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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

GO - Molecular functioni

  • complement component C5a receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303027 C5ar2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 78CytoplasmicSequence analysisAdd BLAST11
Transmembranei79 – 101Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini102 – 120ExtracellularSequence analysisAdd BLAST19
Transmembranei121 – 143Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 208ExtracellularSequence analysisAdd BLAST30
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 243CytoplasmicSequence analysisAdd BLAST12
Transmembranei244 – 266Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini267 – 280ExtracellularSequence analysisAdd BLAST14
Transmembranei281 – 300Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini301 – 343CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030841 – 343C5a anaphylatoxin chemotactic receptor 2Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 192PROSITE-ProRule annotation
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ695P6
PRIDEiQ695P6

PTM databases

iPTMnetiQ695P6
PhosphoSitePlusiQ695P6

Expressioni

Gene expression databases

BgeeiENSRNOG00000049028 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067721

Structurei

3D structure databases

ProteinModelPortaliQ695P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH Eukaryota
ENOG4111DWV LUCA
GeneTreeiENSGT00760000118990
HOVERGENiHBG107547
InParanoidiQ695P6
OMAiAACHWAL
OrthoDBiEOG091G0FUR
PhylomeDBiQ695P6

Family and domain databases

InterProiView protein in InterPro
IPR027809 Anaphtx_C5AR2
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF1 PTHR24225:SF1, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q695P6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNDTTSKDY EYEYDQEQYS DLLNVPVDCP AGNCFSNDAY LIVLLGLYSV
60 70 80 90 100
IFLVGVPGNT LLAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI
110 120 130 140 150
AQKGHWPYGT AGCWLLSSIT VLSMYASVLL LTGLSGDLFL LAFRPSWKNA
160 170 180 190 200
DQRTCGVRVV QVSSWMLALL LTVPGAVYRK LLQEHYPPRL VCGTNYGGSV
210 220 230 240 250
TAEVTITTVR FLFGFLVPLV FMASCHGILQ RQMARRHWPL GTAVVVGFFI
260 270 280 290 300
CWTPFHLLRV IIAVASSHSP LLAWALEAEP LVTGLALAHS ALNPIMFLYF
310 320 330 340
GRKQLCKSLQ AACHWALRDL QDEEESAVTK VSTSQEMVSE MPV
Length:343
Mass (Da):38,123
Last modified:September 13, 2004 - v1
Checksum:iBB3C9C9E517003C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600435 mRNA Translation: AAT12287.1
RefSeqiXP_006228415.1, XM_006228353.3
UniGeneiRn.127117

Genome annotation databases

EnsembliENSRNOT00000071576; ENSRNOP00000067721; ENSRNOG00000049028
GeneIDi445269

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600435 mRNA Translation: AAT12287.1
RefSeqiXP_006228415.1, XM_006228353.3
UniGeneiRn.127117

3D structure databases

ProteinModelPortaliQ695P6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067721

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ695P6
PhosphoSitePlusiQ695P6

Proteomic databases

PaxDbiQ695P6
PRIDEiQ695P6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071576; ENSRNOP00000067721; ENSRNOG00000049028
GeneIDi445269

Organism-specific databases

CTDi27202
RGDi1303027 C5ar2

Phylogenomic databases

eggNOGiENOG410IHWH Eukaryota
ENOG4111DWV LUCA
GeneTreeiENSGT00760000118990
HOVERGENiHBG107547
InParanoidiQ695P6
OMAiAACHWAL
OrthoDBiEOG091G0FUR
PhylomeDBiQ695P6

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-977606 Regulation of Complement cascade

Miscellaneous databases

PROiPR:Q695P6

Gene expression databases

BgeeiENSRNOG00000049028 Expressed in 9 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR027809 Anaphtx_C5AR2
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF1 PTHR24225:SF1, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC5AR2_RAT
AccessioniPrimary (citable) accession number: Q695P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2004
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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