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Entry version 79 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Epstein-Barr nuclear antigen 6

Gene

EBNA6

Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral latency, Viral latency initiation and maintenance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epstein-Barr nuclear antigen 6
Short name:
EBNA-6
Short name:
EBV nuclear antigen 6
Alternative name(s):
Epstein-Barr nuclear antigen 3C
Short name:
EBNA-3C
Short name:
EBV nuclear antigen 3C
Epstein-Barr nuclear antigen 4B
Short name:
EBNA-4B
Short name:
EBV nuclear antigen 4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EBNA6
ORF Names:BERF3-BERF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri82830 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007639 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003759401 – 1069Epstein-Barr nuclear antigen 6Add BLAST1069

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q69140

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host CTPB1; this interaction seems important for EBNA6-mediated transcriptional repression.

Interacts with host MYC; this interaction enhances MYC stability.

Interacts (via N-terminus) with host RBPJ.

Interacts (via N-terminus) with host histone H2AX; this interaction facilitates H2AX proteasomal degradation.

Interacts with host TP73; this interaction inhibits TP73-mediated apoptotic pathway.

By similarity

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
Q69140

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi391 – 976Pro-richAdd BLAST586

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae EBNA-6 family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007706, EBNA-3/4/6

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05009, EBV-NA3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q69140-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFEGEGDS IQSPDNARGD DVQNTGEHIQ DPGPGPSTGG ASEGLVQNEP
60 70 80 90 100
DSRDQQSRGQ RRGDENRGWM QRIRRRRRRR AALSGHLLDM EDNVPPWFPP
110 120 130 140 150
HDITPYVARN IRDAACQAVK HSHLQALSNL ILDSGLDTQH LLCFVMAARQ
160 170 180 190 200
RLQDIRRGPL VVEGGVGWRH WLLTSPSRSW SMGYRTATLR TLTPVPNRVG
210 220 230 240 250
ADSIMLTATF GCQNGALAIN TFSATVWIPP PAGPREQERY AREAEVRFLR
260 270 280 290 300
GKWQRRFRRI FDLIELCGSL HHVWQNMLQT EENLLDFVRF MGVMSSCNSS
310 320 330 340 350
SVNYWFHKTI GNFKPYYPWN APPNENPYHA RRGIKEQVIQ KAFLKAQRQG
360 370 380 390 400
LSMLATGGGP RGDATSETSS DEDTGRQGSD VELESSDDEL PYIDPNMEPV
410 420 430 440 450
QQRPVMFVSR VPVRKPRTLP WPTPKTHPVK RTIVKTSYRS DEAEEAQSTP
460 470 480 490 500
ERPGPSKQPS EPVEPAHTTP AGRSTVILHE PPREPEAVSF KPPPPPSRRR
510 520 530 540 550
RGACVVYDDD IIEVIDVETT EEETTSMQRQ PPLGQQPPPP VISTGSAMSS
560 570 580 590 600
SHTDPSVTQP SKPHRKPQDG FQRSGRRQKR AMPPPVSPSD AGPPSTRPRV
610 620 630 640 650
MAPPSTGPRV MATPSTGPRD MAPPSTGPRD MAPPSTGPRD MAPPSTGPRD
660 670 680 690 700
MAPTVVHMFT RERLLTQSTG PAPRSFWEMR AGRDAPKIQQ EPSSQQQPAT
710 720 730 740 750
QSTPPCQSWV PSVYVLPAVD AGNAQPLQIS HLSSMSPTQP ISHEEQPRYE
760 770 780 790 800
DPDTPLDLSL HPDTATLPPT QDLYPGREDL QATQAPYPGY EEPRPPQAPF
810 820 830 840 850
VGDYGFVQIP SAQWEPHPSQ GTYQGHIDPQ LPAALDLGPE QPRFPQDPYV
860 870 880 890 900
YSGGQLSSCP GYAGPWPSRP QHPRYRHTLA LWPREPRHGH SQGPWKPWSA
910 920 930 940 950
HLPPQWDGSA GHGQDQVSQF PHLHSETGPP RLQLSSVPQV LYPQPLVSSS
960 970 980 990 1000
APSWSSPQPR APIRPIPTRF PPPPMPLQDS MAVGCDSSGT ACPSMPFASD
1010 1020 1030 1040 1050
YSQGAFTPLD INAPTPKSPR VEESSHGPAR CSQATSEAQE ILSDNSEISV
1060
FPKDAKQTDY DASTESELD
Length:1,069
Mass (Da):118,146
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD83B23C41C98709F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34440 Genomic DNA Translation: AAA45895.1
DQ279927 Genomic DNA Translation: ABB89245.1

Protein sequence database of the Protein Information Resource

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PIRi
S27922

NCBI Reference Sequences

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RefSeqi
YP_001129465.1, NC_009334.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5176150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:5176150

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34440 Genomic DNA Translation: AAA45895.1
DQ279927 Genomic DNA Translation: ABB89245.1
PIRiS27922
RefSeqiYP_001129465.1, NC_009334.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

MINTiQ69140

Proteomic databases

PRIDEiQ69140

Genome annotation databases

GeneIDi5176150
KEGGivg:5176150

Family and domain databases

InterProiView protein in InterPro
IPR007706, EBNA-3/4/6
PfamiView protein in Pfam
PF05009, EBV-NA3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEBNA6_EBVA8
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69140
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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