVEKSIAE APMSELPRKD ALGTAGSELL
610 620 630 640 650
QCIIKENTVA RAPAESLLII TRPMQDVKVK AGETALLECF IAGSQAVDVD
660 670 680 690 700
WLANGKLIQP ALFDCKMQFD GHRCRLLFKS AHENDSGCYT CKLSTAKEEL
710 720 730 740 750
ICTANLLVIP SKEPLFTRKL EVLEAIEGRS AQFDCKVSGC PPPEVTWTHC
760 770 780 790 800
EKPLVESDNI HILNVNGHHS LLITHVNKES EGLYTAIAQN VHGKAASSAE
810 820 830 840 850
LYVQEPRPAI STHMSRLEKM PSIPEEPEVP EGEVERRTMP DFIKPLSDLE
860 870 880 890 900
VIEGKEAVLK CRVTGLPYPK ITWYHNGKKI ESTNDRKMTQ YRDVHSLVIQ
910 920 930 940 950
SVCHDHSGVY KCVISNKVGK AACYAHLYVA VSLPEPPDGP PVIESVTGRM
960 970 980 990 1000
ILLSWKKPKN LDPSIDPASL MYVVQQQVLG STQWTTIASS LTDTSYTVTS
1010 1020 1030 1040 1050
LSKGVCYSFR VLSTTGKTLS KPSQPTDLVQ LVDRGEYFRK APVIIDKPDI
1060 1070 1080 1090 1100
VYAVENQPVT ITITINHVQA TCTWKRRGVV LVNKLGALEM TTPDDDQHAL
1110 1120 1130 1140 1150
HIAKVKSTDV GQLIFMANNQ YGSDLGTLQL VIAVPPIFET IMEDLDVCVG
1160 1170 1180 1190 1200
ETCHFAVVVD GKPDPDILWY KDGVLLAESS HLTFVYDDRE CSLVVLNAQP
1210 1220 1230 1240 1250
EDVGVYTCTA KNLAGSVSCK AELTVHTAQN VEEEEEQMED EATILRRMRM
1260 1270 1280 1290 1300
LTDYYDIHKE IGRGAFSYVK RVKHKNDQSF AAKFISVRAK KKTCALRELA
1310 1320 1330 1340 1350
LLAELDHKSI VRFHDAFEKR RVVIILTELC HEELLERITK RTTILESEVQ
1360 1370 1380 1390 1400
SIIRQLLEGI EYLHQNDIIH LDLKPENILM ADQKTDQIRI CDFGNALKVK
1410 1420 1430 1440 1450
PNEELYCKYG IPEFIAPEIV NQSPISKSTD IWPVGVITYL CLTGVSPFAG
1460 1470 1480 1490 1500
ENDRDTLLNI RNYNVAFEES MFKDLCREAK GFIIKVLVSN KLRPDATECL
1510 1520 1530 1540 1550
LHPWFKSLTK GKSINTTLHK QVLARRKWQC SLIRYGSKMV MRSISELLDD
1560 1570 1580 1590 1600
SSSHVSLAVP RNLKDGSPPP SSSSDSDEDI DELPFIPMPH TMMFSGSRMS
1610 1620 1630 1640 1650
LTEIHEVDDK VIRGSNESYK KNLNQLDDIP ESQIIAGQKN EDYLKNPKRT
1660 1670 1680 1690 1700
DNCLQRGSSV EVDQVASKTR RGLMRRGSSA DSALLLQITP EDNEIKDTTE
1710 1720 1730 1740 1750
DSQKHMKKAV SMELPHRSSS PKTAKLSKED YALKLDLMRQ RLLKGGTVNK
1760 1770 1780 1790 1800
NMSGLRGPLL ETLGVDDERR TSSLDRNFRN ARLNASGDSG TFNNDSSEET
1810 1820 1830 1840 1850
YQKPAFRKRS SLRDENSESI SLHRRSGAPL EIPSSSTGDH NVLKIKSTIL
1860 1870 1880 1890 1900
DENKANLPPL FPRDISSKPP TPVLENKQVS KEEANSDVLI MNSSRSAFNL
1910 1920 1930 1940 1950
EDTEIKVEEM KEQDSVPENM NKSTEFPLDI LPHDISSNYC SKLQANGKKA
1960 1970 1980 1990 2000
SFLTPLPTPV LKISQPNIQP TAGRPGVFAS AFSAHQPNLR SDIKNIDSEE
2010 2020 2030 2040 2050
IFEARFKKRE SSLAHGLKRL TRTKSEESSP VPQRKSDEVV YRPGPVGSPL
2060 2070 2080 2090 2100
EFGSTGLKEK SKSVQDLREV DKEVGLGLIG RFSMRARKLQ PIDKKEKKEI
2110 2120 2130 2140 2150
SDSVTNKRQL TWATRRSKSL DKKENFETNK ENLEKDTKKI AESPVLAVRR
2160 2170 2180 2190 2200
KFESNVSGIF DRVHSRSKDR KDKETKPHID AEAPNVEKQD MKKINDSPVL
2210 2220 2230 2240 2250
ALRKKFETKV SGISYRKQSQ SEGEGTKFEG QKTPLFSRHH RSQSDGLIHK
2260 2270 2280 2290 2300
KMDIPENQLP LQTTTISSKE TLNSSSSAHS IESSQTPETE IRSRWDRWGL
2310 2320 2330 2340 2350
SRGKRDRTPS NSRAPATPKE DFPPVFHIAL KDHVLLEGNP VTLSCLPAGS
2360 2370 2380 2390 2400
PEPKILWLKD KKPLKLCDGM NLEACPDGRQ LLMIMNISKK DAGIYECVAT
2410 2420 2430 2440 2450
NNLASVTTSC ILTLACIPNC PGTPEIRQIY NNTVLVQWKP SDTKVPCTYT
2460 2470 2480 2490 2500
IEKKFDGDDK WLTEATGVTD CFFNSSELPS GSTIRFRVAC VNKAGQSPYS
2510 2520 2530 2540 2550
NESDGVSIDT KVTPQHQPAK MKTHSPASFP AMTAAVATSA FSLSLPSVFS
2560 2570 2580 2590 2600
QSISPTPAQS ADVSNTFLEV QSSPKMSTPL DLPKPASSVN TMPPITQTQT
2610 2620 2630 2640 2650
VSPRSYTAPP SIGRSISPVP TYVPATCSLA PTPVSPSVIV VSSISPIGEG
2660 2670 2680 2690 2700
ASSPTPETPT GQAVSSTKSE TTLRQGVPQK PYSFLDEKAR GRFGVIRDCR
2710 2720 2730 2740 2750
ENATGKMFIA KIIPYDQQTK QTIIKEYEIL KSLRCERIMA LHEAYITPRY
2760 2770 2780 2790 2800
LVLITEYCSG KEILQNLIDR FCYSEDDVVG FIVQILQGLE YLHNCKILHL
2810 2820 2830 2840 2850
DIKPDNIMVT NLNVIKIIDF GSAQRFNPLS LQQCSRYLGT LEYMAPEMLK
2860 2870 2880 2890 2900
GDLVGPPADI WSLGVLSYIM LSGRHPFEDK DPQLTEAKIH EAKFDSTKLY
2910 2920 2930 2940 2950
PKVSQSASTF LKKILNSYPW CRPTIKDCLN HSWLHDSYLK KLRRQTLTFT
2960 2970 2980 2990
TTRLKEFMGE HQRRCAESAT KHKVILRVYQ GGPSSPASPT KYTTQ
Length:2,995
Mass (Da):333,684
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C0F6D54CB6BD34D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1LYE8Q1LYE8_DANRE
Striated muscle-enriched protein ki...
spega
2,995Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IS57A0A0R4IS57_DANRE
Striated muscle-enriched protein ki...
spega
2,995Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY578914 mRNA Translation: AAT80902.1

NCBI Reference Sequences

More...
RefSeqi
NP_001007110.1, NM_001007109.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
570504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:570504

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY578914 mRNA Translation: AAT80902.1
RefSeqiNP_001007110.1, NM_001007109.1

3D structure databases

SMRiQ696W0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000032236

Proteomic databases

PaxDbiQ696W0
PRIDEiQ696W0

Genome annotation databases

GeneIDi570504
KEGGidre:570504

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
570504
ZFINiZDB-GENE-030131-3230 spega

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG0613 Eukaryota
ENOG410XQFD LUCA
HOGENOMiHOG000154379
InParanoidiQ696W0
KOiK08809
OrthoDBi12436at2759
PhylomeDBiQ696W0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q696W0

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015726 Ser/Thr_kin_striated-sp
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR47633:SF3 PTHR47633:SF3, 5 hits
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 6 hits
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 7 hits
SM00408 IGc2, 6 hits
SM00220 S_TKc, 2 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEG_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q696W0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2004
Last modified: May 8, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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